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Personalized medicine, the inevitable future of cancer immunotherapy. 个性化医疗，癌症免疫治疗的必然未来。
Personalized medicine Pub Date : 2023-09-01 Epub Date: 2023-10-06 DOI: 10.2217/pme-2023-0083
Mohsen Basiri
{"title":"Personalized medicine, the inevitable future of cancer immunotherapy.","authors":"Mohsen Basiri","doi":"10.2217/pme-2023-0083","DOIUrl":"10.2217/pme-2023-0083","url":null,"abstract":"","PeriodicalId":94167,"journal":{"name":"Personalized medicine","volume":" ","pages":"413-416"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41169949","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Impact of CYP2C9*2 and *3 polymorphisms on valproate-associated adverse drug reactions in individuals living with epilepsy: a case-control study. CYP2C9*2和*3多态性对癫痫患者丙戊酸钠相关药物不良反应的影响：一项病例对照研究。
Personalized medicine Pub Date : 2023-09-01 Epub Date: 2023-10-09 DOI: 10.2217/pme-2023-0033
Kirubakaran Ramakrishnan, Ramasamy Kesavan, Shravan Venkatraman, Sunil K Narayan, Ramachandran Ramesh Kumar, Deepak Shewade
{"title":"Impact of <i>CYP2C9*2</i> and <i>*3</i> polymorphisms on valproate-associated adverse drug reactions in individuals living with epilepsy: a case-control study.","authors":"Kirubakaran Ramakrishnan,&nbsp;Ramasamy Kesavan,&nbsp;Shravan Venkatraman,&nbsp;Sunil K Narayan,&nbsp;Ramachandran Ramesh Kumar,&nbsp;Deepak Shewade","doi":"10.2217/pme-2023-0033","DOIUrl":"10.2217/pme-2023-0033","url":null,"abstract":"<p><p>Epilepsy is characterized by repeated seizure activity. Valproate, a commonly used antiepileptic drug, shows large inter-individual variation in plasma valproic levels and causes many adverse drug reactions. <b>Aim:</b> To find the influence of <i>CYP2C9*2</i> and <i>*3</i> polymorphisms on valproate-associated adverse drug reactions and plasma valproic acid levels in people with epilepsy. <b>Methods:</b> We recruited 158 people with epilepsy (79 cases and 79 controls) from an epilepsy clinic. Steady-state plasma valproic acid levels were measured using liquid chromatography-mass spectrometry and genotyping of <i>CYP2C9</i> variants was carried out with helps of RT-PCR. <b>Results:</b> The presence of a mutant heterozygous genotype showed an odds ratio (OR) of 2.82 (95% CI: 1.10-7.24) and the adjusted OR was 5.39 (95% CI: 1.69-17.16). There was no significant difference in steady-state plasma valproate concentration between genotypes. <b>Conclusion:</b> The presence of a mutant heterozygous <i>CYP2C9</i> genotype possesses five-times the risk of developing adverse drug reactions to valproate in people with epilepsy.</p>","PeriodicalId":94167,"journal":{"name":"Personalized medicine","volume":" ","pages":"417-424"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41143759","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Complete mesogastric excision for gastric cancer: is it the future of gastric cancer surgery? 癌症完全胃中切除术：这是癌症手术的未来吗？
Personalized medicine Pub Date : 2023-09-01 Epub Date: 2023-10-09 DOI: 10.2217/pme-2023-0028
Georgios D Lianos, Christina D Bali, Konstantinos Vlachos, Panagiota Drosou, Stefano Rausei, Michail Mitsis, Dimitrios Schizas
{"title":"Complete mesogastric excision for gastric cancer: is it the future of gastric cancer surgery?","authors":"Georgios D Lianos,&nbsp;Christina D Bali,&nbsp;Konstantinos Vlachos,&nbsp;Panagiota Drosou,&nbsp;Stefano Rausei,&nbsp;Michail Mitsis,&nbsp;Dimitrios Schizas","doi":"10.2217/pme-2023-0028","DOIUrl":"10.2217/pme-2023-0028","url":null,"abstract":"<p><p>Gastric cancer remains undoubtedly one of the most common and deadly cancers worldwide. The global incidence shows wide geographic variation with a high prevalence in Asia. Besides that, there are evident differences in epidemiology, histopathology, tumor location, diagnosis and treatment strategy between east and west countries. Gastric cancer represents an aggressive disease, with many factors influencing its development and also recurrence after surgical resection. New knowledge of disease spread and new routes of metastases are now emerging and the 'novel' concept of complete mesogastric excision for gastric cancer is under consideration and debate. This article aims to analyze and highlight this new concept after a careful literature review, offering also a view toward the future.