Journal of gastrointestinal and liver diseases : JGLD最新文献

{"title":"Nucleolin as a Potent Biomarker for Predicting Tumor Recurrence among Patients with Hepatocellular Carcinoma after Transplantation.","authors":"Guanrong Chen, Xin Hu, Yingchen Huang, Huigang Li, Libin Dong, Yao Jiang, Di Lu, Feng Jiang, Xiuyang Li, Beicheng Sun, Shusen Zheng, Ren Lang, Xiao Xu, Ronggao Chen","doi":"10.15403/jgld-5873","DOIUrl":"10.15403/jgld-5873","url":null,"abstract":"<p><strong>Background and aims: </strong>Tumor recurrence poses a significant challenge post-liver transplantation (LT) for hepatocellular carcinoma (HCC), necessitating the development of more precise predictive tools. In this study we aimed to investigate nucleolin as a biomarker for predicting HCC recurrence after LT.</p><p><strong>Methods: </strong>A cohort of 241 HCC patients undergoing LT was enrolled from three medical facilities spanning January 1, 2015, to December 31, 2017. Utilizing tissue microarrays, we assessed the predictive potential of nucleolin. Survival analyses, including Kaplan-Meier and log-rank tests, were employed to scrutinize overall survival and recurrence-free survival. Based on univariate and multivariate Cox regression analyses of preoperative parameters, nomogram and risk score were designed to predict HCC recurrence and determine the effectiveness of the model.</p><p><strong>Results: </strong>The expression of nucleolin in HCC nucleus was increased. High nucleolin expression in tumor tissues correlated with poor overall survival and recurrence-free survival (5-year overall survival ratios: 34% vs. 64.8%, 5-year recurrence-free survival ratios: 36.1% vs.67.9%, all p<0.001). Multivariate Cox regression analysis identified nucleolin expression score, Hangzhou criteria, HBsAg, tumor differentiation and alpha-fetoprotein level as independent risk factors for tumor recurrence in HCC patients post- LT. A new nomogram is established based on the above risk factors with effective prediction efficiency (area under time-dependent receiver operating characteristic =0.742, concordance-index =0.7742).</p><p><strong>Conclusions: </strong>Nucleolin can be combined with a nomogram as an effective tool to predict recurrence in HCC patients following LT.</p>","PeriodicalId":94081,"journal":{"name":"Journal of gastrointestinal and liver diseases : JGLD","volume":"34 1","pages":"81-89"},"PeriodicalIF":0.0,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143736312","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply.","authors":"Mustafa Koyun, Bunyamin Ece","doi":"10.15403/jgld-6209","DOIUrl":"https://doi.org/10.15403/jgld-6209","url":null,"abstract":"","PeriodicalId":94081,"journal":{"name":"Journal of gastrointestinal and liver diseases : JGLD","volume":"34 1","pages":"134-135"},"PeriodicalIF":0.0,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143736314","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Shifting trends of liver cirrhosis: causes, complications and future outlook.","authors":"Abhishek Lal, Aqsa Amjad, Samnita Batool Zaidi, Om Parkash","doi":"10.15403/jgld-5929","DOIUrl":"https://doi.org/10.15403/jgld-5929","url":null,"abstract":"","PeriodicalId":94081,"journal":{"name":"Journal of gastrointestinal and liver diseases : JGLD","volume":"34 1","pages":"133-134"},"PeriodicalIF":0.0,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143736315","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cognitive Impairment in IBS: A Narrative Overview.","authors":"Himanshi Banker, Abhishek Goel, Sunita Kumawat, Fnu Anamika, Kanishk Aggarwal, Kofi Clarke, Rohit Jain","doi":"10.15403/jgld-5800","DOIUrl":"10.15403/jgld-5800","url":null,"abstract":"<p><p>Irritable Bowel Syndrome (IBS) is a prevalent functional gastrointestinal disorder that significantly impacts the quality of life and the healthcare system. Beyond well-established symptoms such as recurrent abdominal pain and altered bowel habits, emerging evidence highlights a crucial yet underexplored aspect of cognitive dysfunction in patients suffering from IBS. This review aims to investigate the potential mechanisms linking IBS to cognitive dysfunction, emphasizing the role of the gut-brain axis and its biological and psychosocial determinants. A literature review was conducted using major medical databases, including Pubmed and Scopus, to identify relevant studies published in the last decade, focusing on clinical and experimental research assessing cognitive impairment in IBS patients. The review underscores the need for increased clinical recognition of cognitive dysfunction in IBS by highlighting the cognitive dysfunction in IBS patients with a focus on pathogenesis from disturbances in gut microbiota, inflammation, altered neurotransmitter levels, and psychological stress with various treatment modalities targeting these pathways, including probiotics, cognitive-behavioural therapy, and pharmacological interventions, showing promising results in mitigating cognitive symptoms.