Personalized medicine最新文献_第4页

Association between polymorphisms in microRNA biosynthesis genes and acute lymphoblastic leukemia susceptibility in Chinese children and adolescents. 中国儿童和青少年microRNA生物合成基因多态性与急性淋巴细胞白血病易感性的关系

Personalized medicine Pub Date : 2026-04-01 Epub Date: 2026-04-02 DOI: 10.1080/17410541.2026.2653871

Xiaoqing Cao, Lingyun Wang, Yurou Kang, Ping Tai, Nayun Chen, Yang Liu, Yanli Yang, Daihua Fang, Bangshun He

{"title":"Association between polymorphisms in microRNA biosynthesis genes and acute lymphoblastic leukemia susceptibility in Chinese children and adolescents.","authors":"Xiaoqing Cao, Lingyun Wang, Yurou Kang, Ping Tai, Nayun Chen, Yang Liu, Yanli Yang, Daihua Fang, Bangshun He","doi":"10.1080/17410541.2026.2653871","DOIUrl":"10.1080/17410541.2026.2653871","url":null,"abstract":"Aim: This study investigated associations between SNPs in miRNA-related genes (DROSHA, DGCR8, AGO1, TNRC6B) and acute lymphoblastic leukemia (ALL) susceptibility in Chinese children and adolescents.Methods: A case-control study of 360 patients and 398 matched controls was conducted. Genotyping used the MassARRAY platform, and multifactor dimensionality reduction (MDR) assessed potential SNP-SNP interactions.Results: The DGCR8 rs1640299 was associated with an increased risk under the additive model (AOR = 1.31, 95% CI: 1.05‒1.65, p = 0.02). In males, DGCR8 rs1640299 increased ALL risk (GG vs. TT: AOR = 3.25, 95% CI: 1.49‒7.06, p = 0.003); In females, the C allele of DROSHA rs10035440 demonstrated a protective effect (TC/CC vs. TT: AOR = 0.37, 95% CI: 0.19-0.72, p = 0.004). MDR analysis suggested a high-risk four-SNP combination (OR =2.33, 95% CI:1.73‒3.14, p < 0.0001).Conclusions: This study suggests that DROSHA rs10035440, DGCR8 rs1640299, AGO1 rs636832, and rs139919 May be associated with ALL susceptibility in Chinese children and adolescents. It also suggests that potential interactions may exist between these SNPs.","PeriodicalId":94167,"journal":{"name":"Personalized medicine","volume":" ","pages":"75-82"},"PeriodicalIF":0.0,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147597236","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Assessment of exonic polymorphism of IDH2, KRAS1, TP53, and BRAF2 using PCR-RFLP in hepatocellular carcinoma: a case-control study from Arunachal Pradesh and Sikkim.

Personalized medicine Pub Date : 2026-04-01 Epub Date: 2026-04-13 DOI: 10.1080/17410541.2026.2657976

Chetan Chauhan, Vishal Kumar, Kanwar Narain, Sanjib K Phukan, Santanu Kakoty, Sopai Tawsik, Chewang D Bhutia, Kangjam Rekha Devi

