Journal of clinical and translational research最新文献

{"title":"Effectiveness of health education interventions in patients with fibromyalgia syndrome: an umbrella review","authors":"","doi":"10.18053/jctres.09.202306.23-00108","DOIUrl":"https://doi.org/10.18053/jctres.09.202306.23-00108","url":null,"abstract":"","PeriodicalId":94073,"journal":{"name":"Journal of clinical and translational research","volume":"5 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135561949","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Frequency of consumption of green leafy vegetables and prevalence of hyperglycaemia in Ankole and Teso sub-regions of Uganda","authors":"","doi":"10.18053/jctres.09.202306.23-00096","DOIUrl":"https://doi.org/10.18053/jctres.09.202306.23-00096","url":null,"abstract":"Background: Type 2 diabetes-related hyperglyceamia is a global health problem, with developing countries like Uganda currently experiencing substantial rises in the metabolic disorder. Current hyperglyceamia therapies can bring a patient to glycemic target; however, they are costly and have other limitations. Vegetable extracts have health-protecting effects and contain thousands of components with putative hypoglycemic effects, rendering them a cheaper alternative towards prevention and management of hyperglyceamia. Aim: The goal of this study was to determine the frequency and patterns of consumption of green leafy vegetables, and their relationship with the prevalence of hyperglyceamia in two sub-regions of Uganda. Methods: A cross sectional household survey was conducted in Ankole and Teso sub-regions of Uganda. Using a questionnaire for both face-to-face interviews and focus group discussions (FGDs), the frequently eaten vegetables and their consumption were documented, and fasting blood glucose (FBG) levels measured to determine the prevalence of hyperglyceamia. Results: The most frequently eaten vegetables in both sub-regions were Amaranthus species. Brassica species, Curcubita maxima L. , Solanum nigrum s.l. and Phaseolus vulgaris L. were eaten mostly in Ankole sub-region while Vigna unguiculata (L.) Walp. and Hibiscus sabdariffa L. were eaten mostly in Teso sub-region. In Ankole sub-region, the vegetables were steamed, while boiling and adding peanut/simsim butter was preferred in Teso sub-region. Consumption of leafy vegetables was higher in Teso sub-region than in Ankole sub-region. The overall prevalence of hyperglyceamia was 29.15%; it was higher in Ankole at 35.5% and lower in Teso at 19.5% (95% CI: 0.27-0.69). Conclusion: The difference in prevalence of hyperglycaemia is relatively high in these sub-regions. Consumption of different leafy vegetable species and their various preparation methods likely contributes to this prevalence; however, factors like phytochemical constituents","PeriodicalId":94073,"journal":{"name":"Journal of clinical and translational research","volume":"32 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135611280","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhancing clinical and translational research in Africa: a comprehensive exploration of challenges and opportunities for advancement","authors":"","doi":"10.18053/jctres.09.202305.23-00079","DOIUrl":"https://doi.org/10.18053/jctres.09.202305.23-00079","url":null,"abstract":"","PeriodicalId":94073,"journal":{"name":"Journal of clinical and translational research","volume":"28 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135909694","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of bronchodilator response between Dosivent® and Aerochamber Plus® Flow-Vu® chambers in patients with bronchial hyperreactivity","authors":"","doi":"10.18053/jctres.09.202305.23-00081","DOIUrl":"https://doi.org/10.18053/jctres.09.202305.23-00081","url":null,"abstract":"Background: Aerochambers are used for the administration of inhaled drugs. Dosivent ® is a previously unstudied chamber. This study aimed to validate the Dosivent ® chamber against the widely used Aerochamber Plus ® Flow-Vu ® . Methods: We conducted a non-randomized, open-label, cross-over-controlled, and clinical trial (NCT05821868) in 50 patients with a known positive bronchodilator test. Bronchodilator washout was performed according to standard recommendations. Fifteen minutes after the administration of 400 µ g of salbutamol with either chamber, the changes in forced expiratory volume in the first second (FEV1) and forced vital capacity (FVC) were measured. The agreement was measured by the intraclass correlation coefficient and Bland–Altman graphical analysis. Participants’ satisfaction with the chamber