Journal of gastrointestinal and liver diseases : JGLD最新文献

{"title":"Primary Gastrointestinal Lymphoma: A Prospective Unicentric Study on a Romanian Cohort.","authors":"Petruta Violeta Filip, Ana Maria Vladareanu, Laura Sorina Diaconu, Denisa Cuciureanu, Alina Tomescu, Corina Silvia Pop","doi":"10.15403/jgld-6005","DOIUrl":"10.15403/jgld-6005","url":null,"abstract":"<p><strong>Background and aims: </strong>Lymphomas of the gastrointestinal tract represent a rare pathology, frequently associated with a poor outcome. This study aimed to determine the prognostic factors of digestive tract lymphomas and to evaluate the role of endoscopy in the diagnosis and outcome.</p><p><strong>Methods: </strong>Our prospective study evaluated a number of 63 patients diagnosed with digestive tract lymphomas.</p><p><strong>Results: </strong>The mean age of the patients was 62 years ± 13.1 years. Most of the patients had B-cell lymphoma (88.8%). Localization was represented by the stomach (44.4%), followed by the small bowel (25.4%) and the oropharynx (14.2%). Diffuse large B-cell lymphoma was the most common subtype (52.3%), followed by Mantle cell lymphoma (15.8%) and MALT (14.2%). T-cell lymphoma was present in a small number of patients. Anaplastic large cell lymphoma was the most common subtype of T-cell lymphoma (6.35%) and was localized in the small bowel. One-quarter of the patients had complications such as bleeding, obstruction, or perforation. Chemotherapy alone (38.1%) was the most common treatment option, followed by surgery (28.5%). Endoscopic examination and sampling biopsy were performed on 74.6% of the patients included in the study, with a positive diagnosis for lymphoma in 58.7% of the cases. Age (p=0.208), higher ECOG values (p=0.0487), and level of albumin (p=0.0355) were independent prognostic factors for overall survival. Endoscopic monitoring impacted overall survival (p<0.0001), due to the early detection of relapse.</p><p><strong>Conclusions: </strong>Age, high ECOG value, and low albumin levels are independent prognostic factors for overall survival. Early diagnosis of recurrent gastrointestinal tract lymphomas by endoscopy increases overall survival.</p>","PeriodicalId":94081,"journal":{"name":"Journal of gastrointestinal and liver diseases : JGLD","volume":" ","pages":"23-29"},"PeriodicalIF":0.0,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143674951","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Programmed Cell Death-ligand 1 as Biomarker of Poor Prognosis in Patients with Gastrointestinal Stromal Tumour.","authors":"Duolikun Yasheng, Abuduwaili Aierken, Yiliang Li, Aikebaier Aili, Kelimu Abudureyimu","doi":"10.15403/jgld-5858","DOIUrl":"10.15403/jgld-5858","url":null,"abstract":"<p><strong>Background and aims: </strong>To explore the prognostic role of programmed cell death-ligand 1 (PD-L1) in patients with gastrointestinal stromal tumours (GISTs).</p><p><strong>Methods: </strong>PD-L1 expression was detected using immunohistochemistry in tissue microarrays from 96 GISTs samples. Survival of patients was assessed using Kaplan - Meier analysis. Possible risk factors for GISTs were explored using Cox proportional hazards regression models. The role of PD-L1 in GISTs proliferation, invasion, and metastasis was assessed using colony formation assay, scratch, transwell invasion, and migration assays.</p><p><strong>Results: </strong>Survival in GISTs patients was significantly associated with PD-L1 expression (p < 0.05). High PD-L1 expression in GISTs resulted in relatively short overall survival (p=0.016). Univariate regression analysis showed that PD-L1 was a risk factor for poor prognosis (p<0.05). Compared with the control group, knockdown of PD-L1 significantly decreased the colony formation rate, and cell migration and invasion were inhibited compared with the control group. The wound healing ability of PD-L1 knockdown group was significantly weaker than that of the control group.</p><p><strong>Conclusions: </strong>The results suggest that overexpression of PD-L1 is a risk factor for a poor prognosis in patients with GISTs. Knockdown of PD-L1 significantly inhibited the development of GISTs. PD-L1 may serve as a biomarker for the poor prognosis of GISTs and a potential therapeutic target.