Neurologia最新文献

{"title":"Influence of dehydration on collateral circulation and clinical outcome after endovascular therapy in patients with acute ischemic stroke.","authors":"M Guasch-Jiménez, P Camps-Renom, C Toscano-Prat, D Guisado-Alonso, A Martínez-Domeño, L Prats-Sánchez, A Ramos-Pachón, I Fernández-Cadenas, J P Martínez-González, I Fernández-Pérez, C Avellaneda-Gómez, E de Celis-Ruiz, J Rodríguez-Pardo, M Del Mar Freijo, A Luna, F Moniche, B Pardo-Galiana, J Ortega-Quintanilla, J F Arenillas, E Cortijo, J Martí-Fàbregas","doi":"10.1016/j.nrleng.2025.10.007","DOIUrl":"https://doi.org/10.1016/j.nrleng.2025.10.007","url":null,"abstract":"<p><strong>Introduction: </strong>Dehydration in patients with acute ischemic stroke (AIS) is associated with poor outcome. Our aim is to investigate whether dehydration is associated with collateral circulation (CC) and functional outcome in patients with AIS treated with mechanical thrombectomy (MT).</p><p><strong>Methods: </strong>Prospective multicenter study of patients with anterior circulation AIS treated with MT (January 2020-June 2021). Dehydration was assessed with two formulas: plasma osmolarity and urea/creatinine (U/C) ratio. CC was quantified with an automated software (Brainomix Ltd.) on baseline computed tomography angiography. The primary outcome was the association between CC (expressed numerically as the percentage of change between hemispheres) and dehydration (osmolarity ≥295mmol/L, U/C ≥ 80). Secondary outcomes included disability at discharge and at three months of follow-up, assessed using the modified Rankin scale (poor outcome: 3-6). Multivariable logistic and ordinal regression analyses were performed.</p><p><strong>Results: </strong>Two hundred sixty patients were included. 65.8% were dehydrated according to osmolarity and 2.9% according to U/C. There was no association between CC score and dehydration [71% in dehydrated vs 73% in non-dehydrated; p = 0.875]. 64.3% of dehydrated patients vs. 46.7% of non-dehydrated patients had a poor outcome at discharge (p = 0.026). In multivariable logistic regression analysis, dehydration was an independent predictor of poor outcome at discharge (OR 2.50; p = 0.011) and at three months of follow-up (OR 2.27; p = 0.046).</p><p><strong>Conclusions: </strong>Dehydration on admission is associated with poor outcome in patients with AIS treated with MT, but it is not related to CC.</p>","PeriodicalId":94155,"journal":{"name":"Neurologia","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145282377","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of fatigue on quality of life in adults with relapsing-remitting multiple sclerosis.","authors":"Raquel Piñar Morales, Pedro Antonio Guirado Ruíz, Francisco Javier Barrero Hernández","doi":"10.1016/j.nrleng.2025.10.006","DOIUrl":"https://doi.org/10.1016/j.nrleng.2025.10.006","url":null,"abstract":"<p><strong>Introduction: </strong>Fatigue in multiple sclerosis (MS) is defined as the lack of physical and/or mental energy perceived by the individual that interferes with normal activities. It is the most common symptom in MS, present up to 90% of people with MS. Fatigue along with disability, depression, cognitive impairment, and disease-modifying therapy (DMT) affect quality of life (QoL).</p><p><strong>Method: </strong>We designed a prospective observational study in patients with MS and DMT of moderate efficacy to assess the association between fatigue and the epidemiological, clinical, and pharmacological aspects that influence in the QoL. We analyzed variables related to patients, disability, fatigue (MFIS), clinical and radiological activity, depression (BDI), cognitive impairment (SDMT), and QoL (EQ-5D).</p><p><strong>Results: </strong>we included 91 people, 65.9% women, mean age 43.9 years. The DMT were: 27.4% interferon-β, 15.38% glatiramer acetate, 9.89% teriflunomide, and 47.25% dimethyl fumarate. The median of the EDSS was 1.5 points. 40.9% have presented fatigue, 36.3% cognitive deterioration and 30.7% of the patients depression.