</p>","PeriodicalId":94081,"journal":{"name":"Journal of gastrointestinal and liver diseases : JGLD","volume":"34 1","pages":"122-127"},"PeriodicalIF":0.0,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143736311","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Machine Learning Models predicting Decompensation in Cirrhosis.","authors":"Sophie Elisabeth Müller, Markus Casper, Cristina Ripoll, Alexander Zipprich, Paul Horn, Marcin Krawczyk, Frank Lammert, Matthias Christian Reichert","doi":"10.15403/jgld-5876","DOIUrl":"10.15403/jgld-5876","url":null,"abstract":"<p><strong>Background and aims: </strong>Decompensation of cirrhosis significantly decreases survival, thus, prevention of complications is paramount. We used machine learning techniques to identify parameters predicting decompensation.</p><p><strong>Methods: </strong>Several machine learning techniques were applied to the INCA trial database containing pro- and retrospective data from 983 patients. Laboratory, clinical, and genetic data were analysed. After performing hierarchical clustering, Permutation Feature Importance was used to evaluate the impact of parameters on the prediction of decompensation.</p><p><strong>Results: </strong>Achieving an accuracy of 81.6% on training and 70.5% on test data, Random Forests were best for retrospective prediction. In prospective assessment, Support Vector Machines performed best with an accuracy of 78.6% and 73.8%, respectively. Permutation Feature Importance demonstrated that baseline albumin and bilirubin levels and maximum bilirubin were the highest ranked parameters associated with former decompensation. In the prospective analysis, the maximum bilirubin value and the baseline values of sodium and albumin were ranked highest. In addition to the parameters of established scores, NOD2 genotype and inflammatory markers were highly ranked.</p><p><strong>Conclusions: </strong>Laboratory parameters, genetic variants and infections can help to predict the risk of cirrhosis decompensation. This proof-of-concept study adds data for the future development of advanced models to identify patients at risk.</p>","PeriodicalId":94081,"journal":{"name":"Journal of gastrointestinal and liver diseases : JGLD","volume":"34 1","pages":"71-80"},"PeriodicalIF":0.0,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143736279","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of Effectiveness Between Protein and BCAA in Late Evening Snack on Vietnamese Liver Cirrhotic Outpatients: a Randomized Clinical Trial.","authors":"Trang Thu Nguyen, Linh Thuy Nguyen, Shigeru Yamamoto, Thu Minh Thi Nguyen, Huong Mai Thi Nguyen, Tra Cam Thi Bui","doi":"10.15403/jgld-5926","DOIUrl":"10.15403/jgld-5926","url":null,"abstract":"<p><strong>Background and aims: </strong>Late-evening snacks bring multiple benefits to liver cirrhosis patients. However, a consensus on the nutrient composition of the snack is still not clear. This study showed a direct comparison between a protein snack and a a branched-chained amino acid (BCAA) snack.</p><p><strong>Methods: </strong>A randomized clinical trial with 32 Vietnamese liver cirrhosis outpatients (61.0, 57-63 years), allocated into two groups: Protein group (n=16) and BCAA group (n=16) took place. Both groups received a snack providing 270-300 kcal, 50g carbohydrates, <5g lipid, and 13g of protein with 8g being protein powder in Protein group and 4g protein powder and 4g BCAA powder in BCAA group. Serum biochemical parameters, anthropometric data, and Chronic Liver Disease Questionnaire scores were examined in both groups before and after the 3-week intervention.</p><p><strong>Results: </strong>After receiving the snacks for 3 weeks, albumin was significantly increased in the Protein group (p<0.01) while it was not in the BCAA group. Only the ALT liver enzyme was statistically decreased in the Protein group (p<0.01). After the intervention, the handgrip strength of the Protein group increased from 24.3kg (±9.1 SD) to 25.7kg (±9.2 SD) (p=0.012); while, in BCAA group, the mean also changed from 24.7kg (±6.6 SD) to 25.6kg (±7.4 SD) (p=0.237). The overall Chronic Liver Disease Questionnaire score was significantly increased from 6.0 to 6.7 and 6.6 in the Protein group and the BCAA group, respectively.