Mathematical medicine and biology : a journal of the IMA最新文献_第2页

Inference on an interacting diffusion system with application to in vitro glioblastoma migration (publication template). 应用于体外胶质母细胞瘤迁移的交互扩散系统推论。

Mathematical medicine and biology : a journal of the IMA Pub Date : 2024-09-16 DOI: 10.1093/imammb/dqae010

Gustav Lindwall, Philip Gerlee

引用次数: 0

Selector of amino-acid scales set. 氨基酸刻度选择器套装。

Mathematical medicine and biology : a journal of the IMA Pub Date : 2024-09-16 DOI: 10.1093/imammb/dqae007

Anton Vrdoljak, Damir Vukičević

{"title":"Selector of amino-acid scales set.","authors":"Anton Vrdoljak, Damir Vukičević","doi":"10.1093/imammb/dqae007","DOIUrl":"10.1093/imammb/dqae007","url":null,"abstract":"Experimental and theoretical properties of amino acids as building blocks of peptides and proteins have been extensively researched. Each such method assigns a number to each amino acid, and one such assignment is called amino-acid scale. Their usage in bioinformatics to explain and predict behaviour of peptides and proteins is of essential value. The number of such scales is very large. There are more than a hundred scales related just to hydrophobicity. A large number of scales can be a computational burden for algorithms that try to define peptide descriptors combining several of these scales. Hence, it is of interest to construct a smaller, but still representative set of scales. Here, we present software that does this. We test it on the set of scales using a database constructed by Kawashima and collaborators and show that it is possible to significantly reduce the number of scales observed without losing much of the information. An algorithm is implemented in C#. As a result, we provide a smaller database that might be a very useful tool for the analyses and construction of new peptides. Another interesting application of this database would be to compare the artificial intelligence construction of peptides having as an input the complete Kawashima database and this reduced one. Obtaining in both cases similar results would give much credibility to the constructs of such AI algorithms.","PeriodicalId":94130,"journal":{"name":"Mathematical medicine and biology : a journal of the IMA","volume":" ","pages":"157-168"},"PeriodicalIF":0.0,"publicationDate":"2024-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141560650","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Infection spreading in tissue as a reaction-diffusion wave. 感染在组织中以反应-扩散波的形式传播。

Mathematical medicine and biology : a journal of the IMA Pub Date : 2024-09-16 DOI: 10.1093/imammb/dqae009

Saddam Hussain, Moitri Sen, Vitaly Volpert

引用次数: 0

Assessing marginal effects of non-pharmaceutical interventions on the transmission of SARS-CoV-2 across Africa: a hybrid modeling study. 评估非药物干预对 SARS-CoV-2 跨非洲传播的边际效应：混合模型研究

Mathematical medicine and biology : a journal of the IMA Pub Date : 2024-09-16 DOI: 10.1093/imammb/dqae013

Yvette Montcho, Sidoine Dako, Valère Kolawole Salako, Chénangnon Frédéric Tovissodé, Martin Wolkewitz, Romain Glèlè Kakaï

{"title":"Assessing marginal effects of non-pharmaceutical interventions on the transmission of SARS-CoV-2 across Africa: a hybrid modeling study.","authors":"Yvette Montcho, Sidoine Dako, Valère Kolawole Salako, Chénangnon Frédéric Tovissodé, Martin Wolkewitz, Romain Glèlè Kakaï","doi":"10.1093/imammb/dqae013","DOIUrl":"10.1093/imammb/dqae013","url":null,"abstract":"Since 2019, a new strain of coronavirus has challenged global health systems. Due its fragile healthcare systems, Africa was predicted to be the most affected continent. However, past experiences of African countries with epidemics and other factors, including actions taken by governments, have contributed to reducing the spread of SARS-CoV-2. This study aims to assess the marginal impact of non-pharmaceutical interventions in fifteen African countries during the pre-vaccination period. To describe the transmission dynamics and control of SARS-CoV-2 spread, an extended time-dependent SEIR model was used. The transmission rate of each infectious stage was obtained using a logistic model with NPI intensity as a covariate. The results revealed that the effects of NPIs varied between countries. Overall, restrictive measures related to assembly had, in most countries, the largest reducing effects on the pre-symptomatic and mild transmission, while the transmission by severe individuals is influenced by privacy measures (more than $10%$). Countries should develop efficient alternatives to assembly restrictions to preserve the economic sector. This involves e.g. training in digital tools and strengthening digital infrastructures.","PeriodicalId":94130,"journal":{"name":"Mathematical medicine and biology : a journal of the IMA","volume":" ","pages":"225-249"},"PeriodicalIF":0.0,"publicationDate":"2024-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141857499","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Forecasting the changes between endemic and epidemic phases of a contagious disease, with the example of COVID-19. 以 COVID-19 为例，预测传染病在流行期和流行期之间的变化。

Mathematical medicine and biology : a journal of the IMA Pub Date : 2024-08-20 DOI: 10.1093/imammb/dqae012

