Oncoscience最新文献_第2页

Modifiable risk factors of prostate cancer: Insights from a hospital-based study. 前列腺癌可改变的危险因素：来自医院研究的见解

Oncoscience Pub Date : 2026-04-28 eCollection Date: 2026-01-01 DOI: 10.18632/oncoscience.657

Maya Kulshekar, Anuradha B Patil, Rajendra B Nerli

{"title":"Modifiable risk factors of prostate cancer: Insights from a hospital-based study.","authors":"Maya Kulshekar, Anuradha B Patil, Rajendra B Nerli","doi":"10.18632/oncoscience.657","DOIUrl":"10.18632/oncoscience.657","url":null,"abstract":"Introduction: Prostate Cancer (PCa) is the second most common cancer and the fifth leading cause of cancer among men worldwide. The prevalence of Prostate cancer is much lower in India and it is likely that the incidence of prostate cancer will show an increase in the future. Modifiable habits like smoking, tobacco chewing, alcohol consumption and others have shown to be associated with Prostate Cancer. All these variables show conflicting results in various studies. Hence more research on the various determinants of Prostate Cancer for the Indian population will help in reducing the burden of this disease through scientific and empirical approach. The present study aims to study association of various modifiable risk factors with Prostate Cancer and Benign Prostatic Hyperplasia.Methods: 72 histologically proven prostate 'Cancer Cases' and 132 'BPH controls' were included for the study after obtaining their Informed Consent. This was confirmed by performing the PSA (Prostate Specific Antigen Test), DRE (Digital Rectal Examination) test and histopathological investigations. Odds ratio was obtained to study the association of the risk factors.Results: Our study revealed that Modifiable risk factors associated with decreased risk of Prostate cancer are Coffee intake and meat with an odds ratio of 0.355 (95% CI 0.175 to 0.72, p = 0.004) and 0.516 (95% CI 0.269 to 0.992, p = 0.047). No significant association was observed with other modifiable risk factors.Conclusions: The present study concludes that an increased intake of coffee and meat may be linked to a reduced risk of developing prostate cancer.","PeriodicalId":94164,"journal":{"name":"Oncoscience","volume":"13 ","pages":"143-151"},"PeriodicalIF":0.0,"publicationDate":"2026-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13141943/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147848094","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ileal leiomyoma disguised as intussusception: Imaging pitfalls in a 28-year-old female. 伪装成肠套叠的回肠平滑肌瘤：28岁女性的影像学缺陷。

Oncoscience Pub Date : 2026-04-15 eCollection Date: 2026-01-01 DOI: 10.18632/oncoscience.656

Reshmi Sultana, A M Adarsha, Tushar M Parmeshwar, Akula Nynasindhu, Abhimanyu Sharma

{"title":"Ileal leiomyoma disguised as intussusception: Imaging pitfalls in a 28-year-old female.","authors":"Reshmi Sultana, A M Adarsha, Tushar M Parmeshwar, Akula Nynasindhu, Abhimanyu Sharma","doi":"10.18632/oncoscience.656","DOIUrl":"10.18632/oncoscience.656","url":null,"abstract":"Leiomyomas are benign mesenchymal tumors that commonly occur in uterus and rarely in gastrointestinal tract with esophagus being the most frequent site followed by stomach and colon. Duodenal leiomyoma is rarest of all with ileal leiomyoma being the second rarest. This report discusses a case of a 28-year-old female with an enlarging lower abdominal mass post-hysterectomy, initially misinterpreted as an adnexal tumor based on imaging. Various diagnostic modalities, including ultrasound, CECT, and MRI, provided conflicting interpretations, complicating preoperative assessment. Exploratory laparotomy confirmed an intraluminal ileal leiomyoma, highlighting the importance of integrated imaging and histopathological evaluation for accurate diagnosis. Genetic studies indicate associations with syndromic conditions like NF1 and Reed syndrome, emphasizing the need for vigilant surveillance and potential molecular-targeted therapies. While traditionally managed surgically, emerging research suggests epigenetic modifications may play a role in tumor behaviour and therapeutic advancements.","PeriodicalId":94164,"journal":{"name":"Oncoscience","volume":"13 ","pages":"138-142"},"PeriodicalIF":0.0,"publicationDate":"2026-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13142175/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147848128","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sebaceous adenoma of the eyelid: A clinical, histopathological, and immunohistochemical perspective. 眼睑皮脂腺瘤：临床、组织病理学和免疫组织化学的观点。

