Oncoscience最新文献

{"title":"Lifestyle and hormonal factors affecting semen quality and sperm DNA integrity: A cross-sectional study.","authors":"Saniya Imtiyaz Chamanmalik, Rajendra B Nerli, Pankaja Umarane","doi":"10.18632/oncoscience.627","DOIUrl":"10.18632/oncoscience.627","url":null,"abstract":"<p><strong>Introduction: </strong>Male infertility is a growing public health concern, influenced by modifiable lifestyle factors and hormonal imbalances. However, limited data from India have evaluated their combined impact on semen quality and sperm DNA fragmentation (SDF).</p><p><strong>Methods: </strong>This cross-sectional study included 278 men aged 21-50 years from a tertiary care centre. Semen analysis was performed according to the WHO's 6th edition guidelines. The SDF was evaluated using the Sperm Chromatin Dispersion (SCD) test. Lifestyle details, occupational exposures, and hormonal profiles (FSH, LH, testosterone, AMH, prolactin) were gathered through structured interviews and laboratory testing. Statistical analysis was conducted using SPSS, with <i>p</i> < 0.05 regarded as statistically significant.</p><p><strong>Results: </strong>Men aged >40 years showed a significantly elevated SDF (<i>p</i> = 0.038), although no significant differences were observed in conventional semen parameters. Tobacco and alcohol use were strongly associated with reduced sperm concentration, motility, and morphology (<i>p</i> < 0.001). Alcohol use was also associated with an increased SDF (<i>p</i> = 0.023). Abnormal BMI was correlated with poorer semen quality and higher SDF (<i>p</i> < 0.001). Occupational heat exposure significantly contributed to elevated SDF levels (<i>p</i> = 0.013). Hormonal analysis showed that low testosterone and elevated prolactin levels were associated with abnormal semen profiles, whereas low AMH levels were significantly correlated with increased SDF (<i>p</i> = 0.011).</p><p><strong>Conclusions: </strong>Lifestyle habits and hormonal imbalances significantly affect the fertility of men. Clinical evaluation should be integrated into infertility assessments and counselling.</p>","PeriodicalId":94164,"journal":{"name":"Oncoscience","volume":"12 ","pages":"115-129"},"PeriodicalIF":0.0,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12490863/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145234858","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"When strokes reveal a hidden malignancy: An atypical case of metastatic colorectal cancer with extensive thromboembolism.","authors":"Md Tanzim Ahsan, Sultana Azreen","doi":"10.18632/oncoscience.626","DOIUrl":"10.18632/oncoscience.626","url":null,"abstract":"<p><p>Cancer-associated thromboembolism and Trousseau's syndrome, which are paraneoplastic hypercoagulable states, are significant yet frequently underrecognized causes of cryptogenic stroke. We report a 71-year-old male who presented with recurrent embolic strokes and systemic thrombosis, later diagnosed with metastatic colorectal adenocarcinoma. Despite extensive investigations, no initial cancer-related symptoms were noted, and the diagnosis was made retrospectively after supraclavicular lymph node biopsy. The patient exhibited multi-territory infarcts, deep vein thrombosis, and renal and splenic infarcts, highlighting the aggressive thrombotic potential of malignancy-associated stroke. This case highlights the importance of early consideration of occult malignancy in cryptogenic embolic events, supporting comprehensive oncologic evaluation for unexplained hypercoagulable states.</p>","PeriodicalId":94164,"journal":{"name":"Oncoscience","volume":"12 ","pages":"107-114"},"PeriodicalIF":0.0,"publicationDate":"2025-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12453219/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145133157","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adult fibrosarcoma: From clinical challenges to cutting-edge innovations.","authors":"Reshmi Sultana, Suryadevara Sailaja","doi":"10.18632/oncoscience.624","DOIUrl":"10.18632/oncoscience.624","url":null,"abstract":"<p><p>Adult fibrosarcoma is a rare and aggressive soft tissue malignancy originating from spindle-shaped fibroblasts, primarily affecting deep soft tissues in the extremities, trunk, head, and neck. Surgical resection with R0 margins remains the gold standard, with adjuvant radiation therapy recommended for large or high-grade tumors to reduce recurrence risk. Chemotherapy and immunotherapy play complementary roles in disease management, with emerging strategies targeting matrix metalloproteinases and tumor microenvironment interactions to enhance chemosensitivity and overcome drug resistance. Despite advances in treatment, prognosis remains poor due to the tumor's aggressive nature. However, early detection with complete surgical excision and multimodal therapies offer the best prospects for improved patient survival.