发布求助
文献互助 智能选刊 最新文献

Skinmed最新文献

筛选
英文 中文
XdemvyTM (Lotilaner Ophthalmic Solution) 0.25% Topical Solution for the Treatment of Demodex Blepharitis. XdemvyTM (Lotilaner Ophthalmic Solution) 0.25% 局部溶液，用于治疗眼睑霉菌病。
Skinmed Pub Date : 2024-03-18 eCollection Date: 2024-01-01
Aditya K Gupta, Avantika Mann, Kimberly Vincent, William Abramovits
{"title":"Xdemvy<sup>TM</sup> (Lotilaner Ophthalmic Solution) 0.25% Topical Solution for the Treatment of <i>Demodex</i> Blepharitis.","authors":"Aditya K Gupta, Avantika Mann, Kimberly Vincent, William Abramovits","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Xdemvy<sup>TM</sup> (lotilaner ophthalmic solution) 0.25% topical solution was recently approved for the treatment of <i>Demodex</i> blepharitis in adults aged ≥18 years. As an antiparasitic agent, lotilaner selectively inhibits gamma-aminobutyric acid chloride channels specific to the parasite and induces spastic paralysis, leading to death of <i>Demodex</i> blepharitis mites. In two randomized, double-masked, vehicle-controlled, multi-center, phase-3 clinical trials (Saturn-1 and Satuirn-2), lotilaner 0.25% topical solution was investigated for the treatment of <i>Demodex</i> blepharitis. Patients were assigned to receive either lotilaner 0.25% topical solution or vehicle (solution that did not contain lotilaner as an active ingredient) twice daily for 6 weeks. On day 43, lotilaner group demonstrated primary efficacy in achieving collarette cure ([collarette grade 0], Saturn-1: study group 44% [92/209], vehicle 7.4% [15/204]; Saturn-2: study group 56% [108/193], vehicle 12.5% [25/200]). Secondary efficacy was achieved by eradication of mite ([0 mite/lash], Saturn-1: study group 67.9% [142/209], vehicle 17.6% [36/304]; Saturn-2: study group 51.8% [99/193], vehicle 14.6% [29/200]), composite cure ([grade 0 collarette as well as grade 0 erythema], Saturn-1: study group 13.9% [29/209], vehicle 1.0% [2/204]; Saturn-2: study group 19.2% [37/193], vehicle 4% [8/200]), and erythema cure ([grade 0 erythema], study group 19.1% [40/209], vehicle 6.9% [14/204]; Saturn-2: study group 31.1% [60/193], vehicle 9.0% [18/199]). The adverse events were mild, with the most common being pain at instillation site. The recommended regimen for lotilaner 0.25% solution is one drop in each eye twice daily for 6 weeks.</p>","PeriodicalId":94206,"journal":{"name":"Skinmed","volume":"22 1","pages":"61-66"},"PeriodicalIF":0.0,"publicationDate":"2024-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140144961","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Atlas of Genital Dermoscopy. 生殖器皮肤镜图谱。
Skinmed Pub Date : 2024-03-18 eCollection Date: 2024-01-01
Annie Jin
{"title":"Atlas of Genital Dermoscopy.","authors":"Annie Jin","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":94206,"journal":{"name":"Skinmed","volume":"22 1","pages":"80"},"PeriodicalIF":0.0,"publicationDate":"2024-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140144948","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
DERM Author Taken to the Cleaners by a Reviewer: So, Do You Think the Reviewer of Your Submission Was Unkind? Read This. DERM 作者被审稿人告上清洁工：那么，你认为你的作品的审稿人不近人情吗？读读这个。
Skinmed Pub Date : 2024-03-18 eCollection Date: 2024-01-01
Mark C Valentine
{"title":"DERM Author Taken to the Cleaners by a Reviewer: So, Do You Think the Reviewer of Your Submission Was Unkind? Read This.","authors":"Mark C Valentine","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Highly critical reviews of medical books are rarely encountered in our age, but this was not always the case. I provide an example of a very negative review of an early medical book that may have blocked the author from further publication.Papers published in reputable journals are subjected to review by experts, whose task is to find weakness in research and/or flaws in its arguments. Published reviews of textbooks that appear these days are generally laudatory, calling attention to the strengths of the book with little mention of any shortcomings. Non-meritorious works are usually winnowed out by the editing process and never make it to publication.</p>","PeriodicalId":94206,"journal":{"name":"Skinmed","volume":"22 1","pages":"14-16"},"PeriodicalIF":0.0,"publicationDate":"2024-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140144951","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Monkeypox: What the Dermatologist Needs to Know. 猴痘：皮肤科医生须知。
Skinmed Pub Date : 2024-03-18 eCollection Date: 2024-01-01
Francisca Regina Oliveira Carneiro, Egon Luiz Rodrigues Daxbacher, Adilson DaCosta, Heitor de Sá Gonçalves, Marcia Ramos-E-Silva, Gerson Oliveira Penna
{"title":"Monkeypox: What the Dermatologist Needs to Know.","authors":"Francisca Regina Oliveira Carneiro, Egon Luiz Rodrigues Daxbacher, Adilson DaCosta, Heitor de Sá Gonçalves, Marcia Ramos-E-Silva, Gerson Oliveira Penna","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Monkeypox, an endemic disease in some African countries, has provoked public health activeness on a global scale that even the World Health Organization (WHO), invoking international health regulations, declared it a public health emergency of international concern (PHEIC). The WHO called attention of member states to exert maximum surveillance over the disease, its patients, and contact persons in order to standardize control measures. A need was directed to provide complete knowledge about the disease, allowing the administration of prior diagnoses as well as isolation and more effective epidemiologic control measures. An updated review on monkeypox emphasized upon having the fundamental aspects of the lesions caused by the disease, and appropriate management of patients upon clinical and epidemiologic evaluation.</p>","PeriodicalId":94206,"journal":{"name":"Skinmed","volume":"22 1","pages":"18-27"},"PeriodicalIF":0.0,"publicationDate":"2024-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140144955","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Preoperative Labile Hypertension with a Perioperative Resolution during Hair Transplant Surgery. 植发手术围手术期可缓解的术前易感高血压。
