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Evolving insights in blood-based liquid biopsies for prostate cancer interrogation. 基于血液的液体活检在前列腺癌审讯中的发展见解。
Oncoscience Pub Date : 2023-11-30 eCollection Date: 2023-01-01 DOI: 10.18632/oncoscience.592
R Daniel Bonfil, Ghaith Al-Eyd
{"title":"Evolving insights in blood-based liquid biopsies for prostate cancer interrogation.","authors":"R Daniel Bonfil, Ghaith Al-Eyd","doi":"10.18632/oncoscience.592","DOIUrl":"10.18632/oncoscience.592","url":null,"abstract":"<p><p>During the last decade, blood sampling of cancer patients aimed at analyzing the presence of cells, membrane-bound vesicles, or molecules released by primary tumors or metastatic growths emerged as an alternative to traditional tissue biopsies. The advent of this minimally invasive approach, known as blood-based liquid biopsy, began to play a pivotal role in the management of diverse cancers, establishing itself as a vital component of precision medicine. Here, we discuss three blood-based liquid biopsies, namely circulating tumor cells (CTCs), circulating tumor DNA (ctDNA) and tumor-derived exosomes, as they relate to prostate cancer (PCa) management. The advances achieved in the molecular characterization of these types of liquid biopsies and their potential to predict recurrence, improve responses to certain treatments, and evaluate prognosis, in PCa patients, are highlighted herein. While there is currently full clinical validation for only one CTC-based and one ctDNA-based liquid biopsy for patients with metastatic castration-resistant PCa, the adoption of additional methods is anticipated as they undergo standardization and achieve analytical and clinical validation. Advantages and disadvantages of different blood-based liquid biopsy approaches in the context of PCa are outlined herein, while also considering potential synergies through combinatory strategies.</p>","PeriodicalId":94164,"journal":{"name":"Oncoscience","volume":"10 ","pages":"69-80"},"PeriodicalIF":0.0,"publicationDate":"2023-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10688444/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138465251","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Be mindful of potential pitfalls when using the Cre-LoxP system in cancer research 在癌症研究中使用Cre-LoxP系统时，要注意潜在的陷阱
Oncoscience Pub Date : 2023-11-14 DOI: 10.18632/oncoscience.591
{"title":"Be mindful of potential pitfalls when using the Cre-LoxP system in cancer research","authors":"","doi":"10.18632/oncoscience.591","DOIUrl":"https://doi.org/10.18632/oncoscience.591","url":null,"abstract":"","PeriodicalId":94164,"journal":{"name":"Oncoscience","volume":"38 27","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134953647","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
An immunoinformatics assessment of the cancer testis antigen, DDX53, as a potential early esophageal cancer antigen. 睾丸癌抗原DDX53作为潜在的早期食管癌抗原的免疫信息学评估。
Oncoscience Pub Date : 2023-11-10 eCollection Date: 2023-01-01 DOI: 10.18632/oncoscience.590
Peter Cheng, Konrad J Cios, Mallika Varkhedi, Vayda R Barker, Michelle Yeagley, Andrea Chobrutskiy, Boris I Chobrutskiy, George Blanck
{"title":"An immunoinformatics assessment of the cancer testis antigen, DDX53, as a potential early esophageal cancer antigen.","authors":"Peter Cheng, Konrad J Cios, Mallika Varkhedi, Vayda R Barker, Michelle Yeagley, Andrea Chobrutskiy, Boris I Chobrutskiy, George Blanck","doi":"10.18632/oncoscience.590","DOIUrl":"10.18632/oncoscience.590","url":null,"abstract":"<p><p>T-lymphocytes have been implicated in facilitating a pro-inflammatory, pro-tumorigenic microenvironment that worsens prognosis for esophageal carcinoma (ESCA). In this study, we identified tumor resident, T-cell receptor (TCR) complementarity determining region-3 (CDR3) amino acid sequences and employed an algorithm particularly suited to the big data setting to evaluate TCR CDR3-cancer testis antigen (CTA) chemical complementarities. Chemical complementarity of the ESCA TCR CDR3s and the cancer testis antigen DDX53 represented a disease-free survival (DFS) distinction, whereby the upper fiftieth percentile complementarity group correlated with worse DFS. The high TCR CDR3-DDX53 complementarity group also represented a greater proportion of tumor samples lacking DDX53 expression. These data and analyses raise the question of whether the TCR CDR3-DDX53 chemical complementarity assessment detected an ESCA immune response that selected for DDX53-negative cells?</p>","PeriodicalId":94164,"journal":{"name":"Oncoscience","volume":"10 ","pages":"59-66"},"PeriodicalIF":0.0,"publicationDate":"2023-11-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10637345/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89721429","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Diagnosis and management of postoperative wound infections in the head and neck region. 头颈部术后伤口感染的诊断和处理。
