Laboratory medicine最新文献_第4页

Review of the American Heart Association PREVENT guidelines: how non-high-density lipoprotein cholesterol and apolipoprotein B fit in. 回顾美国心脏协会预防指南：非高密度脂蛋白胆固醇和载脂蛋白B如何适应。

IF 1

Laboratory medicine Pub Date : 2026-08-04 DOI: 10.1093/labmed/lmag054

Stanley S Levinson

{"title":"Review of the American Heart Association PREVENT guidelines: how non-high-density lipoprotein cholesterol and apolipoprotein B fit in.","authors":"Stanley S Levinson","doi":"10.1093/labmed/lmag054","DOIUrl":"10.1093/labmed/lmag054","url":null,"abstract":"Introduction: A remarkable new American Heart Association calculator for estimating risk of cardiovascular disease was released in 2024, with guidelines following in 2026. These guidelines now use non-high-density lipoprotein cholesterol (HDL-C) along with low-density lipoprotein cholesterol to guide and escalate therapy. Moreover, the calculator uses non-HDL-C as the primary screening lipoprotein marker to fully capture the hidden cholesterol burden.Methods: For its Predicting Risk of Cardiovascular Disease EVENTs (PREVENT) calculator, the American Heart Association compiled an immense, diverse dataset comprising more than 6.5 million US adults. The PREVENT equations not only use the conventional nonlipid risk markers but also reframe how cardiovascular disease is assessed by embedding it into a cardiovascular-kidney-metabolic syndrome framework.Results: Why did PREVENT not use apolipoprotein B (apo B) for the primary marker? In head-to-head comparisons, apo B has consistently been shown to outperform non-HDL-C, especially in high-risk syndromes. Here, using receiver operating characteristic curve analysis and C statistics, I show that after adjustment for conventional risk factors, apo B and non-HDL-C are equivalent for screening.Discussion: The guidelines suggest that apo B be used for risk reclassification and as needed for targeting of statin and ezetimibe therapy. Here, I clarify the reasons for this suggestion.","PeriodicalId":94124,"journal":{"name":"Laboratory medicine","volume":"57 5","pages":""},"PeriodicalIF":1.0,"publicationDate":"2026-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148835076","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Transient peripheral blood plasmacytosis and hematology analyzer scattergrams in acute dengue virus infection: case report with literature review. 急性登革病毒感染的短暂性外周血浆细胞病和血液学分析仪散射图：1例报告并文献复习。

IF 1

Laboratory medicine Pub Date : 2026-08-04 DOI: 10.1093/labmed/lmag064

Florent Broussal, Omer Beganovic, Delphine Borgel, Claire Auditeau

{"title":"Transient peripheral blood plasmacytosis and hematology analyzer scattergrams in acute dengue virus infection: case report with literature review.","authors":"Florent Broussal, Omer Beganovic, Delphine Borgel, Claire Auditeau","doi":"10.1093/labmed/lmag064","DOIUrl":"10.1093/labmed/lmag064","url":null,"abstract":"Introduction: Circulating plasmablasts and plasma cells are characteristic but underrecognized features of acute dengue virus (DENV) infection because of their transient nature. Their presence on peripheral blood smears may erroneously suggest a plasma cell dyscrasia.Methods: We report a case of secondary acute DENV serotype 3 infection in a 57-year-old traveler returning from the Caribbean that had morphologically suspected circulating plasma cells and thrombocytopenia, documented by peripheral blood smear and serial hematology analyzer scattergrams. Immunophenotypic confirmation was unavailable. We also performed a narrative review of published reports of plasmablast/plasma cell kinetics in DENV.Results: An abnormal reactive lymphocyte scattergram with an increased very high-fluorescence cell signal prompted smear review, which revealed the abrupt appearance of reactive (activated) lymphocytes (25%) and suspected plasma cells (5%) on day 6 after symptom onset, coinciding with the platelet nadir, despite clinical improvement. Published reports have described circulating plasmablasts/plasma cells from day 2, peaking around day 6, and disappearing by day 12, mirroring thrombocytopenia.Discussion: Increased very high-fluorescence cell signal on the lymphocyte scattergram should prompt peripheral blood smear review to assess suspected plasmacytosis because high-fluorescence gating, although sensitive, is not definitive. In the appropriate context, circulating plasma cells with thrombocytopenia should raise suspicion of DENV rather than a plasma cell neoplasm. These cells' kinetics may represent a potential adjunctive, phase-related laboratory clue that requires prospective validation.","PeriodicalId":94124,"journal":{"name":"Laboratory medicine","volume":"57 5","pages":""},"PeriodicalIF":1.0,"publicationDate":"2026-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149009430","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Assessment of a chemiluminescence immunoassay for antimitochondrial antibody subtype M2 in the diagnosis of primary biliary cholangitis. 化学发光免疫法检测抗线粒体抗体M2亚型诊断原发性胆管炎的价值。

