Medical research archives最新文献

{"title":"Design and testing of Hepatitis Delta Ribozymes for suppression of Chikungunya virus infection in cell cultures.","authors":"Mark E Fraser, Cheryl Kucharski, Zoe Loh, Erin Hanahoe, Malcolm J Fraser","doi":"10.18103/mra.v12i8.5762","DOIUrl":"https://doi.org/10.18103/mra.v12i8.5762","url":null,"abstract":"<p><p>Chikungunya virus is an emerging pathogen with widespread distribution in regions of Africa, India, and Asia that threatens to spread into temperate climates following the introduction of its major vector, <i>Aedes albopictus</i>. Recent cases have been documented in Europe, the Caribbean, and the Americas. Chikungunya virus causes a disease frequently misdiagnosed as Dengue fever, with potentially life-threatening symptoms that can result in long term debilitating arthritis. There have been ongoing investigations of possible therapeutic interventions for both acute and chronic symptoms, but to date none have proven effective in reducing the severity or lasting effects of this disease. Recently, a promising vaccine candidate has received accelerated approval, indicating the importance of remedies to this emerging worldwide health threat. Nonetheless, therapeutic interventions for Chikungunya and other mosquito borne virus diseases are urgently needed yet remain elusive. The increasing risk of spread from endemic regions via human travel and commerce, coupled with the absence of a vaccine or approved therapeutic, puts a significant proportion of the world population at risk for this disease. In this report we explore the possibility of using Specific On/oFf Adapter Hepatitis Delta Virus Ribozymes as antivirals in cells infected with Chikungunya virus. The results we obtained suggest there could be some role in using these ribozyme molecules as antiviral therapies for not only Chikungunya virus, but potentially other viruses as well.</p>","PeriodicalId":94137,"journal":{"name":"Medical research archives","volume":"12 8","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11423935/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142335384","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Medical Mistrust on Prostate Cancer Screening: A mixed method study among African Americans, Caribbean immigrants and African immigrants.","authors":"Malika Nipher, Roberts Lisa, Alemi Qais, Casiano Carlos A, Montgomery Susanne","doi":"10.18103/mra.v12i8.5727","DOIUrl":"10.18103/mra.v12i8.5727","url":null,"abstract":"<p><strong>Objectives: </strong>The contribution of medical mistrust to healthcare utilization delays has been gaining increasing attention. However, few studies have examined these associations among subgroups of Black men (African Americans, Caribbean, and African immigrants) in relation to prostate cancer (PCa). This study addresses this gap by assessing how medical mistrust affects PCa screening behavior and to further understand perceptions of medical mistrust among subgroups of Black men.</p><p><strong>Methods: </strong>This research employs a mixed-methods approach comprising two distinct phases. In Phase 1, a cross-sectional examination was conducted to evaluate the influence of medical mistrust toward healthcare organizations on prostate cancer screening among 498 Black men. In Phase 2, a qualitative investigation was undertaken to delve into the nuances of medical mistrust through six focus groups (n=51) and ten key informant interviews (n=10). Logistic regression and grounded theory methods were employed for data analysis.</p><p><strong>Results: </strong>Quantitative findings unveiled disparities in mistrust among subgroups, with Caribbean immigrants exhibiting higher levels of medical mistrust. Nevertheless, individuals with a family history of PCa showed elevated likelihoods of undergoing screening, despite mistrust. Qualitative results revealed 1) differences in reasons for medical mistrust among Black subgroups, 2) cultural perceptions which influence medical mistrust and medical care seeking, 3) lack of education in relation to PCa that contributes to medical mistrust, 4) negative past experiences and poor provider communication contribute, and 5) when PCa directly affected one's life, either personally or within the family, there was a recognized importance placed on monitoring one's risk despite mistrust.</p><p><strong>Conclusion: </strong>While medical mistrust may not significantly deter healthcare utilization among individuals with a family history or diagnosis of PCa, it underscores the variability of medical mistrust and its underlying reasons among different Black subgroups.