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Targeting inflammatory factors for chemoprevention and cancer interception to tackle malignant mesothelioma. 针对炎症因子进行化学预防和癌症拦截，以应对恶性间皮瘤。
Oncoscience Pub Date : 2024-05-23 eCollection Date: 2024-01-01 DOI: 10.18632/oncoscience.605
Joseph R Testa, Yuwaraj Kadariya, Joseph S Friedberg
{"title":"Targeting inflammatory factors for chemoprevention and cancer interception to tackle malignant mesothelioma.","authors":"Joseph R Testa, Yuwaraj Kadariya, Joseph S Friedberg","doi":"10.18632/oncoscience.605","DOIUrl":"10.18632/oncoscience.605","url":null,"abstract":"<p><p>Mesothelioma is an incurable cancer of the mesothelial lining often caused by exposure to asbestos. Asbestos-induced inflammation is a significant contributing factor in the development of mesothelioma, and genetic factors also play a role in the susceptibility to this rapidly progressive and treatment-resistant malignancy. Consequently, novel approaches are urgently needed to treat mesothelioma and prevent or reduce the overall incidence of this fatal disease. In this research perspective, we review the current state of chemoprevention and cancer interception progress in asbestos-induced mesothelioma. We discuss the different preclinical mouse models used for these investigations and the inflammatory factors that may be potential targets for mesothelioma prevention. Preliminary studies with naturally occurring phytochemicals and synthetic agents are reviewed. Results of previous clinical chemoprevention trials in populations exposed to asbestos and considerations regarding future trials are also presented.</p>","PeriodicalId":94164,"journal":{"name":"Oncoscience","volume":"11 ","pages":"53-57"},"PeriodicalIF":0.0,"publicationDate":"2024-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11115283/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141089410","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Entering the golden age for antibody-drug conjugates in gynecologic cancer. 进入妇科癌症抗体药物结合的黄金时代。
Oncoscience Pub Date : 2024-05-20 eCollection Date: 2024-01-01 DOI: 10.18632/oncoscience.604
Michelle Greenman, Blair McNamara, Levent Mutlu, Alessandro D Santin
{"title":"Entering the golden age for antibody-drug conjugates in gynecologic cancer.","authors":"Michelle Greenman, Blair McNamara, Levent Mutlu, Alessandro D Santin","doi":"10.18632/oncoscience.604","DOIUrl":"10.18632/oncoscience.604","url":null,"abstract":"","PeriodicalId":94164,"journal":{"name":"Oncoscience","volume":"11 ","pages":"51-52"},"PeriodicalIF":0.0,"publicationDate":"2024-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11104406/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141072207","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Role of Erk5 expressed in bone marrow mesenchymal stem cells on bone homeostasis and its potential applications in cancer treatment. 骨髓间充质干细胞中表达的 Erk5 对骨稳态的作用及其在癌症治疗中的潜在应用。
Oncoscience Pub Date : 2024-05-20 eCollection Date: 2024-01-01 DOI: 10.18632/oncoscience.601
Tetsuhiro Horie, Eiichi Hinoi
{"title":"Role of Erk5 expressed in bone marrow mesenchymal stem cells on bone homeostasis and its potential applications in cancer treatment.","authors":"Tetsuhiro Horie, Eiichi Hinoi","doi":"10.18632/oncoscience.601","DOIUrl":"10.18632/oncoscience.601","url":null,"abstract":"","PeriodicalId":94164,"journal":{"name":"Oncoscience","volume":"11 ","pages":"45-46"},"PeriodicalIF":0.0,"publicationDate":"2024-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11104408/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141072301","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Primary hepatic angiosarcoma: Treatment options for a rare tumor. 原发性肝血管肉瘤：罕见肿瘤的治疗方案。
Oncoscience Pub Date : 2024-05-20 eCollection Date: 2024-01-01 DOI: 10.18632/oncoscience.602
Gregory L Guzik, Ankit Mangla
{"title":"Primary hepatic angiosarcoma: Treatment options for a rare tumor.","authors":"Gregory L Guzik, Ankit Mangla","doi":"10.18632/oncoscience.602","DOIUrl":"10.18632/oncoscience.602","url":null,"abstract":"","PeriodicalId":94164,"journal":{"name":"Oncoscience","volume":"11 ","pages":"47-48"},"PeriodicalIF":0.0,"publicationDate":"2024-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11104409/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141072144","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Deep learning-assisted lesion segmentation in PET/CT imaging: A feasibility study for salvage radiation therapy in prostate cancer. PET/CT 成像中的深度学习辅助病灶分割：前列腺癌挽救性放射治疗的可行性研究