was assessed with the FSI-10 questionnaire. Results: The mean participant age was 58.0 (SD = 18.5) years, half were women, and only 31 (62%) participants had an FEV1/FVC of <0.7. The median increases in FEV1 obtained with the Aerochamber Plus ® Flow-Vu ® and Dosivent ® were 0.28 L (interquartile range [IQR]: 0.21 – 0.38) and 0.29 L (IQR: 0.20 – 0.43), respectively, and the median increases in FVC were 0.29 L (IQR: 0.19 – 0.37) and 0.28 L (IQR: 0.19 – 0.45). The intraclass correlation coefficient for increases in FEV1 was 0.865, and it was 0.820 for increases in FVC. The median FSI-10 questionnaire score was 42 (IQR: 37 – 47) with Aerochamber Plus ® Flow-Vu ® and 44 (39 – 48) with Dosivent ® ( P < 0.001). Conclusions: Our study revealed a strong agreement between salbutamol responses when utilizing both the Dosivent ® and Aerochamber Plus ® Flow-Vu ® chambers. This suggests that these devices are interchangeable and can be effectively employed in routine clinical practice. Relevance for Patients: For patients using inhaled medications, this study provides reassurance regarding the equivalence of the Dosivent ® chamber with the widely used Aerochamber Plus ® Flow-Vu ® . This provides patients with more options for device selection, potentially improving convenience and satisfaction with their inhalation therapy. Patients and healthcare providers can consider the Dosivent ® chamber as a viable alternative, which may positively impact treatment adherence and overall respiratory health management.","PeriodicalId":94073,"journal":{"name":"Journal of clinical and translational research","volume":"7 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135844972","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of appendectomy with colorectal cancer: a systematic review and meta-analysis","authors":"","doi":"10.18053/jctres.09.202305.23-00090","DOIUrl":"https://doi.org/10.18053/jctres.09.202305.23-00090","url":null,"abstract":"Background: Appendectomy is a common surgical procedure done worldwide. The appendix is known as a sanctuary for commensal organisms in the gut, and an inflamed appendix may alter the gut microbiome, leading to inflammation and oncogenesis. An association between appendectomy and subsequent colorectal cancer development has been postulated; however, previous studies have differed in study design and results. Method: We performed a systematic review and meta-analysis of studies evaluating the association between appendectomy and colorectal cancer in adults. A literature search of MEDLINE and EMBASE was conducted through September 2022. Search terms included “appendectomy” and “colon cancer” or “rectal cancer” or “colorectal cancer.” Odds ratios and sensitivity analyses were calculated. Result: Of the 541 studies identified in our search, 10 studies met our inclusion criteria. The eight papers that studied the association between appendectomy and colorectal cancer reported no association with the odds ratio (OR) of 1.30 (0.92, 1.83). However, studies on the association of appendectomy and proximal versus distal colon cancer reported a statistically significant increase in proximal colon cancer compared to distal colon cancer OR of 1.48 (1.29, 1.69). Conclusion: Our study demonstrates that appendectomy is associated with the development of proximal colon cancer but not distal colon cancer. Relevance for patients: Patients who have had an appendectomy should be aware of the potentially increased risk for colon cancer. Consequently, they should provide this information during routine clinic visits, especially if they are having gastrointestinal symptoms.","PeriodicalId":94073,"journal":{"name":"Journal of clinical and translational research","volume":"33 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135497225","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between response to neoadjuvant chemotherapy and survival outcome after radical surgery in patients with yielding pathological T2 and/or N+ urothelial carcinoma","authors":"","doi":"10.18053/jctres.09.202306.23-00106","DOIUrl":"https://doi.org/10.18053/jctres.09.202306.23-00106","url":null,"abstract":"Background and Aim: In early 2022, the use of adjuvant nivolumab for patients with high-risk muscle-invasive urothelial carcinoma was approved in Japan, European countries, and USA based on the positive results of CheckMate 274 trial, which included participants who received neoadjuvant chemotherapy (NAC). Subgroup analyses of CheckMate 274 trial does not report response to neoadjuvant chemotherapy and benefit from adjuvant nivolumab. Herein, we investigated the association