Nephrologie & therapeutique最新文献_第2页

Efficient removal of oxalate from tea by pre-infusion. 预浸法有效去除茶叶中的草酸盐。

Nephrologie & therapeutique Pub Date : 2025-04-15 DOI: 10.1684/ndt.2025.115

Cécile Clément, Jordan Desenclos, Valentine Forté, Carole Martori, Catherine Prats, Jean-Philippe Haymann, Michel Daudon, Emmanuel Letavernier

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The highlights of kidney transplantation in 2024 2024年肾移植的亮点

Nephrologie & therapeutique Pub Date : 2025-04-10 DOI: 10.1684/ndt.2025.111

Thomas Jouve

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The highlights of nephrology in 2024 2024年肾脏病学的亮点

Nephrologie & therapeutique Pub Date : 2025-04-10 DOI: 10.1684/ndt.2025.110

Camille Cohen

{"title":"The highlights of nephrology in 2024","authors":"Camille Cohen","doi":"10.1684/ndt.2025.110","DOIUrl":"10.1684/ndt.2025.110","url":null,"abstract":"The year 2024 marks significant progress in nephrology, particularly in immunoglobulin A (IgA) nephropathy and nephroprotection. In IgA nephropathy, new molecules such as sibeprenlimab and atacicept, targeting the BAFF and APRIL pathways, have shown a reduction in proteinuria and stabilization of glomerular filtration rate (GFR), confirming the importance of these pathways in the disease. Furthermore, the involvement of the microbiota in the pathology opens up promising therapeutic prospects. In nephroprotection, the combination of SGLT2 inhibitors, endothelin receptors and GLP1 agonists enhances the management of chronic kidney disease, including diabetic nephropathy, with positive effects on proteinuria and renal survival. The discovery of anti-nephrin antibodies in idiopathic nephrotic syndrome (INS) marks a major step forward, enabling better prediction of the response to immunosuppressants and a more refined diagnosis between autoimmune and genetic pathologies, and opening up the future prospect of more personalized management of this pathology. Derived from hematology, anti-CD38 therapies are also showing promising results in glomerulopathies, while CAR-T cells are opening the way to new therapeutic options for refractory autoimmune diseases such as lupus. These advances testify to a move towards precision medicine in nephrology, where the personalization of treatments could, in time, significantly improve the management of patients with kidney pathologies.","PeriodicalId":94153,"journal":{"name":"Nephrologie & therapeutique","volume":"21 S1","pages":"5-10"},"PeriodicalIF":0.0,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144039875","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The highlights of dialysis in 2024 2024年透析的亮点

Nephrologie & therapeutique Pub Date : 2025-04-10 DOI: 10.1684/ndt.2025.112

Sébastien Rubin

{"title":"The highlights of dialysis in 2024","authors":"Sébastien Rubin","doi":"10.1684/ndt.2025.112","DOIUrl":"10.1684/ndt.2025.112","url":null,"abstract":"In 2024, dialysis is experiencing advancements, particularly in environmental sustainability. “Green dialysis” is emerging as a priority, aiming to reduce the carbon footprint of dialysis centers (water and resource consumption, patient transportation). Innovative strategies, such as adjusting dialysate flow rate and temperature, have demonstrated similar effectiveness to standard dialysis in terms of Kt/V while reducing water consumption. A recent Cochrane review confirms the equivalence between peritoneal dialysis (PD) and hemodialysis (HD) in terms of mortality. Additionally, hemodiafiltration (HDF) is regaining attention thanks to the CONVINCE study and its ancillary studies, which show a reduction in mortality risk and an improvement in quality of life. Furthermore, technical adaptations are making HDF more environmentally friendly. Anticoagulation strategies are also evolving: heparin-free dialysis, using calcium-free dialysate and reinjection controlled by ionic dialysance, has proven effective. A large French study based on the Rein registry and the National Health Data System database shows that direct oral anticoagulants, particularly apixaban, although not officially approved for dialysis (off-label use), offer promising prospects for reducing thromboembolic risk. Chronic inflammation, a major cardiovascular risk factor in dialysis patients, is the focus of therapeutic trials targeting IL-6 (clazakizumab), with encouraging phase II results. Meanwhile, dialysate sodium management is being reassessed: individualized reductions can help better control blood pressure but must be used cautiously in certain patients. Finally, in elderly patients contraindicated for transplantation, initiating hemodialysis provides only a modest survival benefit, sometimes at the cost of reduced time spent at home. Decisions between dialysis and conservative management (opting not to dialyze) should therefore be guided by patient preferences and quality of life.","PeriodicalId":94153,"journal":{"name":"Nephrologie & therapeutique","volume":"21 S1","pages":"11-17"},"PeriodicalIF":0.0,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144048497","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The highlights of the SFNDT congress - October 1st to 4th 2024, Bordeaux SFNDT大会的亮点- 2024年10月1日至4日，波尔多

Nephrologie & therapeutique Pub Date : 2025-04-10 DOI: 10.1684/ndt.2025.109

François Vrtovsnik

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Activité physique adaptée en hémodialyse. 适合血液透析的身体活动。

Nephrologie & therapeutique Pub Date : 2025-04-01 DOI: 10.1684/ndt.2025.116

Quentin Bellanger, Antoine Desvergée, Mélanie Hanoy, Hélène Azambourg, Nicolas Gautier, Patrick Henri

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Peritoneal dialysis in the management of acute kidney injury in children and young adults within French-speaking countries - Partnership between the Société francophone de néphrologie, dialyse et transplantation (SFNDT) and the Saving Young Lives program 腹膜透析在法语国家儿童和青年急性肾损伤治疗中的应用——法语国家社会组织、透析和移植（SFNDT）和拯救年轻生命计划之间的伙伴关系