</p>","PeriodicalId":94164,"journal":{"name":"Oncoscience","volume":"12 ","pages":"91-95"},"PeriodicalIF":0.0,"publicationDate":"2025-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12410976/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145016940","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prognostic significance of trophoblastic differentiation and β-hCG secretion in somatic malignancies of uterine corpus: A systematic review with survival analysis.","authors":"Mishu Mangla, Seetu Palo, Harpreet Kaur, Poojitha Kalyani Kanikaram, Emine A Rahiman","doi":"10.18632/oncoscience.625","DOIUrl":"10.18632/oncoscience.625","url":null,"abstract":"<p><strong>Background: </strong>Trophoblastic differentiation or beta-human chorionic gonadotropin (β-hCG) secretion in endometrial carcinoma has been associated with poorly differentiated and aggressive tumors; however, the evidence is largely inconclusive. The review aimed to explore the prognostic role of trophoblastic differentiation and β-hCG in non-trophoblastic, primary uterine corpus cancers.</p><p><strong>Methodology: </strong>A comprehensive electronic search across databases was conducted for all cases of cancers of the uterine corpus that were either associated with elevated levels of β-hCG or showed evidence of trophoblastic differentiation upon microscopy or both. Cases of gestational choriocarcinoma, trophoblastic tumors, tumors other than uterine corpus, and those tumors of uterine corpus but not reporting β-hCG as a marker were excluded. Data regarding patients' clinic-demographic details, tumor characteristics, β-hCG levels at the time of presentation, and how these values change with treatment, its peak levels, the extent of loco-regional metastasis, details of treatment received, and case fatality were extracted and analysed statistically.</p><p><strong>Results: </strong>A total of 35 case reports/case series with a total of 40 cases were included in the present review. The mean age at presentation was 57.75 ± 17.22 years. Nulliparity, obesity, hypertension, and diabetes were important risk factors. Post-menopausal or abnormal uterine bleeding was the commonest presenting complaint. Trophoblastic differentiation or β-hCG expression was found to be associated with high tumor grade, poor differentiation, and poor overall patient survival. The lung was the most common site of metastasis.</p><p><strong>Conclusions: </strong>Trophoblastic differentiation or elaboration of β-hCG in cancers of the uterine corpus is a rarity, and the majority of them are associated with a grim prognosis, secondary to being associated with poor differentiation, early hematogenous dissemination, and resistance to chemo-radiotherapy. Measurement of pre-operative β-hCG may be considered in all cases of endometrial carcinomas and sarcomas, and if found elevated, immunohistochemical examination with β-hCG should be carried out.</p>","PeriodicalId":94164,"journal":{"name":"Oncoscience","volume":"12 ","pages":"96-106"},"PeriodicalIF":0.0,"publicationDate":"2025-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12410977/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145016989","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Burnout among oncology nurses and technicians in Morocco: Prevalence, risk factors, and structural equation modeling.","authors":"Imane Errami, Saber Boutayeb, Hassan Errihani","doi":"10.18632/oncoscience.623","DOIUrl":"10.18632/oncoscience.623","url":null,"abstract":"<p><strong>Background: </strong>Burnout is an increasing concern in oncology, with significant implications for staff well-being and the quality of care delivery. This study aimed to determine the prevalence of burnout among oncology healthcare professionals in Morocco, primarily nurses and technicians, and to identify associated sociodemographic and occupational factors.