{"title":"Assessment of exonic polymorphism of IDH2, KRAS1, TP53, and BRAF2 using PCR-RFLP in hepatocellular carcinoma: a case-control study from Arunachal Pradesh and Sikkim.","authors":"Chetan Chauhan, Vishal Kumar, Kanwar Narain, Sanjib K Phukan, Santanu Kakoty, Sopai Tawsik, Chewang D Bhutia, Kangjam Rekha Devi","doi":"10.1080/17410541.2026.2657976","DOIUrl":"10.1080/17410541.2026.2657976","url":null,"abstract":"Introduction: The primary liver cancer of greatest concern is hepatocellular carcinoma (HCC). It covers almost 80% of liver cancer in the global population, and in the next two decades, it is expected to increase by 15%. The biomarker-based study has therapeutic potential to enhance therapy responses for HCC.Aim: Thus, the present study investigates genetic polymorphisms in key genes from HCC patients in Arunachal Pradesh and Sikkim, India, where regional and ethnic variation possibly establishes the pattern of mutations.Methods: Hence, we used an in-house structured questionnaire to collect demographic and clinical information. Blood samples were collected from 222 individual patients and those of healthy controls. After sample collection, Genomic DNA was extracted from the whole blood sample for amplification of the key gene region, and PCR-RFLP was followed by Sanger sequencing.Results: Subsequently, the demographic and clinical findings thus highlight that older age, lower educational level, higher exposure to tobacco, and metabolic and alcohol-related comorbidity collectively designate the case population. Additionally, base-level confirmation for KRAS1 (exon 2) and IDH2 (exon 4) through Sanger sequencing, which verified the range of PCR-RFLP-detected mutations.Conclusion: Our findings in the genetic landscape highlight the complexity of hepatocarcinogenesis but also point to potential therapeutic exploitation.","PeriodicalId":94167,"journal":{"name":"Personalized medicine","volume":" ","pages":"97-106"},"PeriodicalIF":0.0,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147679624","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Machine learning-enabled early risk stratification of β-Iactam-induced electrolyte imbalances. 机器学习支持β-内酰胺引起的电解质失衡的早期风险分层。

Personalized medicine Pub Date : 2026-02-01 Epub Date: 2026-02-26 DOI: 10.1080/17410541.2026.2634748

Inho Ryu, Da Hoon Lee, Hyeonwoo Cho, Yunpil Yum, Jiwon Yu, Yewon Cho, Sooryeol Choi, Ki Nam Nam, Yong Duk Jeon, Woorim Kim

{"title":"Machine learning-enabled early risk stratification of β-Iactam-induced electrolyte imbalances.","authors":"Inho Ryu, Da Hoon Lee, Hyeonwoo Cho, Yunpil Yum, Jiwon Yu, Yewon Cho, Sooryeol Choi, Ki Nam Nam, Yong Duk Jeon, Woorim Kim","doi":"10.1080/17410541.2026.2634748","DOIUrl":"10.1080/17410541.2026.2634748","url":null,"abstract":"Aims: To estimate the incidence of β-lactam/β-lactamase inhibitor - associated electrolyte imbalances and develop an internally validated, interpretable prediction model for early risk identification.Patients and methods: We retrospectively analyzed 240 hospitalized adults treated with piperacillin - tazobactam or ampicillin - sulbactam. Electrolyte imbalance was defined as any post-treatment abnormality in sodium, potassium, chloride, calcium, or phosphate using CTCAE v5.0 and predefined reference ranges. Predictors were evaluated using logistic regression and machine learning - based feature selection across five algorithms, followed by repeated stratified cross-validation.Results: Electrolyte imbalances occurred in 71 patients (29.6%). Respiratory disease was associated with higher risk (AOR 2.616; 95% CI 1.072-6.386). Six consensus predictors were selected (age ≥65 years, ARBs, cardiovascular disease, endocrine disease, expectorants, respiratory disease). Logistic regression showed the best overall performance (AUROC 0.68; AUPRC 0.52) with high NPV (~0.80).Conclusions: Electrolyte imbalances were common during β-lactam/β-lactamase inhibitor therapy. An interpretable model using routine clinical variables may support risk-informed monitoring; external validation is warranted.","PeriodicalId":94167,"journal":{"name":"Personalized medicine","volume":" ","pages":"35-42"},"PeriodicalIF":0.0,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147313879","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dual testing with immunohistochemistry and PCR for enhanced accuracy in dMMR/MSI detection in Greek colorectal cancer population: the impact of retesting. 免疫组织化学和PCR双重检测提高希腊结直肠癌人群dMMR/MSI检测的准确性：重新检测的影响

Personalized medicine Pub Date : 2026-02-01 Epub Date: 2026-03-13 DOI: 10.1080/17410541.2026.2644210

Panagiotis Travlos, Alexandros Pergaris, Andreas C Lazaris, Eirini Thymara, Antonis Vylliotis, Charalampos Fanariotis, Stratigoula Sakellariou