</p><p><strong>Conclusions: </strong>Patients with fatigue are older, more disabled, have a higher prevalence of depression and worse QoL. Evolution time, relapses, MRI lesion load, and DMTs are not associated with fatigue. Fatigue is a frequent symptom in patients with MS that influences in the QoL, hence the importance of its diagnosis and treatment.</p>","PeriodicalId":94155,"journal":{"name":"Neurologia","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145260383","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Case series of Epilepsy with Palpebral Myoclonus.","authors":"Marcela Henao-Pérez, Diana Carolina López-Medina, Alejandra Arboleda-Ramírez, Nancy Liceth Patiño-Jaramillo, José Fernando Zapata-Berruecos, René Andrade","doi":"10.1016/j.nrleng.2025.10.005","DOIUrl":"https://doi.org/10.1016/j.nrleng.2025.10.005","url":null,"abstract":"<p><strong>Introduction: </strong>epilepsy with palpebral myoclonus is an idiopathic generalized childhood epilepsy, which is underdiagnosed because it is confused with tics or behavioral actions.</p><p><strong>Patients and methods: </strong>quantitative, observational, descriptive of 16 patients with epilepsy and myoclonic eyelids treated at an institution specialized in neurology, between the years 2017 and 2022. Clinical histories and videoelectroencephalograms were evaluated.</p><p><strong>Results: </strong>of 16 patients, 11 were women (68.8%), the median age was 17.5 years (IQR 12.5). The first diagnosis most frequently received by patients was idiopathic generalized epilepsy. Stressful situations were the most reported precipitant. 93.75% of the patients initially presented palpebral myoclonic seizures and after several years presented generalized tonic-clonic seizures. The time elapsed between the first seizure and the diagnosis varied between 1 and more than 40 years, being greater among patients with a subsidized health system. Men had a high frequency of family history of epilepsy in the first and second degrees of consanguinity, had a longer delay in diagnosis and reported greater drug resistance. In both women and men, the posterior regions (occipital, temporoccipital and parietoccipital) presented a greater focal epileptiform activity. The photoparoxysmal response occurred with greater predominance in women, with the Waltz type III and IV responses being the most frequent.</p><p><strong>Conclusion: </strong>the importance of suspecting this pathology before palpebral myoclonus in children should be highlighted, guaranteeing quality and timely management.</p>","PeriodicalId":94155,"journal":{"name":"Neurologia","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145260306","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adaptation and norming of the Spanish version of the Attention, Memory and Frontal Abilities Test (AMFAST) for people aged 55 years and older.","authors":"J Oltra-Cucarella, B Bonete-López, E Sitges-Maciá, C Iñesta, M S San-Segundo, M Berbegal Bernabeu, M Tomé Fernández, A Zaragoza-Martí, B Freilich, J A Hurtado Sánchez","doi":"10.1016/j.nrleng.2025.10.002","DOIUrl":"https://doi.org/10.1016/j.nrleng.2025.10.002","url":null,"abstract":"<p><strong>Introduction: </strong>Screening tests are useful to identify cognitive impairments during aging. However, they need to assess different cognitive abilities and be easily accessible to researchers and clinicians. The objective of this work is to develop normative data for the population 55 years of age or older for the Attention, Memory and Frontal Abilities Screening Test (AMFAST).</p><p><strong>Method: </strong>One-hundred and fifty-five cognitively healthy participants between 55 and 82 years old were assessed both with a comprehensive neuropsychological battery and the AMFAST. The ability of the AMFAST to identify objective cognitive impairment in the neuropsychological assessment was analyzed using binary logistic regression, and sensitivity (Sen), specificity (Spe), and positive (PPV) and negative (NPV) predictive values were calculated. Normative data were developed using linear regression controlling for the effects of age, gender, and educational level.