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Deep learning-assisted lesion segmentation in PET/CT imaging: A feasibility study for salvage radiation therapy in prostate cancer. PET/CT 成像中的深度学习辅助病灶分割：前列腺癌挽救性放射治疗的可行性研究
Oncoscience Pub Date : 2024-05-20 eCollection Date: 2024-01-01 DOI: 10.18632/oncoscience.603
Richard L J Qiu, Chih-Wei Chang, Xiaofeng Yang
{"title":"Deep learning-assisted lesion segmentation in PET/CT imaging: A feasibility study for salvage radiation therapy in prostate cancer.","authors":"Richard L J Qiu, Chih-Wei Chang, Xiaofeng Yang","doi":"10.18632/oncoscience.603","DOIUrl":"10.18632/oncoscience.603","url":null,"abstract":"","PeriodicalId":94164,"journal":{"name":"Oncoscience","volume":"11 ","pages":"49-50"},"PeriodicalIF":0.0,"publicationDate":"2024-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11104407/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141072085","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Restoring our ubiquitination machinery to overcome resistance in cancer therapy. 恢复泛素化机制，克服癌症治疗中的抗药性。
Oncoscience Pub Date : 2024-05-06 eCollection Date: 2024-01-01 DOI: 10.18632/oncoscience.600
Xiaoling Li, Ping Mu
{"title":"Restoring our ubiquitination machinery to overcome resistance in cancer therapy.","authors":"Xiaoling Li, Ping Mu","doi":"10.18632/oncoscience.600","DOIUrl":"10.18632/oncoscience.600","url":null,"abstract":"","PeriodicalId":94164,"journal":{"name":"Oncoscience","volume":"11 ","pages":"43-44"},"PeriodicalIF":0.0,"publicationDate":"2024-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11073315/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140869693","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
PH-binding motifs as a platform for drug design: Lessons from protease-activated receptors; PARs PH 结合基团作为药物设计的平台：蛋白酶激活受体（PAR）的启示
Oncoscience Pub Date : 2024-04-25 DOI: 10.18632/oncoscience.599
J. K. Nag, Amnon Hoffman, Chaim Gilon, Beatrice Uziely, R. Bar-Shavit
{"title":"PH-binding motifs as a platform for drug design: Lessons from protease-activated receptors; PARs","authors":"J. K. Nag, Amnon Hoffman, Chaim Gilon, Beatrice Uziely, R. Bar-Shavit","doi":"10.18632/oncoscience.599","DOIUrl":"https://doi.org/10.18632/oncoscience.599","url":null,"abstract":"","PeriodicalId":94164,"journal":{"name":"Oncoscience","volume":"18 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140658506","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The price of hope: CAR-T therapy in pediatric leukemia 希望的代价小儿白血病的 CAR-T 疗法
Oncoscience Pub Date : 2024-04-25 DOI: 10.18632/oncoscience.598
Alex Hoover
{"title":"The price of hope: CAR-T therapy in pediatric leukemia","authors":"Alex Hoover","doi":"10.18632/oncoscience.598","DOIUrl":"https://doi.org/10.18632/oncoscience.598","url":null,"abstract":"","PeriodicalId":94164,"journal":{"name":"Oncoscience","volume":"3 8","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140653952","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Therapeutic opportunities for hypermutated urothelial carcinomas beyond immunotherapy 免疫疗法之外的高突变尿路上皮癌治疗机会
Oncoscience Pub Date : 2024-04-25 DOI: 10.18632/oncoscience.596
Ioannis A. Voutsadakis
{"title":"Therapeutic opportunities for hypermutated urothelial carcinomas beyond immunotherapy","authors":"Ioannis A. Voutsadakis","doi":"10.18632/oncoscience.596","DOIUrl":"https://doi.org/10.18632/oncoscience.596","url":null,"abstract":"","PeriodicalId":94164,"journal":{"name":"Oncoscience","volume":"4 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140654744","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Exploring oncogenic driver molecular alterations in Hispanic/Latin American cancer patients: A call for enhanced molecular understanding 探索西班牙裔/拉美裔癌症患者的致癌驱动分子改变：呼吁加强分子认识
Oncoscience Pub Date : 2024-04-22 DOI: 10.18632/oncoscience.597
Rafael Parra-Medina
{"title":"Exploring oncogenic driver molecular alterations in Hispanic/Latin American cancer patients: A call for enhanced molecular understanding","authors":"Rafael Parra-Medina","doi":"10.18632/oncoscience.597","DOIUrl":"https://doi.org/10.18632/oncoscience.597","url":null,"abstract":"","PeriodicalId":94164,"journal":{"name":"Oncoscience","volume":"11 24","pages":"34 - 35"},"PeriodicalIF":0.0,"publicationDate":"2024-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140674016","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A very long and winding road: developing novel therapeutics for metastatic tumors. 漫长而曲折的道路：开发治疗转移性肿瘤的新型疗法。
Oncoscience Pub Date : 2024-02-09 eCollection Date: 2024-01-01 DOI: 10.18632/oncoscience.595
Paul Dent
{"title":"A very long and winding road: developing novel therapeutics for metastatic tumors.","authors":"Paul Dent","doi":"10.18632/oncoscience.595","DOIUrl":"https://doi.org/10.18632/oncoscience.595","url":null,"abstract":"","PeriodicalId":94164,"journal":{"name":"Oncoscience","volume":"11 ","pages":"32-33"},"PeriodicalIF":0.0,"publicationDate":"2024-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10856472/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139725518","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
My battle with cancer. Part 1. 我与癌症的斗争第 1 部分.
