Rejuvenation research最新文献_第4页

The Clinical Effects of Pharmacotherapy Combined with Blood Flow Restriction and Isometric Exercise Training in Rehabilitating Patients with Heart Failure with Reduced Ejection Fraction. 药物治疗结合血流限制和等长运动训练对射血分数降低型心力衰竭患者康复的临床效果。

Rejuvenation research Pub Date : 2024-02-01 DOI: 10.1089/rej.2023.0070

Pinxia Wu, Yu Liu

{"title":"The Clinical Effects of Pharmacotherapy Combined with Blood Flow Restriction and Isometric Exercise Training in Rehabilitating Patients with Heart Failure with Reduced Ejection Fraction.","authors":"Pinxia Wu, Yu Liu","doi":"10.1089/rej.2023.0070","DOIUrl":"10.1089/rej.2023.0070","url":null,"abstract":"Heart failure with reduced ejection fraction (HFrEF) is associated with reduced cardiac function and impaired quality of life. Blood flow restriction (BFR) training is emerging as a potential adjunctive therapy. This study aimed at evaluating the efficacy of combination of BFR and isometric exercises on cardiac function, functional status, and quality of life in HFrEF patients. Totally 44 patients with HFrEF were equally divided into a control group and a combined treatment group. Both groups received standard pharmacotherapy and upper limb exercise, with the combined group also undergoing BFR and isometric exercise training. We assessed demographic and clinical characteristics, New York Heart Association (NYHA) functional classification, cardiac function parameters, serum Brain Natriuretic Peptide levels, physical capacity via the 6-minute walking test, and quality of life using the Heart Failure Questionnaire (Minnesota Living with Heart Failure Questionnaire). Post-treatment, the combined group significantly improved in NYHA classification (p = 0.012), with more patients shifting to a better class. Cardiac function improved in both groups, with the combined group showing a greater increase in mean left ventricular ejection fractions (p < 0.001), and reductions in left ventricular end-diastolic and end-systolic diameters (p < 0.05). The addition of BFR training to standard pharmacotherapy with upper limb exercise in HFrEF patients led to significant enhancements in cardiac function, functional status, and quality of life. These findings support the integration of BFR training into conventional HFrEF treatment regimens to maximize patient recovery outcomes.","PeriodicalId":94189,"journal":{"name":"Rejuvenation research","volume":" ","pages":"33-40"},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139673961","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Acknowledgment of Reviewers 2023. 鸣谢 2023 年审稿人。

Rejuvenation research Pub Date : 2024-02-01 Epub Date: 2023-12-18 DOI: 10.1089/rej.2023.29010.ack

引用次数: 0

Melatonin Ameliorates Sevoflurane Anesthesia-Induced Deficits in Learning and Memory of Aged Mice Through Nrf2 Signaling Related Ferroptosis. 褪黑素通过与铁突变相关的Nrf2信号转导改善七氟醚麻醉引起的老年小鼠学习和记忆缺陷。

Rejuvenation research Pub Date : 2024-02-01 Epub Date: 2024-02-06 DOI: 10.1089/rej.2023.0051

Honghu Ni, Yijia Chen, Yongxiang Xie

{"title":"Melatonin Ameliorates Sevoflurane Anesthesia-Induced Deficits in Learning and Memory of Aged Mice Through Nrf2 Signaling Related Ferroptosis.","authors":"Honghu Ni, Yijia Chen, Yongxiang Xie","doi":"10.1089/rej.2023.0051","DOIUrl":"10.1089/rej.2023.0051","url":null,"abstract":"Our research aimed at investigating the protective effects in aged mice exposed to sevoflurane anesthesia. To assess learning and memory abilities and exploratory behavior, the novel object recognition (NOR) test, Morris water maze (MWM) test, and open field test were employed. Commercial kits were used to measure levels of malondialdehyde, nicotinamide adenine dinucleotide phosphate oxidase activity, superoxide dismutase activity, catalase activity, and iron. The messenger RNA and protein levels of ferritin heavy chain 1, nuclear factor erythroid 2-related factor 2 (Nrf2), heme oxygenase-1, and glutathione peroxidase 4 in the hippocampus were detected. Treatment with melatonin significantly ameliorated the decrease in exploration time of novel objects and the discrimination index induced by sevoflurane anesthesia. Melatonin also reduced escape latencies and increased the time spent in the target quadrant in the MWM test. In the open field test, melatonin-treated mice exhibited greater exploratory activity, including longer distances traveled and a higher number of rearing events. Further, melatonin treatment markedly decreased the levels of oxidative stress markers and iron in the hippocampus of aged mice exposed to sevoflurane anesthesia. However, the beneficial effects of melatonin were significantly attenuated following treatment with the Nrf2 inhibitor ML385. Our results suggest that melatonin could alleviate learning and memory impairment induced by sevoflurane anesthesia in aged mice through its antioxidant properties, partially through the Nrf2 pathway.","PeriodicalId":94189,"journal":{"name":"Rejuvenation research","volume":" ","pages":"24-32"},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139111407","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Irreplaceable Judy Campisi. 无可替代的朱迪-坎皮西

