Journal of clinical and translational research最新文献

{"title":"The impact of mode of birth delivery on child health in India","authors":"U. Das, Nishamani Kar, Sailajananda Saikia, Nihar Ranjan Rout","doi":"10.36922/jctr.22.00239","DOIUrl":"https://doi.org/10.36922/jctr.22.00239","url":null,"abstract":"Background: A skilled birth attendant and the place of delivery have significant effects on child growth.\u0000Aims: The present paper aims to examine the mode of delivery and its impact on child health among children (0 – 59 months) in India.\u0000Methods: The life table estimation of mortality and both bivariate and multivariate logistic regressions were used to identify the association between child health and mode of delivery using data from the National Family Health Survey conducted in 2015 – 2016.\u0000Results: After adjusting for socioeconomic and biodemographic factors, poor child growth (measured through Z-scores for stunting, wasting, and underweight categories) was more significant in cesarean delivery compared to normal delivery. In contrast, live birth for different groups of women was reportedly higher in normal vaginal delivery than in cesarean delivery. Neonatal and infant mortality rates were lower for normal delivery than cesarean delivery, particularly in public hospitals. The risk of child death was also higher in cesarean delivery, particularly in the neonatal period.\u0000Conclusion: The findings from this study could inform the development of health-care policies and the implementation of strategies aimed at improving the quality of painless labor and prompt delivery in health-care facilities, particularly public hospitals.\u0000Relevance for Patients: The present study may help pregnant women and their providers decide whether a cesarean delivery is appropriate.","PeriodicalId":94073,"journal":{"name":"Journal of clinical and translational research","volume":"5 9","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141384804","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development and validation of an ex vivo porcine model of functional tricuspid regurgitation","authors":"Hannah Rando, Rachael Quinn, Emily L. Larson, Zachary Darby, Ifeanyi Chinedozi, J. K. Kang, Gyeongtae Moon, James S. Gammie","doi":"10.36922/jctr.24.00003","DOIUrl":"https://doi.org/10.36922/jctr.24.00003","url":null,"abstract":"Background and Aim: Ex vivo models of functional tricuspid regurgitation (FTR) are needed for pre-clinical testing of novel surgical and interventional repair strategies, but current options are costly or have not been formally validated. The objective of this research was to create and validate an ex vivo model to test novel repair methods for FTR.\u0000Methods: In explanted porcine hearts, the right atrium was excised to visualize the tricuspid valve. The pulmonary artery and aorta were clamped and cannulated, the coronary arteries ligated, and the right and left ventricles statically pressurized with air to 30 mmHg and 120 mmHg, respectively. FTR was induced by increasing right ventricular pressure to 80 mmHg for 3 h, which resulted in progressive tricuspid annular enlargement, right ventricular dilation, papillary muscle displacement, and central tricuspid malcoaptation. A structured light scanner was used to image the 3D topography of the tricuspid valve in both the native and FTR state, and images were exported into scan-to-computer-aided design software, which allowed for high-resolution 3D computational reconstruction. Relevant geometric measurements were sampled including annular circumference and area, major and minor axis diameter, and tenting height, angle, and area. Geometric measurements from the ex vivo model were compared to clinical transthoracic echocardiographic (TTE) measurements using two-sample t-tests.\u0000Results: A total of 12 porcine hearts were included in the study. Annular measurements of the native valve were comparable to published TTE data, except for the minor axis diameter, which was shorter in the ex vivo model (2.5 vs. 3.1 cm, P = 0.007). Induction of FTR in the ex vivo model resulted in annular enlargement (FTR vs. native: circumference 13.7 vs.11.8 cm, P = 0.012; area 14 vs. 11 cm2, P = 0.011). Ex vivo leaflet measurements in both the native and FTR model differed from published TTE data, but demonstrated comparable directional changes between the native and regurgitant states, including increased tenting height, area, and volume.\u0000Conclusion: The ex vivo pneumatically-pressurized porcine model closely recapitulates the geometry of both the native and regurgitant tricuspid valve complex in humans and holds promise for testing novel FTR repair strategies.