Nephrologie & therapeutique最新文献

Néphrologie & Thérapeutique on the way! nsamrology和thsamrapeutique在路上了！

Nephrologie & therapeutique Pub Date : 2025-06-18 DOI: 10.1684/ndt.2025.127

Valérie Moal, François Vrtovsnik, Bacchetta Justine, Olivia Boyer, Christophe Mariat, Sandrine Lemoine

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Once upon a time in nephrology - Episode 1: Management of thrombotic microangiopathy< 曾几何时在肾脏病-第1集：血栓性微血管病的管理

Nephrologie & therapeutique Pub Date : 2025-06-18 DOI: 10.1684/ndt.2025.128

Simon Ville, Pierre Delanaye, Christophe Mariat

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Once upon a time in nephrology, or how did we get here? 从前在肾脏学，或者我们是怎么走到这一步的？

Nephrologie & therapeutique Pub Date : 2025-06-18 DOI: 10.1684/ndt.2025.126

Simon Ville, Pierre Delanaye, Christophe Mariat

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Exploring quality of life among chronic hemodialysis patients: Navigating the cumulative impact of multiple crises 探索慢性血液透析患者的生活质量：导航多重危机的累积影响

Nephrologie & therapeutique Pub Date : 2025-06-11 DOI: 10.1684/ndt.2025.123

Rayyan Wazzi-Mkahal, Ranim Razzouk, Krystel Aouad, Najat Fares, Valerie Hage

{"title":"Exploring quality of life among chronic hemodialysis patients: Navigating the cumulative impact of multiple crises","authors":"Rayyan Wazzi-Mkahal, Ranim Razzouk, Krystel Aouad, Najat Fares, Valerie Hage","doi":"10.1684/ndt.2025.123","DOIUrl":"https://doi.org/10.1684/ndt.2025.123","url":null,"abstract":"Introduction: Hemodialysis patients have poorer health-related quality of life (HRQOL) compared to the general population. HRQOL is influenced by many sociodemographic and clinical factors. The aim of our study is to describe the HRQOL among adult patients undergoing hemodialysis during a period of economic and health crisis.Methods: This is a cross-sectional study including patients who had been on hemodialysis for at least 3 months. We interviewed a total of 90 hemodialysis patients using the 36-Item Short Form Health Survey (SF36). The SF-36 measures eight scales and two distinct concepts: the Physical Component Summary (PCS) and the Mental Component Summary (MCS). Data analyses was performed with RStudio version 2022.12.0.Results: The mean age (±SD) was 69.67±12.80 years. The mean PCS score (±SD) was 48.55±24.7 and the mean MCS score (±SD) was 58.62±22.1. The highest scores among the SF-36 were emotional well-being (66.65±20.02) and social functioning (66.53±27.40). Multivariate analysis showed that PTH levels and occupational status are significantly associated with PCS scores (p=0.007 and p=0.03 respectively), and that age at onset of dialysis, PTH levels, occupational status, marital status, and COVID-19 infection are significantly associated with MCS scores (p=0.04, p<0.001, p=0.003, p=0.006 and p=0.007 respectively).Conclusion: The overall PCS and MCS scores were low, indicating poor HRQOL. However, the crises did not appear to directly worsen it, due to a strong social support system. A multidisciplinary team approach may improve the HRQOL of these patients.","PeriodicalId":94153,"journal":{"name":"Nephrologie & therapeutique","volume":"21 2","pages":"1-8"},"PeriodicalIF":0.0,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144268288","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Administration of lumasiran in a child with infantile oxalosis undergoing chronic peritoneal dialysis: A case report 鲁马西兰治疗慢性腹膜透析的草化病患儿1例

Nephrologie & therapeutique Pub Date : 2025-06-11 DOI: 10.1684/ndt.2025.121

Chloé Grosyeux, Arnaud Wiedemann, Marie-Christine Camoin-Schweitzer, Cécile Acquaviva-Bourdain, Noël Boussard, Justine Bacchetta, Isabelle Vrillon

