Personalized medicine最新文献_第4页

Classification and immunotherapy assessment of lung adenocarcinoma based on coagulation-related genes. 基于凝血相关基因的肺腺癌分类及免疫治疗评估。

Personalized medicine Pub Date : 2024-01-01 Epub Date: 2023-12-01 DOI: 10.2217/pme-2023-0094

Yi Zhou, Wangju Fan, Jian Zhou, Shengjie Zhong, Jun Yang, Yanxia Zhong, Guoxiong Huang

引用次数: 0

The roots of (in)equity in precision medicine: gaps in the discourse. 精准医疗（不）公平的根源：话语中的差距。

Personalized medicine Pub Date : 2024-01-01 Epub Date: 2023-12-13 DOI: 10.2217/pme-2023-0097

Sara Green, Barbara Prainsack, Maya Sabatello

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Recent advances in personalized cancer immunotherapy with immune checkpoint inhibitors, T cells and vaccines. 利用免疫检查点抑制剂、T 细胞和疫苗进行个性化癌症免疫疗法的最新进展。

Personalized medicine Pub Date : 2024-01-01 Epub Date: 2023-12-13 DOI: 10.2217/pme-2023-0054

Elnaz Faghfuri

引用次数: 0

Lung cancer, platinum analog-based frontline treatment and pharmacogenetic limitations. 肺癌、以铂类药物为基础的一线治疗和药物遗传学限制。

Personalized medicine Pub Date : 2024-01-01 Epub Date: 2024-11-19 DOI: 10.1080/17410541.2024.2391269

Maryam Saqib, Zari Salahud Din, Sehrish Zafar, Nayla Munawar, Rukhsana Nawaz, Sagheer Ahmed, Mohammad Hamid Hamdard

引用次数: 0

The effect of RNLS gene polymorphisms on preeclampsia susceptibility: a meta-analysis study. RNLS基因多态性对子痫前期易感性的影响：一项荟萃分析研究。

Personalized medicine Pub Date : 2024-01-01 Epub Date: 2024-05-28 DOI: 10.1080/17410541.2024.2341608

Saeedeh Salimi, Abbas Mohammadpour-Gharehbagh, Mohaddeseh Hedayat, Hamidreza Galavi, Mahdiyeh Harati-Sadegh

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Assessment of ADRB1 polymorphism in patients with acute coronary syndrome treated with ticagrelor and aspirin. 评估接受替卡格雷和阿司匹林治疗的急性冠状动脉综合征患者的 ADRB1 多态性。

Personalized medicine Pub Date : 2024-01-01 Epub Date: 2024-04-29 DOI: 10.2217/pme-2024-0004

Xiang Zhang, Qi Yuan, Dawei Zhang

{"title":"Assessment of ADRB1 polymorphism in patients with acute coronary syndrome treated with ticagrelor and aspirin.","authors":"Xiang Zhang, Qi Yuan, Dawei Zhang","doi":"10.2217/pme-2024-0004","DOIUrl":"10.2217/pme-2024-0004","url":null,"abstract":"Background: This study investigated the influence of ADRB1 gene rs1801253 polymorphism on the treatment response of ticagrelor and aspirin in patients with acute coronary syndrome (ACS). Methods: Genetic typing was detected by Sanger sequencing. Platelet inhibition was assessed using thromboelastography. Kaplan-Meier and Cox regression were applied for prognosis analysis. Results: Out of 200 participants, 94 cases with rs1801253-CC genotype and 106 cases with CG+GG genotype were found. There was no significant difference between the rs1801253-CC and CG+GG groups in the number of ST-segment elevation myocardial infarction, non-ST-segment elevation myocardial infarction and unstable angina patients. There was no statistical difference in the basic data of patients in the two groups in terms of age, sex, medical history and medicine use in the dominant model. The rs1801253-CC genotype was a risk prognostic factor for ACS patients based on the Cox regression analysis results. Conclusion: Detecting ADRB1 polymorphism is crucial for ACS patients undergoing treatment with ticagrelor and aspirin.","PeriodicalId":94167,"journal":{"name":"Personalized medicine","volume":" ","pages":"167-174"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140854436","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Precision medicine activities and opportunities for shaping maternal and neonatal health in Qatar. 精准医疗活动和机遇，促进卡塔尔孕产妇和新生儿健康。

Personalized medicine Pub Date : 2024-01-01 Epub Date: 2024-09-30 DOI: 10.1080/17410541.2024.2394397

Nader Al-Dewik, Tala Abuarja, Salma Younes, Gheyath Nasrallah, Mohamed Alsharshani, Faisal E Ibrahim, Muthanna Samara, Thomas Farrell, Palli Valapila Abdulrouf, M Walid Qoronfleh, Hilal Al Rifai

引用次数: 0

miR-559 rs58450758 polymorphism is associated with colorectal cancer risk and prognosis in Chinese Han population. miR-559 rs58450758 多态性与中国汉族人群的结直肠癌风险和预后有关。

