Nephrologie & therapeutique最新文献_第3页

Néphrologie & Thérapeutique on the way! nsamrology和thsamrapeutique在路上了！

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Nephrologie & therapeutique Pub Date : 2025-06-27 DOI: 10.1684/ndt.2025.127

Valérie Moal, François Vrtovsnik, Bacchetta Justine, Olivia Boyer, Christophe Mariat, Sandrine Lemoine

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Catheter placement by nephrologists: A safe and effective method for improving access to peritoneal dialysis 肾科医师置管：一种安全有效的改善腹膜透析的方法。

Nephrologie & therapeutique Pub Date : 2025-06-27 DOI: 10.1684/ndt.2025.119

Maria Lafrid, Abdelaali Bahadi, Narjiss Labioui, Ismail Hanine, Hajar Laasli, Theresia Peya Mponguili, Mohammed Hallak, Sanae Benbria, Driss El Kabbaj

{"title":"Catheter placement by nephrologists: A safe and effective method for improving access to peritoneal dialysis","authors":"Maria Lafrid, Abdelaali Bahadi, Narjiss Labioui, Ismail Hanine, Hajar Laasli, Theresia Peya Mponguili, Mohammed Hallak, Sanae Benbria, Driss El Kabbaj","doi":"10.1684/ndt.2025.119","DOIUrl":"10.1684/ndt.2025.119","url":null,"abstract":"Introduction: Peritoneal dialysis (PD) is an effective treatment option for patients with kidney failure and offers them a better quality of life. Despite its advantages, PD remains underutilized, particularly in Morocco. The aim of our study was to evaluate the impact of catheter placement by nephrologists on the number of incident PD patients, compare the success rates of this technique with those of surgical placement, and assess the short- and long-term complications associated with the two approaches.Methods: This was a single-center retrospective study including 69 PD patients, conducted from January 2008 to December 2022.Results: A total of 28 patients received PD catheter placement by nephrologists (Group A), while 41 underwent the procedure performed by urologists (Group B). Since the introduction of nephrologist-led catheter placement, the incidence of patients starting PD significantly increased, with a growth rate of over 100% every two years. The waiting time for catheter placement was significantly shorter in Group A (5 days versus 20 days; p < 0.001). No significant difference was observed in the incidence of short-term mechanical and infectious complications between the two groups. Although univariable analysis revealed a higher incidence of long-term mechanical and infectious complications in Group B compared to group A, this difference was not statistically significant in multivariable analysis (p > 0.05). The success rate of PD catheter placement in Group A was 92.85%, while it was 97.56% in Group B. The one-year catheter survival rate was significantly higher in Group B than in Group A (100% versus 75%; p = 0.031), and mean catheter survival was significantly longer in Group B (17 months versus 11 months; p = 0.026).Conclusion: PD catheter placement by nephrologists proved to be a safe and effective approach.","PeriodicalId":94153,"journal":{"name":"Nephrologie & therapeutique","volume":"21 2","pages":"143-152"},"PeriodicalIF":0.0,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144103446","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Administration of lumasiran in a child with infantile oxalosis undergoing chronic peritoneal dialysis: A case report 鲁马西兰治疗慢性腹膜透析的草化病患儿1例

Nephrologie & therapeutique Pub Date : 2025-06-27 DOI: 10.1684/ndt.2025.121

Chloé Grosyeux, Arnaud Wiedemann, Marie-Christine Camoin-Schweitzer, Cécile Acquaviva-Bourdain, Noël Boussard, Justine Bacchetta, Isabelle Vrillon

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Once upon a time in nephrology - Episode 1: Management of thrombotic microangiopathy 曾几何时在肾脏病-第1集：血栓性微血管病的管理

Nephrologie & therapeutique Pub Date : 2025-06-27 DOI: 10.1684/ndt.2025.128

Simon Ville, Pierre Delanaye, Christophe Mariat

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Once upon a time in nephrology, or how did we get here? 从前在肾脏学，或者我们是怎么走到这一步的？

Nephrologie & therapeutique Pub Date : 2025-06-27 DOI: 10.1684/ndt.2025.126

Simon Ville, Pierre Delanaye, Christophe Mariat

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Vitamin D, anemia, and fibroblast growth factor 23: Ethnic disparities in Algerian chronic kidney disease patients 维生素D、贫血和成纤维细胞生长因子23：阿尔及利亚慢性肾病患者的种族差异

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Nephrologie & therapeutique Pub Date : 2025-06-27 DOI: 10.1684/ndt.2025.124