</p>","PeriodicalId":94137,"journal":{"name":"Medical research archives","volume":"12 8","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11466240/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142402480","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Linking alcohol use to Alzheimer's disease: Interactions with aging and APOE along immune pathways.","authors":"Mollie Monnig, Krish Shah","doi":"10.18103/mra.v12i8.5228","DOIUrl":"10.18103/mra.v12i8.5228","url":null,"abstract":"<p><p>Although it is known that APOE genotype is the strongest genetic risk factor for late-onset Alzheimer's disease, development is a multifactorial process. Alcohol use is a contributor to the epidemic of Alzheimer's disease and related dementias in the US and globally, yet mechanisms are not fully understood. Carriers of the APOE ε4 allele show elevated risk of dementia in relation to several lifestyle factors, including alcohol use. In this review, we describe how alcohol interacts with APOE genotype and aging with potential implications for Alzheimer's disease promotion. Age-related immune senescence and \"inflammaging\" (i.e., low-grade inflammation associated with aging) are increasingly recognized as contributors to age-related disease. We focus on three immune pathways that are likely contributors to Alzheimer's disease development, centering on alcohol and APOE genotype interactions, specifically: 1) microbial translocation and immune activation, 2) the senescence associated secretory phenotype, and 3) neuroinflammation. First, microbial translocation, the unphysiological movement of gut products into systemic circulation, elicits a proinflammatory response and increases with aging, with proposed links to Alzheimer's disease. Second, the senescence associated secretory phenotype is a set of intercellular signaling factors, e.g., proinflammatory cytokines and chemokines, growth regulators, and proteases, that drives cellular aging when senescent cells remain metabolically active. The senescence associated secretory phenotype can drive development of aging-diseases such as Alzheimer's disease. Third, neuroinflammation occurs via numerous mechanisms such as microglial activation and is gaining recognition as an etiological factor in the development of Alzheimer's disease. This review focuses on interactions of alcohol with APOE genotype and aging along these three pathways that may promote Alzheimer's disease. Further research on these processes may inform development of strategies to prevent onset and progression of Alzheimer's disease and to delay associated cognitive decline.</p>","PeriodicalId":94137,"journal":{"name":"Medical research archives","volume":"12 8","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11563488/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142634709","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Co-occurring trauma- and stressor-related and substance-related disorders in youth: A narrative review.","authors":"Jesse D Hinckley, Zachary W Adams, Trey V Dellucci, Steven Berkowitz","doi":"10.18103/mra.v12i8.5688","DOIUrl":"10.18103/mra.v12i8.5688","url":null,"abstract":"<p><p>Adolescence is characterized by ongoing neurodevelopment and psychosocial development, resulting in a unique window to the adverse effects of traumatic events and substance use. In addition, trauma- and stressor-related disorders and substance use disorders (SUDs) commonly co-occur in adolescents. Youth with interpersonal violence and who have experienced multiple past traumas, or poly-victimization, are at the highest risk of developing these co-occurring disorders. There is a strong bidirectional relationship between traumatic events and substance use that predisposes youth to developing post-traumatic stress symptoms (PTSS) and SUDs. PTSD and states of substance intoxication and withdrawal also exhibit overlap in symptomatology. High rates of comorbidity may be explained in part by the self-medication hypothesis, that posits that individuals use substances to temporarily alleviate trauma-related symptoms. However, this results in negative reinforcement, often with increasing patterns of substance use and worsening symptoms of hyperarousal, dysphoria, and anxiety. In addition, PTSS and substance use problems share common risk factors and neurobiologic etiology, conceptualized as the susceptibility hypothesis. Youth who experience traumatic events and/or have substance use problems access the healthcare system at multiple levels, including through acute care and crisis services. Notably, substance use in adolescence increases the likelihood of experiencing a traumatic event, and youth presenting to the emergency department for substance-related problems are at higher risk of having a PTSD. Youth presenting for mental health, behavioral, or substance-related problems should be screened for PTSS and substance use problems. Given the strong clinical overlap and bidirectional relationship, evidence-based treatment integrates management of both disorders. An interdisciplinary approach with psychotherapy, psychopharmacologic therapy, and case management is often vital to engaging and maintaining youth in treatment.</p>","PeriodicalId":94137,"journal":{"name":"Medical research archives","volume":"12 8","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11600332/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142741732","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Addictive Behavior and Evolutionary Adaptation: Mitigated through Genetic Addiction Risk Severity Early Identification and Awareness Integration Theory.","authors":"Foojan Zeine, Nicole Jafari, Eileen Manoukian, Kenneth Blum","doi":"10.18103/mra.v12i8.5702","DOIUrl":"10.18103/mra.v12i8.5702","url":null,"abstract":"<p><strong>Objectives: </strong>Humans, with their unique genetic profile, exhibit a greater propensity to develop and maintain addiction compared to other animals. This paper offers a detailed examination of addiction, co-occurring traits, and psychologic disorders, focusing on neurobiological and molecular aspects. Furthermore, the authors investigate the potential of the Awareness Integration Theoretical model as an effective therapeutic addiction treatment.