Rejuvenation research最新文献_第5页

Rejuvenation research Pub Date : 2023-12-01 DOI: 10.1089/rej.2023.0062

Rhys Anderson

引用次数: 0

Dietary Restriction Delays But Cannot Heal Irradiation-Induced Hair Graying by Preserving Hair Follicle Stem Cells in Quiescence. 饮食限制通过保持毛囊干细胞静止来延缓但不能治愈辐射诱导的头发变白。

Rejuvenation research Pub Date : 2023-12-01 Epub Date: 2023-11-29 DOI: 10.1089/rej.2023.0037

Rongrong Qiu, Xingxing Qiu, Mingyue Su, Man Sun, Yiting Wang, Jianying Wu, Hua Wang, Duozhuang Tang, Si Tao

{"title":"Dietary Restriction Delays But Cannot Heal Irradiation-Induced Hair Graying by Preserving Hair Follicle Stem Cells in Quiescence.","authors":"Rongrong Qiu, Xingxing Qiu, Mingyue Su, Man Sun, Yiting Wang, Jianying Wu, Hua Wang, Duozhuang Tang, Si Tao","doi":"10.1089/rej.2023.0037","DOIUrl":"10.1089/rej.2023.0037","url":null,"abstract":"DNA damage represents one of the cell intrinsic causes of stem cell aging, which leads to differentiation-induced removal of damaged stem cells in skin and blood. Dietary restriction (DR) retards aging across various species, including several strains of laboratory mice. Whether, DR has the potential to ameliorate DNA damage-driven stem cell exhaustion remains incompletely understood. In this study, we show that DR strongly extends the time to hair graying in response to γ-irradiation (ionizing radiation [IR])-induced DNA damage of C57BL/6 J mice. The study shows that DR prolongs resting phase of hair follicles. DR-mediated prolongation of hair follicle stem cell (HFSC) quiescence blocks hair growth and prevents the depletion of HFSCs and ckit+ melanoblasts in response to IR. However, prolongation of HFSC quiescence also correlates with a suppression of DNA repair and cannot prevent melanoblast loss and hair graying in the long run, when hair cycling is reinitiated even after extended periods of time. Altogether, these results support a model indicating that nutrient deprivation can delay but not heal DNA damage-driven extinction of melanoblasts by stalling HFSCs in a prolonged state of quiescence coupled with inhibition of DNA repair. Disconnecting these two types of responses to DR could have the potential to delay stem cell aging.","PeriodicalId":94189,"journal":{"name":"Rejuvenation research","volume":" ","pages":"242-252"},"PeriodicalIF":0.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71490714","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

As Rejuvenation Research Expands, We Need to Focus on Identifying the Most Effective, Safest Approaches. 随着返老还童研究的扩展，我们需要把重点放在确定最有效、最安全的方法上。

Rejuvenation research Pub Date : 2023-12-01 Epub Date: 2023-12-04 DOI: 10.1089/rej.2023.29009.editorial

Irina Conboy

引用次数: 0

Retraction of: Tangzhiqing-mediated NRF2 Reduces Autophagy-dependent Ferroptosis to Mitigate Diabetes-related Cognitive Impairment Neuronal Damage (10.1089/rej.2023.0013). 收回：糖志清介导的NRF2减少自噬依赖性铁下垂，以减轻糖尿病相关的认知障碍神经元损伤（10.1089/rej.2023.0013）。

Rejuvenation research Pub Date : 2023-12-01 Epub Date: 2023-11-03 DOI: 10.1089/rej.2023.0013.retract

引用次数: 0

The Association Between Sleep Duration and Sleep-Related Gene Methylation with Osteoporosis in Chinese Postmenopausal Women. 中国绝经后妇女睡眠时间和睡眠相关基因甲基化与骨质疏松症的关系。

Rejuvenation research Pub Date : 2023-12-01 Epub Date: 2023-11-08 DOI: 10.1089/rej.2023.0045

Qianqian Ma, Ting Liu, Ying Li, Hongyu Xu, Qianqian Xiao, Qi Yao

{"title":"The Association Between Sleep Duration and Sleep-Related Gene Methylation with Osteoporosis in Chinese Postmenopausal Women.","authors":"Qianqian Ma, Ting Liu, Ying Li, Hongyu Xu, Qianqian Xiao, Qi Yao","doi":"10.1089/rej.2023.0045","DOIUrl":"10.1089/rej.2023.0045","url":null,"abstract":"This study aims to investigate the association between sleep duration and osteoporosis. In addition, sleep-related gene methylation was also detected in this study and we explored its relationship with osteoporosis. The epidemiological investigation section of this study was designed as a retrospective cross-sectional study. We gathered 148 postmenopausal women from two communities and used questionnaires to collect data of sleep duration and other sleep patterns. Biochemical variables were tested, and bone mineral density was measured by dual-energy X-ray absorptiometry. In addition, sleep-related gene (PER2 and PER3) methylation was tested, and the association with osteoporosis was further studied. Twenty-nine of the 148 participants (aged from 65 to 86 years) who suffered from osteoporosis were tested for osteopenia. A significant difference was observed in the association between sleep duration and osteoporosis; the p-value was 0.013. In addition, in our study, we found that short sleep duration (<7 hours) may increase the risk of osteoporosis compared with longer sleep duration. Moreover, sleep-related genes such as PER2 and PER3 and their CpG island methylation were tested, and there was no significant difference between PER2 and PER3 CpG island methylation and osteoporosis. Short sleep duration may increase the risk of osteoporosis. However, the association between sleep-related gene methylation and osteoporosis was not found.","PeriodicalId":94189,"journal":{"name":"Rejuvenation research","volume":" ","pages":"221-228"},"PeriodicalIF":0.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41143835","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Divide-and-Conquer Approach to Delaying Age-Related Functional Decline: Where Are We Now? 分而治之的方法延缓与年龄相关的功能衰退:我们现在在哪里?

Rejuvenation research Pub Date : 2023-12-01 Epub Date: 2023-12-04 DOI: 10.1089/rej.2023.0057

Aubrey D N J de Grey

引用次数: 0