Medical research archives最新文献

{"title":"Diastolic Dysfunction Unveiling Cardiac Light-Chain Amyloidosis: A Case Report.","authors":"Somesh Saha, Ritwick Mondal, Shramana Deb, Biswarup Sarkar, Julián Benito-León","doi":"10.18103/mra.v12i12.6168","DOIUrl":"10.18103/mra.v12i12.6168","url":null,"abstract":"<p><strong>Background: </strong>Cardiac light-chain amyloidosis represents a critical component of this multi-systemic disease, significantly impacting prognosis. The extent of cardiac free light-chain deposition is the primary determinant of survival.</p><p><strong>Case presentation: </strong>We report the case of a 67-year-old male with a 10-year history of diabetes mellitus and arterial hypertension who presented with a two-day history of chest discomfort and difficulty lying down or sleeping, along with a two-month history of progressively worsening exertional dyspnea. On examination, the patient exhibited low blood pressure. A 12-lead electrocardiogram revealed poor R-wave progression and left ventricular hypertrophy. Further evaluation using 2D echocardiography demonstrated significant concentric left ventricular hypertrophy, a restrictive filling pattern, and mild pericardial effusion. Cardiac magnetic resonance imaging, nuclear imaging, and biopsy confirmed the diagnosis of cardiac light-chain amyloidosis.</p><p><strong>Conclusion: </strong>Timely recognition and a high index of suspicion are essential for the early diagnosis of cardiac amyloidosis. Prompt diagnosis enables the initiation of definitive therapy, which may halt disease progression and significantly improve prognosis.</p>","PeriodicalId":94137,"journal":{"name":"Medical research archives","volume":"12 12","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11900892/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143618078","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cultural Effects on the Performance of Older Haitian Immigrants on Timed Cognitive Tests.","authors":"Marie Adonis-Rizzo, Ruth M Tappen, Monica Rosselli, David Newman, Joshua Conniff, Jinwoo Jang, KwangSoo Yang, Borko Furht","doi":"10.18103/mra.v12i11.5868","DOIUrl":"10.18103/mra.v12i11.5868","url":null,"abstract":"<p><strong>Background: </strong>Ignoring the cultural factors that can affect performance on cognitive tests may result in use of tests that have not been validated for that group. One example is testing of Haitian Creole speaking adults who are increasingly affected by Alzheimer's disease and related dementias, for whom few tests have been validated.</p><p><strong>Aims: </strong>Our purpose is to describe differences in timed test performance between Haitian Creole and English-speaking participants and explore factors that may account for any differences in results found.</p><p><strong>Methods: </strong>Data was obtained from an ongoing longitudinal driving and cognition study \"In Vehicle Sensors to Detect Cognitive Change in Older Drivers.\" Two groups consisting of 12 Creole speaking and 12 English speaking older adults were matched by age and gender. Test scores were selected from the battery of tests administered in the parent study. The measures were translated by two bilingual Creole-English researchers. Group performance on five timed cognitive tests commonly used in research was compared.</p><p><strong>Results: </strong>The English-speaking group's mean scores were significantly higher than the Creole speaking group on the MoCA and the timed Animal category fluency, letter P fluency, Stroop Color Test, and Trail Making Test A and B. The most significant effects were noted in Letter P fluency, Trail Making Test A and B and Animal category fluency where the differences had large effect sizes. However, the Creole speaking group had higher mean scores than the English-Speaking group on the Stroop Color Word Test, although the difference was not statistically significant. It was not feasible to match education levels due to the differences in years of education across the groups. These results highlight the significant role of culture and linguistic context in cognitive task performance.</p><p><strong>Conclusions: </strong>The results suggest performance in cognitive testing among non-English speaking groups may be impacted by cultural factors related to time perception and the testing approach employed, leading to misinterpretation and misdiagnosis. Future studies should explore the fairness of various cognitive testing approaches with Haitian older adults and other societies with cultures and educational approaches different from those of Western cultures.</p>","PeriodicalId":94137,"journal":{"name":"Medical research archives","volume":"12 11","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11736698/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143019086","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Achieving Chronic Care Equity by Leveraging the Telehealth Ecosystem (ACCTIVATE): A Multilevel Randomized Controlled Trial Protocol.","authors":"Adenike Omomukuyo, Andy Ramirez, Aliyah Davis, Alexandra Velasquez, Adriana L Najmabadi, Marianna Kong, Rachel Willard-Grace, William Brown, Andrew Broderick, Karla Suomala, Charles E McCulloch, Nora Franco, Urmimala Sarkar, Courtney Lyles, Amber S Tran, Anjana E Sharma, Delphine S Tuot","doi":"10.18103/mra.v12i11.6087","DOIUrl":"10.18103/mra.v12i11.6087","url":null,"abstract":"<p><strong>Background: </strong>Racial/ethnic and socioeconomic disparities in diabetes and hypertension outcomes persist in the United States (U.S.), and worsened during the COVID-19 pandemic. This was in part due to suboptimal implementation of telehealth in U.S. safety-net settings alongside the pre-existing \"digital divide\" - structural determinants that limit access to digital tools by marginalized communities. To improve health equity, it is critical that health systems in the U.S. integrate principles of digital and health literacy for more equitable chronic disease care.