Oncoscience Pub Date : 2026-04-02 eCollection Date: 2026-01-01 DOI: 10.18632/oncoscience.655

Gunvanti Rathod, Monica Mishra, Banka Sai Swetha, Siddharam S Janti, Shamli D Zalke, Kolavali Raghavendra Rao, Alisha Khan

引用次数: 0

Selective blood-brain barrier penetration and tumor targeting of nitrosylcobalamin in glioblastoma: Pharmacokinetics, tissue distribution, and synergistic activity with trail and temozolomide. 亚硝基钴胺在胶质母细胞瘤中的选择性血脑屏障穿透和肿瘤靶向：药代动力学、组织分布和与trail和替莫唑胺的协同活性。

Oncoscience Pub Date : 2026-04-02 eCollection Date: 2026-01-01 DOI: 10.18632/oncoscience.654

Joseph A Bauer, Annette M Sysel, Michael J Dunphy

{"title":"Selective blood-brain barrier penetration and tumor targeting of nitrosylcobalamin in glioblastoma: Pharmacokinetics, tissue distribution, and synergistic activity with trail and temozolomide.","authors":"Joseph A Bauer, Annette M Sysel, Michael J Dunphy","doi":"10.18632/oncoscience.654","DOIUrl":"10.18632/oncoscience.654","url":null,"abstract":"Background: Glioblastoma multiforme (GBM) remains a lethal brain tumor characterized by poor response to chemotherapy and limited blood-brain barrier (BBB) permeability. Nitrosylcobalamin (NO-Cbl), a nitric oxide (NO)-releasing cobalamin analog, was developed to selectively deliver cytotoxic NO to tumors through the transcobalamin II receptor (CD320).Methods: NO-Cbl was evaluated across the NCI-60 tumor panel, followed by pharmacokinetic and biodistribution studies in glioblastoma-bearing rats using nitrate and cobalamin quantification in tissues, serum, and cerebrospinal fluid (CSF). Synergistic activity with TRAIL or temozolomide was assessed in human U87 and D54 glioma cells using SRB assays and Chou-Talalay analysis.Results: NO-Cbl showed broad antitumor activity in vitro, with central nervous system tumor cell lines displaying intermediate sensitivity (mean ID50 = 17.6 μM). In vivo, NO-Cbl effectively crossed the BBB, with tumor nitrate levels peaking at 20.4 nmol/g at 30 min and remaining elevated at 24 h, confirming tumor-selective accumulation. Serum nitrate exhibited a rapid half-life (4-5 h), while serum and CSF B12 showed slower and variable clearance (21-26 h and 11-12 h, respectively). In glioma cell lines, NO-Cbl synergized with TRAIL and temozolomide (TMZ) (combination index < 1.0), enhancing antiproliferative effects and suggesting potential to overcome resistance mechanisms.Conclusion: This pilot study demonstrates that NO-Cbl crosses the BBB, accumulates selectively in brain tumor tissue, and synergizes with established and experimental glioblastoma therapies. These findings establish a translational foundation for developing cobalamin-based therapeutics as a novel treatment strategy for glioblastoma.","PeriodicalId":94164,"journal":{"name":"Oncoscience","volume":"13 ","pages":"120-129"},"PeriodicalIF":0.0,"publicationDate":"2026-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13142176/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147848133","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Unprecedented non-luminal esophageal adenocarcinoma invading the spine. 前所未有的非腔内食道腺癌侵袭脊柱。

Oncoscience Pub Date : 2026-03-19 eCollection Date: 2026-01-01 DOI: 10.18632/oncoscience.653