\u0000Relevance for Patients: Currently available interventions for the tricuspid valve have a risk of permanent conduction abnormalities and are insufficient in addressing tricuspid disease for a subset of patients. This ex vivo model provides a platform for testing of novel interventions that address the deficiencies of current tricuspid therapies.","PeriodicalId":94073,"journal":{"name":"Journal of clinical and translational research","volume":"25 2‐3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141383345","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chances and challenges of combined antegrade and retrograde endoscopic recanalization of complete hypopharyngoesophageal obliteration: a case series","authors":"Ronald Koschny, Philippe Federspil, Peter Sauer, Christian Brunner, Peter K. Plinkert, Gerhard Dyckhoff","doi":"10.36922/jctr.23.00116","DOIUrl":"https://doi.org/10.36922/jctr.23.00116","url":null,"abstract":"Background: Complete hypopharyngeal obliteration is a serious problem after radiochemotherapy. Data on rendezvous techniques using percutaneous retrograde endoscopy through the gastrostomy channel and antegrade laryngoscopy are limited with a possible bias on positive results.\u0000Aim: This study aimed to review the clinical success, challenges, complications, and failure rates of this technique.\u0000Methods: We prospectively collected data on endoscopic recanalization techniques, subsequent bougienages, adverse events, and final outcomes in seven patients.\u0000Results: Recanalization was technically successful in all patients. However, normal food intake was achieved in only two patients, with one of them under ongoing bougienage. Additive treatment was needed in all patients, including microsurgical scar excision, temporary stent application, argon plasma coagulation, and surgical fistula closure. Salvage laryngopharyngectomy had to be performed in two of the seven patients. Preexisting hypopharyngo-tracheal fistula and therapy-induced fistula represent a technically demanding obstacle, necessitating endoscopic stenting and surgical closure.\u0000Conclusion: Endoscopic recanalization of esophageal obliterations is feasible, although technically demanding. The clinical success rate for long-term normalization of oral food intake is, however, low. Prospective data collection in a larger cohort is urgently needed.\u0000Relevance for Patients: Patients should be informed about the possibility of long-term follow-up treatments and the low clinical success rate of endoscopic recanalization by the rendezvous technique, as well as other alternative approaches while making the decision to accept the treatment.","PeriodicalId":94073,"journal":{"name":"Journal of clinical and translational research","volume":"29 18","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140372710","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Three-dimensional analysis of pharyngeal airway volume in Class I, II, and III malocclusion","authors":"Arkia Mardany, Alireza Naeimi Jafari, Alireza Khoshdel, F. Momeni, Nikan Mardany, A. Jamilian","doi":"10.36922/jctr.23.00110","DOIUrl":"https://doi.org/10.36922/jctr.23.00110","url":null,"abstract":"Aim: This study aimed to evaluate pharyngeal airway dimensions using cone-beam computed tomography (CBCT) in patients with Class I, II, and III malocclusions and normal growth patterns.\u0000Methods: All CBCT images were categorized into three groups: Class I (0° < ANB < 4°, −1 mm < Wits < 0 mm), Class II (ANB > 4°, Wits > 0 mm), and Class III (ANB < 0°, Wits < −1 mm). CBCT images were obtained from individuals with normal growth patterns (32 ± 5° = GN/GO – SN), where GN represents gonion, GN is gnathion, and SN equates to the sella-nasion distance. Measurements were taken for total pharyngeal volume, velopharyngeal volume, glossopharyngeal volume, and oropharyngeal volume, and the narrowest area of the airway was measured. ANOVA and Tukey’s post hoc test were used to compare the airway dimensions among skeletal classes I, II, and III.\u0000Results: The CBCT images were captured from 90 patients (45 males and 45 females) aged 17 to 39. The mean volume of the total pharyngeal airway, velopharyngeal, glossopharyngeal, and oropharyngeal and the most constricted area were significantly greater in patients with skeletal Class III malocclusion compared to patients with skeletal Class II malocclusion showing normal growth pattern. Total pharyngeal airway, velopharyngeal, and oropharyngeal volumes were lower in Class II patients compared to Class I and III patients with normal growth patterns. There was a significant difference in the pharyngeal space between males and females with Class II malocclusion. Pharyngeal space in female Class II malocclusion was higher than that in males. There was no difference regarding airway space between female and male patients with Class 1 malocclusion. Pharyngeal space between females and males with Class III malocclusion showed no difference.\u0000Conclusion: Class III pharyngeal volumes were generally larger in Class I and II malocclusions. Sex differences in the volumes of various pharyngeal spaces were only present in the case of Class II malocclusions.