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Shear Wave Optical Coherence Elastography and Structural Analysis of the Postnatal Mouse Cornea Through Development. 出生后小鼠角膜发育的剪切波光学相干弹性成像及结构分析。
Journal of biophotonics Pub Date : 2024-12-02 DOI: 10.1002/jbio.202400331
Andrew L Lopez, Mohammad Dehshiri, Alexander W Schill, Salavat Aglyamov, Kirill Larin
{"title":"Shear Wave Optical Coherence Elastography and Structural Analysis of the Postnatal Mouse Cornea Through Development.","authors":"Andrew L Lopez, Mohammad Dehshiri, Alexander W Schill, Salavat Aglyamov, Kirill Larin","doi":"10.1002/jbio.202400331","DOIUrl":"10.1002/jbio.202400331","url":null,"abstract":"<p><p>The cornea is a transparent lens at the forefront of the eye, serving as a structural barrier that protects the eye and provides the majority of the eye's refractive power. In this study, we utilized the postnatal mouse eye to characterize corneal structure and biomechanics. Between postnatal day (PN) 6 and PN24, we observed that elastic wave speeds are highest at PN6, gradually decrease through PN24, and then start to rise in adulthood (6 months). We found that corneal thickness is uncoupled from elastic wave speed and that the content and organization of the cornea primarily influence its mechanical properties. To the best of our knowledge, this work is the first detailed assessment of the postnatal mouse cornea's structure and biomechanics and warrants further investigation into the dynamic properties of the postnatal eye.</p>","PeriodicalId":94068,"journal":{"name":"Journal of biophotonics","volume":" ","pages":"e202400331"},"PeriodicalIF":0.0,"publicationDate":"2024-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12127497/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142775773","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effects of 1267 nm Illumination on Microcirculation Regulatory Mechanisms. 1267 纳米光照对微循环调节机制的影响
Journal of biophotonics Pub Date : 2024-11-26 DOI: 10.1002/jbio.202400296
Lyubov Eratova, Irina Makovik, Viktor Dremin
{"title":"Effects of 1267 nm Illumination on Microcirculation Regulatory Mechanisms.","authors":"Lyubov Eratova, Irina Makovik, Viktor Dremin","doi":"10.1002/jbio.202400296","DOIUrl":"https://doi.org/10.1002/jbio.202400296","url":null,"abstract":"<p><p>This study explored the effects of 1267 nm laser irradiation on changes in blood flow parameters and activation of the regulatory mechanisms of the microcirculatory bed (MCB). Using laser Doppler flowmetry (LDF) technique and time-frequency analysis of perfusion signals, changes in the MCB of 16 healthy volunteers, targeting the distal phalanx of the third finger with 1267 nm laser irradiation were evaluated. Results indicated no significant differences in perfusion between control and target measurements, likely due to blood flow redistribution caused by vessel dilation/constriction. However, differences in oscillation amplitudes in endothelial and myogenic ranges were observed, suggesting microcirculation self-regulation. Detailed analysis revealed characteristic peaks in the endothelial range during and after irradiation, indicating endothelial mediator release. It is assumed that the identified effects may be related to the singlet oxygen generated by 1267 nm laser irradiation, which directly affects the MCB, manifesting as endothelium-dependent vascular activity.</p>","PeriodicalId":94068,"journal":{"name":"Journal of biophotonics","volume":" ","pages":"e202400296"},"PeriodicalIF":0.0,"publicationDate":"2024-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142735437","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Estimation of Scattering Properties Modifications Caused by In Vivo Human Skin Optical Clearing Using Line-Field Confocal Optical Coherence Tomography. 利用线场共焦光学相干断层成像技术估算体内人体皮肤光学清除造成的散射特性改变。
Journal of biophotonics Pub Date : 2024-11-11 DOI: 10.1002/jbio.202400264
Sergey M Zaytsev, Léna Waszczuk, Jonas Ogien, Arnaud Dubois, Walter Blondel, Marine Amouroux