Lydia Ziouani, Damien Gruson, Messaoud Saidani, Elhadj-Ahmed Koceir

{"title":"Vitamin D, anemia, and fibroblast growth factor 23: Ethnic disparities in Algerian chronic kidney disease patients","authors":"Lydia Ziouani, Damien Gruson, Messaoud Saidani, Elhadj-Ahmed Koceir","doi":"10.1684/ndt.2025.124","DOIUrl":"10.1684/ndt.2025.124","url":null,"abstract":"This study investigates ethnic differences in vitamin D levels and bone-related biomarkers among Algerian CKD patients, focusing on the interactions between vitamin D, anemia, and FGF23. A multicenter, cross-sectional study involved 284 CKD patients in stages 3 and 4, with a mean age of 54±1.17 years. Participants were recruited from nephrology units in three distinct geographic regions of Algeria: Algiers (Mediterranean), Ghardaïa (sub-Saharan), and Tamanrasset (Saharan). Biochemical analyses included serum levels of 25OH vitamin D, iPTH, iFGF23, calcium, phosphorus, and hemoglobin. Multiple logistic regression was used to assess the association between anemia and vitamin D levels. Linear regression analysis identified predictors of iFGF23 in hemoglobin levels. A two-way ANOVA was performed to examine the influence of vitamin D levels across different ethnic groups. Patients from Tamanrasset exhibited significantly lower levels of 25OH vitamin D and hemoglobin, and higher levels of phosphorus, iFGF23, and iPTH, compared to those from Ghardaïa and Algiers. Anemia was independently associated with lower serum 25OH vitamin D concentrations (β=-0.11, P=0.001), while iFGF23 levels were inversely associated with hemoglobin levels (β=-3.3, P=0.01). A significant interaction between anemia and vitamin D status was observed among Black patients (P=0.0001), but not among white patients (P=0.7). These findings underscore notable ethnic disparities in vitamin D status and mineral biomarkers among Algerian CKD patients. The interplay between vitamin D, anemia, and FGF23 highlights the need for ethnically tailored care, particularly for patients in the Saharan region of Tamanrasset.","PeriodicalId":94153,"journal":{"name":"Nephrologie & therapeutique","volume":"21 3","pages":"161-169"},"PeriodicalIF":0.7,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144268291","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Effectiveness of virtual reality interventions on anxiety and depressive symptoms in hemodialysis patients: A systematic review 虚拟现实干预对血液透析患者焦虑和抑郁症状的有效性：系统综述

Nephrologie & therapeutique Pub Date : 2025-06-27 DOI: 10.1684/ndt.2025.122

Safia Mecerli, Valentine Cazauvieilh, Romain Vial, Sébastien Colson, Christophe Roman, Mickaël Bobot, Philippe Brunet

{"title":"Effectiveness of virtual reality interventions on anxiety and depressive symptoms in hemodialysis patients: A systematic review","authors":"Safia Mecerli, Valentine Cazauvieilh, Romain Vial, Sébastien Colson, Christophe Roman, Mickaël Bobot, Philippe Brunet","doi":"10.1684/ndt.2025.122","DOIUrl":"10.1684/ndt.2025.122","url":null,"abstract":"Background: End-stage chronic kidney disease affects millions of people worldwide, and its treatment through hemodialysis results in a high rate of depression and anxiety. To address these disorders, virtual reality can be used as a non-pharmacological psychological intervention.Objective: To describe the effectiveness of virtual reality interventions on depression and anxiety symptoms in hemodialysis patients.Methods: A systematic review was conducted in the PubMed, Embase, ScienceDirect, and PsycInfo databases. Six quantitative studies published between 2019 and 2024 that address the impact of virtual reality on anxiety and depressive symptoms in hemodialysis patients were included according to the PRISMA method. A methodical analysis of these studies was performed.Results: These studies utilize various virtual reality interventions, both immersive and non-immersive, such as “exergaming.” They predominantly report a significant improvement in depression and anxiety scores in hemodialysis patients. The benefit of these studies varies according to the type and duration of the intervention. The main limitations include the small number of available studies and limited sample sizes.Conclusion: Virtual reality interventions show promising potential for improving anxiety and depressive symptoms in hemodialysis patients. They can find a place in non-pharmacological management. Large additional studies are needed to better understand their potential benefits and to optimize their handling by patients and caregivers.","PeriodicalId":94153,"journal":{"name":"Nephrologie & therapeutique","volume":"21 3","pages":"170-179"},"PeriodicalIF":0.0,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144268290","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Biopsy-based transcriptomics in kidney transplantation: Where do we stand in 2025? 肾脏移植中的分子生物学工具用于诊断排斥反应。2025年我们在哪里？