IF 1

Laboratory medicine Pub Date : 2026-08-04 DOI: 10.1093/labmed/lmag063

Yujiao Jin, Ying Wang, Aifang Xu, Miaochan Wang, Kenv Pan

{"title":"Assessment of a chemiluminescence immunoassay for antimitochondrial antibody subtype M2 in the diagnosis of primary biliary cholangitis.","authors":"Yujiao Jin, Ying Wang, Aifang Xu, Miaochan Wang, Kenv Pan","doi":"10.1093/labmed/lmag063","DOIUrl":"https://doi.org/10.1093/labmed/lmag063","url":null,"abstract":"Introduction: We sought to evaluate the diagnostic performance of and interassay agreement between a chemiluminescence immunoassay for antimitochondrial antibody subtype M2 (AMA-M2) in patients with primary biliary cholangitis and clinically relevant disease controls with other liver diseases.Methods: In this retrospective study, 164 patients with primary biliary cholangitis and 403 patients with other liver diseases were enrolled between December 2020 and January 2023. The AMAs were detected using indirect immunofluorescence, line immunoassay (LIA), and chemiluminescence immunoassay. Diagnostic performance was evaluated by sensitivity, specificity, accuracy, and receiver operating characteristic curve analysis. Agreement between methods was assessed using the Cohen κ coefficient and correlation analysis.Results: AMA-M2 detected by chemiluminescence immunoassay had a sensitivity of 84.1%, a specificity of 90.1%, and an accuracy of 88.4%. Our receiver operating characteristic curve analysis showed an area under the curve of 0.927 (95% CI, 0.903-0.951) for AMA-M2 by chemiluminescence immunoassay, which was higher than the area under the curves for AMA-M2 by LIA (0.772) and M2-3E by LIA (0.862) (both P < .001). High concordance was observed between AMA-M2 by chemiluminescence immunoassay and M2-3E by LIA (96.1%, κ = 0.908), with a strong correlation between the 2 assays.Discussion: Chemiluminescence immunoassay-based detection of AMA-M2 showed high diagnostic performance and strong agreement with conventional assays in this cohort, supporting its utility as a reliable quantitative method for clinical diagnosis.","PeriodicalId":94124,"journal":{"name":"Laboratory medicine","volume":"57 5","pages":""},"PeriodicalIF":1.0,"publicationDate":"2026-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148984383","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A 50-base pair DNA ladder from human DNA as a cost-effective molecular marker for health care researchers in low-resource laboratory settings. 从人类DNA中提取50碱基对的DNA阶梯，作为卫生保健研究人员在资源匮乏的实验室环境中具有成本效益的分子标记。

IF 1

Laboratory medicine Pub Date : 2026-08-04 DOI: 10.1093/labmed/lmag062

Putri Chalya Firjatu, Zulham Yamamoto, Muhammad Ilmam Bariqi, Bayu Harly Putra, Nurhazlin

{"title":"A 50-base pair DNA ladder from human DNA as a cost-effective molecular marker for health care researchers in low-resource laboratory settings.","authors":"Putri Chalya Firjatu, Zulham Yamamoto, Muhammad Ilmam Bariqi, Bayu Harly Putra, Nurhazlin","doi":"10.1093/labmed/lmag062","DOIUrl":"https://doi.org/10.1093/labmed/lmag062","url":null,"abstract":"Introduction: DNA ladders are predominantly purchased from manufacturers and tend to be more expensive than ladders created in laboratories. This study aimed to report on a practical method for preparing a 50-base pair (bp) DNA ladder using human DNA as a template.Method: Human DNA from blood was isolated by spin column. Thirteen DNA fragments were amplified by polymerase chain reaction using designed primers and quantified. Amplicons were combined in 1.5-mL tubes. Laboratory-made and commercial 50-bp DNA ladders were compared qualitatively and quantitatively.Results: The isolated DNA purity was 1.89. The 50-bp DNA ladder obtained from human DNA exhibited good quality, with clearly visible fragments. Approximately 2 years after production, the laboratory-made DNA ladder's stability was acceptable, with a band intensity reduction of 5.45 arbitrary units compared with 5.58 arbitrary units observed in the commercial ladder. This protocol required only $20 in materials to produce a 50-bp DNA ladder for 100 runs, making it 4 to 15 times more economical than commercial products.Discussion: The laboratory-made DNA ladder is a useful standard in molecular research and has the potential to help health care professionals save both time and financial resources.","PeriodicalId":94124,"journal":{"name":"Laboratory medicine","volume":"57 5","pages":""},"PeriodicalIF":1.0,"publicationDate":"2026-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149066997","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Laboratory characteristics of direct antiglobulin test-positive anemia in patients with newly diagnosed multiple myeloma. 新诊断多发性骨髓瘤患者直接抗球蛋白试验阳性贫血的实验室特征。