between response to NAC and survival outcomes after radical surgery in patients with residual muscle-invasive urothelial carcinoma and/or lymph node disease. Methods: This multicenter retrospective study included a total of 95 NAC-treated patients with yielding pathological (yp) T2  and/or ypN+ urothelial carcinoma on radical surgery specimens. Based on the comparison of clinical T and N category with yp T and N category, the patients were categorized into three groups: down-staged ypT2  (n=14), no-changed ypT2  (n=39), and up-staged ypT2  groups (n=42). Results: There was no significant difference in extra-urinary tract recurrence-free survival, cancer-specific survival, and overall survival after the radical surgery among three groups. Subgroup analysis of a bladder cancer cohort showed a marginal association between better response and longer cancer-specific survival ( P =0.073). Conclusion: Our finding suggested that adjuvant nivolumab should be considered for all the patients with pathological ypT2  or ypN+ urothelial carcinoma regardless of response to NAC. Further research is mandatory in finding predictive factors that serve in decision-making for NAC-treated patients who are likely to benefit from adjuvant nivolumab. Relevance for patients: To develop a decision-making tool for adjuvant nivolumab, we investigated the association between response to neoadjuvant chemotherapy and survival after radical surgery. Further research","PeriodicalId":94073,"journal":{"name":"Journal of clinical and translational research","volume":"136 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135611282","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Changes in correlations between cervical and distal spinal sagittal alignments in asymptomatic population with aging","authors":"","doi":"10.18053/jctres.09.202305.23-00059","DOIUrl":"https://doi.org/10.18053/jctres.09.202305.23-00059","url":null,"abstract":"","PeriodicalId":94073,"journal":{"name":"Journal of clinical and translational research","volume":"39 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135846630","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Inactivated COVID-19 vaccine triggering hemophagocytic lymphohistiocytosis in an immunocompetent adult - A case report.","authors":"Saad Nasir, Saqib Raza Khan, Rodaba Iqbal, Alizah Pervaiz Hashmi, Munira Moosajee, Noreen Nasir","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background and aim: </strong>Hemophagocytic lymphohistiocytosis (HLH) is a severe hyperinflammatory syndrome that is induced by hyper-activated macrophages, cytotoxic T cells, and reduced natural killer cell activity. A 46-year-old gentleman presented to us with complaints of intermittent fever for the past 2 weeks associated with fatigue along with oral ulcers and skin rashes which resolved spontaneously. These symptoms started after he received the second dose of the BBIP-CorV COVID-19 vaccine. His complete blood picture showed pancytopenia. A detailed infectious disease workup was unrevealing; however, his bone marrow biopsy revealed increased histiocyte activity, with some showing hemophagocytosis and dysplasia. Immunohistochemistry profile demonstrated strong CD 68 positivity. Further investigations showed raised serum ferritin and fasting triglyceride levels. He was immediately started on dexamethasone acetate at a dose of 10 mg/m², after which his clinical symptoms, as well as his blood parameters, improved remarkably. This is the first documented case in Pakistan.</p><p><strong>Conclusion: </strong>The data from clinical trials support the general safety profile of inactivated COVID-19 vaccines. We endorse its mass implementation. However, we believe that robust data need to be generated to evidence any adverse events, especially those with serious outcomes. Physicians should be aware of inactivated COVID-19 vaccine as a possible trigger for HLH and start prompt treatment, resulting in favorable outcomes.</p><p><strong>Relevance for patients: </strong>The presentation of HLH may vary and can present in an immunocompetent patient with no underlying risk factor. HLH should be kept in differentials when a patient presents with pancytopenia with a recent history of receiving COVID-19 vaccination. Steroids play a major role in the treatment of HLH, and definitive diagnosis and early treatment improve clinical outcomes.