Skinmed Pub Date : 2024-03-18 eCollection Date: 2024-01-01
Smriti Shrestha, Dhiraj Kc, Barun Bahadur Pradhan, Kamal Subedi, Aseem Sharma
{"title":"Preoperative Labile Hypertension with a Perioperative Resolution during Hair Transplant Surgery.","authors":"Smriti Shrestha, Dhiraj Kc, Barun Bahadur Pradhan, Kamal Subedi, Aseem Sharma","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":94206,"journal":{"name":"Skinmed","volume":"22 1","pages":"72-78"},"PeriodicalIF":0.0,"publicationDate":"2024-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140144956","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Zoonotic Majocchi's Granuloma of the Vulva. 人畜共患的外阴马约奇肉芽肿。
Skinmed Pub Date : 2024-03-18 eCollection Date: 2024-01-01
Larissa M Pastore, Camille E Introcaso
{"title":"Zoonotic Majocchi's Granuloma of the Vulva.","authors":"Larissa M Pastore, Camille E Introcaso","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>A healthy 32-year-old woman presented to clinic with tender pruritic lesions of 2-month duration at the vulva and lesions for weeks on the shins. She was treated with topical corticosteroids and intravenous vancomycin without significant improvement. On examination, dozens of follicular hemorrhagic papulopustules were detected at the suprapubic area and vulva (Figure 1). Similar but less prominent lesions were observed on the shins as well. Biopsies of the vulva and shin revealed a follicular inflammatory infiltrate of neutrophils, histiocytes, and lymphocytes as well as fungal hyphae within the follicular infundibulum and hair shafts, consistent with Majocchi's granuloma (MG). Gram and Fite-Faraco staining, direct immunofluorescence, and bacterial culture were negative. Tissue culture grew <i>Trichophyton mentagrophytes</i>, which was identified using sequence analysis of the D1/D2 region of the 28s rDNA. Minimum inhibitory concentrations for terbinafine, ketoconazole, and itraconazole were determined, with terbinafine having the lowest concentration. Additional history revealed that shortly prior to commencement of her clinical manifestations, the patient had acquired a pet guinea pig with eruptions and hair loss (Figure 2). The patient was prescribed ketoconazole cream and terbinafine, 250 mg daily, with almost immediate improvement. Based on clinical response, the patient remained on terbinafine and ketoconazole cream for 6 months. Her skin remained clear 4 months after discontinuing all antifungals. Based on the results of patient's culture, a veterinarian treated her guinea pig successfully with systemic terbinafine and miconazole lotion.</p>","PeriodicalId":94206,"journal":{"name":"Skinmed","volume":"22 1","pages":"67-68"},"PeriodicalIF":0.0,"publicationDate":"2024-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140144962","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Roundtable Discussion: New Advances in Dermal Health and Technology. 圆桌讨论：皮肤健康与技术的新进展。
Skinmed Pub Date : 2024-03-18 eCollection Date: 2024-01-01
{"title":"Roundtable Discussion: New Advances in Dermal Health and Technology.","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":94206,"journal":{"name":"Skinmed","volume":"22 1","pages":"55-60"},"PeriodicalIF":0.0,"publicationDate":"2024-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140144957","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Diagnostic Dilemma of an Adult-Onset Vascular Tumor. 成人血管肿瘤的诊断难题
Skinmed Pub Date : 2024-03-18 eCollection Date: 2024-01-01
Sanjiv Choudhary, Ankita Srivastava, Rasika Gadkari
{"title":"Diagnostic Dilemma of an Adult-Onset Vascular Tumor.","authors":"Sanjiv Choudhary, Ankita Srivastava, Rasika Gadkari","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":94206,"journal":{"name":"Skinmed","volume":"22 1","pages":"69-70"},"PeriodicalIF":0.0,"publicationDate":"2024-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140144952","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
An Unusual Clinical Presentation of Mibelli's Porokeratosis. 米贝利角化病的异常临床表现
Skinmed Pub Date : 2024-03-18 eCollection Date: 2024-01-01
Antonio Mastrolorenzo, Daniela Massi, Nicola Pimpinelli
{"title":"An Unusual Clinical Presentation of Mibelli's Porokeratosis.","authors":"Antonio Mastrolorenzo, Daniela Massi, Nicola Pimpinelli","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":94206,"journal":{"name":"Skinmed","volume":"22 1","pages":"52-54"},"PeriodicalIF":0.0,"publicationDate":"2024-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140144947","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Spread of STDs-A Preventable Public Health Crisis in the United States. 性传播疾病的蔓延--美国可预防的公共卫生危机。
Skinmed Pub Date : 2024-03-18 eCollection Date: 2024-01-01
Matthew Penna, Theodore Rosen
{"title":"The Spread of STDs-A Preventable Public Health Crisis in the United States.","authors":"Matthew Penna, Theodore Rosen","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":94206,"journal":{"name":"Skinmed","volume":"22 1","pages":"11-13"},"PeriodicalIF":0.0,"publicationDate":"2024-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140144958","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
首页 上一页
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整，为了账户安全，请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们：info@booksci.cn Book学术提供免费学术资源搜索服务，方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号：481959085
Book学术官方微信