Oncoscience Pub Date : 2024-01-03 eCollection Date: 2024-01-01 DOI: 10.18632/oncoscience.593
Mikhail V Blagosklonny
{"title":"My battle with cancer. Part 1.","authors":"Mikhail V Blagosklonny","doi":"10.18632/oncoscience.593","DOIUrl":"10.18632/oncoscience.593","url":null,"abstract":"<p><p>In January 2023, diagnosed with numerous metastases of lung cancer in my brain, I felt that I must accomplish a mission. If everything happens for a reason, my cancer, in particular, I must find out how metastatic cancer can be treated with curative intent. This is my mission now, and the reason I was ever born. In January 2023, I understood the meaning of life, of my life. I was born to write this article. In this article, I argue that monotherapy with targeted drugs, even when used in sequence, cannot cure metastatic cancer. However, preemptive combinations of targeted drugs may, in theory, cure incurable cancer. Also, I share insights on various topics, including rapamycin, an anti-aging drug that can delay but not prevent cancer, through my personal journey.</p>","PeriodicalId":94164,"journal":{"name":"Oncoscience","volume":"11 ","pages":"1-14"},"PeriodicalIF":0.0,"publicationDate":"2024-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10765422/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139379085","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evolving insights in blood-based liquid biopsies for prostate cancer interrogation. 基于血液的液体活检在前列腺癌审讯中的发展见解。
Oncoscience Pub Date : 2023-11-30 eCollection Date: 2023-01-01 DOI: 10.18632/oncoscience.592
R Daniel Bonfil, Ghaith Al-Eyd
{"title":"Evolving insights in blood-based liquid biopsies for prostate cancer interrogation.","authors":"R Daniel Bonfil, Ghaith Al-Eyd","doi":"10.18632/oncoscience.592","DOIUrl":"10.18632/oncoscience.592","url":null,"abstract":"<p><p>During the last decade, blood sampling of cancer patients aimed at analyzing the presence of cells, membrane-bound vesicles, or molecules released by primary tumors or metastatic growths emerged as an alternative to traditional tissue biopsies. The advent of this minimally invasive approach, known as blood-based liquid biopsy, began to play a pivotal role in the management of diverse cancers, establishing itself as a vital component of precision medicine. Here, we discuss three blood-based liquid biopsies, namely circulating tumor cells (CTCs), circulating tumor DNA (ctDNA) and tumor-derived exosomes, as they relate to prostate cancer (PCa) management. The advances achieved in the molecular characterization of these types of liquid biopsies and their potential to predict recurrence, improve responses to certain treatments, and evaluate prognosis, in PCa patients, are highlighted herein. While there is currently full clinical validation for only one CTC-based and one ctDNA-based liquid biopsy for patients with metastatic castration-resistant PCa, the adoption of additional methods is anticipated as they undergo standardization and achieve analytical and clinical validation. Advantages and disadvantages of different blood-based liquid biopsy approaches in the context of PCa are outlined herein, while also considering potential synergies through combinatory strategies.</p>","PeriodicalId":94164,"journal":{"name":"Oncoscience","volume":"10 ","pages":"69-80"},"PeriodicalIF":0.0,"publicationDate":"2023-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10688444/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138465251","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Be mindful of potential pitfalls when using the Cre-LoxP system in cancer research 在癌症研究中使用Cre-LoxP系统时，要注意潜在的陷阱
Oncoscience Pub Date : 2023-11-14 DOI: 10.18632/oncoscience.591
{"title":"Be mindful of potential pitfalls when using the Cre-LoxP system in cancer research","authors":"","doi":"10.18632/oncoscience.591","DOIUrl":"https://doi.org/10.18632/oncoscience.591","url":null,"abstract":"","PeriodicalId":94164,"journal":{"name":"Oncoscience","volume":"38 27","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134953647","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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