\u0000Relevance for Patients: Class II pharyngeal volumes were generally smaller in Class I and III malocclusions.","PeriodicalId":94073,"journal":{"name":"Journal of clinical and translational research","volume":"51 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140460009","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prognostic nutritional index instead of serum Vitamin D levels as a determinant of the presence of osteoporosis in adult male patients with neurological impairment","authors":"A. Tsunou, Hiroyo Hiroyo Miyata, Y. Hokotachi, Isaku Horiuchi, T. Amagai","doi":"10.36922/jctr.00110","DOIUrl":"https://doi.org/10.36922/jctr.00110","url":null,"abstract":"Background: Complications of non-traumatic fractures and osteoporosis, which reduce mobility and quality of life, should not be ignored in patients with neurological impairment (NI).\u0000Aim: To diagnose osteoporosis in adult patients with NI, a readily available and easily obtained index, instead of serum Vitamin D level or bone mineral density (BMD), was explored.\u0000Methods: This was a single-center retrospective study. The participants were inpatients with NI admitted between August 2020 and June 2022. Patient data regarding (1) patient information, (2) blood data, including the prognostic nutrition index (PNI), which predicts outcomes of various diseases, (3) body composition, (4) T-score by BMD, (5) nutritional measures, and (6) outcome measures were collected. Enrolled patients were divided into two groups, with or without osteoporosis, according to their T-score. The data were analyzed by three methods: (1) comparison of all collected data between the two groups to analyze the factors influencing osteoporosis; (2) multiple logistic regression analysis; and (3) receiving operating characteristic curve analysis.\u0000Results: Patients with osteoporosis had a significantly lower PNI (45 vs. 49, P = 0.045), and higher Vitamin D insufficiency (71% vs. 31%, P = 0.031). PNI was the strongest influencing factor, and its cutoff value for osteoporosis was 50.\u0000Conclusion: The PNI is the strongest determinant of osteoporosis in patients with NI. Therefore, PNI can potentially be used as a surrogate for BMD instead of serum Vitamin D levels in institutionalized and homebound patients who do not have BMD measurement devices.\u0000Relevance for Patients: Prognostic nutrition index, which is a simple blood test, outperforms serum vitamin D concentration as a good indicator for early detection of osteoporosis.","PeriodicalId":94073,"journal":{"name":"Journal of clinical and translational research","volume":"259 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140460684","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Heart failure research paradigms using bedside observation on endothelialmuscle common denominators to highlight important translational questions","authors":"","doi":"10.18053/jctres.09.202305.23-00010","DOIUrl":"https://doi.org/10.18053/jctres.09.202305.23-00010","url":null,"abstract":"Background & aim : Congestive heart failure (CHF) imposes a relevant burden on healthcare systems, as it is associated with high morbidity and mortality rates and considerable costs. Within the last three to four decades, there have been revolutionary advancements, particularly in the pharmaceutical industry. In addition, health services research at the population level has also delivered. A third avenue for advancing the clinical management of CHF is to explore established therapies with a new approach. In this perspective, we explore these established concepts and provide impetus for using bedside observations to find improvements in CHF outcomes. Conclusion: There are potentially new concepts that can be brought to established solutions for CHF. Encouraging observations when delivering established guideline-directed medical therapies are issues that the evidence-based medicine community should factor alongside novel discoveries to improve CHF prognosis. An emphasis on innovating on the known can be considered as an important paradigm for discovery. Relevance for patients : Patients with CHF receiving current available treatments have improved outcomes; however those not improving could be considered under evolving research paradigms.","PeriodicalId":94073,"journal":{"name":"Journal of clinical and translational research","volume":"66 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135845254","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pancreas sparing duodenal resection in colorectal adenocarcinoma with local invasion to the duodenum: a case report and literature review","authors":"","doi":"10.18053/jctres.09.202305.22-00228","DOIUrl":"https://doi.org/10.18053/jctres.09.202305.22-00228","url":null,"abstract":"","PeriodicalId":94073,"journal":{"name":"Journal