</p>","PeriodicalId":94081,"journal":{"name":"Journal of gastrointestinal and liver diseases : JGLD","volume":"34 1","pages":"30-39"},"PeriodicalIF":0.0,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143736313","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epigastric Pain after ERCP.","authors":"Hsu-Huan Tseng, Hsueh-Chien Chiang","doi":"10.15403/jgld-5818","DOIUrl":"10.15403/jgld-5818","url":null,"abstract":"<p><p>.</p>","PeriodicalId":94081,"journal":{"name":"Journal of gastrointestinal and liver diseases : JGLD","volume":"34 1","pages":"15"},"PeriodicalIF":2.0,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143736277","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Case of Verrucous Esophageal Carcinoma with Submucosal Invasion Resected by Endoscopic Submucosal Dissection after Long-term Observation.","authors":"Kazuya Maruo, Naoya Tomatsuri, Akio Yanagisawa, Yoji Urata, Yusuke Okuyama","doi":"10.15403/jgld-5921","DOIUrl":"https://doi.org/10.15403/jgld-5921","url":null,"abstract":"","PeriodicalId":94081,"journal":{"name":"Journal of gastrointestinal and liver diseases : JGLD","volume":"34 1","pages":"12"},"PeriodicalIF":0.0,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143735746","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Thrombophlebitis of the Umbilical Vein: A Rare Complication of Acute Pancreatitis.","authors":"Megan Ml Engels, Aart Spilt, Johan P Kuijvenhoven","doi":"10.15403/jgld-5988","DOIUrl":"https://doi.org/10.15403/jgld-5988","url":null,"abstract":"","PeriodicalId":94081,"journal":{"name":"Journal of gastrointestinal and liver diseases : JGLD","volume":"34 1","pages":"14"},"PeriodicalIF":0.0,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143736320","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Abscess-like Evolution of Non-occlusive Caecum Ischemia.","authors":"Francesco Michele Ronza, Teresa Letizia Di Gennaro, Vittorio Patanè, Stefania Tamburrini","doi":"10.15403/jgld-6056","DOIUrl":"https://doi.org/10.15403/jgld-6056","url":null,"abstract":"","PeriodicalId":94081,"journal":{"name":"Journal of gastrointestinal and liver diseases : JGLD","volume":"34 1","pages":"13"},"PeriodicalIF":0.0,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143735811","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Magnifying Narrow-band Imaging with Endoscopic Ultrasound for the Diagnosis of Synchronous Triple Primary Tumors of the Esophagus.","authors":"Feifan Chen, Zhihan Wu, Kai Deng, Mingguang Zhang, Jinlin Yang","doi":"10.15403/jgld-5893","DOIUrl":"https://doi.org/10.15403/jgld-5893","url":null,"abstract":"","PeriodicalId":94081,"journal":{"name":"Journal of gastrointestinal and liver diseases : JGLD","volume":"34 1","pages":"11"},"PeriodicalIF":0.0,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143736280","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Current Clinical Assessment of Prognosis of Chronic Pancreatitis.","authors":"Petr Dite, David Solil, Marie Precechtelova, Martina Bojkova, Magdalena Uvirova, Jiri Dolina, Bohuslav Kianička","doi":"10.15403/jgld-6198","DOIUrl":"https://doi.org/10.15403/jgld-6198","url":null,"abstract":"","PeriodicalId":94081,"journal":{"name":"Journal of gastrointestinal and liver diseases : JGLD","volume":"34 1","pages":"7-10"},"PeriodicalIF":0.0,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143736275","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Mucosal Protection in the Treatment of Erosive Reflux Esophagitis: Mechanisms for Restoring Epithelial Permeability. A Randomized Clinical Trial.","authors":"Dmitry S Bordin, Maria A Livzan, Sergei I Mozgovoi, Olga V Gaus, Irina V Lapteva","doi":"10.15403/jgld-5859","DOIUrl":"10.15403/jgld-5859","url":null,"abstract":"<p><strong>Background and aims: </strong>Gastroesophageal reflux disease (GERD) is widespread in the population and is characterized by the risk of developing Barrett's esophagus and associated adenocarcinoma. Key factors in the progression of the disease are not only the frequency and duration of reflux episodes, but also the resistance of the esophageal mucosa to aggressive reflux molecules. Assessment of the state of tight junction proteins, the rate of their recovery under the influence of various treatment regimens is an urgent task for choosing optimal approaches to curing patients with GERD. The purpose of the study was to evaluate the efficacy and safety of the combination therapy with a proton pump inhibitor (PPI) and a topical mucosal protective agent (MPA) to relieve GERD symptoms and achieve a complete remission of reflux esophagitis faster.