IF 1

Laboratory medicine Pub Date : 2026-08-04 DOI: 10.1093/labmed/lmag044

Yutong Zheng, YanTian Zhao, Di Wu, Hong Zong, Hong Huo, ChuanYing Geng, Sha Li, YongQi He, YinChu Liu, HongShuai Li, JunQin Liu, YaJun Zhao, Xin Liu, Juan Lv

{"title":"Laboratory characteristics of direct antiglobulin test-positive anemia in patients with newly diagnosed multiple myeloma.","authors":"Yutong Zheng, YanTian Zhao, Di Wu, Hong Zong, Hong Huo, ChuanYing Geng, Sha Li, YongQi He, YinChu Liu, HongShuai Li, JunQin Liu, YaJun Zhao, Xin Liu, Juan Lv","doi":"10.1093/labmed/lmag044","DOIUrl":"https://doi.org/10.1093/labmed/lmag044","url":null,"abstract":"Introduction: This study retrospectively characterized the laboratory features of direct antiglobulin test (DAT)-positive anemia in newly diagnosed multiple myeloma (MM) and explored associated immunologic alterations to better understand MM-related immune dysregulation.Methods: We enrolled 77 patients with newly diagnosed MM admitted to our hospital between 2021 and 2025. Based on DAT results, patients were assigned to a DAT-positive group (n = 52) or a DAT-negative group (n = 25). Clinical characteristics, laboratory parameters, and peripheral blood T-cell subsets were compared between groups.Results: Monoclonal immunoglobulin (M protein) isotype distribution was statistically significantly different between groups (P < .001), with immunoglobulin G predominating in the DAT-positive group (88.46%). Compared with the DAT-negative group, DAT-positive patients had lower albumin, sodium, and potassium levels as well as a lower albumin to globulin ratio but higher levels of globulin and ferritin as well as higher absolute lymphocyte counts (all P < .05). Flow cytometric analysis showed increased T-cell-related parameters, particularly CD8-positive T cells, in the DAT-positive group, whereas reduced natural killer-cell and B-cell counts were more common in the DAT-negative group.Discussion: The observed laboratory profile suggested a more pronounced state of inflammatory or immune activation and electrolyte disturbances, highlighting the need for improved clinical recognition and detection of potential immune-mediated red blood cell injury, hemolytic predisposition, and related immune abnormalities.","PeriodicalId":94124,"journal":{"name":"Laboratory medicine","volume":"57 5","pages":""},"PeriodicalIF":1.0,"publicationDate":"2026-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148703198","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Modified double-volume exchange transfusion in 2 infants with severe pertussis and hyperleukocytosis. 改良双容积换血治疗重症百日咳伴白细胞增多2例。

IF 1

Laboratory medicine Pub Date : 2026-06-10 DOI: 10.1093/labmed/lmag036

Si-Meng Wu, Qiu-Shi Wang

{"title":"Modified double-volume exchange transfusion in 2 infants with severe pertussis and hyperleukocytosis.","authors":"Si-Meng Wu, Qiu-Shi Wang","doi":"10.1093/labmed/lmag036","DOIUrl":"10.1093/labmed/lmag036","url":null,"abstract":"Introduction: Pertussis is an acute respiratory infectious disease caused by Bordetella pertussis. Hyperleukocytosis in pertussis contributes to a drastically worsened prognosis by promoting pulmonary hypertension and multiorgan failure, leading to accelerated disease progression and elevated mortality. Exchange transfusion can improve the prognosis of in children with pertussis and increase the success rate of treatment.Methods: We retrospectively analyzed 2 infants with severe pertussis treated with modified exchange transfusion. Reconstituted whole blood was prepared using O-type leukoreduced concentrated red blood cells and AB-type leukocyte-reduced, virus-inactivated fresh frozen plasma, with a red blood cell to plasma ratio of 1:1 to 2:1 and a hematocrit of 40% to 50%. The total exchange volume was 150 to 180 mL/kg (approximately twice the blood volume).Results: After exchange transfusion, both infants showed marked reduction in white blood cell count and clinically significant improvement in dyspnea. No severe adverse reactions occurred, and both children were discharged.Discussion: Modified double-volume exchange transfusion is a safe and effective treatment for infants with severe pertussis and hyperleukocytosis.","PeriodicalId":94124,"journal":{"name":"Laboratory medicine","volume":"57 4","pages":""},"PeriodicalIF":1.0,"publicationDate":"2026-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148229782","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Medical laboratory science course performance and grade point average as indicators of ASCP certification success: a 10-year review from an NAACLS-accredited program. 医学实验室科学课程表现和平均成绩作为ASCP认证成功的指标：来自naacls认证项目的10年回顾。