Personalized medicine Pub Date : 2024-01-01 Epub Date: 2024-10-22 DOI: 10.1080/17410541.2024.2412512

Hanxing Huang, Lihan Xiao, Min Xiao, Kaiying Chen, Wentian Zheng, Ning Wu

{"title":"miR-559 rs58450758 polymorphism is associated with colorectal cancer risk and prognosis in Chinese Han population.","authors":"Hanxing Huang, Lihan Xiao, Min Xiao, Kaiying Chen, Wentian Zheng, Ning Wu","doi":"10.1080/17410541.2024.2412512","DOIUrl":"10.1080/17410541.2024.2412512","url":null,"abstract":"Aim: This research examined the correlation between miR-559 rs58450758 and the clinical pathological characteristics and prognosis of CRC.Materials & methods: RT-qPCR was utilized to assess the miR-559 expression levels. Chi-square test was used to investigate the relationship between miR-559 and clinical features. The association between rs58450758 different genotypes and CRC risk, as well as clinical pathological parameters, was explored, utilizing logistic regression analysis and chi-square tests. The Cox regression model and Kaplan-Meier analysis evaluated overall survival in individuals with CRC.Results: The miR-559 was down-regulated in CRC patients' serum. The expressions of miR-559 were significantly associated with tumor size, differentiation, TNM stage and lymph node metastasis. The rs58450758 TT genotype and T allele carriers were more prevalent among CRC patients. The rs58450758 polymorphism was notably linked to tumor size, differentiation, TNM stage and lymph node metastasis in CRC patients. Furthermore, CC genotype carriers exhibited a longer survival period than CT/TT genotypes within the CRC population.Conclusion: The miR-559 rs58450758 polymorphism exhibits promise as a potential biomarker for prognosticating the outcomes of CRC.","PeriodicalId":94167,"journal":{"name":"Personalized medicine","volume":" ","pages":"303-311"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142515568","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Diagnostic utility of the 23-gene expression profile test for an atypical intradermal melanocytic proliferation. 23基因表达谱测试对非典型皮内黑色素细胞增殖的诊断效用。

Personalized medicine Pub Date : 2024-01-01 Epub Date: 2023-12-07 DOI: 10.2217/pme-2023-0110

Etan Marks, Anais A Badia, Matthew S Goldberg

引用次数: 0

Introduction of a single-nucleotide variant, rs16851030, into the ADORA1 gene increased cellular susceptibility to hypoxia. 在 ADORA1 基因中引入单核苷酸变体 rs16851030 会增加细胞对缺氧的敏感性。

Personalized medicine Pub Date : 2024-01-01 Epub Date: 2024-10-23 DOI: 10.1080/17410541.2024.2412514

Poh Kuan Wong, Saiful Effendi Syafruddin, Fook Choe Cheah, Norazrina Azmi, Pei Yuen Ng, Eng Wee Chua

{"title":"Introduction of a single-nucleotide variant, rs16851030, into the ADORA1 gene increased cellular susceptibility to hypoxia.","authors":"Poh Kuan Wong, Saiful Effendi Syafruddin, Fook Choe Cheah, Norazrina Azmi, Pei Yuen Ng, Eng Wee Chua","doi":"10.1080/17410541.2024.2412514","DOIUrl":"10.1080/17410541.2024.2412514","url":null,"abstract":"Aim: Rs16851030, a single-nucleotide variant located in the 3'-untranslated region of the ADORA1 gene, has been proposed as a potential marker of caffeine sensitivity in apnea of prematurity. Besides, it is associated with aspirin-induced asthma and the development of acute chest syndrome. However, its functional significance is still unconfirmed. This study aimed to elucidate the functional impact of rs16851030 by using CRISPR/Cas9 approach to induce the DNA variant and attendant physiological changes.Methods: Rs16851030 was introduced into HEK293 cells via homology-directed repair (HDR). Edited cells were fluorescence-enriched, sorted, isolated, and expanded into single-cell-derived clones. The edit was confirmed by Sanger sequencing. RNA sequencing was used to analyze affected pathways.Results: Rs16851030-mutant cells showed increased susceptibility to hypoxia, a condition related to apnea of prematurity. After 24 h of hypoxia, the viability of mutant clones 1 and 2 was low compared with wild-type cells (75.45% and 74.47% vs. 96.34%). RNA sequencing revealed transcriptomic changes linked to this increased vulnerability.Conclusion: Rs16851030 impairs cellular resistance to hypoxia, suggesting its role in conditions like apnea of prematurity. Further research should investigate the molecular mechanisms and transcriptomic alterations caused by rs16851030 under hypoxic conditions.","PeriodicalId":94167,"journal":{"name":"Personalized medicine","volume":" ","pages":"353-366"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142515567","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0