{"title":"Estimation of Scattering Properties Modifications Caused by In Vivo Human Skin Optical Clearing Using Line-Field Confocal Optical Coherence Tomography.","authors":"Sergey M Zaytsev, Léna Waszczuk, Jonas Ogien, Arnaud Dubois, Walter Blondel, Marine Amouroux","doi":"10.1002/jbio.202400264","DOIUrl":"https://doi.org/10.1002/jbio.202400264","url":null,"abstract":"<p><p>The image contrast and probing depth of optical methods applied to in vivo skin could be improved by reducing skin scattering using the optical clearing method. The aim of this study was to quantify, from line-field confocal optical coherence tomography (LC-OCT) 3D images, the modifications of skin scattering properties in vivo during optical clearing. Nine mixtures of optical clearing agents were used in combination with physical and chemical permeation enhancers on the human skin of three healthy volunteers. Scattering coefficient and anisotropy factor of the epidermis and the upper dermis were estimated from the 3D LC-OCT images of skin using an exponential decay model of the in-depth intensity profile. We were able to demonstrate a decrease in epidermal scattering (down to 33%) related to optical clearing, with the best results obtained by a mixture of polyethylene glycol, oleic acid, and propylene glycol.</p>","PeriodicalId":94068,"journal":{"name":"Journal of biophotonics","volume":" ","pages":"e202400264"},"PeriodicalIF":0.0,"publicationDate":"2024-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142635090","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Developmental Imaging of Radish Sprouts Using Dynamic Optical Coherence Tomography. 利用动态光学相干断层扫描技术对萝卜芽进行发育成像。
Journal of biophotonics Pub Date : 2024-11-05 DOI: 10.1002/jbio.202400254
Yiheng Lim, Shumpei Kojima, Pradipta Mukherjee, Ibrahim Abd El-Sadek, Shuichi Makita, Yoshiaki Yasuno
{"title":"Developmental Imaging of Radish Sprouts Using Dynamic Optical Coherence Tomography.","authors":"Yiheng Lim, Shumpei Kojima, Pradipta Mukherjee, Ibrahim Abd El-Sadek, Shuichi Makita, Yoshiaki Yasuno","doi":"10.1002/jbio.202400254","DOIUrl":"https://doi.org/10.1002/jbio.202400254","url":null,"abstract":"<p><p>The germination process of radish sprouts was investigated in detail using volumetric dynamic optical coherence tomography (OCT). Dynamic OCT involves the sequential acquisition of 16 OCT images and subsequent temporal variance analysis of each pixel, enabling non-invasive visualization of the cellular and tissue activities of plants. The radish sprouts were longitudinally investigated for up to 12 days, and changes in morphology and dynamic OCT image patterns were observed as the plants developed. The dynamic OCT signals in the vessels and growing roots were relatively high in the early stage of germination and decreased as the tissue matured. These results suggest that dynamic OCT is sensitive to water and nutrient transport as well as cellular activities associated with plant growth.</p>","PeriodicalId":94068,"journal":{"name":"Journal of biophotonics","volume":" ","pages":"e202400254"},"PeriodicalIF":0.0,"publicationDate":"2024-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142576041","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effects of FOLFOX Chemotherapy on Tumor Oxygenation and Perfused Vasculature: An In Vivo Study by Optical Techniques. FOLFOX 化疗对肿瘤氧合和灌注血管的影响：利用光学技术进行的体内研究。
Journal of biophotonics Pub Date : 2024-10-29 DOI: 10.1002/jbio.202400339
Irina Druzhkova, Kseniya Bylinskaya, Anton Plekhanov, Alexey Kostyuk, Mikhail Kirillin, Valeriya Perekatova, Aleksandr Khilov, Anna Orlova, Anastasiya Polozova, Anastasiya Komarova, Uliyana Lisitsa, Marina Sirotkina, Marina Shirmanova, Ilya Turchin
{"title":"Effects of FOLFOX Chemotherapy on Tumor Oxygenation and Perfused Vasculature: An In Vivo Study by Optical Techniques.","authors":"Irina Druzhkova, Kseniya Bylinskaya, Anton Plekhanov, Alexey Kostyuk, Mikhail Kirillin, Valeriya Perekatova, Aleksandr Khilov, Anna Orlova, Anastasiya Polozova, Anastasiya Komarova, Uliyana Lisitsa, Marina Sirotkina, Marina Shirmanova, Ilya Turchin","doi":"10.1002/jbio.202400339","DOIUrl":"https://doi.org/10.1002/jbio.202400339","url":null,"abstract":"<p><p>The effects of cytotoxic chemotherapy on tumor vasculature and oxygenation are in the focus of modern investigations because vascular structure and distribution of oxygen influence tumor behavior and treatment response. The aim of our study was to monitor changes in the vascular component of colorectal tumor xenografts induced by a clinical combination of chemotherapy drugs FOLFOX in vivo using two complementary techniques: diffuse reflectance spectroscopy (DRS) and optical coherence tomography-based microangiography (OCT-MA). These techniques revealed a slower decrease in tumor blood oxygenation in treated tumors as compared to untreated ones, faster suppression of tumor vasculature perfusion and increase in water content as a result of treatment, and decrease in total hemoglobin in untreated tumors. Immunohistochemical analysis of hypoxia-inducible factor HIF-2α detected tissue hypoxia as a consequence of inappropriate oxygen supply in the treated tumors. The obtained results show the prospects for monitoring of treatment efficacy using DRS and OCT-MA.