{"title":"Administration of lumasiran in a child with infantile oxalosis undergoing chronic peritoneal dialysis: A case report","authors":"Chloé Grosyeux, Arnaud Wiedemann, Marie-Christine Camoin-Schweitzer, Cécile Acquaviva-Bourdain, Noël Boussard, Justine Bacchetta, Isabelle Vrillon","doi":"10.1684/ndt.2025.121","DOIUrl":"https://doi.org/10.1684/ndt.2025.121","url":null,"abstract":"Background: Lumasiran is a small interfering RNA molecule indicated for the treatment of primary hyperoxaluria type 1 (PH1).Case diagnosis/treatment: We report a case of infantile PH1 in a 3-month-old girl admitted with anuria and kidney failure. Peritoneal dialysis (PD) and conservative treatment were immediately initiated. The first dose of lumasiran was administered at 12 months, while the patient was still on PD. Despite very high baseline plasma oxalate (POx) levels of around 200 µmol/L, treatment with lumasiran led to a nearly 50% reduction in POx levels, even during PD. Once the patient reached a sufficient body weight to safely initiate hemodialysis (HD), she was switched to HD; POx levels remained around 100 µmol/L, despite an intensive HD regimen.Conclusion: This is one of the first reported cases of lumasiran therapy during PD in an infant with PH1; even with this dialysis modality, POx levels can be decreased to a certain extent.","PeriodicalId":94153,"journal":{"name":"Nephrologie & therapeutique","volume":"21 2","pages":"1-4"},"PeriodicalIF":0.0,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144268279","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effectiveness of virtual reality interventions on anxiety and depressive symptoms in hemodialysis patients: A systematic review 虚拟现实干预对血液透析患者焦虑和抑郁症状的有效性：系统综述

Nephrologie & therapeutique Pub Date : 2025-06-11 DOI: 10.1684/ndt.2025.122

Safia Mecerli, Valentine Cazauvieilh, Romain Vial, Sébastien Colson, Christophe Roman, Mickaël Bobot, Philippe Brunet

{"title":"Effectiveness of virtual reality interventions on anxiety and depressive symptoms in hemodialysis patients: A systematic review","authors":"Safia Mecerli, Valentine Cazauvieilh, Romain Vial, Sébastien Colson, Christophe Roman, Mickaël Bobot, Philippe Brunet","doi":"10.1684/ndt.2025.122","DOIUrl":"https://doi.org/10.1684/ndt.2025.122","url":null,"abstract":"Contexte: La maladie rénale chronique terminale affecte des millions de personnes dans le monde et son traitement par hémodialyse entraîne un taux élevé de dépression et d'anxiété. Pour traiter ces troubles, la réalité virtuelle peut être utilisée comme intervention psychologique non médicamenteuse.Objectif: Cette revue a pour objectif de décrire l'efficacité des interventions de réalité virtuelle sur les symptômes de dépression et d'anxiété des patients hémodialysés.Méthodes: Une revue systématique a été réalisée dans les bases de données Pubmed, Embase, ScienceDirect et PsycInfo. Six études quantitatives publiées entre 2019 et 2024, traitant de l'impact de la réalité virtuelle sur les symptômes anxieux et dépressifs des patients hémodialysés ont été incluses selon la méthode PRISMA. Une analyse méthodique de ces études a été réalisée.Résultats: Ces études utilisent des interventions de réalité virtuelle différentes, immersives ou non immersives de type « exergaming ». Elles rapportent majoritairement une amélioration significative des scores de dépression et d'anxiété chez les patients hémodialysés. Le bénéfice de ces études est variable selon le type et la durée de l'intervention. Les principales limites existantes concernent le peu d'études disponibles et la taille des échantillons souvent limitée.Conclusion: Les interventions de réalité virtuelle ont un potentiel prometteur pour améliorer les symptômes anxio-dépressifs des patients hémodialysés. Elles trouvent leur place dans la prise en charge non médicamenteuse. De larges études supplémentaires sont nécessaires pour mieux comprendre leurs potentiels bénéfices et pouvoir optimiser leur prise en main par les patients et les équipes de soin.","PeriodicalId":94153,"journal":{"name":"Nephrologie & therapeutique","volume":"21 3","pages":"1-10"},"PeriodicalIF":0.0,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144268290","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Vitamin D, anemia, and fibroblast growth factor 23 : ethnic disparities in Algerian chronic kidney disease patients. 维生素D、贫血和成纤维细胞生长因子23：阿尔及利亚慢性肾病患者的种族差异