</p><p><strong>Conclusions: </strong>A protein snack is an effective dietary intervention in improving albumin, biochemical parameters, and nutritional status for compensated liver cirrhosis outpatients. Considering cost, availability, and taste, a BCAA snack might be unnecessary for liver cirrhosis outpatients.</p>","PeriodicalId":94081,"journal":{"name":"Journal of gastrointestinal and liver diseases : JGLD","volume":"34 1","pages":"64-70"},"PeriodicalIF":0.0,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143736273","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Effects of Advanced Diagnostic Methods and Disease Phenotypes on the Response to PPI in Patients with Gastroesophageal Reflux Disease.","authors":"Nilay Danis, Serhat Bor","doi":"10.15403/jgld-5963","DOIUrl":"10.15403/jgld-5963","url":null,"abstract":"<p><strong>Aims: </strong>The purpose of this study was to evaluate proton pump inhibitor (PPI) response rates for gastroesophageal reflux disease (GERD) phenotypes and functional heartburn (FH) according to the different diagnostic techniques.</p><p><strong>Methods: </strong>This was a retrospective, noninterventional, single-center study, presenting real-life data. Among 1,233 patients, 510 patients agreed to respond and were evaluated via a validated questionnaire consisting of 28 questions. Patients were classified into: Group I (n=54) if the diagnosis was based only on history, Group II (n=151) if diagnosis was documented on history and upper gastrointestinal endoscopy (UGE), and Group III (n=305) if diagnosis was based on history, UGE, high-resolution manometry and intraesophageal 24-h ambulatory pH-impedance monitoring. Patients were classified into 5 phenotypes (according to the final diagnosis): erosive esophagitis (EE) (n=117), non-erosive reflux disease (NERD) (n=94), FH (n=58), reflux hypersensitivity (RH) (n=16) and Barrett esophagus (BE) (n=20). A response rate under 50% was accepted as being nonresponsive with double doses after 8 weeks of treatment. A very good response was defined as being over 80% improvement of typical symptoms.</p><p><strong>Results: </strong>The response rates for heartburn and regurgitation of all the patients were 85.3% and 82.2%, respectively. The heartburn and regurgitation response rates of Group I patients were 79.6% and 70.4%; 91.4% and 85.4% for Group II; whereas 83.3% and 82.6% for Group III. The heartburn and regurgitation response rates of BE were 90% and 90%, for EE 88% and 87.2%, for NERD 85.2% and 85.1%, for RH 68.8% and 62.5% and for FH 72.4% and 74.1%. Response rates for both heartburn and regurgination were 40% in BE, 41.4% in EE, 18.8% in NERD, 24.1% in RH and 15.5% in FH.</p><p><strong>Conclusions: </strong>We demonstrated higher PPI response rates than Western populations in all the GERD patients. More than 1/3 of the patients exhibited very good response rates for both heartburn and regurgitation. The response rates of patients who were diagnosed via all the diagnostic modalities are lower than those who were diagnosed via only history and UGE.</p>","PeriodicalId":94081,"journal":{"name":"Journal of gastrointestinal and liver diseases : JGLD","volume":"34 1","pages":"17-22"},"PeriodicalIF":0.0,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143736317","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Vegan Diet During Greek-Orthodox Religious Fasting on Symptoms of Disorders of Gut-Brain Interaction.","authors":"Daniel Corneliu Leucuta, Dan L Dumitrascu, Shrikant I Bangdiwala, Olafur S Palsson, Ami D Sperber","doi":"10.15403/jgld-6082","DOIUrl":"10.15403/jgld-6082","url":null,"abstract":"<p><strong>Background and aims: </strong>Religious fasting observed in diverse populations may influence the reporting of digestive symptoms. Greek-Orthodox (Byzantine style) religious fasting is prolonged and similar to a vegan diet. We aimed to evaluate the association between functional gastrointestinal symptoms and disorders of gut-brain interaction (DGBI) with this religious fasting.</p><p><strong>Methods: </strong>We investigated Romanian participants in the Rome Foundation Global Epidemiology Study who observe Greek-Orthodox religious fasting, by adding specific questions on religious fasting to the study questionnaire. Data were analyzed in connection with the reported gastrointestinal symptoms.