Skinmed最新文献_第10页

Laboratory Monitoring in Isotretinoin Therapy for Acne: How Long and How Often Must We Test Our Patients? 异维A酸治疗痤疮的实验室监测：我们必须对患者进行多长时间、多频繁的检测？

Skinmed Pub Date : 2024-08-02 eCollection Date: 2024-01-01

Manuel Gonzalez, Catherine Higham, Sara Al Janahi, Jean S McGee, Hye Jin Chung

{"title":"Laboratory Monitoring in Isotretinoin Therapy for Acne: How Long and How Often Must We Test Our Patients?","authors":"Manuel Gonzalez, Catherine Higham, Sara Al Janahi, Jean S McGee, Hye Jin Chung","doi":"","DOIUrl":"","url":null,"abstract":"The optimal frequency and timing of laboratory monitoring during isotretinoin treatment remains controversial. We aimed to investigate the frequency, timing, and severity of abnormal results during isotretinoin for acne. We conducted a retrospective cohort study comprising 444 acne patients prescribed isotretinoin at Boston Medical Center from 2004 to 2017; these patients had at least one available baseline laboratory result. We categorized patients into two groups: group A (normal values at baseline and during the first 2 months of isotretinoin therapy) and group B (abnormal values at baseline or during the first 2 months of isotretinoin therapy) and assessed the laboratory values after 2 months. The frequency of abnormal results for triglycerides, cholesterol, aspartate aminotransferase (AST), and alanine aminotransferase (ALT) after 2 months for patients in group A was 21.1%, 13.6%, 8.8%, and 6.0%, respectively, with very rare grade 2 (moderate) or higher abnormalities. In contrast, the frequency of abnormal results for patients in group B for triglycerides, cholesterol, AST, and ALT was higher at 67.9%, 88.0%, 40.0%, and 25.0%, respectively (P < 0.05, except for ALT). No patient developed higher than grade 1 (mild) complete blood count (CBC) abnormality. This study proposed that healthy patients with normal results at baseline and during the first 2 months of isotretinoin therapy might not need routine monitoring after month 2 of medication. Routine monitoring of CBC is not necessary.","PeriodicalId":94206,"journal":{"name":"Skinmed","volume":"22 2","pages":"100-107"},"PeriodicalIF":0.0,"publicationDate":"2024-08-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141877071","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Multiple Brown Papules in a Zosteriform Distribution. 带状分布的多发性棕色丘疹

Skinmed Pub Date : 2024-08-02 eCollection Date: 2024-01-01

Anissa Zaouak, Wafa Koubaa, Houda Hammami, Samy Fenniche

引用次数: 0

Veganism in Dermatology: Special Considerations for the Vegan Hair Loss Patient. 皮肤病学中的素食主义：素食者脱发患者的特殊考虑。

Skinmed Pub Date : 2024-08-02 eCollection Date: 2024-01-01

Maria Karim, Elizabeth J Klein, Jamie Widawsky, Jerry Shapiro, Kristen Lo Sicco

引用次数: 0

Dresden to "Down Under": The Career of German Dermatologist Erwin Oppenheim. 从德累斯顿到 "大洋彼岸"：德国皮肤科医生埃尔温-奥本海姆的职业生涯。

Skinmed Pub Date : 2024-08-02 eCollection Date: 2024-01-01

Sophie Walter

引用次数: 0

Sign of Leser-Trélat Associated with Kaposi Sar-coma in an Immunocompetent Man. 一名免疫功能正常男子的莱瑟-特雷拉征兆与卡波西肉瘤有关

Skinmed Pub Date : 2024-08-02 eCollection Date: 2024-01-01

Hershel E Dobkin, Juan P Estrada, Allen Sapadin, Nardin Awad

引用次数: 0

Unilateral Onychodystrophy and Puffy Fingers: Think about Carpal Tunnel Syndrome. 单侧软骨营养不良症和浮肿手指：想想腕管综合症。