</p>","PeriodicalId":94073,"journal":{"name":"Journal of clinical and translational research","volume":"8 2","pages":"152-155"},"PeriodicalIF":0.0,"publicationDate":"2022-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9035139/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144910568","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Endoscopic tightening of the cardia mucosa in gastroesophageal reflux disease: A case series of 120 patients up to 1-year follow-up.","authors":"Zhenhua Li, Yongliang Li, Yue Wu, Mingyan Li, Zhaobin Yan, Shanwen Nie, Zhitao Liang, Bo Li, Peiwen Zhu, Peilin Cui, Qinsheng Zhang","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background and aim: </strong>A technique of endoscopic tightening of the cardia mucosa for the treatment of gastroesophageal reflux disease (GERD) was developed and its clinical efficacy was observed.</p><p><strong>Methods: </strong>120 patients with GERD who underwent endoscopic tightening surgery from December 2017 to December 2019 were included in this study. GERD-Q score and constitution type of patients were evaluated preoperatively and at 1 month, 3 months, 6 months, and 1 year after surgery. In addition, effectiveness and side effects of the procedure were graded based on gastroesophageal flap valve (GEFV) function.</p><p><strong>Results: </strong>GERD-Q score of 1 month, 3 months, 6 months, and 1 year after surgery were significantly decreased (<i>P</i><0.01) compared with preoperative score. There were no significant differences between GERD-Q score of 1 month, 3 months, 6 months, and 1 year after surgery. The surgery proves to be effective in all GEFV grades, especially in Hill-III.</p><p><strong>Conclusion: </strong>Endoscopic tightening is an effective method for the treatment of patients with GERD, especially of Hill-III patients. Attention should be paid to cardia width, ligation ring depth, and ring number during operation.</p><p><strong>Relevance for patients: </strong>ETCM is a safe endoscopic procedure with minimal trauma, which has been proved effective for patients who are diagnosed with GERD.</p>","PeriodicalId":94073,"journal":{"name":"Journal of clinical and translational research","volume":"8 2","pages":"147-151"},"PeriodicalIF":0.0,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9389572/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144910567","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lichen planus drugs re-purposing as potential anti COVID-19 therapeutics through molecular docking and molecular dynamics simulation approach.","authors":"Unnati Soni, Pratyush Singh, Om Prakash Gupta, Shalini Gupta, Saurabh Pratap Singh, Prerna Singh, Sangeeta Singh, Krishna Mishra","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background and aim: </strong>The present study intends to investigate COVID-19 by targeting their main proteins with 17 selected drugs used for treating Oral Lichen Planus (OLP) which is a chronic muco-cutaneous disorder. Here, an attempt is made to gain better insight into the structure of various drugs targeting specific proteins which will be helpful in developing drugs useful for therapeutic and preventive measures.</p><p><strong>Method: </strong><i>In silico</i> studies, molecular docking and molecular dynamic simulations were performed to repurpose the therapeutic drugs (n = 17) which were used to treat OLP against COVID-19. In addition, the maximum binding affinities of the key protein spike glycoprotein, main-protease (M^pro) of coronavirus, and Angiotensin-Converting Enzyme-2 (ACE-2) in the human body were evaluated with the selected drugs.</p><p><strong>Results: </strong>Epigallocatechin-3-gallate (EGCG) showed the highest docking values among the drugs selected for repurposing. Among the target proteins, EGCG has shown maximum binding affinity with ACE-2 receptor. Further, according to the molecular dynamic simulation studies, EGCG has shown the least conformational fluctuations with M^pro.</p><p><strong>Conclusion: </strong>EGCG can be a potential inhibitor drug which can bind with ACE-2 receptor thus inhibiting the interaction of mainly M^pro protein and spike glycoprotein of SARS-CoV-2.</p><p><strong>Relevance for patients: </strong>EGCG, a natural compound shows antiviral potential having considerably high affinity and stability with SARS-CoV-2. It might be further employed as a lead drug against selective inhibitors of SARS-CoV-2 for the therapeutic management of COVID-19 patients after necessary clinical trials.</p>","PeriodicalId":94073,"journal":{"name":"Journal of clinical and translational research","volume":"8 2","pages":"127-146"},"PeriodicalIF":0.0,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9036082/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144910569","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}