</p>","PeriodicalId":94167,"journal":{"name":"Personalized medicine","volume":" ","pages":"461-466"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41176534","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Maternal and placental ANRIL polymorphisms and preeclampsia susceptibility. 母体和胎盘ANRIL多态性与先兆子痫易感性。
Personalized medicine Pub Date : 2023-09-01 Epub Date: 2023-10-18 DOI: 10.2217/pme-2023-0073
Mina Asadi-Tarani, Mohsen Saravani, Marzieh Ghasemi, Mahnaz Rezaei, Saeedeh Salimi
{"title":"Maternal and placental <i>ANRIL</i> polymorphisms and preeclampsia susceptibility.","authors":"Mina Asadi-Tarani,&nbsp;Mohsen Saravani,&nbsp;Marzieh Ghasemi,&nbsp;Mahnaz Rezaei,&nbsp;Saeedeh Salimi","doi":"10.2217/pme-2023-0073","DOIUrl":"10.2217/pme-2023-0073","url":null,"abstract":"<p><p><b>Aim:</b> The possible effects of maternal and placental <i>ANRIL</i> polymorphisms on preeclampsia were examined. <b>Methods:</b> The maternal blood of 315 preeclamptic and 317 control women and the placentas of 103 preeclamptic and 133 control women were enrolled in the study. <i>ANRIL</i> polymorphisms were genotyped using a PCR-RFLP method. <b>Results:</b> The maternal <i>ANRIL</i> rs1333048C variant showed a relationship with a lower risk of preeclampsia in codominant and dominant models. The maternal <i>ANRIL</i> rs4977574G variant had a relationship with a lower risk of preeclampsia in codominant and recessive models. There was an association between the placental rs1333048C variant and a lower risk of preeclampsia in codominant and dominant models. <b>Conclusion:</b> Maternal <i>ANRIL</i> rs1333048C and rs4977574G variants and placental rs1333048 variant showed a relationship with a lower risk of preeclampsia.</p>","PeriodicalId":94167,"journal":{"name":"Personalized medicine","volume":"20 5","pages":"445-452"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41242784","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cloud-based digital healthcare development for precision medical hospital information system. 基于云的数字医疗开发，用于精准医疗的医院信息系统。
Personalized medicine Pub Date : 2023-09-01 Epub Date: 2023-10-09 DOI: 10.2217/pme-2023-0074
SeJun Oh, Hyung Joon Joo, Jang Wook Sohn, Sangsoo Park, Jin Su Jang, Jiwon Seong, Kwang Jin Park, Sang Heon Lee
{"title":"Cloud-based digital healthcare development for precision medical hospital information system.","authors":"SeJun Oh,&nbsp;Hyung Joon Joo,&nbsp;Jang Wook Sohn,&nbsp;Sangsoo Park,&nbsp;Jin Su Jang,&nbsp;Jiwon Seong,&nbsp;Kwang Jin Park,&nbsp;Sang Heon Lee","doi":"10.2217/pme-2023-0074","DOIUrl":"10.2217/pme-2023-0074","url":null,"abstract":"<p><p><b>Aim:</b> This study aims to develop a cloud-based digital healthcare system for precision medical hospital information systems (P-HIS). <b>Methods:</b> In 2020, international standardization of P-HIS clinical terms and codes was performed. In 2021, South Korea's first tertiary hospital cloud was established and implemented successfully. <b>Results:</b> P-HIS was applied at Korea's first tertiary general hospital. Common data model-compatible precision medicine/medical service solutions were developed for medical support. Ultrahigh-quality medical data for precision medicine were acquired and built using big data. Joint global commercialization and dissemination/spreading were achieved using the P-HIS consortium and global common data model-based observational medical outcome partnership network. <b>Conclusion:</b> To provide personalized precision medical services in the future, establishing and using big medical data is essential.