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[Neurosurgical treatment of tumors of the pineal region - literature review and overview of cases at OMIII]. [松果体区肿瘤的神经外科治疗--文献综述和OMIII病例概述]。
Magyar onkologia Pub Date : 2024-03-14 Epub Date: 2023-11-23
Tamás Mezei, János Báskay, Péter Pollner, Viktória Kovács, Balázs Markia, Gábor Nagy, András Bajcsay, László Sipos
{"title":"[Neurosurgical treatment of tumors of the pineal region - literature review and overview of cases at OMIII].","authors":"Tamás Mezei, János Báskay, Péter Pollner, Viktória Kovács, Balázs Markia, Gábor Nagy, András Bajcsay, László Sipos","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Pineal region tumors account for less than 1% of adult supratentorial tumors. Their treatment requires a multimodality approach. Previously, the treatment of choice was direct surgery, which is associated with high surgical risk. Advances in minimally invasive techniques and onco-radiotherapy offer a safe and multimodal personalized therapy. The aim of our study was to describe the practice of our Institute based on combined endoscopic and radiotherapy techniques. We performed a retrospective clinical study. We processed data from 23 adult patients who underwent endoscopic third ventricle fenestration and pineal tumor biopsy between 2014 and 2023. Descriptive statistics, t-test, Fisher's exact test and Kaplan-Meier analysis were performed. Clinical improvement with endoscopic intervention was achieved in 78.3% of cases. Significant increase in preoperative performance status was observed in the postoperative period (p=2.755e-5), and radiotherapy resulted in regression or stable disease. Our results suggest a safe treatment with good clinical outcome and an excellent alternative to direct surgery.</p>","PeriodicalId":94127,"journal":{"name":"Magyar onkologia","volume":"68 1","pages":"27-35"},"PeriodicalIF":0.0,"publicationDate":"2024-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140133682","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Local treatment of ipsilateral breast cancer recurrences: comparison of alternative therapeutic options]. [同侧乳腺癌复发的局部治疗：替代疗法的比较]。
Magyar onkologia Pub Date : 2024-03-14 Epub Date: 2024-01-30
Viktor Smanykó
{"title":"[Local treatment of ipsilateral breast cancer recurrences: comparison of alternative therapeutic options].","authors":"Viktor Smanykó","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>We compared the clinical outcomes of second breast conserving therapy (2ndBCT) versus salvage mastectomy (sMT) for the treatment of ipsilateral breast tumour recurrences (IBTR). 195 patients who presented with an IBTR after previous breast conserving treatment were salvaged either with re-excision and perioperative interstitial brachytherapy (n=39) or sMT (n=156). A total dose of 5×4.4Gy was delivered to the tumour bed, on 3 consecutive days. The median follow-up time was 59 and 56 months. During follow-up 4 (10.2%) and 28 (17.9%) second local recurrences occurred after 2ndBCT and sMT, respectively. There were no significant differences between treatments in 5-year oncological outcomes (local and regional recurrence-free survival, disease- and metastasis-free survival, cancer-specific and overall survival). After 2ndBCT, the rate of good to excellent cosmesis was 70%. 2ndBCT is a safe and feasible option for the management of IBTR, resulting similar 5-year oncological outcomes and better cosmetic results compared to sMT.</p>","PeriodicalId":94127,"journal":{"name":"Magyar onkologia","volume":"68 1","pages":"86-88"},"PeriodicalIF":0.0,"publicationDate":"2024-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140133681","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Stereotactic radiosurgery of brain tumors]. [脑肿瘤的立体定向放射外科]。
Magyar onkologia Pub Date : 2024-03-14 Epub Date: 2023-11-02
Imre Fedorcsák, András Bajcsay, Levente Jánváry
{"title":"[Stereotactic radiosurgery of brain tumors].","authors":"Imre Fedorcsák, András Bajcsay, Levente Jánváry","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Stereotactic radiosurgery is today a well-established treatment modality for various intracranial pathologies. The principle of high dose focused intracranial radiation guided by stereotactic technique (\"Gamma Knife\") was introduced by the Swedish neurosurgeon Prof. Lars Leksell in 1968. After the advent of CT and later MR imaging, stereotactic radiosurgery evolved rapidly regarding indications, and new technical solutions made it possible for linear accelerator systems to perform radiosurgery. A huge number of patients are treated yearly worldwide with this technology. In this article we overview the major indications, advantages and possible complications of stereotactic radiosurgery.</p>","PeriodicalId":94127,"journal":{"name":"Magyar onkologia","volume":"68 1","pages":"53-59"},"PeriodicalIF":0.0,"publicationDate":"2024-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140133683","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[External radiation therapy of primary central nervous system tumors - current trends and practice]. [原发性中枢神经系统肿瘤的体外放射治疗--当前趋势与实践]。
Magyar onkologia Pub Date : 2024-03-14 Epub Date: 2023-10-22
Árpád Kovács