</p>","PeriodicalId":94068,"journal":{"name":"Journal of biophotonics","volume":" ","pages":"e202400339"},"PeriodicalIF":0.0,"publicationDate":"2024-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142549829","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Quantitative In Vivo Assessment of Diabetic and Non-Diabetic Skin Wound Healing Using Phasor-FLIM Approach. 利用 Phasor-FLIM 方法对糖尿病和非糖尿病皮肤伤口愈合进行体内定量评估
Journal of biophotonics Pub Date : 2024-10-29 DOI: 10.1002/jbio.202400227
Hala Zuhayri, Tatiana B Lepekhina, Viktor V Nikolaev, Houssain Baalbaki, Anastasia I Knyazkova, Alexey V Borisov, Natalya A Krivova, Yury V Kistenev
{"title":"The Quantitative In Vivo Assessment of Diabetic and Non-Diabetic Skin Wound Healing Using Phasor-FLIM Approach.","authors":"Hala Zuhayri, Tatiana B Lepekhina, Viktor V Nikolaev, Houssain Baalbaki, Anastasia I Knyazkova, Alexey V Borisov, Natalya A Krivova, Yury V Kistenev","doi":"10.1002/jbio.202400227","DOIUrl":"https://doi.org/10.1002/jbio.202400227","url":null,"abstract":"<p><p>A quantitative assessment of wound status in a murine model was developed using phasor plot presentation of fluorescence lifetime imaging microscopy (FLIM) data. The quantitative assessment is based on calculating Bhattacharyya distance between g coordinates of FLIM data phasor plot density distributions of wound and healthy skin. The approach was validated for both diabetic and non-diabetic mice wounds, including during low-dose photodynamic therapy (LDPDT). Analysis revealed a shift in the FLIM data phasor plot g coordinates, suggesting altered metabolic processes involved in wound healing. Bhattacharyya distances in the LDPDT groups were closer to zero compared to the control group, which was not treated by LDPDT. Bhattacharyya distances in the non-diabetic LDPDT groups were closer to zero compared to the diabetic LDPDT groups that is consistent with the literature regarding the positive role of LDPDT in accelerating wound healing and the role of diabetes mellitus in impairing wound healing.</p>","PeriodicalId":94068,"journal":{"name":"Journal of biophotonics","volume":" ","pages":"e202400227"},"PeriodicalIF":0.0,"publicationDate":"2024-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142549830","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Tutorial on the Use of the Photon Diffusion Approximation for Fast Calculation of Tissue Optical Properties. 关于使用光子扩散近似法快速计算组织光学特性的教程。
Journal of biophotonics Pub Date : 2024-10-26 DOI: 10.1002/jbio.202400257
Maria R Pinheiro, Maria I Carvalho, Luís M Oliveira
{"title":"Tutorial on the Use of the Photon Diffusion Approximation for Fast Calculation of Tissue Optical Properties.","authors":"Maria R Pinheiro, Maria I Carvalho, Luís M Oliveira","doi":"10.1002/jbio.202400257","DOIUrl":"https://doi.org/10.1002/jbio.202400257","url":null,"abstract":"<p><p>Computer simulations, which are performed at a single wavelength at a time, have been traditionally used to estimate the optical properties of tissues. The results of these simulations need to be interpolated. For a broadband estimation of tissue optical properties, the use of computer simulations becomes time consuming and computer demanding. When spectral measurements are available for a tissue, the use of the photon diffusion approximation can be done to perform simple and direct calculations to obtain the broadband spectra of some optical properties. The additional estimation of the reduced scattering coefficient at a small number of discrete wavelengths allows to perform further calculations to obtain the spectra of other optical properties. This study used spectral measurements from the heart muscle to explain the calculation pipeline to obtain a complete set of the spectral optical properties and to show its versatility for use with other tissues for various biophotonics applications.</p>","PeriodicalId":94068,"journal":{"name":"Journal of biophotonics","volume":" ","pages":"e202400257"},"PeriodicalIF":0.0,"publicationDate":"2024-10-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142515343","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Investigation of Changes in the Reflection Spectrum of Human Blood When Exposed to Laser Radiation With Wavelengths of 450 or 980 nm. 波长为 450 或 980 纳米的激光照射下人体血液反射光谱变化的研究。