Benjamin Wenyuan Xie, Shreyas Kalantri

{"title":"Unprecedented non-luminal esophageal adenocarcinoma invading the spine.","authors":"Benjamin Wenyuan Xie, Shreyas Kalantri","doi":"10.18632/oncoscience.653","DOIUrl":"10.18632/oncoscience.653","url":null,"abstract":"Background: Upper endoscopy with biopsy is the gold standard for diagnosing esophageal cancer. However, esophageal tumors can rarely escape endoscopic detection by growing in atypical patterns, such as entirely outside the esophageal lumen.Case: We report a unique case of primary esophageal adenocarcinoma that presented with spinal cord compression due to local invasion of the T5 vertebral body, despite an initially normal upper endoscopy. A 68-year-old man developed progressive paraparesis and sensory loss due to a T5 pathological fracture. He had classic symptoms of esophageal cancer (dysphagia and weight loss), yet endoscopic evaluation one month prior showed no intraluminal tumor. Imaging revealed a posterior mediastinal mass contiguous with the esophagus and invading the T4-T6 vertebrae. Surgical resection of the epidural tumor confirmed poorly differentiated adenocarcinoma consistent with an esophageal primary. The patient declined chemoradiation and succumbed one month later.Conclusions: This unprecedented pattern of esophageal adenocarcinoma-growing extraluminally with isolated posterior extension to the spine-highlights the potential for esophageal cancer to present with no mucosal lesion on endoscopy. Clinicians should remain vigilant for malignancy in patients with high suspicion, even if initial endoscopic findings are benign.","PeriodicalId":94164,"journal":{"name":"Oncoscience","volume":"13 ","pages":"115-119"},"PeriodicalIF":0.0,"publicationDate":"2026-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13248710/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148221315","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A low-cost color sensor device for rapid detection of high-grade serous ovarian carcinoma (HGSOC). 一种用于高级别浆液性卵巢癌（HGSOC）快速检测的低成本颜色传感器装置。

Oncoscience Pub Date : 2026-03-11 eCollection Date: 2026-01-01 DOI: 10.18632/oncoscience.652

Faisal Iqbal

{"title":"A low-cost color sensor device for rapid detection of high-grade serous ovarian carcinoma (HGSOC).","authors":"Faisal Iqbal","doi":"10.18632/oncoscience.652","DOIUrl":"10.18632/oncoscience.652","url":null,"abstract":"A sensitive nucleic acid detection approach based on tracing the inorganic phosphate (Pi) created during amplification by means of the colorimetric method has been presented. This method relies on nucleic acid amplification. Pyrophosphate (PPi), a result of the nucleic acid polymerization reaction, was hydrolyzed into inorganic phosphate (Pi) by the addition of inorganic pyrophosphatase. To create the phosphomolybdate precipitate, the obtained Pi could react with acid molybdate. The color of amplified sample was changed into green. Using high grade serous ovarian carcinoma (HGSOC) as an example, this tactic's usefulness was proven. Here, describe the Ercose (Eraser + Color Sensor) device proof-of-concept, which uses a straightforward strategy without sacrificing the accuracy of the outcomes. Ercose is a simple, quick, weightless and inexpensive. A low-cost, user-friendly color sensor is suggested for development in this study to identify the hue of the objects. The test objects were progressively illuminated by the sensor's RGB light emitting diodes, which served as the light sources. The analogue voltage data were converted to digital form and serially delivered to a graphical user interface (GUI). To determine the test objects colors, the digitized voltage values were employed (i.e., RGB values). The microcontroller arduino nano was managed by the GUI, which also showed the needed color values. The Ercose device can be used in a variety of real-world scenarios where standard spectrophotometer devices are not practical.","PeriodicalId":94164,"journal":{"name":"Oncoscience","volume":"13 ","pages":"104-114"},"PeriodicalIF":0.0,"publicationDate":"2026-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12998687/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147488834","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Deceptive clinical course of mucinous ovarian carcinoma mimicking pelvic abscess in a postmenopausal woman: An exceptional case report. 1例绝经后妇女粘液性卵巢癌伴盆腔脓肿的临床病程：一个例外病例报告。

