Association of XRCC gene family and CDH1 gene polymorphisms with gastric cancer risk in a Chinese population.

Personalized medicine Pub Date : 2025-04-01 Epub Date: 2025-03-09 DOI:10.1080/17410541.2025.2473306

Yalan Sun, Ying Wang, Mengqiu Xiong, Ping Tai, Lubanga Nasifu, William Chi Shing Cho, Chengbin Zhu, Panfei Hou, Bangshun He

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Abstract

Background: Gastric carcinogenesis is associated with defects in DNA damage repair pathways, in which the XRCC gene family (XRCC1, XRCC5, and XRCC6) play an important role in DNA repair. It is also well known that the CDH1 gene, as a tumor suppressor, influences the development of gastric cancer.

Methods: We recruited 484 gastric cancer patients and 471 controls. DNA genotyping and Helicobacter pylori infection were determined by commercial kits. Association between polymorphisms and gastric cancer risk and survival was evaluated through SPSS 26.0.

Results: Stratified analysis revealed that XRCC1 rs25487 TC/TT was associated with increased gastric cancer risk in the following four subgroups of males (adjusted OR = 1.40, 95% CI: 1.03-1.90, p = 0.031), positive Helicobacter pylori (adjusted OR = 1.58, 95% CI: 1.09-2.28, p = 0.015), tumor stage III-IV (adjusted OR = 1.42, 95% CI: 1.06-1.89, p = 0.017), and non-gastric cardiac adenocarcinoma (adjusted OR = 1.36, 95% CI: 1.02-1.82, p = 0.034). Additionally, survival analysis indicated that XRCC1 rs25487 TC/TT genotype (HR = 1.35, 95% CI: 1.08-1.69, p = 0.010) was associated with unfavorable survival in gastric cancer patients.

Conclusion: XRCC1 rs25487 CC genotype decreased the risk of gastric cancer, and predicted a favorable survival prognosis.

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XRCC基因家族和CDH1基因多态性与中国人群胃癌风险的关系

背景：胃癌发生与DNA损伤修复通路缺陷相关，其中XRCC基因家族（XRCC1、XRCC5、XRCC6）在DNA修复中发挥重要作用。众所周知，CDH1基因作为肿瘤抑制因子，影响胃癌的发生发展。方法：选取胃癌患者484例，对照组471例。DNA基因分型及幽门螺杆菌感染检测试剂盒。通过SPSS 26.0软件评估多态性与胃癌风险和生存的关系。结果：分层分析显示，XRCC1 rs25487 TC/TT与以下4个男性亚组（校正OR = 1.40, 95% CI: 1.03-1.90, p = 0.031）、幽门螺杆菌阳性（校正OR = 1.58, 95% CI: 1.09-2.28, p = 0.015）、肿瘤III-IV期（校正OR = 1.42, 95% CI: 1.06-1.89, p = 0.017）和非胃心腺癌（校正OR = 1.36, 95% CI: 1.02-1.82, p = 0.034）的胃癌风险增加相关。此外，生存分析显示，XRCC1 rs25487 TC/TT基因型（HR = 1.35, 95% CI: 1.08-1.69, p = 0.010）与胃癌患者的不良生存相关。结论：XRCC1 rs25487 CC基因型可降低胃癌发生风险，并预示良好的生存预后。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Personalized medicine

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