</p><p><strong>Results: </strong>The AMFAST total score was statistically associated with age and education, but not with sex. Using 3 or more low scores as the criterion for objective cognitive impairment, the AMFAST total score was associated with the number of low scores on the neuropsychological battery (r=-.33, p < .001), as well as with objective cognitive impairment (OR = 0.95, 95%CI:0.92-0.98, p = .003). A total score lower than 74 was associated with Sen = 85.71%, Spe = 71.63%, PPV = 23.08%, and NPV = 98.06%.</p><p><strong>Conclusions: </strong>As a simple and quick test, the AMFAST could help identify early objective cognitive impairment. Normative data of the Spanish adaptation of the AMFAST for its use in clinical and research are provided.</p>","PeriodicalId":94155,"journal":{"name":"Neurologia","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145254384","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neuropsychological differential diagnosis of Alzheimer's Disease and Lewy Body Dementia: A systematic review.","authors":"Teresa Julio-Ramos, Valentina Mora-Castelleto, Camila Foncea-González, Catherine Adames-Valencia, Igor Cigarroa, Carolina Méndez-Orellana, David Toloza-Ramírez","doi":"10.1016/j.nrleng.2025.10.001","DOIUrl":"https://doi.org/10.1016/j.nrleng.2025.10.001","url":null,"abstract":"<p><strong>Introduction: </strong>Alzheimer's disease (AD) reports heterogeneity of neuropsychological symptoms misleading the differential diagnosis with other forms of dementia, such as dementia with Lewy bodies (DLB). About 50% of DLB patients are misdiagnosed as AD cases. Likewise, the diagnosis of both diseases is mainly based on clinical characteristics. However, differentiating AD of those with DLB based on neuropsychological symptoms and anatomical and functional brain changes remains challenging.</p><p><strong>Aim: </strong>To establish the main neuropsychological, anatomical, and functional similarities and differences in patients with AD and DLB.</p><p><strong>Methods: </strong>The present study followed the PRISMA guidelines and included studies from the PubMed, Scopus, and Web of Sciences databases, published between January 2000 and July 2022.</p><p><strong>Results: </strong>41 articles were included in this systematic review for critical analysis. Our results suggest that the cognitive key domains to consider in the differential diagnosis are memory, executive function, attention, visuospatial/visuoconstructive skills, and verbal fluency (both semantic and phonological). The stage and severity of both diseases would be essential for differential diagnosis. On the other hand, the anatomical and functional changes suggest a similar atrophy pattern between AD and DLB in the frontal, parietal, temporal, hippocampal, and precuneus regions.</p><p><strong>Conclusion: </strong>The differential diagnosis between AD and DLB is challenging in clinical practice. Therefore, our results suggest exploring cognitive linguistic markers along with correlating these markers with anatomical and functional brain changes.</p>","PeriodicalId":94155,"journal":{"name":"Neurologia","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145254318","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multiple Sclerosis mortality trend by sex: Chile 1997-2019.","authors":"J Arriagada Opazo, V Farah González, M González Delgadillo, L Nuñez-Franz, C Morales Garcia, P Jiménez Rodríguez","doi":"10.1016/j.nrleng.2025.10.003","DOIUrl":"https://doi.org/10.1016/j.nrleng.2025.10.003","url":null,"abstract":"<p><strong>Background: </strong>An increasing trend has been observed in the prevalence of Multiple Sclerosis (MS) globally. It is estimated that a total of 2.8 million people live with MS worldwide. In 2008, Chile started a pilot program for the Modifying Therapy of MS, and its clinical practice guideline.</p><p><strong>Aim: </strong>This study aims to analyze the trend of the MS mortality rate in Chile from 1997 to 2019 disaggregated by sex and latitude.</p><p><strong>Methods: </strong>MS mortality data (ICD-10, G35) from 1997-2019 were extracted from the Department of Health Statistical Information and population data from the National Institute of Statistics. Standardized mortality rates (SMRs) by age were calculated. The trend of the SMR was analyzed using Joinpoint and with RiskDiff the effect of the risk of dying, the structure, and the size of the population on the crude mortality rate was evaluated.