Oncoscience Pub Date : 2024-05-20 eCollection Date: 2024-01-01 DOI: 10.18632/oncoscience.603
Richard L J Qiu, Chih-Wei Chang, Xiaofeng Yang
{"title":"Deep learning-assisted lesion segmentation in PET/CT imaging: A feasibility study for salvage radiation therapy in prostate cancer.","authors":"Richard L J Qiu, Chih-Wei Chang, Xiaofeng Yang","doi":"10.18632/oncoscience.603","DOIUrl":"10.18632/oncoscience.603","url":null,"abstract":"","PeriodicalId":94164,"journal":{"name":"Oncoscience","volume":"11 ","pages":"49-50"},"PeriodicalIF":0.0,"publicationDate":"2024-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11104407/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141072085","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Restoring our ubiquitination machinery to overcome resistance in cancer therapy. 恢复泛素化机制，克服癌症治疗中的抗药性。
Oncoscience Pub Date : 2024-05-06 eCollection Date: 2024-01-01 DOI: 10.18632/oncoscience.600
Xiaoling Li, Ping Mu
{"title":"Restoring our ubiquitination machinery to overcome resistance in cancer therapy.","authors":"Xiaoling Li, Ping Mu","doi":"10.18632/oncoscience.600","DOIUrl":"10.18632/oncoscience.600","url":null,"abstract":"","PeriodicalId":94164,"journal":{"name":"Oncoscience","volume":"11 ","pages":"43-44"},"PeriodicalIF":0.0,"publicationDate":"2024-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11073315/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140869693","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
PH-binding motifs as a platform for drug design: Lessons from protease-activated receptors; PARs PH 结合基团作为药物设计的平台：蛋白酶激活受体（PAR）的启示
Oncoscience Pub Date : 2024-04-25 DOI: 10.18632/oncoscience.599
J. K. Nag, Amnon Hoffman, Chaim Gilon, Beatrice Uziely, R. Bar-Shavit
{"title":"PH-binding motifs as a platform for drug design: Lessons from protease-activated receptors; PARs","authors":"J. K. Nag, Amnon Hoffman, Chaim Gilon, Beatrice Uziely, R. Bar-Shavit","doi":"10.18632/oncoscience.599","DOIUrl":"https://doi.org/10.18632/oncoscience.599","url":null,"abstract":"","PeriodicalId":94164,"journal":{"name":"Oncoscience","volume":"18 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140658506","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The price of hope: CAR-T therapy in pediatric leukemia 希望的代价小儿白血病的 CAR-T 疗法
Oncoscience Pub Date : 2024-04-25 DOI: 10.18632/oncoscience.598
Alex Hoover
{"title":"The price of hope: CAR-T therapy in pediatric leukemia","authors":"Alex Hoover","doi":"10.18632/oncoscience.598","DOIUrl":"https://doi.org/10.18632/oncoscience.598","url":null,"abstract":"","PeriodicalId":94164,"journal":{"name":"Oncoscience","volume":"3 8","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140653952","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Therapeutic opportunities for hypermutated urothelial carcinomas beyond immunotherapy 免疫疗法之外的高突变尿路上皮癌治疗机会
Oncoscience Pub Date : 2024-04-25 DOI: 10.18632/oncoscience.596
Ioannis A. Voutsadakis
{"title":"Therapeutic opportunities for hypermutated urothelial carcinomas beyond immunotherapy","authors":"Ioannis A. Voutsadakis","doi":"10.18632/oncoscience.596","DOIUrl":"https://doi.org/10.18632/oncoscience.596","url":null,"abstract":"","PeriodicalId":94164,"journal":{"name":"Oncoscience","volume":"4 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140654744","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Exploring oncogenic driver molecular alterations in Hispanic/Latin American cancer patients: A call for enhanced molecular understanding 探索西班牙裔/拉美裔癌症患者的致癌驱动分子改变：呼吁加强分子认识
Oncoscience Pub Date : 2024-04-22 DOI: 10.18632/oncoscience.597
Rafael Parra-Medina
{"title":"Exploring oncogenic driver molecular alterations in Hispanic/Latin American cancer patients: A call for enhanced molecular understanding","authors":"Rafael Parra-Medina","doi":"10.18632/oncoscience.597","DOIUrl":"https://doi.org/10.18632/oncoscience.597","url":null,"abstract":"","PeriodicalId":94164,"journal":{"name":"Oncoscience","volume":"11 24","pages":"34 - 35"},"PeriodicalIF":0.0,"publicationDate":"2024-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140674016","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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