Oncoscience Pub Date : 2023-10-04 eCollection Date: 2023-01-01 DOI: 10.18632/oncoscience.589
Filip Barbarewicz, Kai-Olaf Henkel, Florian Dudde
{"title":"Diagnosis and management of postoperative wound infections in the head and neck region.","authors":"Filip Barbarewicz,&nbsp;Kai-Olaf Henkel,&nbsp;Florian Dudde","doi":"10.18632/oncoscience.589","DOIUrl":"10.18632/oncoscience.589","url":null,"abstract":"","PeriodicalId":94164,"journal":{"name":"Oncoscience","volume":"10 ","pages":"56-58"},"PeriodicalIF":0.0,"publicationDate":"2023-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10549770/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41174703","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The mutational signatures of cancer: can passengers set a direction for prognosis? 癌症的突变特征：乘客能为预后设定方向吗？
Oncoscience Pub Date : 2023-10-02 eCollection Date: 2023-01-01 DOI: 10.18632/oncoscience.588
Peeter Karihtala
{"title":"The mutational signatures of cancer: can passengers set a direction for prognosis?","authors":"Peeter Karihtala","doi":"10.18632/oncoscience.588","DOIUrl":"https://doi.org/10.18632/oncoscience.588","url":null,"abstract":"","PeriodicalId":94164,"journal":{"name":"Oncoscience","volume":"10 ","pages":"54-55"},"PeriodicalIF":0.0,"publicationDate":"2023-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10545096/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41125376","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Activity of pazopanib in EWSR1-NFATC2 translocation-associated bone sarcoma. 帕唑帕尼在EWSR1-NFATC2易位相关骨肉瘤中的活性。
Oncoscience Pub Date : 2023-09-20 eCollection Date: 2023-01-01 DOI: 10.18632/oncoscience.587
Mohamed A Gouda, Maria A Zarzour, Ara A Vaporciyan, Kalevi Kairemo, Hubert H Chuang, Vivek Subbiah
{"title":"Activity of pazopanib in <i>EWSR1-NFATC2</i> translocation-associated bone sarcoma.","authors":"Mohamed A Gouda,&nbsp;Maria A Zarzour,&nbsp;Ara A Vaporciyan,&nbsp;Kalevi Kairemo,&nbsp;Hubert H Chuang,&nbsp;Vivek Subbiah","doi":"10.18632/oncoscience.587","DOIUrl":"https://doi.org/10.18632/oncoscience.587","url":null,"abstract":"<p><p>Pazopanib is a multi-kinase inhibitor that is currently approved for treatment of advanced renal cell carcinoma and chemotherapy-refractory soft tissue sarcoma. In this case report, we discuss the case of a patient with a <i>EWSR1-NFATC2</i> fusion positive bone sarcoma who had exceptional tumor control through using pazopanib and surgery for an overall duration exceeding 5 years. We also review the literature on <i>EWSR1-NFATC2</i> translocation-associated sarcomas and use of pazopanib in bone sarcomas.</p>","PeriodicalId":94164,"journal":{"name":"Oncoscience","volume":"10 ","pages":"44-53"},"PeriodicalIF":0.0,"publicationDate":"2023-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10511123/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41143758","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Multi-disciplinary management of recurrent gastrointestinal stromal tumor harboring KIT exon 11 mutation with the switch-control kinase inhibitor ripretinib and surgery. 应用开关控制激酶抑制剂瑞普替尼对携带KIT外显子11突变的复发性胃肠道间质瘤进行多学科治疗和手术。
Oncoscience Pub Date : 2023-09-20 eCollection Date: 2023-01-01 DOI: 10.18632/oncoscience.586
Mohamed A Gouda, Filip Janku, Neeta Somaiah, Kelly K Hunt, Sireesha Yedururi, Vivek Subbiah