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Nephrologie & therapeutique Pub Date : 2025-06-27 DOI: 10.1684/ndt.2025.125

Rachna Baguant, Dominique Bertrand, Arnaud François, Steven Grangé, Dominique Guerrot, Charlotte Laurent, Mathilde Lemoine, Sophie Candon, Tristan de Nattes

{"title":"Biopsy-based transcriptomics in kidney transplantation: Where do we stand in 2025?","authors":"Rachna Baguant, Dominique Bertrand, Arnaud François, Steven Grangé, Dominique Guerrot, Charlotte Laurent, Mathilde Lemoine, Sophie Candon, Tristan de Nattes","doi":"10.1684/ndt.2025.125","DOIUrl":"10.1684/ndt.2025.125","url":null,"abstract":"Despite advances in the physiopathological understanding of kidney transplantation immunology, kidney transplant rejection remains the leading cause of allograft loss. The current gold standard for diagnosing rejection is histological assessment of kidney transplant biopsies.\u0000Biopsy-based transcriptomics have been the subject of numerous studies, enabling the analysis of hundreds of transcripts expressed in biopsy samples. These tools allow for the identification of new pathophysiological pathways, providing a better understanding of rejection and potentially revealing therapeutic targets.\u0000Biopsy-based transcriptomics may also improve the diagnosis of rejection, in particular antibody-mediated rejection. However, the use of these tools in routine practice is limited due to restricted availability, the challenge of interpreting data from hundreds of transcripts without clear guidelines, and their cost. In addition, due to the limited accessibility of molecular tools, their exact impact on patient management has not yet been determined.\u0000This update provides an overview of biopsy-based transcriptomics in 2025, focusing on the limitations of current diagnostic methods for rejection, the molecular biology tools available, and their use in clinical practice.","PeriodicalId":94153,"journal":{"name":"Nephrologie & therapeutique","volume":"21 2","pages":"184-194"},"PeriodicalIF":0.7,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144268289","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Are your kidneys ok? Early detection to protect kidney health. 你的肾脏还好吗？早期发现，保护肾脏健康。

Nephrologie & therapeutique Pub Date : 2025-05-15 DOI: 10.1684/ndt.2025.120

Joseph A Vassalotti, Anna Francis, Augusto Cesar Soares Dos Santos, Ricardo Correa-Rotter, Dina Abdellatif, Li-Li Hsiao, Stefanos Roumeliotis, Agnes Haris, Latha A Kumaraswami, Siu-Fai Lui, Alessandro Balducci, Vassilios Liakopoulos

{"title":"Are your kidneys ok? Early detection to protect kidney health.","authors":"Joseph A Vassalotti, Anna Francis, Augusto Cesar Soares Dos Santos, Ricardo Correa-Rotter, Dina Abdellatif, Li-Li Hsiao, Stefanos Roumeliotis, Agnes Haris, Latha A Kumaraswami, Siu-Fai Lui, Alessandro Balducci, Vassilios Liakopoulos","doi":"10.1684/ndt.2025.120","DOIUrl":"10.1684/ndt.2025.120","url":null,"abstract":"Early detection of kidney disease can protect kidney health, prevent kidney disease progression and related complications, reduce the risk of cardiovascular disease, and decrease mortality. We must ask, “Are your kidneys ok?” by using serum creatinine to estimate kidney function and urine albumin to assess kidney and endothelial damage. Evaluation of causes and risk factors for chronic kidney disease (CKD) includes testing for diabetes, as well as measuring blood pressure and body mass index. This World Kidney Day we assert that case-finding in high-risk populations – or even population-level screening – can significantly reduce the global burden of kidney disease. Early-stage CKD is asymptomatic and simple to test for. Recent paradigm-shifting CKD treatments, such as sodium-glucose cotransporter-2 inhibitors, dramatically improve outcomes and favor the cost-benefit analysis for screening or case-finding programs. Despite this, numerous barriers exist, including resource allocation, health care funding, infrastructure, and both health care professionals’ and the public’s awareness of kidney disease. Coordinated efforts by major kidney-focused non-governmental organizations to prioritize kidney health within government agendas and align early detection efforts with other current programs will maximize efficiencies.","PeriodicalId":94153,"journal":{"name":"Nephrologie & therapeutique","volume":"21 2","pages":"65-72"},"PeriodicalIF":0.0,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144083039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Physical activity in hemodialysis 血液透析中的体力活动

Nephrologie & therapeutique Pub Date : 2025-05-15 DOI: 10.1684/ndt.2025.116

Quentin Bellanger, Antoine Desvergée, Mélanie Hanoy, Hélène Azambourg, Nicolas Gautier, Patrick Henri

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