Skinmed Pub Date : 2024-08-02 eCollection Date: 2024-01-01

Anissa Zaouak, Amal Chamli, Houda Hammami, Samy Fenniche

{"title":"Unilateral Onychodystrophy and Puffy Fingers: Think about Carpal Tunnel Syndrome.","authors":"Anissa Zaouak, Amal Chamli, Houda Hammami, Samy Fenniche","doi":"","DOIUrl":"","url":null,"abstract":"An 87-year-old man was referred to our department for evaluation of his dystrophic left fingernails that developed progressively for the past 2 years. His past medical history included hemodialysis for 10 years for chronic renal failure. Examination of his nails revealed xanthonychia, onycholysis, Beau's lines, and marked hyperkeratosis of the nail plate involving all of his left fingernails. However, his right fingernails were not affected (Figure 1). He also had edema of the left hand associated with puffy fingers but without trophic disorders (Figure 2). Mycologic exam-ination with direct microscopy and culture of his affected nails were negative. Antinuclear antibodies (ANAs), Scl-70 (anti-topoisomerase) antibodies, anti-centromere antibodies, and anti-RNA polymerase III antibodies were all negative. Capillaroscopy showed no abnormalities. An X-ray of his left hand showed no bony abnormalities. For the past 5 years, the patient had suffered from paresthesia and numbness on the left hand in the area of the median nerve. Paresthesia, pain, burning, and tingling involved mainly the thumb, plus the index and middle fingers, but not the little finger. Carpal tunnel syndrome (CTS) was suspected. Neurologic examination and electromyography (EMG) confirmed the diagnosis of CTS of the left hand explaining his unilateral onychodystrophy. The patient was then referred to a hand surgeon for his CTS.","PeriodicalId":94206,"journal":{"name":"Skinmed","volume":"22 2","pages":"145-146"},"PeriodicalIF":0.0,"publicationDate":"2024-08-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141877082","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Triad of Thyroid Ophthalmopathy, Dermopathy, and Acropachy. 甲状腺眼病、皮肤病和甲状腺肿三联征

Skinmed Pub Date : 2024-08-02 eCollection Date: 2024-01-01

Annie Jin, Medhavi Jogi, Sylvia Hsu

引用次数: 0

Spevigo® (Spesolimab-Sbzo) Injection for the Treatment of Generalized Pustular Psoriasis. 用于治疗泛发性脓疱型银屑病的 Spevigo®（Spesolimab-Sbzo）注射液。

Skinmed Pub Date : 2024-08-02 eCollection Date: 2024-01-01

Aditya K Gupta, Avantika Mann, Kimberly Vincent, William Abramovits

{"title":"Spevigo® (Spesolimab-Sbzo) Injection for the Treatment of Generalized Pustular Psoriasis.","authors":"Aditya K Gupta, Avantika Mann, Kimberly Vincent, William Abramovits","doi":"","DOIUrl":"","url":null,"abstract":"Spevigo® (spesolimab-sbzo) injection was recently approved for the treatment of generalized pustular psoriasis (GPP) in adults aged 18- 75 years. Spesolimab, a monoclonal antibody, binds to the interleukin-36 (IL-36) receptor and prevents its activation by IL-36 cytokines, leading to reduced inflammation, skin lesions, and flares. In a randomized placebo-controlled, phase 2 study (Effisayil-1, NCT03782792), 53 patients were randomized to spesolimab (n = 35) and placebo (n = 18) to evaluate the effect of a one-time 900-mg dose of spesolimab versus placebo against GPP flares. The primary endpoint was Generalized Pustular Psoriasis Physician Global Assessment (GPPGA) pustulation subscore of 0 (no visible pustules) and the key secondary endpoint was the GPPGA total score of 0 or 1 (clear or almost clear skin) at the end of week 1. The primary endpoint was achieved by 54% (19/35) of patients in the spesolimab group and 6% (1/18) of patients in the placebo group. The key secondary endpoint was achieved by 43% (15/35) of patients in the spesolimab group and 11% (2/18) of patients in the placebo group. In the first week, adverse events (mild to severe) were reported in 66% (22/35) of patients in the spesolimab group and 56% (10/18) in the placebo group.","PeriodicalId":94206,"journal":{"name":"Skinmed","volume":"22 2","pages":"134-137"},"PeriodicalIF":0.0,"publicationDate":"2024-08-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141877079","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Scapegoats and Silence. 替罪羊与沉默

Skinmed Pub Date : 2024-08-02 eCollection Date: 2024-01-01

Eve J Lowenstein

引用次数: 0

A Case Report of Red Lunulae after Liver Transplantation. 肝移植后的红肺病例报告

Skinmed Pub Date : 2024-08-02 eCollection Date: 2024-01-01

Gaurav Agnihotri, Amy Z Xu

引用次数: 0