</p><p><strong>Methods: </strong>We are conducting a 2x2 factorial randomized controlled trial, in partnership with a Community Advisory Board, assessing a multi-level intervention addressing barriers that affect the equitable use of telehealth amongst low-income patients in San Francisco County. Patient-level support is provided through the evidence-based strategies of health coaching and digital navigation (\"digital coaching\"); clinic-level support includes equity dashboards, patient advisory councils, and practice facilitation. We are randomizing 600 low-income, racially/ethnically diverse English and Spanish-speaking patients with uncontrolled diabetes to receive digital coaching (n=200) vs. usual care (n=400) for 3 months; and 11 public health primary care clinics to clinic support vs. usual care for 24 months. We aim to evaluate the impact of patient and clinic level interventions to determine individual effectiveness and potential synergistic impact on clinical and process measures related to diabetes and telehealth outcomes.</p><p><strong>Results: </strong>The study's primary clinical outcome is change in patient-level Hemoglobin A1C (A1c); the primary process outcome is patient portal usage. Secondary clinical outcomes include changes in patient-level systolic blood pressure (SBP) and microalbuminuria (UACR), and changes in clinic-level A1c, SBP, and UACR. Secondary process outcomes assess patient-level changes in digital literacy, medication adherence, patient activation, and visit show rates, and clinic-level measures of telehealth adoption.</p><p><strong>Discussion: </strong>The ACCTiVATE trial tests a multi-level intervention developed through a stakeholder-engaged research approach and user-centered design to be feasible and acceptable for impacted communities. If efficacious, ACCTiVATE may provide a scalable model to improve chronic health outcomes and telehealth equity among marginalized racial/ethnic populations experiencing structural and interpersonal access barriers.</p><p><strong>Trial registration: </strong>ClinicalTrials.gov identifier NCT06598436. Registered 15 September 2024.</p>","PeriodicalId":94137,"journal":{"name":"Medical research archives","volume":"12 11","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11646453/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142831590","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Augmenting the Hospital Score with social risk factors to improve prediction for 30-day readmission following acute myocardial infarction.","authors":"Iben Ricket, Michael E Matheny, Ruth M Reeves, Rashmee U Shah, Christine A Goodrich, Glenn Gobbel, Meagan E Stabler, Amy M Perkins, Freneka Minter, Chad Dorn, Bruce E Bray, Lee Christensen, Ramkiran Gouripeddi, John Higgins, Wendy W Chapman, Todd MacKenzie, Jeremiah R Brown","doi":"10.18103/mra.v12i11.6089","DOIUrl":"10.18103/mra.v12i11.6089","url":null,"abstract":"<p><strong>Background: </strong>Hospital Score is a well-known and validated tool for predicting readmission risk among diverse patient populations. Integrating social risk factors using natural language processing with the Hospital Score may improve its ability to predict 30-day readmissions following an acute myocardial infarction.</p><p><strong>Methods: </strong>A retrospective cohort included patients hospitalized at Vanderbilt University Medical Center between January 1, 2007, and December 31, 2016, with a primary index diagnosis of acute myocardial infarction, who were discharged alive. To supplement ascertainment of 30-day readmissions, data were linked to Center for Medicare & Medicaid Services (CMS) administrative data. Clinical notes from the cohort were extracted, and a natural language processing model was deployed, counting mentions of eight social risk factors. A logistic regression prediction model was run using the Hospital Score composite, its component variables, and the natural language processing-derived social risk factors. ROC comparison analysis was performed.</p><p><strong>Results: </strong>The cohort included 6,165 unique patients, where 4,137 (67.1%) were male, 1,020 (16.5%) were Black or other people of color, the average age was 67 years (SD: 13), and the 30-day hospital readmission rate was 15.1% (N=934). The final test-set AUROCs were between 0.635 and 0.669. The model containing the Hospital Score component variables and the natural language processing-derived social risk factors obtained the highest AUROC.</p><p><strong>Discussion: </strong>Social risk factors extracted using natural language processing improved model performance when added to the Hospital Score composite. Clinicians and health systems should consider incorporating social risk factors when using the Hospital Score composite to evaluate risk for readmission among patients hospitalized for acute myocardial infarction.