{"title":"[External radiation therapy of primary central nervous system tumors - current trends and practice].","authors":"Árpád Kovács","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The family of primary central nervous system (CNS) tumors is a highly heterogeneous group of diseases. In the complex care of CNS tumors, in addition to surgical and systemic treatments, modern external beam radiation therapy (EBRT) plays a prominent role. This summary article provides an overview of the current indications related to EBRT, diagnostic procedures, contouring, planning, and radiation therapy techniques and applications that can be used in daily routine for adults' most common primary CNS tumors.</p>","PeriodicalId":94127,"journal":{"name":"Magyar onkologia","volume":"68 1","pages":"37-50"},"PeriodicalIF":0.0,"publicationDate":"2024-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140133679","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Intra- and perioperative imaging options in neurosurgery]. [神经外科术中和围术期成像方案]。
Magyar onkologia Pub Date : 2024-03-14 Epub Date: 2024-01-12
Loránd Erőss, László Halász, Gabriella Miklós
{"title":"[Intra- and perioperative imaging options in neurosurgery].","authors":"Loránd Erőss, László Halász, Gabriella Miklós","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The treatment of central nervous system tumors is still a major challenge for the oncological and neurosurgical teams. Due to the heterogeneous histological and topological characteristics of these neoplasms, every case requires individual evaluation. In addition to histology and stage, survival is largely determined by the extent of resection, which can be severely limited by the proximity of eloquent brain regions. A key component of current modern neuro-oncological care is the planning and execution of surgical intervention to ensure the longest possible progression-free survival with adequate quality of life. The simultaneous development of several pre- and intra-operative imaging modalities is making optimal therapy more and more accessible and safe. Structural, diffusion and functional MRI offers the possibility to visualize the tumor and the surrounding areas both before and during surgery. For the surgeon, the optimal intra-operative environment, orientation and visual acuity are provided by increasingly sophisticated microscopes, navigation devices, intra-operative imaging equipment, endo- and exoscopes.</p>","PeriodicalId":94127,"journal":{"name":"Magyar onkologia","volume":"68 1","pages":"5-12"},"PeriodicalIF":0.0,"publicationDate":"2024-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140133680","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[The importance and areas of modern supportive and early integrated palliative care in the treatment of brain tumor patients]. [现代支持性和早期综合姑息治疗在脑肿瘤患者治疗中的重要性和领域]。
Magyar onkologia Pub Date : 2024-03-14 Epub Date: 2023-10-22
Orsolya Horváth, Péter Kovács
{"title":"[The importance and areas of modern supportive and early integrated palliative care in the treatment of brain tumor patients].","authors":"Orsolya Horváth, Péter Kovács","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>During the care of brain tumor patients, supportive care and palliation are carried out in an individualized manner, accompanied by adequate communication, in a multidisciplinary professional environment. In the case of brain tumor patients, the burden of symptoms resulting from the progression of the disease and the complications of treatments occur in a particularly high proportion. The supportive care of patients in a modern approach covers the targeted treatment of physical and psychosocial problems and also includes integrated palliation. Palliative care is a form of care that can be used in addition to curative therapies, and it is advisable and necessary to introduce it as early as possible among brain tumor patients due to the significant deterioration of the quality of life. Dealing with seriously ill patients on a daily basis is also an emotional burden for the professional staff, and carries the risk of burnout. The support of the staff and family members, as well as the issues of adequate communication, are also part of the scope of the supportive care approach.</p>","PeriodicalId":94127,"journal":{"name":"Magyar onkologia","volume":"68 1","pages":"77-85"},"PeriodicalIF":0.0,"publicationDate":"2024-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140133685","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Surgical treatment of paediatric brain tumours]. [小儿脑肿瘤的外科治疗]。
Magyar onkologia Pub Date : 2023-12-18 Epub Date: 2023-11-23
Balázs Markia, Renáta Kiss-Miki, Gabriella Déri
{"title":"[Surgical treatment of paediatric brain tumours].","authors":"Balázs Markia, Renáta Kiss-Miki, Gabriella Déri","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Central nervous system (CNS) tumours are the second most common neoplasm types in children. In most cases the aetiology is unknown, but some genetic syndromes can be related to CNS tumours. The symptoms are not specified, that is why in case of younger ages the tumour can reach extreme sizes. In case of infants the surgical technique is determined by the amount of circulating blood. Precise haemostasis is of utmost importance. In the last years, because of the development of imaging, surgical and anaesthetic techniques, the overall survival rate increased among paediatric brain cancer patients, and with this, the quality of life as well has improved significantly. Between 1975 and 2010 there was a 50% improvement in 5-year survival.</p>","PeriodicalId":94127,"journal":{"name":"Magyar onkologia","volume":"67 4","pages":"333-339"},"PeriodicalIF":0.0,"publicationDate":"2023-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138815850","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Effect of long-term medical nutrition therapy on the survival of head and neck cancer patients - based on real-world data]. [长期医学营养疗法对头颈部癌症患者生存期的影响--基于真实世界的数据]。