Nephrologie & therapeutique Pub Date : 2025-03-26 DOI: 10.1684/ndt.2025.113

Annabel Boyer, Abdou Niang, Rasha Darwish, Nadia Kabbali, Karim Dardim, Céline Nodimar, Victor Fages, Chetan Kumar Velumurugan, Mignon Mcculloch, Brett Cullis, Clémence Bechade, Thierry Lobbedez

{"title":"Peritoneal dialysis in the management of acute kidney injury in children and young adults within French-speaking countries - Partnership between the Société francophone de néphrologie, dialyse et transplantation (SFNDT) and the Saving Young Lives program","authors":"Annabel Boyer, Abdou Niang, Rasha Darwish, Nadia Kabbali, Karim Dardim, Céline Nodimar, Victor Fages, Chetan Kumar Velumurugan, Mignon Mcculloch, Brett Cullis, Clémence Bechade, Thierry Lobbedez","doi":"10.1684/ndt.2025.113","DOIUrl":"10.1684/ndt.2025.113","url":null,"abstract":"Acute kidney injury (AKI) is a common event associated with a high mortality rate in the absence of adequate treatment. In lower-income countries, peritoneal dialysis (PD) plays an essential role in the treatment of AKI, especially in the paediatric population. In 2013, the International Society of Nephrology (ISN) launched the ‘0 by 25’ project, which aims to eliminate preventable deaths from AKI worldwide by 2025. The Saving Young Lives (SYL) program is a key component of this initiative, with the objective that by 2025 there will be no deaths resulting from AKI. Despite SYL’s efforts, access to the program and seminars, which were previously held in English, had been limited to English-speaking countries. As a result, French-speaking African countries were underrepresented among participants due to the language barrier. Since 2023, to promote PD training in French-speaking African regions, the Société francophone de néphrologie, dialyse et transplantation (SFNDT) has sought to form a partnership with the SYL program. The objective of this partnership is to train healthcare providers from French-speaking African countries in the use of PD and PD catheter placement for the management of AKI. This partnership aims to establish seminars in French with both theoretical and practical workshops. Here, we describe the local context, challenges, and perspectives of this partnership.","PeriodicalId":94153,"journal":{"name":"Nephrologie & therapeutique","volume":"21 2","pages":"1-9"},"PeriodicalIF":0.0,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143712572","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ten propositions to reduce the carbon footprint of clinical research 减少临床研究碳足迹的十项建议

Nephrologie & therapeutique Pub Date : 2025-03-26 DOI: 10.1684/ndt.2025.114

Maryvonne Hourmant, Anna-Julie Peired

引用次数: 0

Intraperitoneal pressure measurements in children: a retrospective study. 儿童腹腔内压力测量：一项回顾性研究。

Nephrologie & therapeutique Pub Date : 2025-03-11 DOI: 10.1684/ndt.2025.106

Anne-Louise Sawaya, Ivan Damgov, Soraya Menouer, Joëlle Terzic, Claus Peter Schmitt, Ariane Zaloszyc

{"title":"Intraperitoneal pressure measurements in children: a retrospective study.","authors":"Anne-Louise Sawaya, Ivan Damgov, Soraya Menouer, Joëlle Terzic, Claus Peter Schmitt, Ariane Zaloszyc","doi":"10.1684/ndt.2025.106","DOIUrl":"10.1684/ndt.2025.106","url":null,"abstract":"Background: The peritoneal dialysis (PD) regimes should be individualized based on clinical tolerance and adequacy. Routine hydrostatic intraperitoneal pressure (IPP) measurements have been suggested to define optimal intraperitoneal dialysate volume (IPV), data on applicability and variability in clinical routine are few.Methods: We retrospectively analysed 655 IPP measurements monthly performed in 21 children on stable automated PD. IPP was measured with the day-time dwell volume (IPV 606 ± 303 mL/m2) after two-hour dwell time (IPP1; n = 430), and again with the night-time dwell volume (IPV 958 ± 274 mL/m2) after 10 min dwell time (IPP2; n = 225), using bicarbonate (BPDF) and lactate buffered (LPDF) low GDP fluids and icodextrin fluid (IPDF), respectively. Findings were related to PD related complications and Kt/V.Results: Mean of all IPP measurements was 11.0 ± 2.6 cmH2O or 2.1 ± 0.8 cmH2O/100 mL/m2, with a mean IPV of 7.3 ± 3.4 mL/100 mL/m². Mean IPP1 was 10.3 ± 2.2 cmH2O, corresponding to 6.1 ± 3.1 mL/100 mL/m² IPV, IPP2 was 12.5 ± 2.5 cmH2O, corresponding to 9.6 ± 2.6 mL/100 mL/m² IPV (IPP1 vs IPP2 p < 0.0001).Conclusion: The values of IPP were acceptable in this pediatric population. IPP is relatively higher with higher fill volumes per BSA. Using single fill volume IPP measurements provides IPP with high intra- and interindividual variability. The relation to patient outcome is uncertain.","PeriodicalId":94153,"journal":{"name":"Nephrologie & therapeutique","volume":"21 1","pages":"13-22"},"PeriodicalIF":0.0,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143597987","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Early conversion to belatacept post-transplantation: state of the art and expert opinion 移植后早期转化为可接受移植：最新进展和专家意见

Nephrologie & therapeutique Pub Date : 2025-03-11 DOI: 10.1684/ndt.2025.104

Johan Noble, Dany Anglicheau, Gilles Blancho, Dominique Bertrand, Lionel Couzi, Antoine Durrbach, Philippe Grimbert, Nassim Kamar, Yannick Le Meur, Bruno Moulin, Lionel Rostaing

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