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Sign of Leser-Trélat Associated with Kaposi Sar-coma in an Immunocompetent Man. 一名免疫功能正常男子的莱瑟-特雷拉征兆与卡波西肉瘤有关
Skinmed Pub Date : 2024-08-02 eCollection Date: 2024-01-01
Hershel E Dobkin, Juan P Estrada, Allen Sapadin, Nardin Awad
{"title":"Sign of Leser-Trélat Associated with Kaposi Sar-coma in an Immunocompetent Man.","authors":"Hershel E Dobkin, Juan P Estrada, Allen Sapadin, Nardin Awad","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>A 68-year-old Latino man presented at our clinic with asymptomatic, indurated red nodules and macules of 2-month duration on the left arm, forearm, and palm (Figure 1). Performed punch biopsy presented characteristic -features of Kaposi sarcoma (KS). Immunohistochemistry was positive for human herpesvirus 8 (HHV8), a highly correlated viral marker, confirming the diagnosis of KS (Figure 2). He was referred to oncology for further management, where he was found to be fully immunocompetent with a negative assessment of human immunodefi-ciency virus (HIV). Computed tomography (CT) performed of his chest and abdomen revealed no involvement of internal organs.</p>","PeriodicalId":94206,"journal":{"name":"Skinmed","volume":"22 2","pages":"147-148"},"PeriodicalIF":0.0,"publicationDate":"2024-08-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141877077","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Dresden to "Down Under": The Career of German Dermatologist Erwin Oppenheim. 从德累斯顿到 "大洋彼岸"：德国皮肤科医生埃尔温-奥本海姆的职业生涯。
Skinmed Pub Date : 2024-08-02 eCollection Date: 2024-01-01
Sophie Walter
{"title":"Dresden to \"Down Under\": The Career of German Dermatologist Erwin Oppenheim.","authors":"Sophie Walter","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Erwin Oppenheim (1893-1975) was a successful dermatologist in Dresden, Germany. He with his family fled the country in 1939 because of National Socialism and settled in Melbourne in the Australian state of Victoria. The regulations of Australian universities and medical boards of that era in relation to refugee medicos hindered Oppenheim's registration as a medical practitioner. He was permitted to treat skin conditions, but not allowed to prescribe medications other than some topical preparations. In spite of these restrictions, Oppenheim soon established a busy private practice. He also contributed to dermatology by providing guidance to \"Ego Pharmaceuticals,\" a large company formed by Oppenheim's son and daughter-in-law in 1953 that produces a range of skin and other healthcare products for Australian and global markets.</p>","PeriodicalId":94206,"journal":{"name":"Skinmed","volume":"22 2","pages":"114-119"},"PeriodicalIF":0.0,"publicationDate":"2024-08-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141877069","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Subcutaneous Nodules of the Vulva. 外阴皮下结节
Skinmed Pub Date : 2024-08-02 eCollection Date: 2024-01-01
Anissa Zaouak, Ehsen Ben Brahim, Takoua Bacha, Olfa Midassi, Houda Hammami, Samy Fenniche
{"title":"Subcutaneous Nodules of the Vulva.","authors":"Anissa Zaouak, Ehsen Ben Brahim, Takoua Bacha, Olfa Midassi, Houda Hammami, Samy Fenniche","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>A 32-year-old patient complained of three slow-growing subcutaneous nodules on her right labius majus, present for 3 years. Her past medical history was unremarkable. Cutaneous examination revealed three subcutaneous nodules of 1 cm diameter firmly adherent to the underlying tissues, located on her right labium majorum (Figure 1). Regional lymph nodes were not enlarged. She underwent an excision biopsy of a subcuta-neous nodule under local anesthesia. The gross specimen was firm, white and fleshy in appearance. A skin biopsy was performed, and histological findings revealed a non-encapsulated dermal nodule composed of clusters of polygonal cells with small central nuclei and abundant eosinophilic cytoplasm (Figure 2a). The tumor cells formed sheets and nests irregularly infiltrating between collagen bundles. There was no significant cyto-logic atypia and mitotic features. There were no necrosis and hemorrhage. The cells were positive for S-100 immunostain (Figure 2b). Hence, the diagnosis of benign vulvar granular cell tumor was assessed. The patient underwent surgical excision of the subcutaneous nodules with no recurrence at 2 years.</p>","PeriodicalId":94206,"journal":{"name":"Skinmed","volume":"22 3","pages":"213-214"},"PeriodicalIF":0.0,"publicationDate":"2024-08-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141877098","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Case Report of Red Lunulae after Liver Transplantation. 肝移植后的红肺病例报告