{"title":"Dual testing with immunohistochemistry and PCR for enhanced accuracy in dMMR/MSI detection in Greek colorectal cancer population: the impact of retesting.","authors":"Panagiotis Travlos, Alexandros Pergaris, Andreas C Lazaris, Eirini Thymara, Antonis Vylliotis, Charalampos Fanariotis, Stratigoula Sakellariou","doi":"10.1080/17410541.2026.2644210","DOIUrl":"10.1080/17410541.2026.2644210","url":null,"abstract":"Background: Deficient mismatch repair (dMMR) and microsatellite instability (MSI) are pivotal biomarkers in colorectal cancer (CRC). This study aimed to evaluate their prevalence in a Greek CRC cohort and assess the correlation of immunohistochemistry (IHC) with polymerase chain reaction (PCR) analyses, focusing on the role of retesting to resolve discrepancies.Methods: Formalin-fixed, paraffin-embedded tumor samples from 96 patients were tested for four MMR proteins (MLH1, MSH2, MSH6, PMS2) via IHC and five mononucleotide markers (BAT25, BAT26, NR21, NR24, NR27) via PCR. Discordant cases (pMMR/MSI or dMMR/MSS) underwent retesting to refine classification.Results: Thirteen tumors (13.54%) were dMMR/MSI. Before retesting, the correlation coefficient (r) between IHC and PCR was 0.883, with four conflicting cases. Retesting resolved three inconsistencies, improving the correlation to 0.958 and leaving a single persistent discrepancy (pMMR/MSI). PMS2 deficiency, either alone or co-deleted with MLH1, predominated among dMMR tumors. Dual testing of 5 MSI markers and 4 MMR proteins provided diagnostic clarity.Conclusion: In this retrospective, single-center cohort, dual assessment of MMR status by IHC and PCR was associated with near-perfect inter-method agreement and reduced the likelihood of technical misclassification. These findings support the practical value of reflex retesting as a quality-assurance step within a workflow-oriented diagnostic strategy.","PeriodicalId":94167,"journal":{"name":"Personalized medicine","volume":" ","pages":"43-49"},"PeriodicalIF":0.0,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147461530","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

MLH1 rs63749795 variant confers increased risk for endometriosis: a genetic association study. MLH1 rs63749795变异可增加子宫内膜异位症的风险：一项遗传关联研究

Personalized medicine Pub Date : 2026-02-01 Epub Date: 2026-02-24 DOI: 10.1080/17410541.2026.2634750

Niloofar Nazarikhah, Mohammad Javad Mokhtari

{"title":"MLH1 rs63749795 variant confers increased risk for endometriosis: a genetic association study.","authors":"Niloofar Nazarikhah, Mohammad Javad Mokhtari","doi":"10.1080/17410541.2026.2634750","DOIUrl":"10.1080/17410541.2026.2634750","url":null,"abstract":"Aims: The present study aimed to investigate the association between two MutL homolog 1 (MLH1) single-nucleotide polymorphisms (SNPs), rs63749795 and rs63749820, and the risk of endometriosis.Methods: This case-control study included 150 patients with endometriosis and 150 matched healthy controls. Genotyping of the MLH1 polymorphisms was performed using the tetra-primer ARMS-PCR methods.Results: The frequency of alleles and genotypes for the MLH1 rs63749820 polymorphism and the allelic distribution of MLH1 rs63749795 did not differ significantly between patients with endometriosis and healthy controls. However, the MLH1 rs63749795 polymorphism was found to be significantly associated with increased susceptibility to endometriosis in individuals carrying the CT genotype (OR = 2.42, 95% CI = 1.39-4.23, p = 0.001). Furthermore, analysis of the MLH1 rs63749795 and rs63749820 haplotypes revealed that CC and TT were associated with an increased risk of endometriosis. After applying Bonferroni correction for multiple comparisons (adjusted p < 0.0125), the association for TT remained statistically significant. In contrast, the TC haplotype (OR = 0.50, p = 0.0003) demonstrated a robust protective effect against the disease.Conclusion: In the present study, we report for the first time a significant association between the MLH1 rs63749795 polymorphism and susceptibility to endometriosis.","PeriodicalId":94167,"journal":{"name":"Personalized medicine","volume":" ","pages":"1-7"},"PeriodicalIF":0.0,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147278104","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association of XRCC4 and XRCC5 gene polymorphisms with polycystic ovarian syndrome in an Indian cohort. 印度人群中XRCC4和XRCC5基因多态性与多囊卵巢综合征的相关性