IF 1

Laboratory medicine Pub Date : 2026-06-10 DOI: 10.1093/labmed/lmag024

Sumbul Bushra, Rana Abozoor, Taghreed Abu-Nada, Mohammad Al-Hamdani, Atiyeh M Abdallah, Marawan Abu-Madi

{"title":"Medical laboratory science course performance and grade point average as indicators of ASCP certification success: a 10-year review from an NAACLS-accredited program.","authors":"Sumbul Bushra, Rana Abozoor, Taghreed Abu-Nada, Mohammad Al-Hamdani, Atiyeh M Abdallah, Marawan Abu-Madi","doi":"10.1093/labmed/lmag024","DOIUrl":"10.1093/labmed/lmag024","url":null,"abstract":"Introduction: Passing the American Society for Clinical Pathology Board of Certification (ASCP BOC) exam is a key milestone, and this study examined its association with academic performance at Qatar University.Methods: For 228 graduates attempting the ASCP BOC exam, use used χ2 tests to assess relationships between (1) performance in ASCP domains and overall exam result (pass/fail) and (2) course grades (C or above vs below C) and ASCP BOC domain performance. The correlation between grade point average (GPA) and ASCP BOC exam score was assessed using the Pearson coefficient.Results: Passing any ASCP BOC domain was statistically significantly associated with passing the overall exam (all P < .001). Students who passed the overall exam demonstrated high pass rates across domains, particularly in chemistry (95.5%), hematology (84.1%), microbiology (86.0%), and blood banking (73.9%). Achieving a grade of C or higher in courses at the university was statistically significantly associated with passing the corresponding ASCP BOC domains in most cases. Graduation GPA was positively correlated with total ASCP BOC score (r = 0.652, P < .001).Discussion: Academic performance at the university level is strongly associated with ASCP BOC certification success, along with other factors that influence student success. Higher graduation GPA and passing grades in core courses are strong predictors of improved ASCP BOC exam outcomes, providing early indicators by which to identify students who may benefit from targeted academic support.","PeriodicalId":94124,"journal":{"name":"Laboratory medicine","volume":"57 4","pages":""},"PeriodicalIF":1.0,"publicationDate":"2026-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13278759/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148280614","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Establishing multianalyte thresholds for automated detection of EDTA contamination. 建立自动检测EDTA污染的多分析物阈值。

IF 1

Laboratory medicine Pub Date : 2026-06-10 DOI: 10.1093/labmed/lmag041

Jillian Kodger, Thomas J S Durant, Dustin Miconi, Joe M El-Khoury

{"title":"Establishing multianalyte thresholds for automated detection of EDTA contamination.","authors":"Jillian Kodger, Thomas J S Durant, Dustin Miconi, Joe M El-Khoury","doi":"10.1093/labmed/lmag041","DOIUrl":"https://doi.org/10.1093/labmed/lmag041","url":null,"abstract":"Introduction: Bias in analytes due to EDTA contamination is easy to miss and represents a common and clinically relevant preanalytical error. We designed a study to determine the in vitro effects of rising rates of EDTA contamination in blood samples and to evaluate how these findings could inform the development of multianalyte thresholds for detecting such errors automatically.Methods: We incrementally spiked blood samples with increasing volumes of EDTA‑contaminated specimen and measured the resulting changes in alkaline phosphatase, calcium, magnesium, potassium, and iron levels. Using these observations, we developed a series of multianalyte thresholds and evaluated their performance against 1 year of retrospective clinical data (n = 2407).Results: Our experiments demonstrated that increasing rates of EDTA contamination produced changes in several analytes. Accordingly, we applied multianalyte thresholds using potassium and calcium to retrospective samples. Across all samples, smaller magnitudes of analyte deviation resulted in higher detection rates of subtle EDTA contamination but poorer specificity. We selected a rule of a potassium level of 6.5 mmol/L or higher and a calcium level below 6.5 mg/dL (1.63 mmol/L), which identified 14 samples with a contamination rate of 42.8%.Discussion: Multianalyte thresholds show promise as an effective approach for automatically identifying clinically significant EDTA contamination in clinical specimens.","PeriodicalId":94124,"journal":{"name":"Laboratory medicine","volume":"57 4","pages":""},"PeriodicalIF":1.0,"publicationDate":"2026-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148474946","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An evaluation of the necessity of repeat testing of critical and dangerous values in a medical center in Taiwan. 台湾某医疗中心重复检测临界和危险值的必要性评估。