</p>","PeriodicalId":94137,"journal":{"name":"Medical research archives","volume":"12 11","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11788934/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143191660","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Osteosarcoma: A comprehensive review of model systems and experimental therapies.","authors":"Gabrielle M Robbins, Young Y Vue, Eric P Rahrmann, Branden S Moriarity","doi":"10.18103/mra.v12i11.6000","DOIUrl":"10.18103/mra.v12i11.6000","url":null,"abstract":"<p><p>Osteosarcoma (OSA) is a highly malignant bone tumor for which more than 50% of patients have or will develop metastatic disease, resulting in an abysmal 5-year survival rate of <29%. Despite the advances in science and medicine, the etiology of OSA remains unclear. Similarly, the standard of care (surgery and chemotherapy) has changed little in the past 5 decades. This stagnation in treatment options is in part due to inadequate preclinical models for OSA; many of these models are oversimplified and do not account for the complexities of patient disease. Further, current treatments are harsh and invasive (e.g. high dose chemotherapy and potential limb removal) leading to a reduction in a patient's quality of life (e.g. hearing loss, infertility, neuropathy), highlighting a need for developing more effective treatment strategies. Many experimental therapies have been tested in the preclinical and preclinical setting, with varying degrees of success. In this review, we will focus on pediatric and adolescent OSA, highlighting current animal models and experimental therapies.</p>","PeriodicalId":94137,"journal":{"name":"Medical research archives","volume":"12 11","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11801376/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143367167","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mini-Dose Glucagon for Mild and Moderate Hypoglycemia in Type 1 Diabetes.","authors":"Hal Steven Farkas, Ellen Werber Leschek","doi":"10.18103/mra.v12i10.5866","DOIUrl":"10.18103/mra.v12i10.5866","url":null,"abstract":"<p><p>Tight glycemic control reduces the development and progression of microvascular and macrovascular complications in individuals with type 1 diabetes. However, it is also associated with an increased risk of hypoglycemia, which can deter some individuals from striving to achieve tight glycemic control. For this and other reasons, it is important to optimize the treatment of hypoglycemia in type 1 diabetes. The conventional approach to the management of mild to moderate hypoglycemia is oral carbohydrate ingestion, which can result in significant rebound hyperglycemia and the consumption of excess calories with resulting unwanted weight gain. Studies of the use of subcutaneous mini-dose glucagon for the prevention and treatment of mild to moderate hypoglycemia in a variety of settings have demonstrated that this approach is safe and effective and is less likely to result in significant hyperglycemia and the ingestion of unwanted oral carbohydrate calories.</p>","PeriodicalId":94137,"journal":{"name":"Medical research archives","volume":"12 10","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11816725/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143412139","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characteristics associated with social anxiety in adults with developmental stuttering: A review.","authors":"K R Bauerly","doi":"10.18103/mra.v12i10.5876","DOIUrl":"10.18103/mra.v12i10.5876","url":null,"abstract":"<p><p>People who stutter are at a greater risk for developing symptoms of social anxiety, with up to 22-60% of adults who stutter meeting the criteria for a clinical diagnosis. Negative attitudes and feelings about speaking and stuttering are reported to emerge as early as the preschool years and are suspected to be due to exposure to negative listener reactions, stereotyping and social isolation. Repeated negative experiences lead to feelings of fear, embarrassment and loss of control during speaking which over time, leads to the development of more severe difficulties with speaking and an overall apprehension to speak as they perceive themselves as an incompetent communicator. The present review aims to summarize risk factors, particularly temperament and environmental factors, that are reported to play a role in the emergence and maintenance of social anxiety in people who stutter. Another aim of this review is to summarize the features of social anxiety reported in adults who stutter, some of which, are similar to high socially anxious fluent speakers (e.g., avoidant strategies) while others are specific to stuttering (e.g., muscle tension). The clinical implications of these findings and recommendations for future research are also discussed.</p>","PeriodicalId":94137,"journal":{"name":"Medical research archives","volume":"12 10","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11626403/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142803891","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Air Pollution as an Environmental Risk Factor for Alzheimer's Disease and Related Dementias.","authors":"Heui Hye Park, Matthew J Armstrong, Fredric A Gorin, Pamela J Lein","doi":"10.18103/mra.v12i10.5825","DOIUrl":"10.18103/mra.v12i10.5825","url":null,"abstract":"<p><p>Alzheimer's disease and related dementias are a leading cause of morbidity in our aging populations. Although influenced by genetic factors, fewer than 5% of Alzheimer's disease and related dementia cases are due solely to genetic causes. There is growing scientific consensus that these dementias arise from complex gene by environment interactions. The 2020 Lancet Commission on dementia prevention, intervention, and care identified 12 modifiable risk factors of dementia, including lifestyle, educational background, comorbidities, and environmental exposures to environmental contaminants. In this review, we summarize the current understanding and data gaps regarding the role(s) of environmental pollutants in the etiology of Alzheimer's disease and related dementias with a focus on air pollution. In addition to summarizing findings from epidemiological and experimental animal studies that link airborne exposures to environmental contaminants to increased risk and/or severity of Alzheimer's disease and related dementias, we discuss currently hypothesized mechanism(s) underlying these associations, including peripheral inflammation, neuroinflammation and epigenetic changes. Key data gaps in this rapidly expanding investigative field and approaches for addressing these gaps are also addressed.