Rejuvenation research Pub Date : 2024-02-01 DOI: 10.1089/rej.2024.0010

Irina Conboy

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Naringenin Orchestrates and Regulates the Reactive Oxygen Species-Mediated Pathways and Proinflammatory Signaling: Targeting Hallmarks of Aging-Associated Disorders. 柚皮苷协调和调节 ROS 介导的途径和促炎信号传导：针对衰老相关疾病的标志。

Rejuvenation research Pub Date : 2024-02-01 DOI: 10.1089/rej.2023.0065

Deepika, Tikam Chand Dakal, Narendra Kumar Sharma, Vipin Ranga, Pawan Kumar Maurya

{"title":"Naringenin Orchestrates and Regulates the Reactive Oxygen Species-Mediated Pathways and Proinflammatory Signaling: Targeting Hallmarks of Aging-Associated Disorders.","authors":"Deepika, Tikam Chand Dakal, Narendra Kumar Sharma, Vipin Ranga, Pawan Kumar Maurya","doi":"10.1089/rej.2023.0065","DOIUrl":"10.1089/rej.2023.0065","url":null,"abstract":"The therapeutic application of flavonoids in the management of infectious diseases, cancers, chronic wounds, aging, and neurodegenerative disorders has been well documented in scientific literature. The citric flavonoid naringenin comes under the category of flavanone and exhibits a plethora of health benefits. Very few flavonoids such as curcumin, resveratrol, catechin, quercetin, and kaempferol have been studied to exert their anti-aging properties in humans. The effect of naringenin in the context of age-associated disorders in detail has not been elucidated yet. The databases used for the literature search were Science Direct, Google Scholar, and PubMed. More emphasis has been put on the recent literature on \"naringenin\" and its effect on \"age-associated disorders.\" Almost all chronic degenerative disorders are characterized by oxidative stress and inflammatory response. The study aims at highlighting the reactive oxygen species-mediated activity of naringenin and the underlying molecular mechanism leading to the prevention of various age-associated disorders. Altogether, the review presents a systematic comprehension of the pharmaceutical and clinicopathological benefits of naringenin in age-associated disorders.","PeriodicalId":94189,"journal":{"name":"Rejuvenation research","volume":" ","pages":"3-16"},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139673960","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Acknowledgment of Reviewers 2023. 鸣谢 2023 年审稿人。

Rejuvenation research Pub Date : 2023-12-18 DOI: 10.1089/rej.2023.29010.ack

引用次数: 0

Advancing Healthspan as a Cross-Sector, Societal Movement to Redirect Research, Medical Science, and Health Care to a New Paradigm. 推动跨部门的社会运动，将研究、医学科学和医疗保健转向新的范式。

Rejuvenation research Pub Date : 2023-12-01 DOI: 10.1089/rej.2023.0059

Melissa King, Bernard Siegel, Eve Herold

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Crosstalk Between Aging, Circadian Rhythm, and Melatonin. 衰老、昼夜节律和褪黑激素之间的串扰。

Rejuvenation research Pub Date : 2023-12-01 Epub Date: 2023-12-04 DOI: 10.1089/rej.2023.0047