Personalized medicine Pub Date : 2026-02-01 Epub Date: 2026-02-23 DOI: 10.1080/17410541.2026.2634607

Nikitha Sridhar, Gayathri Venkatakrishnan, Jiby Jolly Benjamin, Padmavathi Ramaswamy, Sabari Krishnan Baijumon Bindhu, Sharon Benita Antony, Rahul Rajan Mathews Tholath, Teena Koshy

{"title":"Association of XRCC4 and XRCC5 gene polymorphisms with polycystic ovarian syndrome in an Indian cohort.","authors":"Nikitha Sridhar, Gayathri Venkatakrishnan, Jiby Jolly Benjamin, Padmavathi Ramaswamy, Sabari Krishnan Baijumon Bindhu, Sharon Benita Antony, Rahul Rajan Mathews Tholath, Teena Koshy","doi":"10.1080/17410541.2026.2634607","DOIUrl":"10.1080/17410541.2026.2634607","url":null,"abstract":"Aim: Polycystic ovary syndrome (PCOS) is a common endocrine disorder in Indian women, with prevalence influenced by ethnicity, lifestyle, and associated metabolic conditions. Given the emerging link between genomic instability and PCOS, this study aimed to assess the association of polymorphisms in two DNA repair genes, XRCC4 rs28360071 and XRCC5 rs6147172, with PCOS susceptibility in an Indian cohort.Methods: A case-control study was conducted involving 100 women with clinically diagnosed PCOS and 100 healthy controls. Genotyping for XRCC4 intron 3 indel and XRCC5 promoter VNTR was performed using polymerase chain reaction (PCR). Genotype and allele frequencies were compared between groups, and odds ratios (ORs) with 95% confidence intervals (CIs) were calculated to assess risk. Statistical significance was set at p < 0.05.Results: After Bonferroni correction, the XRCC4 D/D genotype showed a strong increased risk with PCOS (OR = 25.3 [p < 0.001]).Conclusion: XRCC4 polymorphism may influence PCOS susceptibility in Indian women.","PeriodicalId":94167,"journal":{"name":"Personalized medicine","volume":" ","pages":"9-14"},"PeriodicalIF":0.0,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147273660","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

OMICs data from Tunisian population: challenges and opportunities in the era of precision medicine. 突尼斯人口组学数据：精准医疗时代的挑战与机遇。

Personalized medicine Pub Date : 2026-02-01 Epub Date: 2026-02-18 DOI: 10.1080/17410541.2026.2632096

Chaima Hkimi, Hamza Yaiche, Selim Kamoun, Jihenne Ben Aissa-Haj, Maroua Boujemaa, Sonia Abdelhak, Kais Ghedira, Yosr Hamdi