IF 1

Laboratory medicine Pub Date : 2026-06-10 DOI: 10.1093/labmed/lmag037

Chih-Wei Tseng, Jia-Bin Liao, Herng-Sheng Lee

{"title":"An evaluation of the necessity of repeat testing of critical and dangerous values in a medical center in Taiwan.","authors":"Chih-Wei Tseng, Jia-Bin Liao, Herng-Sheng Lee","doi":"10.1093/labmed/lmag037","DOIUrl":"https://doi.org/10.1093/labmed/lmag037","url":null,"abstract":"Introduction: Routine repeat testing of critical laboratory values delays reporting, and its effectiveness lacks empirical evidence. This study investigated the impact of automated repeat testing on report accuracy and timeliness.Methods: This retrospective study of data from a large accredited medical center in Taiwan analyzed the occurrence rate, relative frequency, differences in repeat testing, and reporting delays of critical and dangerous values. Acceptable difference criteria were based on measurement uncertainty or College of American Pathologists criteria. Differences greater than the acceptable difference criteria were defined as \"large differences.\"Results: The occurrence rates of critical and dangerous values were 0.15% and 0.23%, respectively, with an acceptable difference rate of 99.57%. Large differences occurred at 0.39% (within the analytical measurement range [AMR]), 7.69% (above the AMR), and 0% (below the AMR). Repeated testing caused a median reporting delay of 10 to 33 minutes.Discussion: Repeat testing within the AMR is unnecessary. Values above the AMR require repeat testing, whereas values below the AMR warrant investigation of preanalytical errors. Targeted repeat testing policies can reduce reporting times, minimize reagent waste, and enhance patient safety.","PeriodicalId":94124,"journal":{"name":"Laboratory medicine","volume":"57 4","pages":""},"PeriodicalIF":1.0,"publicationDate":"2026-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148335303","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exploring beyond the bench: factors that may influence clinical laboratory professionals to consider leaving the profession. 探索板凳之外：可能影响临床实验室专业人员考虑离开该行业的因素。

IF 1

Laboratory medicine Pub Date : 2026-06-10 DOI: 10.1093/labmed/lmag042

Kelly Ritter, Norman W Gill, Karen Schlumpf, Jehan Abukharmah, Marcia Firmani

{"title":"Exploring beyond the bench: factors that may influence clinical laboratory professionals to consider leaving the profession.","authors":"Kelly Ritter, Norman W Gill, Karen Schlumpf, Jehan Abukharmah, Marcia Firmani","doi":"10.1093/labmed/lmag042","DOIUrl":"10.1093/labmed/lmag042","url":null,"abstract":"Introduction: The clinical laboratory workforce shortage is driven by retirements as well as professionals leaving for other reasons. This study examined the factors contributing to both factors.Methods: We created a nationwide cross-sectional online survey distributed by social media and email. We used descriptive statistics and χ2 tests to examine select demographic and job-related variables, including job title, age, education level, sex, and institution type.Results: Among 302 participants, 16.2% reported having frequent thoughts of leaving the profession, and 17.9% reported intentions to leave within the next year. The retirement rate was 13.9% (73.8% classified as planned). Compensation (73.5%) and stress or burnout (61.2%) emerged as top factors driving thoughts of leaving. Compensation (75.9%) and lack of growth opportunities (51.9%) drove intentions to leave. Moderate associations were found between compensation and both thoughts of leaving (Cramer V = 0.428) and intentions to leave (Cramer V = 0.347; P < .001). Additionally, moderate associations were found between feelings of appreciation and both thoughts of leaving (Cramer V = 0.361) and intentions to leave (Cramer V = 0.379; P < .001).Discussion: The rates of retirement and professional attrition observed in this study align with previous research. Factors such as compensation and feeling undervalued underscore the need for institutions to implement initiatives that address both factors.","PeriodicalId":94124,"journal":{"name":"Laboratory medicine","volume":"57 4","pages":""},"PeriodicalIF":1.0,"publicationDate":"2026-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148611515","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0