Skinmed Pub Date : 2024-08-02 eCollection Date: 2024-01-01
Gaurav Agnihotri, Amy Z Xu
{"title":"A Case Report of Red Lunulae after Liver Transplantation.","authors":"Gaurav Agnihotri, Amy Z Xu","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>A 50-year-old man with a history of alcoholic cirrhosis status post liver transplant about 3 months prior to consultation presented with abnor-mal appearing fingernails for the past month. He had noted discoloration of his fingernails, which was initially dark pink and asymptomatic. He denied trauma or any new contactants to the nails.</p>","PeriodicalId":94206,"journal":{"name":"Skinmed","volume":"22 3","pages":"221-222"},"PeriodicalIF":0.0,"publicationDate":"2024-08-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141877084","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Chronic Blepharitis: Consider Tinea Blepharo-Ciliaris. 慢性睑缘炎：考虑睑缘炎。
Skinmed Pub Date : 2024-08-02 eCollection Date: 2024-01-01
Meriem Ouedern, Anissa Zaouak, Fehmy Nefaa, Sonia Anane, Monia Cheour
{"title":"Chronic Blepharitis: Consider Tinea Blepharo-Ciliaris.","authors":"Meriem Ouedern, Anissa Zaouak, Fehmy Nefaa, Sonia Anane, Monia Cheour","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>A 7-year-old girl with a history of being in contact with a cat was referred to our department due to her 1-month unilateral blepharitis that was initially treated as a herpetic infection without amelioration. She experienced itching and loss of her right eyelashes (Figure 1). Her visual acuity was 20/20. The slit lamp examination revealed anterior blepharitis with madarosis, broken eyelashes, and lesions in right lower eyelid, while the left eyelids were normal.</p>","PeriodicalId":94206,"journal":{"name":"Skinmed","volume":"22 3","pages":"223-224"},"PeriodicalIF":0.0,"publicationDate":"2024-08-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141877086","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Scapegoats and Silence. 替罪羊与沉默
Skinmed Pub Date : 2024-08-02 eCollection Date: 2024-01-01
Eve J Lowenstein
{"title":"Scapegoats and Silence.","authors":"Eve J Lowenstein","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":94206,"journal":{"name":"Skinmed","volume":"22 2","pages":"85-86"},"PeriodicalIF":0.0,"publicationDate":"2024-08-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141877076","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Short-Term Combination Treatment with Urea 50% and Calcipotriene/Betamethasone -Dipropionate Aerosol Foam in Nail Psoriasis. 50％ 尿素和卡泊三烯/倍他米松-二丙酸气雾剂泡沫对指甲银屑病的短期联合治疗。
Skinmed Pub Date : 2024-08-02 eCollection Date: 2024-01-01
Eleftheria Tampouratzi, Konstantinos Sfaelos, Dimitrios Rigopoulos, George Pesiridis, Maria Kostaki, Giuseppe Micali, Stamatios Gregoriou
{"title":"Short-Term Combination Treatment with Urea 50% and Calcipotriene/Betamethasone -Dipropionate Aerosol Foam in Nail Psoriasis.","authors":"Eleftheria Tampouratzi, Konstantinos Sfaelos, Dimitrios Rigopoulos, George Pesiridis, Maria Kostaki, Giuseppe Micali, Stamatios Gregoriou","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":94206,"journal":{"name":"Skinmed","volume":"22 3","pages":"237-239"},"PeriodicalIF":0.0,"publicationDate":"2024-08-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141877096","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Giant Cerebriform Nevus Lipomatosus Cutaneous- Superficialis with Diffuse Lipomatosis: An Unusual Presentation on the Neck. 伴有弥漫性脂肪瘤病的巨大脑形切面脂肪瘤痣：颈部的异常表现
Skinmed Pub Date : 2024-08-02 eCollection Date: 2024-01-01
Vikasdeep Gupta, Arwinder K Brar, Shivani Bansal, Navdeep Kaur, Anita Kumari
{"title":"Giant Cerebriform Nevus Lipomatosus Cutaneous- Superficialis with Diffuse Lipomatosis: An Unusual Presentation on the Neck.","authors":"Vikasdeep Gupta, Arwinder K Brar, Shivani Bansal, Navdeep Kaur, Anita Kumari","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>A 25-year-old man presented with gradually increasing swelling of 15 years' duration on the left side of his neck. There had been occasional foul-smelling discharge from the swelling. Local examination revealed an 8 cm × 5 cm oblong-shaped, yellowish to skin-colored, soft, -cerebriform swelling. There were multiple open comedones (Figure 1a). The surrounding skin had small and soft skin-colored papules. On palpation, there was no ulceration, tenderness, induration, or bag of worms. A scar from the past surgery was visible. Systemic examina- tion was unremarkable. The differential diagnosis demonstrated plexiform neurofibroma and nevus lipomatosus cutaneous superficialis (NLCS; Figure 2).</p>","PeriodicalId":94206,"journal":{"name":"Skinmed","volume":"22 3","pages":"228-229"},"PeriodicalIF":0.0,"publicationDate":"2024-08-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141877091","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Libtayo® (Cemiplimab-rwlc) Injection for Intravenous Use. 用于静脉注射的 Libtayo®（Cemiplimab-rwlc）注射液。