{"title":"OMICs data from Tunisian population: challenges and opportunities in the era of precision medicine.","authors":"Chaima Hkimi, Hamza Yaiche, Selim Kamoun, Jihenne Ben Aissa-Haj, Maroua Boujemaa, Sonia Abdelhak, Kais Ghedira, Yosr Hamdi","doi":"10.1080/17410541.2026.2632096","DOIUrl":"10.1080/17410541.2026.2632096","url":null,"abstract":"Objective: The transition to precision medicine (PM) is revolutionizing healthcare by enabling diagnostics and treatments tailored to individual molecular and genetic profiles, with omics sciences at its core. In Tunisia, growing interest is seen through initiatives such as Personalized Medicine in North Africa (PerMediNA).Methods: This study assesses Tunisia's readiness for PM by mapping publicly available omics datasets and related publications using Tunisian human data. A structured search across PubMed and major repositories covered studies published between 2010 and 2023 involving high-throughput technologies.Results: A total of 11 omics datasets were found, mainly genomic, alongside 104 publications, of which 96 focused on genomics. Whole exome sequencing (n = 46) and targeted gene panels (n = 37) were the most used approaches. Only six proteomics, one transcriptomics, and one metagenomics studies were identified; no epigenomics or metabolomics datasets were found. Research centered mainly on cancers, including breast, colorectal, and leukemia. While Tunisia shows progress in genomics, major gaps exist in other omics domains.Conclusions: Advancing PM in Tunisia requires establishing a national omics data repository with ethical governance, promoting North - South collaborations to build capacity in non-genomic omics fields, and fostering public - private partnerships to strengthen infrastructure, data sharing, and sustainable research development.","PeriodicalId":94167,"journal":{"name":"Personalized medicine","volume":" ","pages":"23-33"},"PeriodicalIF":0.0,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146222584","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A review on prognostic biomarker and phytocompound-mediated modulation of signaling pathways in colorectal cancer. 结直肠癌预后生物标志物及植物化合物介导的信号通路调控研究进展。

Personalized medicine Pub Date : 2026-02-01 Epub Date: 2026-02-26 DOI: 10.1080/17410541.2026.2634747

Bhavyaa Krishnakumar, Benedict Christopher Paul, Sabina Evan Prince, Udhaya Lavinya B

{"title":"A review on prognostic biomarker and phytocompound-mediated modulation of signaling pathways in colorectal cancer.","authors":"Bhavyaa Krishnakumar, Benedict Christopher Paul, Sabina Evan Prince, Udhaya Lavinya B","doi":"10.1080/17410541.2026.2634747","DOIUrl":"10.1080/17410541.2026.2634747","url":null,"abstract":"Primary objective: This review aims to summarize and synthesize current knowledge on prognostic biomarkers in colorectal cancer (CRC).Rationale: CRC is one of the most prevalent malignancies worldwide and a leading cause of cancer-related deaths. Identification of effective prognostic biomarkers is critical for improving early diagnosis, monitoring disease progression, and guiding personalized therapies. This review classifies CRC biomarkers into three categories: DNA mutations, epigenetic alterations, and non-coding RNAs, and highlights the integration of molecular biomarkers with phytomedicine-based therapies.Main outcomes and results: Single nucleotide polymorphisms play a major role on gene function as well as pathways such as Wnt/β-catenin, PI3K/AKT and p53, contributing to tumor behavior and therapy response. Phytocompounds have emerged as potential adjuncts to conventional CRC treatments. Compounds like curcumin, resveratrol, and EGCG exhibit anticancer effects by inducing apoptosis, suppressing proliferation, and modulating key signaling pathways. The HCT-116 CRC cell line serves as a reliable in vitro model to evaluate cytotoxicity and pathway-specific effects of phytochemicals.Conclusions and implications: The integration of molecular biomarker profiling with phytocompound-based therapies has the potential to enable more accurate CRC treatments with minimal adverse effects. The future of cancer research should be aimed at clinical validation, better drug delivery and multi-omics integration.","PeriodicalId":94167,"journal":{"name":"Personalized medicine","volume":" ","pages":"51-63"},"PeriodicalIF":0.0,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147313853","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Study on miRNA-146a-5p rs2910164 polymorphism in attention deficit and hyperactive disorder occurrence and development. miRNA-146a-5p rs2910164多态性在注意缺陷和多动障碍发生发展中的研究

Personalized medicine Pub Date : 2026-02-01 Epub Date: 2026-03-05 DOI: 10.1080/17410541.2026.2634610