</p><p><strong>Results: </strong>The trend of the TME has been decreasing significantly since 2005. When disaggregating by sex the decrease was not significant. According to latitude, the north and center south have a significant decreasing trend; in the south, the decreasing trend is not significant. There is an increase of 25% in the crude mortality rate due to the change in the structure of the population and a decrease of 25.46% is attributed to the risk of dying.</p><p><strong>Conclusion: </strong>The SMR due to MS in Chile during 1997-2019 has decreased, in addition, a decreasing SMR is evidenced only in the northern zone. The crude rate has increased as a consequence of changes in the population, however, the risk of dying has decreased, especially in men.</p>","PeriodicalId":94155,"journal":{"name":"Neurologia","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145254363","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Primary headaches as the reason for consultation in Primary Care: A prospective study.","authors":"Inés Rivera, Noelia Fontanillas, Luis Cadelo, Julio Pascual","doi":"10.1016/j.nrleng.2025.10.004","DOIUrl":"https://doi.org/10.1016/j.nrleng.2025.10.004","url":null,"abstract":"<p><strong>Objectives: </strong>To prospectively study the rate of consultation, diagnoses, burden and historical management patterns of those patients attending due to primary headache in Primary Care.</p><p><strong>Patients and methods: </strong>We included 200 patients with primary headache in a semi-urban Health Center. To study the consultation impact, 100 patients were consecutively recruited in one primary care quota. For every patient we obtained demographic data, comorbidities, rate of consultation, absenteeism, impact in quality of life (MIDAS and HIT-6 scales) and previous patterns of referral and treatment.</p><p><strong>Results: </strong>A total of 2.2% of the demand consultations were due to primary headache. Migraine (60%) was the most frequent reason, followed by tension-type headache (38.5%) and trigeminal autonomic headaches (1.5%). In 58% of cases the diagnosis was incomplete or incorrect. Between 33% (MIDAS) and 50.8% (HIT-6) of cases showed at least a moderate decrease in their quality of life, which was higher for migraine (40.8% and 72.5%, respectively). There was absenteeism in 12% of patients the last year (in 87.5% of cases due to migraine). More than half (58%) of cases had been referred to Neurology and preventive treatments had been initiated in Primary Care in only 5.5% of patients.</p><p><strong>Conclusions: </strong>Primary headaches, and mainly migraine, are a frequent reason for consultation in Primary Care. Even though migraine induces a significant absenteeism and damages quality of life, there is a clear room for improvement in their management. Primary headaches should be included in the health plans of Primary Care.</p>","PeriodicalId":94155,"journal":{"name":"Neurologia","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145253809","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Healthcare impact of electroencephalography performed during clinical neurophysiology on-call duty in a third-level hospital","authors":"F. Vázquez-Sánchez ,&nbsp;M.C. Lloria-Gil ,&nbsp;B. García-López ,&nbsp;O. Pérez-Gil ,&nbsp;A. Saponaro-González ,&nbsp;E. Rivas-Navas ,&nbsp;A.I. Gómez-Menéndez","doi":"10.1016/j.nrleng.2025.09.006","DOIUrl":"10.1016/j.nrleng.2025.09.006","url":null,"abstract":"<div><h3>Introduction</h3><div>The electroencephalogram (EEG) is a useful tool in the diagnosis of pathologies such as non-convulsive status epilepticus (NCSE) or brain death (BD), cardiac arrest (CA), and status epilepticus (SE) treatment monitoring. In addition, it provides irreplaceable information depending on the time it is performed, as is the case with the diagnosis of epilepsy after a first epileptic seizure (ES) or to differentiate these from non-epileptic paroxysmal events (NEPE). Its usefulness is maintained outside the usual working day, but it is not available in many centers.</div></div><div><h3>Subjects and methods</h3><div>Retrospective observational study based on the clinical history of 86 patients who underwent an on-call EEG (ocEEG) at our hospital during 2020.