Jacques Demongeot, Pierre Magal, Kayode Oshinubi

{"title":"Forecasting the changes between endemic and epidemic phases of a contagious disease, with the example of COVID-19.","authors":"Jacques Demongeot, Pierre Magal, Kayode Oshinubi","doi":"10.1093/imammb/dqae012","DOIUrl":"https://doi.org/10.1093/imammb/dqae012","url":null,"abstract":"Background: Predicting the endemic/epidemic transition during the temporal evolution of a contagious disease.Methods: Indicators for detecting the transition endemic/epidemic, with four scalars to be compared, are calculated from the daily reported news cases: coefficient of variation, skewness, kurtosis, and entropy. The indicators selected are related to the shape of the empirical distribution of the new cases observed over 14 days. This duration has been chosen to smooth out the effect of weekends when fewer new cases are registered. For finding a forecasting variable, we have used the principal component analysis (PCA), whose first principal component (a linear combination of the selected indicators) explains a large part of the observed variance and can then be used as a predictor of the phenomenon studied (here the occurrence of an epidemic wave).Results: A score has been built from the four proposed indicators using the PCA, which allows an acceptable level of forecasting performance by giving a realistic retro-predicted date for the rupture of the stationary endemic model corresponding to the entrance in the epidemic exponential growth phase. This score is applied to the retro-prediction of the limits of the different phases of the COVID-19 outbreak in successive endemic/epidemic transitions for three countries, France, India, and Japan.Conclusion: We provided a new forecasting method for predicting an epidemic wave occurring after an endemic phase for a contagious disease.","PeriodicalId":94130,"journal":{"name":"Mathematical medicine and biology : a journal of the IMA","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142010169","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Biological invasions and epidemics with nonlocal diffusion along a line. 沿线非局部扩散的生物入侵和流行病。

Mathematical medicine and biology : a journal of the IMA Pub Date : 2024-08-05 DOI: 10.1093/imammb/dqae014

Henri Berestycki, Jean-Michel Roquejoffre, Luca Rossi

{"title":"Biological invasions and epidemics with nonlocal diffusion along a line.","authors":"Henri Berestycki, Jean-Michel Roquejoffre, Luca Rossi","doi":"10.1093/imammb/dqae014","DOIUrl":"https://doi.org/10.1093/imammb/dqae014","url":null,"abstract":"The goal of this work is to understand and quantify how a line with nonlocal diffusion given by an integral enhances a reaction-diffusion process occurring in the surrounding plane. This is part of a long term programme where we aim at modelling, in a mathematically rigorous way, the effect of transportation networks on the speed of biological invasions or propagation of epidemics. We prove the existence of a global propagation speed and characterise in terms of the parameters of the system the situations where such a speed is boosted by the presence of the line. In the course of the study we also uncover unexpected regularity properties of the model. On the quantitative side, the two main parameters are the intensity of the diffusion kernel and the characteristic size of its support. One outcome of this work is that the propagation speed will significantly be enhanced even if only one of the two is large, thus broadening the picture that we have already drawn in our previous works on the subject, with local diffusion modelled by a standard Laplacian. We further investigate the role of the other parameters, enlightening some subtle effects due to the interplay between the diffusion in the half plane and that on the line. Lastly, in the context of propagation of epidemics, we also discuss the model where, instead of a diffusion, displacement on the line comes from a pure transport term.","PeriodicalId":94130,"journal":{"name":"Mathematical medicine and biology : a journal of the IMA","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141891446","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

KPP transition fronts in a one-dimensional two-patch habitat. 一维双斑块生境中的 KPP 过渡前沿。

Mathematical medicine and biology : a journal of the IMA Pub Date : 2024-07-30 DOI: 10.1093/imammb/dqae011

François Hamel, Mingmin Zhangy

引用次数: 0

Mathematical modelling, selection and hierarchical inference to determine the minimal dose in IFNα therapy against myeloproliferative neoplasms. 通过数学建模、选择和层次推理，确定 IFNα 治疗骨髓增殖性肿瘤的最小剂量。

Mathematical medicine and biology : a journal of the IMA Pub Date : 2024-06-15 DOI: 10.1093/imammb/dqae006

Gurvan Hermange, William Vainchenker, Isabelle Plo, Paul-Henry Cournède

引用次数: 0

Phenotype divergence and cooperation in isogenic multicellularity and in cancer. 同源多细胞和癌症中的表型分化与合作

Mathematical medicine and biology : a journal of the IMA Pub Date : 2024-06-15 DOI: 10.1093/imammb/dqae005

Frank Ernesto Alvarez, Jean Clairambault

{"title":"Phenotype divergence and cooperation in isogenic multicellularity and in cancer.","authors":"Frank Ernesto Alvarez, Jean Clairambault","doi":"10.1093/imammb/dqae005","DOIUrl":"10.1093/imammb/dqae005","url":null,"abstract":"We discuss the mathematical modelling of two of the main mechanisms that pushed forward the emergence of multicellularity: phenotype divergence in cell differentiation and between-cell cooperation. In line with the atavistic theory of cancer, this disease being specific of multicellular animals, we set special emphasis on how both mechanisms appear to be reversed, however not totally impaired, rather hijacked, in tumour cell populations. Two settings are considered: the completely innovating, tinkering, situation of the emergence of multicellularity in the evolution of species, which we assume to be constrained by external pressure on the cell populations, and the completely planned-in the body plan-situation of the physiological construction of a developing multicellular animal from the zygote, or of bet hedging in tumours, assumed to be of clonal formation, although the body plan is largely-but not completely-lost in its constituting cells. We show how cancer impacts these two settings and we sketch mathematical models for them. We present here our contribution to the question at stake with a background from biology, from mathematics and from philosophy of science.","PeriodicalId":94130,"journal":{"name":"Mathematical medicine and biology : a journal of the IMA","volume":" ","pages":"135-155"},"PeriodicalIF":0.0,"publicationDate":"2024-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141545723","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Model of Individual BMI Trajectories. 个人体重指数轨迹模型。

Mathematical medicine and biology : a journal of the IMA Pub Date : 2024-03-15 DOI: 10.1093/imammb/dqad009

Laurens Bogaardt, Anoukh van Giessen, H Susan J Picavet, Hendriek C Boshuizen

引用次数: 0