Wenmin Zhuang, Xuemin Ding, Haixia Luo, Ludan Deng

{"title":"Study on miRNA-146a-5p rs2910164 polymorphism in attention deficit and hyperactive disorder occurrence and development.","authors":"Wenmin Zhuang, Xuemin Ding, Haixia Luo, Ludan Deng","doi":"10.1080/17410541.2026.2634610","DOIUrl":"10.1080/17410541.2026.2634610","url":null,"abstract":"Objectives: This study investigated the role of miR-146a-5p rs2910164 polymorphism in attention deficit hyperactivity disorder (ADHD).Methods: This study included 180 ADHD children and 122 healthy individuals aged 6-12 years. The ADHD children were hospitalized for treatment while healthy individuals were recruited from a local primary school. ADHD patients received 24-week MPH administration, and treatment response was evaluated via ADHD-RS and CGI-S or CGI-I. miR-146a-5p levels were quantified by qRT-PCR. Multivariate logistic regression was employed for the independent risk factors including rs2910164 polymorphism and gender. MiR-146a-5p rs2910164 was genotyped via TaqMan Genotyping method.Results: In ADHD children, GG carriers exhibited markedly higher miR-146a-5p levels than GC/CC carriers. A similar genotype-related elevation was also observed but was less pronounced in control. The effect allele G and male subgroup were significantly associated with ADHD susceptibility. After 24-week MPH administration, GC and CC carriers showed higher odds of successful treatment than GG individuals in both ADHD-RS and CGI-I assessment. miR-146a-5p was increased in ADHD children and showed diagnostic promise.Conclusion: The rs2910164 polymorphism was related to ADHD children in the Chinese population. However, further validation in independent and larger populations is necessary to confirm this relationship and establish its generalizability.","PeriodicalId":94167,"journal":{"name":"Personalized medicine","volume":" ","pages":"15-21"},"PeriodicalIF":0.0,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147358207","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluating the impact of infectious disease pharmacy services on voriconazole dose individualization in pediatric oncology. 评估感染性疾病药房服务对小儿肿瘤科伏立康唑剂量个体化的影响。

Personalized medicine Pub Date : 2025-12-01 Epub Date: 2025-12-02 DOI: 10.1080/17410541.2025.2592525

Mai Samy Azab, Dalia Makhlouf, Omneya Ahmed, Omneya Hassanain, Lobna Shalaby, Mohamed Nagy

{"title":"Evaluating the impact of infectious disease pharmacy services on voriconazole dose individualization in pediatric oncology.","authors":"Mai Samy Azab, Dalia Makhlouf, Omneya Ahmed, Omneya Hassanain, Lobna Shalaby, Mohamed Nagy","doi":"10.1080/17410541.2025.2592525","DOIUrl":"10.1080/17410541.2025.2592525","url":null,"abstract":"Background: The application of personalized medication management for Voriconazole(VCZ), such as therapeutic drug monitoring (TDM), is the gold standard for attaining therapeutic goals in invasive fungal infections. Infectious disease (ID) pharmacists are the best for ensuring the recommendations are properly implemented.Aim: To assess the adherence of healthcare teams to VCZ dose individualization and the impact of the ID pharmacy team.Method: This study included pediatric oncology patients who received VCZ in the inpatient department and had VCZ TDM level measurements for 3 months (from January to March 2019) and after implementing the (ID) pharmacy service during the same months in two different years (2020, 2021).Results: This study included 989 patients who received VCZ; only 588/989 patients (59.5%) had VCZ TDM levels. Dose individualization was required for 62.6% (849/1357) levels, while 37.4% (508/1357) levels were in the therapeutic range. The overall compliance rate with the TDM recommendations was 92.9% (789/849). Additionally, there was a significant increase in VCZ dose individualization adherence after ID pharmacy implementation (88.6% (210/237) vs. 94.6% (579/612), p = 0.002). The rate of doctor acceptance of the ID pharmacist intervention was 94.7%.Conclusion: ID pharmacists' contributions are crucial and can increase clinicians' adherence to individualized dose recommendations.","PeriodicalId":94167,"journal":{"name":"Personalized medicine","volume":" ","pages":"411-420"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145656766","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0