Nephrologie & therapeutique Pub Date : 2025-06-01 DOI: 10.1684/ndt.2025.124

Lydia Ziouani, Damien Gruson, Messaoud Saidani, Elhadj-Ahmed Koceir

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Outils de biologie moléculaire en transplantation rénale pour le diagnostic du rejet. Où en sommes-nous en 2025 ? 肾脏移植中的分子生物学工具用于诊断排斥反应。2025年我们在哪里？

Nephrologie & therapeutique Pub Date : 2025-06-01 DOI: 10.1684/ndt.2025.125

Rachna Baguant, Dominique Bertrand, Arnaud François, Steven Grangé, Dominique Guerrot, Charlotte Laurent, Mathilde Lemoine, Sophie Candon, Tristan de Nattes

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Catheter placement by nephrologists: A safe and effective method for improving access to peritoneal dialysis 肾科医师置管：一种安全有效的改善腹膜透析的方法。

Nephrologie & therapeutique Pub Date : 2025-05-21 DOI: 10.1684/ndt.2025.119

Maria Lafrid, Abdelaali Bahadi, Narjiss Labioui, Ismail Hanine, Hajar Laasli, Theresia Peya Mponguili, Mohammed Hallak, Sanae Benbria, Driss El Kabbaj

{"title":"Catheter placement by nephrologists: A safe and effective method for improving access to peritoneal dialysis","authors":"Maria Lafrid, Abdelaali Bahadi, Narjiss Labioui, Ismail Hanine, Hajar Laasli, Theresia Peya Mponguili, Mohammed Hallak, Sanae Benbria, Driss El Kabbaj","doi":"10.1684/ndt.2025.119","DOIUrl":"10.1684/ndt.2025.119","url":null,"abstract":"Introduction: Peritoneal dialysis (PD) is an effective treatment option for patients with kidney failure and offers them a better quality of life. Despite its advantages, PD remains underutilized, particularly in Morocco. The aim of our study was to evaluate the impact of catheter placement by nephrologists on the number of incident PD patients, compare the success rates of this technique with those of surgical placement, and assess the short- and long-term complications associated with the two approaches.Methods: This was a single-center retrospective study including 69 PD patients, conducted from January 2008 to December 2022.Results: A total of 28 patients received PD catheter placement by nephrologists (Group A), while 41 underwent the procedure performed by urologists (Group B). Since the introduction of nephrologist-led catheter placement, the incidence of patients starting PD significantly increased, with a growth rate of over 100% every two years. The waiting time for catheter placement was significantly shorter in Group A (5 days versus 20 days; p < 0.001). No significant difference was observed in the incidence of short-term mechanical and infectious complications between the two groups. Although univariable analysis revealed a higher incidence of long-term mechanical and infectious complications in Group B compared to group A, this difference was not statistically significant in multivariable analysis (p > 0.05). The success rate of PD catheter placement in Group A was 92.85%, while it was 97.56% in Group B. The one-year catheter survival rate was significantly higher in Group B than in Group A (100% versus 75%; p = 0.031), and mean catheter survival was significantly longer in Group B (17 months versus 11 months; p = 0.026).Conclusion: PD catheter placement by nephrologists proved to be a safe and effective approach.","PeriodicalId":94153,"journal":{"name":"Nephrologie & therapeutique","volume":"21 2","pages":"1-10"},"PeriodicalIF":0.0,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144103446","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Physical activity in hemodialysis 血液透析中的体力活动

Nephrologie & therapeutique Pub Date : 2025-05-15 DOI: 10.1684/ndt.2025.116

Quentin Bellanger, Antoine Desvergée, Mélanie Hanoy, Hélène Azambourg, Nicolas Gautier, Patrick Henri

引用次数: 0