of clinical and translational research","volume":"20 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135653649","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effectiveness of Pendleton's consultation model on the illness perception of heart failure patients","authors":"","doi":"10.18053/jctres.09.202305.22-00161","DOIUrl":"https://doi.org/10.18053/jctres.09.202305.22-00161","url":null,"abstract":"Background and aim : This study aimed to determine the effect of nursing consultation on the illness perception in heart failure patients. Methods : In this experimental study, 100 heart failure patients were recruited through the convenience sampling method and were assigned to intervention and control groups by block randomization. In the first phase of the intervention, the researchers implemented Pendleton’s consultation model. In the second phase, telephone follow-up was performed in four steps (first, second, sixth, and twelfth weeks). The data were collected using a demographic information questionnaire and the Illness Perception Questionnaire (IPQ). Data were analyzed by SPSS 20 and using chi-square , paired t, independent t and covariance tests. Results : There was no significant difference in demographic variables, and illness perception between the two groups before the intervention (P <0.05). In the intervention group, the illness perception score increased from 31.33±10.94 to 33.49±10.25 after the intervention, which was not statistically significant (P >0.05). Comparison between the two groups showed, in the intervention group the mean score of illness perception significantly improved after the intervention compared to the control group (P = 0.003). Conclusion : The application of Pendleton's consultation model could improve the illness perception in heart failure patients. Relevance for patients: Considering that the cost of nursing consultations is not always low, it is suggested that nursing consultations be considered for patients with a higher number of sessions and telephone follow-ups for more efficacy if it is cost-effective.","PeriodicalId":94073,"journal":{"name":"Journal of clinical and translational research","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135653648","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pancreas sparing duodenal resection in colorectal adenocarcinoma with local invasion to the duodenum: a case report and literature review","authors":"","doi":"10.18053/jctres.09.202305.23-00066","DOIUrl":"https://doi.org/10.18053/jctres.09.202305.23-00066","url":null,"abstract":"Background . Pancreas sparing duodenal resection (PSDR) is commonly described in patients with familial duodenal adenomatous polyposis, duodenal gastrointestinal stromal tumours, duodenal trauma, or other primary duodenal lesions where the pancreas is not involved. PSDR in patients with metastatic involvement of the duodenum is rarely described. After reviewing the relevant literature, less than five PSDR for duodenal metastases reports were retrieved. Our patient was treated with PSDR for a local recurrence after a right hemicolectomy performed for right colon adenocarcinoma a year before. Aim . To investigate if PSDR is feasible in this patient with recurrence of a locally advanced right colon adenocarcinoma invading the duodenum Case Summary . A 74-year-old female patient presented with right iliac fossa pain and weight loss one year post-resection of the primary ascending colon cancer. A surveillance computed tomography (CT) scan of the thorax, abdomen and pelvis showed a mass in the third segment of the duodenum. The decision to carry out a PSDR was made. Results . The proximal and distal margins of the resected bowel were uninvolved by the invasive carcinoma, and metastasis in five out of 12 regional lymph nodes was found. The postoperative course was complicated by a grade B postoperative pancreatic fistula (POPF) but recovered well post drainage. Conclusions . PSDR can be utilized in the management of duodenal metastases. Relevance for patients . PSDR can be performed in patients with duodenal metastases, offering a lower morbidity rate as compared to conventional pancreaticoduodenectomy.","PeriodicalId":94073,"journal":{"name":"Journal of clinical and translational research","volume":"36 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135653650","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of bronchodilator response between Dosivent® and Aerochamber Plus® Flow-Vu® chambers in patients with bronchial hyperreactivity","authors":"","doi":"10.18053/jctres.09.202305.23.00081","DOIUrl":"https://doi.org/10.18053/jctres.09.202305.23.00081","url":null,"abstract":"","PeriodicalId":94073,"journal":{"name":"Journal of clinical and translational research","volume":"27 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135844120","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}