Megan Furnari MD , Sean P.M. Rice PhD , Alexis C. Jaggers BA , Abigail Lenhart MD , Marie V. Soller MD
{"title":"Camaraderie: Profession-Specific Facilitated Small Groups to Improve Well-Being in Health Care","authors":"Megan Furnari MD , Sean P.M. Rice PhD , Alexis C. Jaggers BA , Abigail Lenhart MD , Marie V. Soller MD","doi":"10.1016/j.mayocpiqo.2025.100624","DOIUrl":"10.1016/j.mayocpiqo.2025.100624","url":null,"abstract":"<div><h3>Objective</h3><div>To assess the impact of profession-specific small groups for physicians, nurses, advanced practice providers, and managers led by trained peer facilitators with the intention to improve aspects of well-being.</div></div><div><h3>Participants and Methods</h3><div>This is a single-center, pilot, nonrandomized control trial of the Camaraderie group intervention with employees at Oregon Health and Science University (N=151; intervention, n=89; control, n=62). The intervention condition included 8 groups of 10 to 12 participants and 2 facilitators. Groups met 6 times for a 1-hour virtual session during a 3-month period from March to May 2023. Each session had a theme and 2 prompts. Participants were surveyed prior to the first session, immediately after the 6 sessions, and then 3 months after the program concluded. Validated metrics assessed included burnout, belonging, job satisfaction, and perceived stress levels.</div></div><div><h3>Results</h3><div>After completing the 6 sessions, 72.5% of intervention participants reported attending 5 or 6 of the 6 sessions, and 86.0% rated the facilitation as above average or highest value. Belonging on a Likert scale from 1 to 5 (strong agreement) had a statistically significant increase of +0.45 (mean change or difference-in-difference; <em>P</em>=.03), from baseline to postsession relative to the control group. Stress (Likert 0-4 [very often]) and depersonalization (Likert 0-6 [every day]) had a statistically significant decreases from baseline to postsession (−0.21; <em>P</em>=.04, and −0.70; <em>P</em>=.02, respectively), relative to the control. There were no effects on job satisfaction or emotional exhaustion and no maintenance effects at the 3-month survey.</div></div><div><h3>Conclusion</h3><div>Profession-specific facilitated virtual small groups provide a high-impact experience with a minimal time commitment and support the well-being and belonging of the health care workforce.</div></div>","PeriodicalId":94132,"journal":{"name":"Mayo Clinic proceedings. Innovations, quality & outcomes","volume":"9 3","pages":"Article 100624"},"PeriodicalIF":0.0,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144068573","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Godehard A. Scholz MD, PhD , Eleftherios Papagiannoulis MSc , Christoph Blapp MSc , Raphael Micheroli MD , Adrian Ciurea MD , Michael J. Nissen MD , Nikhil Yawalkar MD , Diana Dan MD , Jennifer Amsler MD , Almut Scherer PhD , Burkhard Möller MD
{"title":"Longer Drug Retention of Interleukin-12/23 or Interleukin-17 Inhibitors Compared With TNF Inhibitors in Female Patients With TNF Inhibitor-Experienced Psoriatic Arthritis","authors":"Godehard A. Scholz MD, PhD , Eleftherios Papagiannoulis MSc , Christoph Blapp MSc , Raphael Micheroli MD , Adrian Ciurea MD , Michael J. Nissen MD , Nikhil Yawalkar MD , Diana Dan MD , Jennifer Amsler MD , Almut Scherer PhD , Burkhard Möller MD","doi":"10.1016/j.mayocpiqo.2025.100622","DOIUrl":"10.1016/j.mayocpiqo.2025.100622","url":null,"abstract":"<div><h3>Objective</h3><div>To compare the effectiveness of Interleukin (IL)-12/23 or IL-17A inhibitors (summarized to inhibitors of the Th17 cell generation or function, Th17i) with tumor necrosis factor inhibitors (TNFi) in patients with TNFi-experienced psoriatic arthritis (PsA).</div></div><div><h3>Patients and Methods</h3><div>We conducted a comparative effectiveness study by taking advantage of prospectively collected patients with PsA data from the Swiss Clinical Quality Management in Rheumatic Diseases register, encompassing the interval from January 1, 2015 to August 1, 2021. Drug retention was the primary outcome in unadjusted and inverse propensity-weighted Cox regression models. Secondary outcomes were a static skin score for psoriasis, the American College of Rheumatology (ACR) 20, 50, and 70 response rates, and the disease activity in PsA score.