Oncoscience Pub Date : 2026-03-11 eCollection Date: 2026-01-01 DOI: 10.18632/oncoscience.650

Aparna Jarathi, Sunitha Geddada, Chandramouli Ramalingam, Naina Kumar, Anusha Devalla, Ashwini Pitambra, Ashutosh Rath, NagaSai Divya Kari, Uday Reddy Janke, B Surender Reddy, Ajay Kumar Kondeti

{"title":"Deceptive clinical course of mucinous ovarian carcinoma mimicking pelvic abscess in a postmenopausal woman: An exceptional case report.","authors":"Aparna Jarathi, Sunitha Geddada, Chandramouli Ramalingam, Naina Kumar, Anusha Devalla, Ashwini Pitambra, Ashutosh Rath, NagaSai Divya Kari, Uday Reddy Janke, B Surender Reddy, Ajay Kumar Kondeti","doi":"10.18632/oncoscience.650","DOIUrl":"10.18632/oncoscience.650","url":null,"abstract":"Background: Mucinous ovarian carcinoma (MOC) is a rare subtype of epithelial ovarian cancer (3-5%), typically affecting women between 20 and 40 years old. It often presents diagnostic and management challenges.Case report: We present an exceptional case of a postmenopausal woman with abdominal pain disguised as a pelvic abscess. A 73-year-old postmenopausal woman presented with abdominal pain for 6 months and postmenopausal spotting for 1 month. Initial imaging (CT scan) suggested a pelvic abscess, which was managed conservatively. However, persistent symptoms and a complex adnexal mass prompted further evaluation. MRI revealed a multiloculated right adnexal mass, and tumour markers (CA-125, CEA, HE4) were elevated. Surgical staging included total abdominal hysterectomy, bilateral salpingo-oophorectomy, and omentectomy. Histopathology confirmed stage IC2 mucinous adenocarcinoma. Postoperative recovery was uneventful, and the patient received six cycles of carboplatin and paclitaxel as adjuvant chemotherapy.Conclusions: This case emphasizes the diagnostic challenge of MOC in postmenopausal women. Misinterpretation as benign pelvic pathology can delay appropriate treatment. Precise imaging, tumour markers, and a multidisciplinary approach are critical for early diagnosis and improved outcomes.","PeriodicalId":94164,"journal":{"name":"Oncoscience","volume":"13 ","pages":"80-84"},"PeriodicalIF":0.0,"publicationDate":"2026-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12998691/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147488926","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Erosive pustular dermatosis-like scalp reaction following cranial radiotherapy in a patient with EGFR-mutant NSCLC treated with amivantamab. 阿米万他单抗治疗egfr突变NSCLC患者颅骨放疗后糜烂性脓疱性皮肤病样头皮反应

Oncoscience Pub Date : 2026-03-11 eCollection Date: 2026-01-01 DOI: 10.18632/oncoscience.649

Vasiliki Nikolaou, Antonis Tsimpidakis, Ioannis-Alexios Koumprentziotis, Evdoxia Panou, Theodoros Tegos, Alexander Stratigos

引用次数: 0

Basal cell carcinoma of the head and neck: Surgical management and postoperative strategies - A researcher's perspective. 头颈部基底细胞癌：外科治疗和术后策略-研究人员的观点。

Oncoscience Pub Date : 2026-03-11 eCollection Date: 2026-01-01 DOI: 10.18632/oncoscience.646