Skinmed Pub Date : 2024-08-02 eCollection Date: 2024-01-01
Aditya K Gupta, Avantika Mann, Kimberly Vincent, William Abramovits
{"title":"Libtayo<sup>®</sup> (Cemiplimab-rwlc) Injection for Intravenous Use.","authors":"Aditya K Gupta, Avantika Mann, Kimberly Vincent, William Abramovits","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Libtayo<sup>®</sup> (cemiplimab-rwlc) injection for intravenous use was recently approved by the US Food and Drug Administration (FDA) for locally advanced basal cell carcinoma (laBCC) and metastatic basal cell carcinoma (mBCC), both being the advanced stages of BCC. In the past, it was approved by the FDA for the treatment of metastatic cutaneous squamous cell carcinoma (mCSCC) and locally advanced cutaneous squamous cell carcinoma (laCSCC), both being the advanced stages of CSCC. Cemiplimab is a monoclonal antibody that works by blocking the programmed death-1 pathway. In two open-label, single-arm, phase 2 studies, cemiplimab was investigated for the treatment of advanced stages of BCC (study 1620, NCT03132636) and advanced stages of CSCC (study 1540, NCT02760498). The primary endpoint was objec-tive response rate (ORR) per independent central review. In the study 1620, both mBCC and laBCC received cemiplimab 350 mg every 3 weeks. ORR was 21% (6/28) and 31% (26/84) in the mBCC and laBCC groups, respectively. In the study 1520, mCSCC was divided into two groups: one receiving cemiplimab 350 mg every 3 weeks (Q3W) and another receiving 3-mg/kg cemiplimab every 2 weeks (Q2W); the third group, laCSCC, received cemiplimab 3 mg/kg every 2 weeks. ORR was 41% (23/56) in the Q3W group, 49% (29/59) in the Q2W group, and 44% (34/78) in the laCSCC group. An acceptable safety profile and antitumor activity was discovered in patients treated with cemiplimab. The recommended dosage for cemiplimab to treat advanced stages of BCC and CSCC is 350 mg every 3 weeks administered intravenously over 30 min.</p>","PeriodicalId":94206,"journal":{"name":"Skinmed","volume":"22 2","pages":"138-143"},"PeriodicalIF":0.0,"publicationDate":"2024-08-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141877072","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Immunomodulatory Power of Dupilumab: -Implications for Keloid Scar Treatment. 杜匹单抗的免疫调节能力：--对瘢痕疙瘩治疗的启示
Skinmed Pub Date : 2024-08-02 eCollection Date: 2024-01-01
Anika Pulumati, Yanci A Algarin, Dana Jaalouk, Keyvan Nouri
{"title":"The Immunomodulatory Power of Dupilumab: -Implications for Keloid Scar Treatment.","authors":"Anika Pulumati, Yanci A Algarin, Dana Jaalouk, Keyvan Nouri","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Keloids are pathologic responses to cutaneous injury. Current treatments, such as topical and intralesional steroids and even surgical excision, have limited efficacy, creating a demand for improved therapies. Our study explores the functioning of dupilumab, an interleukin-4 and inter-leukin-13 signaling pathway inhibitor, in this context. We have reviewed the literature for using dupilumab to treat keloids, evaluating safety and efficacy and offering recommendations for its application. We searched PubMed and Google Scholar using \"Dupilumab\" and \"Keloid\" as keywords. To ensure relevance, we limited the search to English language publications of 2018-2023. Dupilumab exhibited efficacy in keloid treatment, with notable improvements in patients. One patient reported a 50% reduction in the fibrotic plaque and complete resolution of smaller keloids without adverse effects. Two other patients reported successful stabilization and reduction in keloids following dupilumab therapy; however, the 12-week treatment demonstrated no response or reduction in post-treatment size or height of keloidals, with disease progression observed in one patient. One report discouraged the use of dupilumab for keloids due to limited positive responses. Considering dupilumab as the last therapeutic option to treat keloids may benef patients resistant to standard therapies and/or those highly motivated to reduce keloids.</p>","PeriodicalId":94206,"journal":{"name":"Skinmed","volume":"22 3","pages":"197-202"},"PeriodicalIF":0.0,"publicationDate":"2024-08-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141877100","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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