</div></div><div><h3>Results</h3><div>At baseline, Th17i (n=341) were initiated in patients with more severe skin disease, but with comparable disease activity as TNFi (n=503) in all other disease domains. In the unadjusted analysis, Th17i were later discontinued than TNFi (median 828 vs 445 days, <em>P</em><.001), but the hazard ratio for discontinuation was significantly lower for Th17i than for TNFi only in women (0.57 [0.37-0.87], <em>P</em>=.01). Furthermore, differences in static skin scores between the groups at baseline were equalized at follow-up. However, improvements in the disease activity in PsA were similar in both groups, and ACR20 (33% [29%] vs 14% [13%]; <em>P</em>=.03) and ACR50 response rates (24% [21%] vs 7% [6%]; <em>P</em>=.02) were even higher for TNFi in unadjusted and (LUNDEX-adjusted) analyses.</div></div><div><h3>Conclusion</h3><div>After TNFi failure, more profound skin improvement and longer drug retention in women argue in favor of switching to Th17i in certain patient populations. However, TNFi may at least be equivalent in improving locomotor system manifestations and remain a viable option in the first and in the later treatment line of PsA.</div></div>","PeriodicalId":94132,"journal":{"name":"Mayo Clinic proceedings. Innovations, quality & outcomes","volume":"9 3","pages":"Article 100622"},"PeriodicalIF":0.0,"publicationDate":"2025-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143935450","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Setting Expectations When Prescribing Medication for the Treatment of Patients With Obesity","authors":"Angela Fitch MD","doi":"10.1016/j.mayocpiqo.2025.100621","DOIUrl":"10.1016/j.mayocpiqo.2025.100621","url":null,"abstract":"<div><div>The worldwide prevalence of obesity more than doubled between 1990 and 2022 (men, 4.8%-14.0%; women, 8.8%-18.5%), with similar trends observed for obesity-related diseases, including type 2 diabetes mellitus. Despite this increase in prevalence, many individuals with obesity remain untreated. There are several barriers limiting access to effective care, including the stigma and bias associated with obesity and lack of insurance coverage as a standard job benefit. Additionally, unrealistic expectations for rate of weight-loss and the weight-loss process as well as a lack of proper education on the weight-loss journey and treatment options can contribute to the inability to achieve weight-loss goals and a reluctance to try evidence-based approaches. Therefore, there is a need for effective management and education focusing on individualized treatment and setting viable expectations for the treatment of patients with obesity. Health care providers should compassionately discuss with their patients the importance of weight-loss, the long-term clinical benefits, and expectations for the weight-loss journey, including amount and timing of weight-loss, as well as the potential financial implications associated with obesity treatment. Health care providers should also be able to inform patients along the treatment journey, including about potential adverse events and how they can be managed. Importantly, treatments and decisions should be tailored to each patient using shared decision making with a focus on their characteristics, history, and goals. In this study, the expectations and current use of approved antiobesity medications in the United States are reviewed.