</p>","PeriodicalId":94137,"journal":{"name":"Medical research archives","volume":"12 10","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11736697/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143019078","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bayesian mediation modeling of racial disparity for maternal birth outcomes in United States.","authors":"James Thompson","doi":"10.18103/mra.v12i9.5858","DOIUrl":"10.18103/mra.v12i9.5858","url":null,"abstract":"<p><strong>Background: </strong>In the United States, racial disparities for adverse maternal health outcomes persist, and the causes remain unknown. The disparities for women of Black ethnicity include increased risk of gestational hypertension, hypertension eclampsia, cesarean section, and admission to an Intensive Care Unit, and reduced risk of parturition induction. Without evaluating racial disparity, studies identify one cause of these conditions as the interaction between pre-gestational body mass index and gestational weight gain. What has not been determined is how body mass index and gestational weight gain contribute to racial disparity. The study's objective was to determine if the interaction between body mass index and gestational weight gain can explain the racial disparity in five maternal outcomes.</p><p><strong>Methods: </strong>The approach involved mediation analysis by performing Bayesian estimation of potential outcomes for each combination of causes. Causes included risk of Black ethnicity, body mass index, and gestational weight gain.</p><p><strong>Results: </strong>Improving both body mass index and gestational weight gain to what is considered optimal would increase the racial disparity for gestational hypertension by 19.2%, have a non-significant effect on racial disparity for hypertension eclampsia, reduce the racial advantage for Black women receiving induction by 16.9%, and reduce the racial disadvantage for delivery by cesarean and admission to an Intensive Care Unit by 49.9% and 36.9%, respectively.</p><p><strong>Conclusion: </strong>Preventive programs can have a wide range of effects on racial disparity, from decreasing to increasing the disparity. Implementing the mediation evaluation approach illustrated here would optimize clinical decisions, guide public health policy, and eventually mitigate racial mistrust.</p>","PeriodicalId":94137,"journal":{"name":"Medical research archives","volume":"12 9","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11887612/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143588896","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hybrid care model: Combining telemedicine and office visits for diabetes management in older adults with type 1 diabetes.","authors":"Elena Toschi, Atif Adam, Nana Frimpong, Rebecca Hurlbert, Christine Slyne, Lori Laffel, Medha Munshi","doi":"10.18103/mra.v12i9.5728","DOIUrl":"10.18103/mra.v12i9.5728","url":null,"abstract":"<p><strong>Aims: </strong>To evaluate the use of hybrid (telehealth and in-person) care on visitation and glycaemia in older adults with type 1 diabetes (T1D).</p><p><strong>Methods: </strong>In this retrospective study, we examined clinical characteristics, number of visits (telehealth and in-person) and continuous glucose monitoring (CGM) metrics for older adults (≥65 years) with T1D from electronic health records during the pre-COVID-19 pandemic (March 1, 2019-March 1, 2020; in-person) and pandemic (September 1, 2020-August 31, 2021; hybrid) periods. Main outcomes were the number of visits and changes in glycaemic control (HbA1c), and in a sub-group of older adults using CGM, changes in CGM metrics between in-person and hybrid care.</p><p><strong>Results: </strong>We analysed data of 661 older adults with T1D (age 72±5 years). The hybrid care resulted in an increased number of annual diabetes visits (6.3 vs 4.2 visits/person) without change in glycaemic control (HbA1c 7.4% vs 7.2%) compared with in-person care alone. In the sub-group of 299 older adults with T1D using CGM, hybrid care compared with in-person care resulted in an improvement of time-in-range (70-180 mg/dL) (68% to 71%; p<0.001) without increasing hypoglycaemia (<70 mg/dL).</p><p><strong>Conclusion: </strong>Compared with in-person only visits, hybrid care maintained visit frequency and preserved glycaemic control measured as HbA1c. In a sub-group of older adults with T1D using CGM, time-in-range improved while time in hypoglycaemia did not change. These data suggest that a hybrid care model is efficacious in maintaining visitation and glycaemic control, and, as demonstrated in a sub-group of older adults with T1D using CGM, safe with respect to time in hypoglycaemia.</p>","PeriodicalId":94137,"journal":{"name":"Medical research archives","volume":"12 9","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11737547/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143019091","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}