</p><p><strong>Materials and methods: </strong>A cross-sectional study was conducted from September to December 2024 at the National Institute of Oncology in Rabat. Ninety-one healthcare professionals completed the Maslach Burnout Inventory-Human Services Survey (MBI-HSS). Structural Equation Modeling (SEM) was used to explore the interrelationships among the three burnout dimensions.</p><p><strong>Results: </strong>Severe burnout was identified in 61.5% of participants. Emotional exhaustion was the most affected dimension (70.4% moderate or high), followed by depersonalization (57.1%). While 50.5% reported high levels of personal accomplishment, 24.2% reported low fulfillment. Higher levels of burnout were associated with younger age, female gender, nursing roles, and night shift work. SEM analysis confirmed the central role of emotional exhaustion in predicting both increased depersonalization (β = 0.524, <i>p</i> = 0.002) and reduced personal accomplishment (β = -0.820, <i>p</i> = 0.003).</p><p><strong>Discussion and conclusion: </strong>Burnout is highly prevalent among oncology healthcare professionals in Morocco, particularly among young female nurses. Key contributing factors include age, gender, level of seniority, and shift schedules. Participants emphasized the importance of reducing workload, improving working conditions, adjusting salaries, and promoting continuing education. Institutional interventions are urgently needed to address burnout and protect healthcare worker well-being.</p>","PeriodicalId":94164,"journal":{"name":"Oncoscience","volume":"12 ","pages":"79-90"},"PeriodicalIF":0.0,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12327364/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144796581","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A rare case of pure non-gestational ovarian choriocarcinoma: Diagnostic mimicry and management strategies.","authors":"Naina Kumar, Abhishek Arora, Gunvanti Rathod, Mishu Mangla, Aparna Setty, Pooja T Rathod, Banka Sai Swetha","doi":"10.18632/oncoscience.622","DOIUrl":"10.18632/oncoscience.622","url":null,"abstract":"<p><strong>Background: </strong>Non-gestational ovarian choriocarcinomas (NGOC) are rare, distinct, highly aggressive tumors, primarily affecting young women. It accounts for less than 0.6% of malignant ovarian germ cell tumors. It is associated with a poorer prognosis compared to gestational choriocarcinoma.</p><p><strong>Case presentation: </strong>A 36-year-old woman (P2L2) presented with intermittent heavy menstrual bleeding for the past three months. The urinary pregnancy test was positive. On abdominal examination, a solid mass consistent with 20-weeks gravid uterus was palpated in right iliac fossa. Bimanual pelvic examination revealed uterus deviated to the left and large (~12 × 10 cm) predominantly solid mass arising from right adnexa, adherent to the uterus. A mobile cystic mass (6 × 5 cm) was palpated in the left fornix. Ultrasonography showed normal-sized uterus with no gestational sac and a well-defined, solid-cystic right adnexal mass (10.2 × 7.8 × 7.8 cm) with vascularized solid areas and hemorrhage, initially suggesting an ectopic pregnancy. Serum β-hCG was markedly elevated (262,809 mIU/mL; normal level <5.0 mIU/mL). Magnetic Resonance Imaging (MRI) and Contrast-enhanced Computed Tomography (CECT) revealed right ovarian germ cell tumor, likely choriocarcinoma, without evidence of metastatic disease. On staging laparotomy, hemorrhagic right tubo-ovarian mass (8.5 × 8 × 7 cm) and left ovarian serous cystadenoma (8 × 7 × 3.5 cm) were identified. Histopathology and genomic studies confirmed stage IA1 NGOC. Patient completed two cycles of adjuvant chemotherapy with Bleomycin, Etoposide, Cisplatin, achieving complete response (β-hCG <5 mIU/mL), and is following up with serial β-hCG monitoring and CT scans for two years.</p><p><strong>Conclusions: </strong>NGOC closely mimics ectopic pregnancy and gestational trophoblastic disease and requires early diagnosis with prompt surgical and chemotherapeutic intervention to optimize outcomes.