</div></div>","PeriodicalId":94132,"journal":{"name":"Mayo Clinic proceedings. Innovations, quality & outcomes","volume":"9 3","pages":"Article 100621"},"PeriodicalIF":0.0,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143921573","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Right Chest Compression for Supplemental Assessment of Laryngeal Mask Airway and Endotracheal Tube Positioning and Functionality","authors":"William L. Lanier MD","doi":"10.1016/j.mayocpiqo.2025.100626","DOIUrl":"10.1016/j.mayocpiqo.2025.100626","url":null,"abstract":"<div><div>The described supplemental airway management technique rapidly facilitates the assessment of proper positioning and functionality of a laryngeal mask airway or traditional endotracheal tube without the need of specialized equipment, such as a positive pressure gas-delivery device, stethoscope, capnograph, or pulse oximeter. The technique also avoids the risk of filling the stomach with gas. After airway placement, the assessor compresses the right upper chest with the heel of the hand, and—with the proximal end of the airway device held to the ear—functionality of the device–patient unit is appreciated primarily by sound and secondarily by airflow against the assessor’s skin.</div></div>","PeriodicalId":94132,"journal":{"name":"Mayo Clinic proceedings. Innovations, quality & outcomes","volume":"9 3","pages":"Article 100626"},"PeriodicalIF":0.0,"publicationDate":"2025-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143906395","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jorge L. Reyes MD, MS , Joseph J. Decker MD , Romil Parikh MBBS, MPH , Michael Zhang MD, PhD , Anne Eaton PhD, MS , Riccardo M. Inciardi MD, PhD , Chiadi Ndumele MD, PhD , Jeremy Van’t Hof MD, MS , Alvaro Alonso MD, PhD , Amil M. Shah MD , Scott D. Solomon MD , Lin Yee Chen MD, MS
{"title":"Greater Central Adiposity Is Associated With Poorer Left Atrial Function: The Atherosclerosis Risk in Communities (ARIC) Study","authors":"Jorge L. Reyes MD, MS , Joseph J. Decker MD , Romil Parikh MBBS, MPH , Michael Zhang MD, PhD , Anne Eaton PhD, MS , Riccardo M. Inciardi MD, PhD , Chiadi Ndumele MD, PhD , Jeremy Van’t Hof MD, MS , Alvaro Alonso MD, PhD , Amil M. Shah MD , Scott D. Solomon MD , Lin Yee Chen MD, MS","doi":"10.1016/j.mayocpiqo.2025.100611","DOIUrl":"10.1016/j.mayocpiqo.2025.100611","url":null,"abstract":"<div><h3>Objective</h3><div>To evaluate the association of longitudinal change in waist circumference (WC), waist-to-hip ratio (WHR), and body mass index (BMI) with left atrial (LA) function in the Atherosclerosis Risk in Communities study, a community-based cohort study.</div></div><div><h3>Patients and Methods</h3><div>We included 4008 participants (mean age, 75.1 years; 59% female; 20% Black) with 2D speckle-tracking echocardiographic LA strain data and without prevalent heart failure or atrial fibrillation at visit (V)5. Measures of adiposity were obtained at V4 (1996-1998) and V5 (2011-2013). We categorized change in WC, BMI, or WHR from V4 to V5 as consistently low (reference group), consistently elevated, increasing, and decreasing. Multivariable linear regression was used to evaluate the association of change in adiposity with LA function.</div></div><div><h3>Results</h3><div>Participants with consistently elevated WC from V4 to V5 had the lowest mean LA reservoir (32.4%) and conduit function (14.4%). Compared with consistently low WC, increasing WC and consistently elevated WC were significantly associated with worse LA reservoir function (<em>β</em>, −0.90; 95% CI, −1.61 to −0.18, and <em>β</em>, −1.00; 95% CI, −1.56 to −0.44, respectively) and conduit function (<em>β</em>, −0.66; 95% CI, −1.22 to −0.10, and <em>β</em>, −1.02; 95% CI, −1.46 to −0.58, respectively), after adjusting for cardiovascular disease risk factors, physical activity, LV size and function, and LA size. Similarly, compared with consistently low WHR, consistently elevated WHR was significantly associated with worse LA reservoir (<em>β</em>, −1.00; 95% CI, −1.61 to −0.39) and conduit functions (<em>β</em>, −1.16; 95% CI, −1.64, −0.69). Compared with consistently low BMI, consistently elevated BMI was associated with significantly lower LA reservoir function (<em>β</em>, −0.66; 95% CI, −1.20 to −0.12). Change in WC, WHR, and BMI were not associated with LA contractile function.</div></div><div><h3>Conclusion</h3><div>Worsening central adiposity from mid-life to late life is associated with reduced LA reservoir and conduit function, independent of LA size and LV size and function. This finding underscores the key role that consistently low adiposity might play in preventing atrial myopathy.</div></div>","PeriodicalId":94132,"journal":{"name":"Mayo Clinic proceedings. Innovations, quality & outcomes","volume":"9 3","pages":"Article 100611"},"PeriodicalIF":0.0,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143882169","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pattara Rattanawong MD , Chieh-Ju Chao MD , Anil Sriramoju MD , Cecilia Tagle-Cornell MS , Juan Maria M. Farina MD , Ellen Beirne MBBS , Marlene E. Girardo MS , Laura M. Koepke MSN , Olubadewa A. Fatunde MD, MPH , Nway L. Ko Ko MBBS , Win-Kuang Shen MD