</p><p><strong>Methods: </strong>Using PsychINFO, PubMed, and Google Scholar, a comprehensive literature review was conducted on the evolutionary and adaptation pathways to addiction, epigenetic factors, and the potentiality of Awareness Integration Theory in treating addiction.</p><p><strong>Results: </strong>Epigenetics allows environmental factors to create lasting and heritable phenotypic changes, enabling rapid adaptation to these stimuli. Addiction \"high-jacks\" this system and the neurochemical mechanisms that control flexibility and innovation and is, thus, the price we pay for adaptability. Drug addiction is thought of as an adjunctive behavior or a subordinate behavior catalyzed by more profound, more significant psychological and biological stimuli.</p><p><strong>Conclusions: </strong>The neurochemical mechanisms underlying addiction, a complex interplay of genetic and environmental factors, are intertwined with the hallmark features of the human species, such as behavioral flexibility and pre-addictive propensity. The dopaminergic system, a key player in addiction, serves as a crucial link between addiction and the shared genetic profile evident in co-occurring traits and psychiatric and psychological disorders. Furthermore, a hypofunctioning dopaminergic system is a common characteristic of addiction and co-occurring psychiatric and psychological disorders. Early childhood preventative measures are vital in re-directing the existing predictive and poor adaptability functioning, which refers to the individual's inability to adapt to changing circumstances and reliance on maladaptive coping strategies. Awareness Integration Theory's approach encompasses a therapeutical model addressing individuals' physical, cognitive, and psychosocial domains, allowing the individual to address intergenerational and ancestral ineffective and harmful adaptability. This, in turn, AIT will allow the human genome to be on a healthier path to recovery from obstacles such as addiction. When a tendency or a characteristic improves your ability to function and survive, and especially your ability to produce and raise children, that will most likely break the cycle of addiction and addictive behavior.</p>","PeriodicalId":94137,"journal":{"name":"Medical research archives","volume":"12 8","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11600381/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142752742","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mental Health Literacy and Public Stigma: Examining the Link in 17 Countries.","authors":"Gabriele Ciciurkaite, Bernice A Pescosolido","doi":"10.18103/mra.v12i7.5471","DOIUrl":"10.18103/mra.v12i7.5471","url":null,"abstract":"<p><strong>Background: </strong>Literacy campaigns stand as the most common approach to raising awareness of mental health problems, increasing the use of services, and reducing stigma. However, research suggests that more informed public beliefs may have little effect or even trigger the stigma backlash. We aim to provide a wider, cross-national examination of how stigma varies globally and to examine whether the ability to recognize a mental health problem and see it as \"a disease like any other\" is the optimal roadmap for stigma reduction.</p><p><strong>Methods: </strong>Data came from the Stigma in Global Context - Mental Health Study (SGC-MHS), which were collected from non-institutionalized adults 18 years of age or older through face-to-face interviews using vignettes meeting the Diagnostic and Statistical Manual of Mental Disorders, 4^th edition clinical criteria for schizophrenia and major depression in 17 countries (N = 18,342; response rate 65.9%). Analyses of association between the public's endorsement of problem recognition, disease attributions, and severity on the desire for social distance were conducted using multivariate regression models in the structural equation modeling framework.</p><p><strong>Results: </strong>For both depression and schizophrenia, countries fell into three groups of low, medium and high levels of public stigma. Consistently, Brazil and Germany anchored the lowest levels, Bangladesh and Hungary reported the highest levels, with Great Britain, USA, Belgium falling in midrange. Measures of mental health literacy did not have uniform effects, but, where significant, tended to align with expectations under labelling theory's ideas about rejection rather than attribution theory's claims for mental health literacy. Ironically, the most stable factor associated with lower stigma is the assessment that the situation will improve on its own, in direct contradiction to literacy theories.</p><p><strong>Conclusion: </strong>Overall results suggest that anti-stigma efforts should move past a focus on mental health literacy or at least recognize its limitation and potential unintended consequences. Recognizing a situation as a mental illness can change the public's support for mental health services to some extent. The association between seeing the problem resolving on its own and lower stigma levels suggests that newer approaches that focus on connectedness and mental health may hold greater purchase to decrease public stigma and increase recovery.