Menin:在癌症中的扩展和二分作用

Oncoscience Pub Date : 2019-08-23 DOI:10.18632/oncoscience.485

Bryson W. Katona, Rebecca A Glynn, Taylor Hojnacki, X. Hua

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引用次数: 1

摘要

Menin是MEN1基因的蛋白产物，是一种普遍表达的蛋白，与其他蛋白家族缺乏同源性，但在各种物种中高度保守[1]。Menin主要存在于细胞核中，作为表观遗传调控因子的支架[1,2]。虽然人们对menin及其在许多细胞过程中的不同作用了解甚多，但仍有许多有待发现，特别是关于其在癌症中的作用。

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Menin: Expanding and dichotomous roles in cancer

Menin, the protein product of the MEN1 gene, is a ubiquitously expressed protein that lacks homology with other protein families, yet is highly conserved among various species [1]. Menin primarily resides in the nucleus, where it serves as a scaffold for epigenetic regulators [1, 2]. While much is known about menin and its diverse roles in numerous cellular processes, there remains much to be discovered, especially with regard to its role in cancer.

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Oncoscience

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