</p><p><strong>Results: </strong>2015 Romanians were included in the analyses. Overall, 716 (35.5%) of the respondents practiced some fasting, of which 446 (62.3%) fasted on Easter and Christmas, 90 (12.6%) observed all fasts, and 625 (87.3%) practiced weekly fasting. Of the latter, 167 (23.3%) fasted every week and 90 (12.6%) reported symptoms during fasting. There were no statistically significant associations between Greek-Orthodox fasting, to any degree, with upper or lower DGBI or gastrointestinal symptoms.</p><p><strong>Conclusions: </strong>The results from this representative sample show that a substantial proportion of the Romanian population adheres to Greek-Orthodox fasting. However, in contrast to the a priori hypothesis, we did not have sufficient evidence that religious fasting is associated with the prevalence of DGBI, or with functional gastrointestinal symptoms.</p>","PeriodicalId":94081,"journal":{"name":"Journal of gastrointestinal and liver diseases : JGLD","volume":"34 1","pages":"40-46"},"PeriodicalIF":0.0,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143736276","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of ABCB6 Polymorphisms and Serum Levels with Susceptibility to Antituberculosis Drug-induced Hepatotoxicity.","authors":"Ruina Chen, Jingru Cheng, Hongqiu Pan, Lihuan Lu, Xiaomin He, Meiling Zhang, Honggang Yi, Shaowen Tang","doi":"10.15403/jgld-5892","DOIUrl":"10.15403/jgld-5892","url":null,"abstract":"<p><strong>Background and aims: </strong>The occurrence of anti-tuberculosis drug-induced hepatotoxicity (ATDH) deserves our attention. To explore the role of ATP-binding cassette B6 (ABCB6) polymorphisms and serum levels in the risk of antituberculosis drug-induced hepatotoxicity (ATDH).</p><p><strong>Methods: </strong>A 1:4 matched case‒control study was conducted. Four single nucleotide polymorphisms (SNPs) and serum ABCB6 levels were analyzed, and false discovery rate (FDR) was performed to correct for multiple comparison.</p><p><strong>Results: </strong>224 ATDH cases and 896 controls were included. SNP rs1109867 in ABCB6 gene had a decreased risk of ATDH under dominant models (FDR corrected p-value = 0.027). Furthermore, serum ABCB6 levels at three different times in the ATDH cases were higher than those in the controls.</p><p><strong>Conclusions: </strong>SNP rs1109867 in ABCB6 gene may contribute to the susceptibility to ATDH among patients receiving anti-TB treatment.</p>","PeriodicalId":94081,"journal":{"name":"Journal of gastrointestinal and liver diseases : JGLD","volume":"34 1","pages":"55-63"},"PeriodicalIF":0.0,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143736310","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Mediation Effects of Type 2 Diabetes Mellitus and Related Biomarkers on the Association of Metabolic Dysfunction-associated Steatotic Liver Disease and Fibrosis.","authors":"Rujun Cai, Zhenqiu Liu, Hong Fan, Xin Zhang, Yizhou Chen, Tiejun Zhang","doi":"10.15403/jgld-5901","DOIUrl":"10.15403/jgld-5901","url":null,"abstract":"<p><strong>Background and aims: </strong>Both metabolic dysfunction-associated steatotic liver disease (MASLD) and fibrosis have been associated with type 2 diabetes mellitus (T2DM), but the roles of T2DM and related biomarkers in the association between MASLD and fibrosis are yet to be fully elucidated. This study aimed at assessing whether the association between MASLD and fibrosis is mediated by T2DM.</p><p><strong>Methods: </strong>A total of 6,060 participants from NHANES 2017-2020 were enrolled in the cross-sectional analyses. Pairwise associations among MASLD, fibrosis, T2DM, and T2DM-related biomarkers [plasma fasting glucose, hemoglobin A1c (HbA1c), serum insulin, and homeostatic model assessment for insulin resistance (HOMA-IR)] were examined, and then the extent to which MASLD progresses to fibrosis through T2DM and the biomarkers was assessed.</p><p><strong>Results: </strong>We found a higher risk of T2DM and higher levels of T2DM-related biomarkers were associated with MASLD. Moreover, T2DM and higher levels of T2DM-related biomarkers were positively associated with fibrosis risk. T2DM, plasma fasting glucose, HbA1c, serum insulin, and HOMA-IR mediated 10.1%, 9.99%, 10.5%, 5.98%, and 7.28% of the association between MASLD and fibrosis, respectively. In addition, the mediation effect of T2DM varied in different groups of age, body mass index, and antidiabetic medication.</p><p><strong>Conclusions: </strong>T2DM and T2DM-related biomarkers partly mediated the association between MASLD and fibrosis.</p>","PeriodicalId":94081,"journal":{"name":"Journal of gastrointestinal and liver diseases : JGLD","volume":"34 1","pages":"47-54"},"PeriodicalIF":0.0,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143736319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}