</p>","PeriodicalId":94137,"journal":{"name":"Medical research archives","volume":"12 7","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11376373/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142142248","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Redefining Cognitive Domains in the Era of ChatGPT: A Comprehensive Analysis of Artificial Intelligence's Influence and Future Implications.","authors":"Souvik Dubey, Ritwik Ghosh, Mahua Jana Dubey, Subhankar Chatterjee, Shambaditya Das, Julián Benito-León","doi":"10.18103/mra.v12i6.5383","DOIUrl":"10.18103/mra.v12i6.5383","url":null,"abstract":"<p><strong>Background and objectives: </strong>Despite its extensive utilization, research on Chat Generative Pre-trained Transformer (ChatGPT)'s potential negative impact on specific cognitive processes is scarce. This article explores the widespread use of ChatGPT in educational, corporate, and various other sectors, focusing on its interaction with distinct cognitive domains such as attention, executive function, language, memory, visuospatial abilities, and social cognition.</p><p><strong>Methods: </strong>A literature review was conducted using PubMed, identifying 256 articles, with 29 peer-reviewed articles analyzed after screening for relevance.</p><p><strong>Results: </strong>The review emphasizes the extraordinary capabilities of the human brain, which often go unrecognized, and argues for the importance of maintaining and enhancing natural cognitive abilities using artificial intelligence tools like ChatGPT as an aid rather than a replacement. The findings highlight the advanced reasoning capabilities of ChatGPT, blending intuitive and deliberate cognitive processes.</p><p><strong>Conclusion: </strong>Building a socio-cognitive architecture for collective human-machine intelligence has significant potential. While ChatGPT offers impressive capabilities, over-reliance on it for cognitive tasks can lead to the erosion of essential skills. It is crucial to find a balance between leveraging artificial intelligence's advantages and preserving our natural cognitive abilities, ensuring continuous practice and engagement in traditional cognitive exercises.</p>","PeriodicalId":94137,"journal":{"name":"Medical research archives","volume":"12 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11515803/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142524006","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"On the efficacy of facial masks to suppress the spreading of pathogen-carrying saliva particles during human respiratory events: Insights gained via high-fidelity numerical modeling.","authors":"Hossein Seyedzadeh, Jonathan Craig, Ali Khosronejad","doi":"10.18103/mra.v12i5.5441","DOIUrl":"10.18103/mra.v12i5.5441","url":null,"abstract":"<p><p>Respiratory fluid dynamics is integral to comprehending the transmission of infectious diseases and the effectiveness of interventions such as face masks and social distancing. In this research, we present our recent studies that investigate respiratory particle transport via high-fidelity large eddy simulation coupled with the Lagrangian particle tracking method. Based on our numerical simulation results for human respiratory events with and without face masks, we demonstrate that facial masks could significantly suppress particle spreading. The studied respiratory events include coughing and normal breathing through mouth and nose. Using the Lagrangian particle tracking simulation results, we elucidated the transport pathways of saliva particles during inhalation and exhalation of breathing cycles, contributing to our understanding of respiratory physiology and potential disease transmission routes. Our findings underscore the importance of respiratory fluid dynamics research in informing public health strategies to reduce the spread of respiratory infections. Combining advanced mathematical modeling techniques with experimental data will help future research on airborne disease transmission dynamics and the effectiveness of preventive measures such as face masks.</p>","PeriodicalId":94137,"journal":{"name":"Medical research archives","volume":"12 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11192503/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141444049","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Barriers to Cervical Cancer Screening and Satisfaction with Self-Sampling among Black Women in Michigan: a Mixed Methods Study.","authors":"Elizabeth Haro, Emma A Butcher, Martha L Alves, Christelle El Khoury, Alexandra Vinson, Diane M Harper","doi":"10.18103/mra.v12i4.5209","DOIUrl":"10.18103/mra.v12i4.5209","url":null,"abstract":"<p><strong>Background: </strong>In recent years, cervical cancer screening among Black women in the United States has declined, followed by increased incidence and mortality. We aim to evaluate the individual, sociocultural, and structural barriers to cervical cancer screening in relationship to the exam technique barriers.