</div></div><div><h3>Results</h3><div>One hundred two records requested by Intensive Care (41.1%), Neurology (37.3%), Pediatrics (17.6%) or other services (4%) were made. Suspected NCSE represented 56.7%, followed by treatment monitoring in EE (21.6%). The ME accounted for only 6.9% of the total. The ocEEG avoided potential iatrogenesis in a 56.3% of cases with therapeutic implications, allowed to treat 27.58% of patients who would have remained without treatment until the conventional EEG. An increase in the level of care was required in only 22,2% of all cases. The ocEEG was anticipated a mean of 31.6 hours to the next conventional EEG that would have been available.</div></div><div><h3>Conclusions</h3><div>The availability of ocEEG is beneficial in terms of diagnosis, therapy, and hospital management, advancing decision-making and avoiding iatrogenesis. Its availability should become widespread.</div></div>","PeriodicalId":94155,"journal":{"name":"Neurologia","volume":"40 8","pages":"Pages 746-752"},"PeriodicalIF":0.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145008626","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sensory neuronopathy in a patient with anti-FGFR3 antibodies and lung adenocarcinoma, coincidence or causality?","authors":"L. Fernández-Llarena,&nbsp;A. Moreno-Estébanez,&nbsp;A. González-Eizaguirre,&nbsp;A. Jauregi-Barrutia","doi":"10.1016/j.nrleng.2025.09.001","DOIUrl":"10.1016/j.nrleng.2025.09.001","url":null,"abstract":"","PeriodicalId":94155,"journal":{"name":"Neurologia","volume":"40 8","pages":"Pages 807-810"},"PeriodicalIF":0.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145016971","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A single institution series of intravascular lymphoma: Neurological manifestations and neuroimaging findings","authors":"J. Corroza ,&nbsp;C. Alburquerque ,&nbsp;L. Martínez-Martínez ,&nbsp;I. Gastón ,&nbsp;L. Torné ,&nbsp;M.C. Gil-Alzueta ,&nbsp;J. Oteiza ,&nbsp;T. Cabada ,&nbsp;M.C. Viguria ,&nbsp;A. Panizo ,&nbsp;M.E. Erro","doi":"10.1016/j.nrleng.2025.09.008","DOIUrl":"10.1016/j.nrleng.2025.09.008","url":null,"abstract":"<div><h3>Background</h3><div>Intravascular lymphoma (IVL) is a diffuse large B-cell lymphoma characterized by occlusion of small vessels of organs by malignant cells with special tropism for the nervous system. Our purpose has been to describe a series of IVL diagnosed in our center and to compare the results with those of the literature.</div></div><div><h3>Methods</h3><div>A retrospective review of the clinical, imaging, and pathological data of consecutive patients with IVL in the last 20 years was performed. Pathology department database was the source of patient identification.</div></div><div><h3>Results</h3><div>We identified six cases (three males and three females), with a median age at diagnosis of 54.64 (interquartile range (IR) 51.93–59.67). Five of them (83.3%) debuted with neurological manifestations. The median time to diagnosis was 3.77 months. On cranial magnetic resonance imaging, the findings consisted of multiple white matter and corpus callosum lesions (some of them with enhancement or hemorrhagic foci) and multifocal infarcts with hemorrhagic transformation. One patient displayed leptomeningeal branch aneurysms. A proton emission tomography with fluorodeoxyglucose (PET-FDG) was performed in five patients showing areas of elevated metabolism in all of them. Four patients underwent targeted biopsy, which allowed the diagnosis of IVL to be established in three. Four of the five patients who received treatment remained in complete remission with a median progression-free survival of 69.62 months (IR 49.11–162.82).</div></div><div><h3>Conclusions</h3><div>IVL begins frequently with neurological manifestations, which must alert the neurologist to be aware of this entity. PET-FDG helps to identify biopsy-accessible lesions and facilitate early diagnosis of IVL.</div></div>","PeriodicalId":94155,"journal":{"name":"Neurologia","volume":"40 8","pages":"Pages 768-776"},"PeriodicalIF":0.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145247993","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}