{"title":"Multi-disciplinary management of recurrent gastrointestinal stromal tumor harboring KIT exon 11 mutation with the switch-control kinase inhibitor ripretinib and surgery.","authors":"Mohamed A Gouda,&nbsp;Filip Janku,&nbsp;Neeta Somaiah,&nbsp;Kelly K Hunt,&nbsp;Sireesha Yedururi,&nbsp;Vivek Subbiah","doi":"10.18632/oncoscience.586","DOIUrl":"https://doi.org/10.18632/oncoscience.586","url":null,"abstract":"<p><p>Ripretinib is a tyrosine kinase inhibitor that was approved by the United States FDA in 2020 for treatment of advanced gastrointestinal stromal tumor (GIST) in patients who received prior treatment with three or more tyrosine kinase inhibitors. In this case report, we show the durable clinical benefit achieved in a patient with GIST by using ripretinib and repeated timely surgical resection of limited disease progression. The total time on ripretinib was 43 months which is longer than the current reported data from ripretinib clinical trials. Such approach for using multi-disciplinary disease management can improve the durability of response to tyrosine kinase inhibitors, including ripretinib, and associated clinical outcomes.</p>","PeriodicalId":94164,"journal":{"name":"Oncoscience","volume":"10 ","pages":"38-43"},"PeriodicalIF":0.0,"publicationDate":"2023-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10511119/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41158950","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A CRISPR-p53 interactome with potential implications for clinical CRISPR/Cas9 use CRISPR-p53相互作用组对临床CRISPR/Cas9应用的潜在影响
Oncoscience Pub Date : 2022-05-09 DOI: 10.18632/oncoscience.557
Long Jiang, F. Wermeling
{"title":"A CRISPR-p53 interactome with potential implications for clinical CRISPR/Cas9 use","authors":"Long Jiang, F. Wermeling","doi":"10.18632/oncoscience.557","DOIUrl":"https://doi.org/10.18632/oncoscience.557","url":null,"abstract":"CRISPR/Cas9-based tools are anticipated to transform the gene therapy field by facilitating the correction of disease-causing mutations. However, CRISPR/Cas9 generates DNA damage, which triggers a DNA damage response centered around the tumor-suppressor p53. In this research perspective, we discuss implications of this and describe a CRISPR-p53 interactome with cancer-related genes that, if mutated, can give cells a selective advantage following exposure to CRISPR/Cas9. We propose that the genes in the CRISPR-p53 interactome should be monitored in the clinical setting and describe that transient p53 inhibition could be used to limit the enrichment of cells with such mutations.","PeriodicalId":94164,"journal":{"name":"Oncoscience","volume":"51 1","pages":"27 - 29"},"PeriodicalIF":0.0,"publicationDate":"2022-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84455461","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
HSP90 as an emerging barrier to immune checkpoint blockade therapy HSP90作为免疫检查点阻断治疗的新屏障
Oncoscience Pub Date : 2022-04-22 DOI: 10.18632/oncoscience.554
D. Tang, Rui Kang
{"title":"HSP90 as an emerging barrier to immune checkpoint blockade therapy","authors":"D. Tang, Rui Kang","doi":"10.18632/oncoscience.554","DOIUrl":"https://doi.org/10.18632/oncoscience.554","url":null,"abstract":"Immunotherapy, especially the use of immune checkpoint inhibitors, has improved overall survival in cancer patients. However, a large proportion of patients initially do not respond to treatment or relapse after a period of response. Heat shock protein 90 (HSP90) is a conserved molecular chaperone that promotes the maturation and folding of substrate proteins involved in many different cellular pathways. Our recent drug screen and functional assay identified HSP90 as a universal control of the protein stability of nuclear transcription factor STAT1 in a variety of different cancer cells, thereby promoting subsequent gene expression of immune checkpoint molecules (IDO1 and PD-L1). In vivo, we used different mouse models of pancreatic cancer and demonstrated that targeting HSP90 enhanced the efficacy of PD-1 blockade therapy. These findings establish HSP90 as a targetable vulnerability in immune therapy.","PeriodicalId":94164,"journal":{"name":"Oncoscience","volume":"1 1","pages":"20 - 22"},"PeriodicalIF":0.0,"publicationDate":"2022-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78037362","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Crosstalk between KIF15 and AR in castrate-resistant prostate cancers 去势抵抗性前列腺癌中KIF15和AR之间的串扰
Oncoscience Pub Date : 2022-04-22 DOI: 10.18632/oncoscience.556
Han Yang, Xuesen Dong
{"title":"Crosstalk between KIF15 and AR in castrate-resistant prostate cancers","authors":"Han Yang, Xuesen Dong","doi":"10.18632/oncoscience.556","DOIUrl":"https://doi.org/10.18632/oncoscience.556","url":null,"abstract":"","PeriodicalId":94164,"journal":{"name":"Oncoscience","volume":"48 1","pages":"25 - 26"},"PeriodicalIF":0.0,"publicationDate":"2022-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89082102","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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