</p>","PeriodicalId":94164,"journal":{"name":"Oncoscience","volume":"12 ","pages":"70-78"},"PeriodicalIF":0.0,"publicationDate":"2025-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12306643/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144746675","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Navigating diagnostic complexity: A case report on uterine lipoleiomyoma, unveiling its benign nature amidst characteristics resembling liposarcoma.","authors":"Seetu Palo, Mishu Mangla, Annapurna Srirambhatla, Anwesha Dutta Chowdhury, Naina Kumar","doi":"10.18632/oncoscience.621","DOIUrl":"10.18632/oncoscience.621","url":null,"abstract":"<p><p>Lipoleiomyomas, rare variants of uterine leiomyomas, are characterized by the presence of mature adipocytes along with benign smooth muscle cells. The literature on this is limited to a few case reports and observational studies only. Presented here is a rare case of co-existing intramural and subserosal uterine lipoleiomyoma in a post-menopausal woman who had attained menopause 25 years prior. The 75-year-old patient, with a history of hypertension and diabetes, presented with lower abdominal pain. Imaging revealed an intramural degenerated fibroid in the anterior wall, measuring 7 × 6 × 5 cm, and another subserosal fibroid, measuring 2.5 × 2 × 1.5 cm, in the posterior uterine wall. A total abdominal hysterectomy with bilateral salpingo-oophorectomy was performed, with microscopy revealing lipoleiomyoma with high intra-tumoral mast cells and eosinophils. This case highlights that lipoleiomyomas can present many years after attaining menopause. Diligent microscopic examination should be carried out to render an accurate diagnosis and to rule out other adipocyte-containing neoplastic lesions. This uncommon variant of uterine lipoleiomyoma poses a distinctive set of considerations for healthcare professionals, and our report seeks to contribute to the expanding knowledge base surrounding this unique condition.</p>","PeriodicalId":94164,"journal":{"name":"Oncoscience","volume":"12 ","pages":"65-69"},"PeriodicalIF":0.0,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12232847/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144585996","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Integrating molecular diagnostics for early prostate cancer detection.","authors":"Pankaja B Umarane, R B Nerli, Saniya Chaman Malik","doi":"10.18632/oncoscience.620","DOIUrl":"10.18632/oncoscience.620","url":null,"abstract":"<p><strong>Introduction: </strong>Prostate cancer (PCa) is one of the most common malignancies in men and accurate diagnostic tools are needed for early detection and risk stratification. Standard diagnostic modalities have limitations including low specificity, overdiagnosis, and procedural invasiveness. We investigate the utility of molecular diagnostics, restriction fragment length polymorphism (RFLP) for identifying mutations in genes that predispose to PCa.</p><p><strong>Methods: </strong>The present prospective case-control study included 136 participants (66 cases and 70 controls). DNA was extracted for the evaluation of specific BRCA1, BRCA2, HOXB13, RNASEL, and ELAC2 single nucleotide polymorphisms (SNPs) using PCR-RFLP.</p><p><strong>Result: </strong>The association of BRCA2 (rs80359550) and HOXB13 (rs9900627) mutations with the risk of developing PCa was statistically significant (<i>p</i> < 0.0001 and <i>p</i> = 0.0139, respectively) and the odds ratios confirmed a strong genetic susceptibility.</p><p><strong>Discussion: </strong>Our findings further underscore the relevance of RFLP-based genotyping as an affordable substitute for NGS, in light of limited accessibility in many resource-limited settings.</p><p><strong>Conclusions: </strong>Integrating genetic, molecular, or imaging readouts with additional imaging modalities, such as mpMRI offers opportunities for improved diagnostic accuracy and conceivable tailored treatment approaches. Larger multiethnic studies are needed to confirm these findings and define a genetic screening protocol for PCa.