{"title":"Syncope and All-Cause Mortality in Heart Failure: A Propensity Score–Matched Analysis","authors":"Pattara Rattanawong MD , Chieh-Ju Chao MD , Anil Sriramoju MD , Cecilia Tagle-Cornell MS , Juan Maria M. Farina MD , Ellen Beirne MBBS , Marlene E. Girardo MS , Laura M. Koepke MSN , Olubadewa A. Fatunde MD, MPH , Nway L. Ko Ko MBBS , Win-Kuang Shen MD","doi":"10.1016/j.mayocpiqo.2025.100620","DOIUrl":"10.1016/j.mayocpiqo.2025.100620","url":null,"abstract":"<div><h3>Objective</h3><div>To examine the association between syncope and all-cause mortality in a large cohort of patients with heart failure (HF) with syncope.</div></div><div><h3>Patients and Methods</h3><div>We retrospectively identified a cohort of patients with HF and syncope from January 1, 2010, to December 31, 2015, and matched them in a 1:1 propensity analysis with patients with HF without syncope. A multivariable Cox regression model was used to estimate the association between syncope and the end point, all-cause mortality.</div></div><div><h3>Results</h3><div>During the study period, 3449 patients with HF were diagnosed with syncope (mean ± SD age, 72.8±14.3 years). At 12 months follow-up, syncope was not an independent risk factor of all-cause mortality in overall patients with HF (hazard ratio [HR], 0.98; 95% CI, 0.91-1.04; <em>P</em>=.467), HF with preserved ejection fraction (EF) (HR, 1.02; 95% CI, 0.93-1.11; <em>P</em>=.686), HF with mid-range EF (HR, 0.92; 95% CI, 0.73-1.16; <em>P</em>=.494), or HF with reduced EF (HR, 0.94; 95% CI, 0.83-1.06; <em>P</em>=284). In the subgroup of those with cardiac implantable electronic devices, syncope significantly increased the risk of all-cause mortality in HF with reduced EF (HR, 1.28; 95% CI, 1.01-1.62; <em>P</em>=.038).</div></div><div><h3>Conclusion</h3><div>Syncope was not an independent risk of all-cause mortality for patients with HF but significantly predicted the all-cause mortality in the subgroup of patients with heart failure reduced EF with cardiac implantable electronic devices.</div></div>","PeriodicalId":94132,"journal":{"name":"Mayo Clinic proceedings. Innovations, quality & outcomes","volume":"9 3","pages":"Article 100620"},"PeriodicalIF":0.0,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143854698","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Omar Jafar BS , Jason Friedman MD , Aamir Muneer BS , Amy Jordan RCS , Heidi Waddell RCS , Dorothy Wakefield MS , Kamran Haleem MD
{"title":"High-Intensity Prolonged Endurance Activity Correlation to Abnormal Cardiac Strain as Measured by Speckle Tracking Echocardiography","authors":"Omar Jafar BS , Jason Friedman MD , Aamir Muneer BS , Amy Jordan RCS , Heidi Waddell RCS , Dorothy Wakefield MS , Kamran Haleem MD","doi":"10.1016/j.mayocpiqo.2025.100610","DOIUrl":"10.1016/j.mayocpiqo.2025.100610","url":null,"abstract":"<div><h3>Objective</h3><div>To assess whether there is a dose-dependent relationship between burden of exercise and myocardial strain in endurance runners.</div></div><div><h3>Patients and Methods</h3><div>In total, 48 runners were selected based on an exercise questionnaire and after excluding individuals based on preexisting cardiovascular risk factors. Data collection was performed between November 9, 2020 and March 18, 2021. Runners were divided into 2 categories: group A consisted of individuals who had participated in at least 10 ultramarathons and/or Ironman competitions in 10 years (extreme-distance runners); and group B consisted of individuals who have competed in at least 10 marathons over 10 years (marathon-distance runners). Global and regional myocardial strain imaging was performed. Linear regression models were used to assess the relationship between runner groups and global as well as regional myocardial strain.