</p><p><strong>Methods: </strong>Participants received cervical cancer self-screening kits in the mail. They returned their samples and a quantitative survey developed from the Health Information National Trends Survey (HINTS) modules designed to address the known individual, sociocultural, and structural barriers to screening. We established the fourteen attributes of cervical cancer screening techniques from prior work. Participants then shared their experiences in a semi-structured qualitative interview informed by the Theoretical Domains Framework (TDF) to explore the answers to the survey questions. We coded themes from the interviews. Women were grouped as younger (30-45 years) and older (46-65 years).</p><p><strong>Results: </strong>Of the 41 women completing the study, 21 were in the younger age group (mean 37.3, SD 4.7), and 20 were in the older age group (56.5 (5.5)). All participants self-identified as African American/Black and were due for cervical cancer screening. Women indicated that individual, sociocultural, and structural barriers influenced their cervical cancer screening, but the most significant barrier was the speculum-based technique itself. Three positive attributes and eight negative attributes significantly differed by screening technique, favoring the self-screening technique.</p><p><strong>Conclusions: </strong>The self-screening technique for screening for cervical cancer is feasible and acceptable to this group of Black women.</p>","PeriodicalId":94137,"journal":{"name":"Medical research archives","volume":"12 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11138408/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141181747","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Proposal of Utilizing Six Types of Involvement Model to Guide Kindergarten to 12th Grade School Parental Communication and Support During a Pandemic.","authors":"Dan Li, Yueqi Li, Ziyi Zheng, Xin Zhou, Danielle Castro, Sten H Vermund, Marie A Brault","doi":"10.18103/mra.v12i4.5178","DOIUrl":"10.18103/mra.v12i4.5178","url":null,"abstract":"<p><strong>Background: </strong>Effective communication between schools and parents Is crucial for fostering understanding, trust, and collaboration to enhance educational outcomes and student well-being, especially during crises such as the COVID-19 pandemic. Moreover, the current level of communication between schools and families is frequently insufficient, exacerbating the difficulties in parental engagement, comprehension, and certain policy implementation. This deficiency becomes even more pronounced during crises due to the added stressors. This study aims to highlight the challenges of parental engagement and communication during the pandemic and propose a viable solution for school districts and schools to enhance trust, understanding, and collaboration in schools to prepare for future crises.</p><p><strong>Method: </strong>The study employs a mixed-methods approach, Including a scoping review of literature and policies on school communication during the pandemic, a survey study conducted among the Connecticut Independent Schools, and the Integration of results from both sources. The scoping review provides key themes and frameworks, while the survey collects quantitative and qualitative data to identify challenges and concerns. The proposed solution utilizes Epstein's Six Types of Involvement Framework for school districts and schools to guide effective communication and collaboration between schools and parents.</p><p><strong>Results: </strong>The scoping review and survey findings reveal several key Issues, Including hesitant parental perception of disease control strategies, the burden on parents in supporting online learning, the lack of resources and guidance for online learning, and the absence of central communication guidelines. The proposed solution, Epstein's Six Types of Involvement Framework, addresses these challenges by emphasizing parenting, communication, volunteering, learning at home, decision-making, and community collaboration.</p><p><strong>Conclusion: </strong>The study highlights the importance of effective communication between schools and parents during crises and proposes Epstein's Six Types of Involvement Framework as a comprehensive solution. By implementing this framework, schools can foster understanding, trust, and collaboration, leading to better educational outcomes for students. The findings have implications for school administrators, policymakers, and educators seeking to improve communication during crises and can facilitate more effective communication and parental engagement beyond health crises. Further research Is needed to evaluate the effectiveness and impact of implementing the framework in real-world crises. Moreover, healthcare professionals like pediatricians, psychologists, and school nurses are crucial in disease control in schools. The study proposes using Epstein's framework to Involve them directly, enhancing collaboration and trust, and empowering them to lead efforts in safeguarding ","PeriodicalId":94137,"journal":{"name":"Medical research archives","volume":"12 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11309007/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141908745","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}