</p>","PeriodicalId":94164,"journal":{"name":"Oncoscience","volume":"12 ","pages":"58-64"},"PeriodicalIF":0.0,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12109692/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144163900","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A rare case: Pure Sertoli cell tumor uncovered in atrophic ovary during postmenopausal vault prolapse evaluation.","authors":"Naina Kumar, Ashutosh Rath, Nireesha Bukke, Pooja T Rathod, Jarathi Aparna","doi":"10.18632/oncoscience.619","DOIUrl":"10.18632/oncoscience.619","url":null,"abstract":"<p><strong>Introduction: </strong>Sertoli-Leydig cell tumors (SLCTs) are rare ovarian neoplasms, accounting for less than 0.2% of all primary ovarian tumors. Among these, pure Sertoli cell tumors (SCTs) are exceptionally rare, comprising only 4% of Sertoli-stromal tumors. While SCTs are more commonly observed in young women, they can occur across all age groups. They are often associated with estrogen or progesterone production, whereas testosterone production is extremely uncommon.</p><p><strong>Case report: </strong>A 70-year-old postmenopausal woman with a history of hysterectomy 20 years ago presented with complaints of a vaginal bulge and reduced urine output for 4-5 months. She had a prior diagnosis of periampullary carcinoma (pT1aN0), treated with surgery and adjuvant chemotherapy using gemcitabine. Clinical examination revealed a fair general condition and unremarkable abdominal findings. Per speculum examination showed vault prolapse with third-degree cystocele and minimal rectocele but no signs of stress urinary incontinence. The patient underwent abdominal sacrocolpopexy for vault prolapse. During surgery, both atrophic ovaries and fallopian tubes were identified and removed. Histopathological examination confirmed a Stage Ia pure SCT in the right ovary, with no malignancy in the left ovary or fallopian tubes.</p><p><strong>Conclusion: </strong>The incidental discovery of a pure SCT in an atrophic ovary during pelvic surgery in a postmenopausal woman is exceedingly rare. This case highlights the importance of meticulous intraoperative inspection and histopathological evaluation, even in asymptomatic atrophic ovaries.</p>","PeriodicalId":94164,"journal":{"name":"Oncoscience","volume":"12 ","pages":"52-57"},"PeriodicalIF":0.0,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12097164/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144129833","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The chemopreventive effects of native Brazilian plants on stomach cancer: A review of the last 25 years.","authors":"Iara Lopes Lemos, Maria Josiane Macedo, Ana Paula da Fonseca Machado, Roberto de Paula do Nascimento, Lívia Mateus Reguengo, Valeria Helena Alves Cagnon, Mario Roberto Marostica Junior","doi":"10.18632/oncoscience.618","DOIUrl":"https://doi.org/10.18632/oncoscience.618","url":null,"abstract":"<p><p>Stomach cancer (SC) is the fifth most prevalent and deathly type of cancer worldwide. This is a multifactorial disease, and its development can be influenced by both genetic factors and dietary habits. On the other hand, a regular consumption of fruit and vegetables rich in bioactive compounds, such as polyphenols and flavonoids, has demonstrated anti-inflammatory, antioxidant, and chemopreventive effects on SC. Brazil, which has a vast plant diversity, appears to be a promising scenario for investigating species with potential anti-tumor action. Thus, the objective of this review is to present and discuss the chemopreventive aspects of native Brazilian species in SC. Less-explored fractions of native plants, such as açaí (<i>Euterpe oleracea</i>), araçá-do-campo (<i>Psidium guineense</i>), yellow araçá (<i>Psidium cattleianum Sabine</i>), cacao (<i>Theobroma cacao</i>), coriander (<i>Eryngium foetidum</i>), physalis (<i>Physalis angulata</i>), guava (<i>Psidium guajava</i>), jambu (<i>Acmella oleracea</i>), pitanga (<i>Eugenia uniflora</i>), and ubaia (<i>Eugenia patrisii</i>), have demonstrated the ability to slow down the progression of the disease, indicating suppression of cell proliferation and survival, induction of apoptosis, and regulation of the cell cycle, despite showing not mechanism of action in the great majority of these studies. Although, still little studied, Brazilian plant matrices could show a promising impact against SC.</p>","PeriodicalId":94164,"journal":{"name":"Oncoscience","volume":"12 ","pages":"36-51"},"PeriodicalIF":0.0,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12060929/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144046815","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}