Avnish Kumar Verma, Mohammad Idreesh Khan, Fauzia Ashfaq, Syed Ibrahim Rizvi

{"title":"Crosstalk Between Aging, Circadian Rhythm, and Melatonin.","authors":"Avnish Kumar Verma, Mohammad Idreesh Khan, Fauzia Ashfaq, Syed Ibrahim Rizvi","doi":"10.1089/rej.2023.0047","DOIUrl":"10.1089/rej.2023.0047","url":null,"abstract":"Circadian rhythms (CRs) are 24-hour periodic oscillations governed by an endogenous circadian pacemaker located in the suprachiasmatic nucleus (SCN), which organizes the physiology and behavior of organisms. Circadian rhythm disruption (CRD) is also indicative of the aging process. In mammals, melatonin is primarily synthesized in the pineal gland and participates in a variety of multifaceted intracellular signaling networks and has been shown to synchronize CRs. Endogenous melatonin synthesis and its release tend to decrease progressively with advancing age. Older individuals experience frequent CR disruption, which hastens the process of aging. A profound understanding of the relationship between CRs and aging has the potential to improve existing treatments and facilitate development of novel chronotherapies that target age-related disorders. This review article aims to examine the circadian regulatory mechanisms in which melatonin plays a key role in signaling. We describe the basic architecture of the molecular circadian clock and its functional decline with age in detail. Furthermore, we discuss the role of melatonin in regulation of the circadian pacemaker and redox homeostasis during aging. Moreover, we also discuss the protective effect of exogenous melatonin supplementation in age-dependent CR disruption, which sheds light on this pleiotropic molecule and how it can be used as an effective chronotherapeutic medicine.","PeriodicalId":94189,"journal":{"name":"Rejuvenation research","volume":" ","pages":"229-241"},"PeriodicalIF":0.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41242727","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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The Longevist. 长寿者-重点关注该领域的发展。

Rejuvenation research Pub Date : 2023-12-01 DOI: 10.1089/rej.2023.0062

Rhys Anderson

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Dietary Restriction Delays But Cannot Heal Irradiation-Induced Hair Graying by Preserving Hair Follicle Stem Cells in Quiescence. 饮食限制通过保持毛囊干细胞静止来延缓但不能治愈辐射诱导的头发变白。

Rejuvenation research Pub Date : 2023-12-01 Epub Date: 2023-11-29 DOI: 10.1089/rej.2023.0037

Rongrong Qiu, Xingxing Qiu, Mingyue Su, Man Sun, Yiting Wang, Jianying Wu, Hua Wang, Duozhuang Tang, Si Tao

{"title":"Dietary Restriction Delays But Cannot Heal Irradiation-Induced Hair Graying by Preserving Hair Follicle Stem Cells in Quiescence.","authors":"Rongrong Qiu, Xingxing Qiu, Mingyue Su, Man Sun, Yiting Wang, Jianying Wu, Hua Wang, Duozhuang Tang, Si Tao","doi":"10.1089/rej.2023.0037","DOIUrl":"10.1089/rej.2023.0037","url":null,"abstract":"DNA damage represents one of the cell intrinsic causes of stem cell aging, which leads to differentiation-induced removal of damaged stem cells in skin and blood. Dietary restriction (DR) retards aging across various species, including several strains of laboratory mice. Whether, DR has the potential to ameliorate DNA damage-driven stem cell exhaustion remains incompletely understood. In this study, we show that DR strongly extends the time to hair graying in response to γ-irradiation (ionizing radiation [IR])-induced DNA damage of C57BL/6 J mice. The study shows that DR prolongs resting phase of hair follicles. DR-mediated prolongation of hair follicle stem cell (HFSC) quiescence blocks hair growth and prevents the depletion of HFSCs and ckit+ melanoblasts in response to IR. However, prolongation of HFSC quiescence also correlates with a suppression of DNA repair and cannot prevent melanoblast loss and hair graying in the long run, when hair cycling is reinitiated even after extended periods of time. Altogether, these results support a model indicating that nutrient deprivation can delay but not heal DNA damage-driven extinction of melanoblasts by stalling HFSCs in a prolonged state of quiescence coupled with inhibition of DNA repair. Disconnecting these two types of responses to DR could have the potential to delay stem cell aging.","PeriodicalId":94189,"journal":{"name":"Rejuvenation research","volume":" ","pages":"242-252"},"PeriodicalIF":0.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71490714","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0