</p><p><strong>Methods: </strong>60 patients (38 men and 22 women with an average age 41.5 years) with GERD duration of 5 years, took part in an open randomized prospective clinical study. Participants were randomized in a 1:1 ratio to be divided into the main group taking MPA and PPI and a comparison group taking a PPI only. The duration of therapy was 4 weeks. Before the treatment onset and after the end of treatment, the occurrence and severity of GERD symptoms were assessed, an endoscopic examination was performed and biopsy specimens were taken from the edge of the erosive area and the area of unchanged esophageal mucosa. The severity of histological signs of esophagitis, the expression of tight junction proteins and the proliferation marker Ki-67 were assessed.</p><p><strong>Results: </strong>A more effective relief of GERD symptoms was documented when using combination therapy PPIs and MPAs. A more pronounced reduction in macroscopic changes was found in patients with erosive esophagitis taking PPIs and MPAs. The use of MPAs in addition to PPIs made it possible to achieve the primary and secondary endpoints more often, which suggested a high efficiency of the drug in combination with PPIs in the treatment of erosive esophagitis.</p><p><strong>Conclusions: </strong>An individualized approach based on the combination therapy of PPIs and MPAs can improve the effectiveness of treatment in achieving clinical, endoscopic and, more importantly, histological remission in a patient with erosive GERD.</p>","PeriodicalId":94081,"journal":{"name":"Journal of gastrointestinal and liver diseases : JGLD","volume":"33 4","pages":"455-462"},"PeriodicalIF":0.0,"publicationDate":"2024-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142904617","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Endoscopic Clips Marking for Transcatheter Arterial Embolization in Refractory Peptic Ulcer Bleeding Patients: A Cohort Study.","authors":"Yuqiang Liu, Xiaocun Xing, Xiaoze Wang, Xuefeng Luo, Jinlin Yang, Xue Xiao","doi":"10.15403/jgld-5820","DOIUrl":"https://doi.org/10.15403/jgld-5820","url":null,"abstract":"<p><strong>Background and aims: </strong>Transcatheter arterial embolization (TAE) is recommended for refractory peptic ulcer bleeding. There are 46% of patients showed no detectable contrast extravasation during TAE. Endoscopic clip in bleeding lesion is visible and could be used as a marker in TAE. We aimed to learn whether endoscopic clips marking would ameliorate the prognosis.</p><p><strong>Methods: </strong>We retrospectively collected data of patents who received TAE because of refractory peptic ulcer bleeding, between 1 January 2016 to 31 December 2022. 188 patients were included and divided into two groups according to clips visibility in angiography. Baseline data about age, gender, bleeding severity, comorbidities, history of antiplatelet or anticoagulation drugs and endoscopic findings were balanced with the inverse probability of treatment weighting method.</p><p><strong>Results: </strong>There were 59 patients without clips received TAE, and 129 with clips. The in-hospital rebleeding rate after TAE was much higher in patients without clip than with clips (45.8% vs 33.3%). Cox regression analysis indicated that endoscopic clips marking decreased the rebleeding (aHR=0.492, 95%CI: 0.242-1.001, p=0.050). Also, in patient with clips, the empirical TAE rate was higher (64.3% vs 11.9%, p<0.001). No difference in in-hospital all-cause mortality was found (without clips vs with clips 11.9% vs 12.4%). The hospital stay length and embolized vessels types showed no differences between the two groups.</p><p><strong>Conclusions: </strong>In refractory peptic ulcer bleeding patients, endoscopic clips marking decreased the in-hospital rebleeding rate after TAE, but did not affect the mortality.</p>","PeriodicalId":94081,"journal":{"name":"Journal of gastrointestinal and liver diseases : JGLD","volume":"33 4","pages":"468-473"},"PeriodicalIF":0.0,"publicationDate":"2024-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142904347","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}