</div></div><div><h3>Results</h3><div>There was no difference in mean global longitudinal strain between both cohorts. However, there was a statically significant difference in regional myocardial strain in the apical lateral (<em>P</em> =.0027) and apical septal (<em>P</em>=.0022) segments.</div></div><div><h3>Conclusion</h3><div>Ultramarathoners and Ironman athletes had evidence of regional differences in myocardial strain when compared with runners participating in shorter events, but no difference in global longitudinal strain. The clinical significance of this is not yet clear and additional studies are required.</div></div>","PeriodicalId":94132,"journal":{"name":"Mayo Clinic proceedings. Innovations, quality & outcomes","volume":"9 3","pages":"Article 100610"},"PeriodicalIF":0.0,"publicationDate":"2025-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143848441","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Taryn G. Vosters MSc , Vianda S. Stel PhD , Kitty J. Jager MD, PhD , Bart Ferwerda PhD , Roos F. Marsman MD, PhD , Frans J. van Ittersum MD, PhD , Bert-Jan H. van den Born MD, PhD , Henrike Galenkamp PhD , Liffert Vogt MD, PhD , Irene G.M. van Valkengoed PhD
{"title":"Performance of Current Chronic Kidney Disease Screening Criteria in Women and Men Across Ethnic Groups: The HELIUS Study","authors":"Taryn G. Vosters MSc , Vianda S. Stel PhD , Kitty J. Jager MD, PhD , Bart Ferwerda PhD , Roos F. Marsman MD, PhD , Frans J. van Ittersum MD, PhD , Bert-Jan H. van den Born MD, PhD , Henrike Galenkamp PhD , Liffert Vogt MD, PhD , Irene G.M. van Valkengoed PhD","doi":"10.1016/j.mayocpiqo.2025.100613","DOIUrl":"10.1016/j.mayocpiqo.2025.100613","url":null,"abstract":"<div><h3>Objective</h3><div>To investigate whether the currently recommended screening criteria in Kidney Disease: Improving Global Outcomes 2024 guidelines (hypertension, diabetes mellitus, and cardiovascular disease) equally detect women and men across ethnic groups and whether consideration of optional criteria (education level, occupation, obesity, and genetic risk factors) listed in the guideline improves performance.</div></div><div><h3>Patients and Methods</h3><div>We included 12,384 women and 9046 men of Dutch, South Asian and African Surinamese, Ghanaian, Turkish, and Moroccan origin from the baseline HELIUS Study (January 1, 2011, through December 31, 2015, Amsterdam, the Netherlands). Chronic kidney disease (CKD) was defined as estimated glomerular filtration rate of <60 mL/min/1.73 m<sup>2</sup> or albumin-to-creatinine ratio of >3 mg/mmol. Poisson regression analyses estimated associations between CKD and optional criteria on top of current screening criteria. Model comparisons were made with likelihood ratio tests and Akaike information criterion estimations in women and men. Area under the curve (AUC), sensitivity, specificity, and positive and negative predictive values were calculated by sex and ethnicity.</div></div><div><h3>Results</h3><div>Chronic kidney disease prevalence ranged from 2.9% to 8.8% in women and 3.2% to 8.6% in men. Low educational level (women only) and obesity significantly improved the models with current criteria with CKD. High-risk occupations and polygenic risk score did not improve the model. However, these criteria did not improve predictive measures across ethnic groups. Overall, the AUCs for the current screening criteria were acceptable in men (AUC, 0.75; 95% CI, 0.73-0.77) and poor in women (AUC, 0.65; 95% CI, 0.63-0.67), and showed minimal change after adding the optional criteria.</div></div><div><h3>Conclusion</h3><div>Current screening criteria may not be equally detecting women and men across ethnic groups with CKD. Optional criteria had limited added value.</div></div>","PeriodicalId":94132,"journal":{"name":"Mayo Clinic proceedings. Innovations, quality & outcomes","volume":"9 3","pages":"Article 100613"},"PeriodicalIF":0.0,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143843091","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}