Lawik Revend, Doha Revend, Florian Dudde

{"title":"Basal cell carcinoma of the head and neck: Surgical management and postoperative strategies - A researcher's perspective.","authors":"Lawik Revend, Doha Revend, Florian Dudde","doi":"10.18632/oncoscience.646","DOIUrl":"10.18632/oncoscience.646","url":null,"abstract":"Introduction: Basal cell carcinoma (BCC) is one of the most common cutaneous malignancies and predominantly affects sun-exposed regions, particularly the head and neck. Although metastatic spread is rare, locally invasive growth may compromise functionally and aesthetically critical structures. Effective management therefore requires not only oncologic tumor control but also carefully planned reconstruction and long-term follow-up.Materials and methods: This study presents a structured narrative review of the literature combined with institutional clinical experience. Relevant publications on diagnosis, surgical management, reconstructive techniques, and postoperative strategies for head and neck BCC were identified through searches of PubMed, Embase, and the Cochrane Library. Clinical studies, systematic reviews, and guidelines published between 2000 and 2025 were analyzed and synthesized narratively due to heterogeneity in study designs and outcome measures.Results: Surgical excision remains the cornerstone of curative treatment, with recommended margins depending on tumor risk stratification. Mohs micrographic surgery provides superior margin control in anatomically critical regions. Reconstruction must be individualized based on defect size, anatomical subunit involvement, and patient factors. Local flaps are commonly used for small- to medium-sized defects, whereas larger or deeply infiltrative tumors may require regional or free tissue transfer.Discussion: Successful management of head and neck BCC requires interdisciplinary collaboration and individualized reconstructive planning. Advances in flap techniques, digital surgical planning, and systemic therapies have expanded treatment possibilities, enabling improved functional and aesthetic outcomes in complex cases.","PeriodicalId":94164,"journal":{"name":"Oncoscience","volume":"13 ","pages":"55-61"},"PeriodicalIF":0.0,"publicationDate":"2026-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12998690/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147488838","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Targeting MD2 in prostate cancer bone metastasis: Mechanistic insights and therapeutic potential. 靶向MD2在前列腺癌骨转移中的作用机制和治疗潜力。

Oncoscience Pub Date : 2026-03-11 eCollection Date: 2026-01-01 DOI: 10.18632/oncoscience.647

Melina A Dattilo, Marina G Ferrari, Alexis P Jimenez-Uribe, Teresa Morales, Kyle T Amber, Adrian P Mansini

{"title":"Targeting MD2 in prostate cancer bone metastasis: Mechanistic insights and therapeutic potential.","authors":"Melina A Dattilo, Marina G Ferrari, Alexis P Jimenez-Uribe, Teresa Morales, Kyle T Amber, Adrian P Mansini","doi":"10.18632/oncoscience.647","DOIUrl":"10.18632/oncoscience.647","url":null,"abstract":"Metastatic prostate cancer (PCa), especially when it involves the bone, remains a significant clinical challenge with limited therapeutic options. Our recent research identified Myeloid Differentiation Protein-2 (MD2/LY96) as a potential biomarker associated with poor prognosis and higher metastatic potential in PCa. In this Research Perspective, we build on those findings and present new preclinical data showing that pharmacological inhibition of MD2 markedly reduces tumor growth in a PCa mouse model of bone metastasis. Analysis of patient tumor tissues demonstrated that high MD2 expression is associated not only with metastasis but also with increased infiltration of T regulatory cells (Tregs) and myeloid-derived suppressor cells (MDSCs), indicating a role in promoting an immunosuppressive environment. Additionally, we show that soluble MD2 (sMD2) may serve as a non-invasive biomarker of metastatic burden and help predict resistance to poly ADP-ribose polymerase (PARP) inhibitor therapy. This Research Perspective aims to consolidate mechanistic and preclinical evidence supporting MD2 as a driver of prostate cancer metastasis and to evaluate the therapeutic potential of pharmacological MD2 inhibition in a bone metastasis model. These findings support MD2 as a novel therapeutic target and identify soluble MD2 as a promising predictive and prognostic biomarker in metastatic PCa, with mechanistic links to immune evasion and inflammatory signaling.","PeriodicalId":94164,"journal":{"name":"Oncoscience","volume":"13 ","pages":"62-68"},"PeriodicalIF":0.0,"publicationDate":"2026-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12998693/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147488997","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0