Magyar onkologia Pub Date : 2023-12-18 Epub Date: 2023-11-23
Barbara Belák, Andrea Molnár, Erzsébet Pálfi, Célia Blasszauer, Dániel Reibl, József Lövey
{"title":"[Effect of long-term medical nutrition therapy on the survival of head and neck cancer patients - based on real-world data].","authors":"Barbara Belák, Andrea Molnár, Erzsébet Pálfi, Célia Blasszauer, Dániel Reibl, József Lövey","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>At the 45th Congress of ESPEN (The European Society for Clinical Nutrition and Metabolism), we presented for the first time the initial results of our 2023 oncology research, in which we revealed positive correlations between the persistence of medical nutrition therapy and overall survival, in head and neck cancer patients. Patients who received longterm nutrition therapy (≥7 months) had a significantly longer survival (p<0.0001) than those who received only short-term nutrition therapy intervention, i.e., for 1-3 months. The aim, methodology and results of the Hungarian research aroused the interest of the congress participants; therefore, we also publish it in Hungarian in the form of a short notice.</p>","PeriodicalId":94127,"journal":{"name":"Magyar onkologia","volume":"67 4","pages":"341-344"},"PeriodicalIF":0.0,"publicationDate":"2023-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138815707","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Childhood brain tumors: diagnosis and therapy - comprehensive genomic profiling]. [儿童脑肿瘤：诊断与治疗--全面基因组剖析]。
Magyar onkologia Pub Date : 2023-12-18 Epub Date: 2023-10-30
Edit Brückner, Gábor Bedics, Lilla Reiniger, Hajnalka Rajnai, Zsuzsanna Jakab, Csaba Bödör, Bálint Scheich, Miklós Garami
{"title":"[Childhood brain tumors: diagnosis and therapy - comprehensive genomic profiling].","authors":"Edit Brückner, Gábor Bedics, Lilla Reiniger, Hajnalka Rajnai, Zsuzsanna Jakab, Csaba Bödör, Bálint Scheich, Miklós Garami","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>With the advancement of molecular oncology, numerous new opportunities are available for the effective and efficient treatment of patients diagnosed with childhood brain tumors. This includes gene panel analysis aiding personalized treatment used in clinical trials, and the application of targeted therapy independent of tissue type (tumor agnostic therapy). Most personalized therapies inhibit certain kinases. In our review, we present the modern pathological diagnosis of childhood brain tumors, as well as the complex intracellular regulation of signal transduction pathways important from the point of view of clinical practice, and we describe their further targets defined on the basis of pharmacological characteristics of the pathway, based on international and our own results. Despite common mutations affecting kinases, personalized therapy is not available in many types of tumors. Through the example of childhood brain tumors, we demonstrate the expected future therapeutic significance of tyrosine kinases.</p>","PeriodicalId":94127,"journal":{"name":"Magyar onkologia","volume":"67 4","pages":"315-320"},"PeriodicalIF":0.0,"publicationDate":"2023-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138815704","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Practical approach to molecular pathology of central nervous system tumours]. [中枢神经系统肿瘤分子病理学实用方法]。
Magyar onkologia Pub Date : 2023-12-18 Epub Date: 2023-10-18
Livia Vida, Bálint Horváth, Béla Kajtár
{"title":"[Practical approach to molecular pathology of central nervous system tumours].","authors":"Livia Vida, Bálint Horváth, Béla Kajtár","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Recent advances in molecular diagnostics are transforming the classification of malignant tumours, it has long played a major role in the field of CNS tumours. Examination of 1p/19q codeletion is indispensable in case of diffuse gliomas. Glioblastoma may be diagnosed even in the absence of characteristic morphological features, when EGFR amplification, TERT promoter mutation or +7/-10 copy number abnormalities are present. The number of entities defined by a genetic abnormality is growing. Comprehensive analysis of DNA methylation may be of considerable help in addition to histology and basic molecular studies, especially in case of small samples. Keeping up with the ever-expanding diagnostic repertoire is difficult, however, advantages and disadvantages of these methods and the context in which they may be useful should be understood by those who are involved in the diagnosis of CNS tumours. This summary provides a general overview of the main methods used in molecular diagnostics.</p>","PeriodicalId":94127,"journal":{"name":"Magyar onkologia","volume":"67 4","pages":"304-313"},"PeriodicalIF":0.0,"publicationDate":"2023-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138815711","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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