</p>","PeriodicalId":94167,"journal":{"name":"Personalized medicine","volume":" ","pages":"435-444"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41173497","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cost-effectiveness of alternative NTRK testing strategies in cancer patients followed by histology-independent therapy with entrectinib: an analysis of three European countries. 癌症患者替代NTRK检测策略的成本-效果：对三个欧洲国家的分析。
Personalized medicine Pub Date : 2023-07-01 Epub Date: 2023-09-25 DOI: 10.2217/pme-2022-0070
Heleen Vellekoop, Simone Huygens, Matthijs Versteegh, László Szilberhorn, Tamás Zelei, Balázs Nagy, Rositsa Koleva-Kolarova, Sarah Wordsworth, Maureen Rutten-van Mölken
{"title":"Cost-effectiveness of alternative <i>NTRK</i> testing strategies in cancer patients followed by histology-independent therapy with entrectinib: an analysis of three European countries.","authors":"Heleen Vellekoop,&nbsp;Simone Huygens,&nbsp;Matthijs Versteegh,&nbsp;László Szilberhorn,&nbsp;Tamás Zelei,&nbsp;Balázs Nagy,&nbsp;Rositsa Koleva-Kolarova,&nbsp;Sarah Wordsworth,&nbsp;Maureen Rutten-van Mölken","doi":"10.2217/pme-2022-0070","DOIUrl":"10.2217/pme-2022-0070","url":null,"abstract":"<p><p><b>Aim:</b> To explore variations in the cost-effectiveness of entrectinib across different testing strategies and settings. <b>Methods:</b> Four testing strategies where adult cancer patients received entrectinib if they tested positive for <i>NTRK</i> gene fusions compared with 'no testing' and standard of care (SoC) for all patients were evaluated. <b>Results:</b> Immunohistochemistry for all patients followed by RNA-based next-generation sequencing after a positive result was the optimal strategy in all included countries. However, the incremental net monetary benefit compared with SoC was negative in all countries, ranging between international euros (int€) -206 and -404. In a subgroup analysis with only <i>NTRK</i>-positive patients, the incremental net monetary benefit was int€ 8405 in England, int€ -53,088 in Hungary and int€ 54,372 in The Netherlands. <b>Conclusion:</b> Using the cost-effectiveness thresholds recommended by national guidelines, none of the testing strategies were cost-effective compared with no testing. The implementation of entrectinib is unlikely to become cost-effective in Hungary, due to the large cost difference between the entrectinib and SoC arms, while there might be more potential in England and The Netherlands.</p>","PeriodicalId":94167,"journal":{"name":"Personalized medicine","volume":"20 4","pages":"321-338"},"PeriodicalIF":0.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41173534","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
HEcoPerMed, personalized medicine from a health economic perspective: lessons learned and potential opportunities ahead. HEcoPerMed，从健康经济角度看个性化医疗：经验教训和未来潜在机遇。
Personalized medicine Pub Date : 2023-07-01 Epub Date: 2023-09-22 DOI: 10.2217/pme-2022-0074
Maureen Rutten-van Mölken, Matthijs Versteegh, Balázs Nagy, Sarah Wordsworth
{"title":"HEcoPerMed, personalized medicine from a health economic perspective: lessons learned and potential opportunities ahead.","authors":"Maureen Rutten-van Mölken,&nbsp;Matthijs Versteegh,&nbsp;Balázs Nagy,&nbsp;Sarah Wordsworth","doi":"10.2217/pme-2022-0074","DOIUrl":"https://doi.org/10.2217/pme-2022-0074","url":null,"abstract":"","PeriodicalId":94167,"journal":{"name":"Personalized medicine","volume":"20 4","pages":"299-303"},"PeriodicalIF":0.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41168381","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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