The Role of Adipokines in Chronic Pancreatitis. A Systematic Review and Meta-Analysis.

Abdulrahman Ismaiel, Max-Ludwig Kiessling, Mohamed Ismaiel, Nahlah Al Srouji, Daniel-Corneliu Leucuta, Stefan-Lucian Popa, Dan Lucian Dumitrascu
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Abstract

Background and aims: Adipokines are among the biomarkers that have been studied in chronic pancreatitis (CP), as well as in pancreatic cancer (PC). So far, the existing findings are contradictory and inconclusive. Therefore, we assessed the levels of three major adipokines in CP in comparison to controls and PC, adiponectin, leptin, and resistin.

Methods: A systematic electronic search was carried out in November 2022 using PubMed, Embase, and Scopus, reviewing observational studies. By using the Newcastle-Ottawa Scale, the included studies' quality was evaluated (NOS). In the examination of the estimated overall effect size, we employed the random-effects model in conjunction with the mean difference (MD) analysis. The MD with 95% confidence interval (CI) served as the primary summary outcome.

Results: Our systematic review included a total of 14 studies, out of which nine were considered in our meta-analysis. A significant MD related to leptin levels in CP patients vs. controls (-1.299, 95%CI: -2.493 - -0.105), resistin levels in CP patients vs. controls (8.356, 95%CI: 3.700-13.012), and adiponectin levels in PC patients vs. controls (11.240, 95%CI: 5.872-16.60) was reported. However, no significant MD was reported in leptin levels between CP vs. PC patients (-0.936, 95%CI: -3.325-1.454), as well as adiponectin levels in CP patients vs. controls (0.422. 95%CI -5.651-6.535]) and in CP vs. PC patients (-6.252, 95%CI -13.269-0.766).

Conclusions: CP was significantly associated with decreased leptin levels and increased resistin levels. Furthermore, increased levels of adiponectin are associated with PC. Yet, no significant MD was seen for leptin and adiponectin levels between CP and PC patients, and likewise for adiponectin levels between CP patients and controls. Results should be interpreted with caution due to the high heterogeneity between the included studies.

脂肪因子在慢性胰腺炎中的作用。系统回顾与元分析》。
背景和目的:脂肪因子是研究慢性胰腺炎(CP)和胰腺癌(PC)的生物标志物之一。迄今为止,现有的研究结果相互矛盾,没有定论。因此,我们评估了 CP 中三种主要脂肪因子(脂肪连通素、瘦素和抵抗素)的水平,并与对照组和 PC 进行了比较:2022 年 11 月,我们使用 PubMed、Embase 和 Scopus 对观察性研究进行了系统的电子检索。采用纽卡斯尔-渥太华量表(Newcastle-Ottawa Scale)对纳入的研究进行了质量评估(NOS)。在检查估计的总体效应大小时,我们采用了随机效应模型和平均差(MD)分析。MD与95%置信区间(CI)是主要的总结性结果:我们的系统综述共纳入了 14 项研究,其中 9 项纳入了荟萃分析。CP患者与对照组的瘦素水平(-1.299,95%CI:-2.493 --0.105)、CP患者与对照组的抵抗素水平(8.356,95%CI:3.700-13.012)以及PC患者与对照组的脂肪连通素水平(11.240,95%CI:5.872-16.60)均有显着的MD相关性。然而,CP 与 PC 患者之间的瘦素水平(-0.936,95%CI:-3.325-1.454)以及 CP 患者与对照组之间的脂肪连通素水平(0.422。95%CI -5.651-6.535])和 CP 患者与 PC 患者之间的脂肪连通素水平(-6.252,95%CI -13.269-0.766)均无明显的 MD 变化:结论:CP 与瘦素水平降低和抵抗素水平升高密切相关。结论:CP 与瘦素水平降低和抵抗素水平升高密切相关。然而,在 CP 和 PC 患者之间,瘦素和脂肪连通素水平没有发现明显的 MD,同样,在 CP 患者和对照组之间,脂肪连通素水平也没有发现明显的 MD。由于所纳入的研究之间存在高度异质性,因此应谨慎解释研究结果。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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