Journal of biophotonics Pub Date : 2024-10-20 DOI: 10.1002/jbio.202400251
V Yu Chuchin, A A Masharskaya, A V Belikov
{"title":"Investigation of Changes in the Reflection Spectrum of Human Blood When Exposed to Laser Radiation With Wavelengths of 450 or 980 nm.","authors":"V Yu Chuchin, A A Masharskaya, A V Belikov","doi":"10.1002/jbio.202400251","DOIUrl":"https://doi.org/10.1002/jbio.202400251","url":null,"abstract":"<p><strong>Objectives: </strong>This study aimed to determine and explain changes in the reflectance spectrum of human blood in vitro when exposed to laser radiation at wavelengths of 450 or 980 nm.</p><p><strong>Methods: </strong>Reflectance spectra of venous blood samples were measured before and after exposure to a single pulse of 450 or 980 nm laser radiation. A numerical optical model based on the Monte Carlo method was applied.</p><p><strong>Results: </strong>Laser irradiation at 450 and 980 nm caused the most significant changes in the reflectance spectrum around 600 nm, associated with alterations in blood oxygen saturation. The maximum efficiency of reducing oxygen saturation was 0.20%/W for 980 nm and 0.72%/W for 450 nm, likely due to differences in blood absorption at these wavelengths.</p><p><strong>Conclusions: </strong>The greatest change in intensity reflectance spectra and oxygen saturation of human venous blood occurs when exposed to laser radiation at 450 nm, not at 980 nm.</p>","PeriodicalId":94068,"journal":{"name":"Journal of biophotonics","volume":" ","pages":"e202400251"},"PeriodicalIF":0.0,"publicationDate":"2024-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142484171","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Raman Microspectroscopy of Hair: Low-Frequency Markers of Protein Secondary Structure. 头发的拉曼微光谱学：蛋白质二级结构的低频标记。
Journal of biophotonics Pub Date : 2024-10-13 DOI: 10.1002/jbio.202400265
E I Travkina, A Yu Chikishev, N N Brandt
{"title":"Raman Microspectroscopy of Hair: Low-Frequency Markers of Protein Secondary Structure.","authors":"E I Travkina, A Yu Chikishev, N N Brandt","doi":"10.1002/jbio.202400265","DOIUrl":"https://doi.org/10.1002/jbio.202400265","url":null,"abstract":"<p><p>Low-frequency intervals that can be used to study the secondary structure of proteins are determined. Compared are Raman spectra of keratins from unpigmented human hair, measured in two experimental configurations: with excitation radiation coaxial with the hair and perpendicular to it. Based on the polarization sensitivity, the bands peaked at 150 and 221 cm<sup>-1</sup> are assigned to vibrations of α-helical structures. The comparison of Raman spectra of hair fragments with different contents of secondary structure elements shows that the vibrations of β-structure are manifested in a spectral interval of 270-340 cm<sup>-1</sup>. The results obtained for a particular object (hair keratin) can be used in the study of the secondary structure of proteins.</p>","PeriodicalId":94068,"journal":{"name":"Journal of biophotonics","volume":" ","pages":"e202400265"},"PeriodicalIF":0.0,"publicationDate":"2024-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142484177","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Novel Diagnostic Approach for Acute Pharyngitis: Combining Machine Learning With Thermal Imaging. 急性咽炎的新型诊断方法：将机器学习与热成像技术相结合。
Journal of biophotonics Pub Date : 2024-10-13 DOI: 10.1002/jbio.202400219
Oshrit Hoffer, Moriya Cohen, Maya Gerstein, Vered Shkalim Zemer, Yael Reichenberg, Dima Bykhovsky, Moshe Hoshen, Herman Avner Cohen
{"title":"Novel Diagnostic Approach for Acute Pharyngitis: Combining Machine Learning With Thermal Imaging.","authors":"Oshrit Hoffer, Moriya Cohen, Maya Gerstein, Vered Shkalim Zemer, Yael Reichenberg, Dima Bykhovsky, Moshe Hoshen, Herman Avner Cohen","doi":"10.1002/jbio.202400219","DOIUrl":"https://doi.org/10.1002/jbio.202400219","url":null,"abstract":"<p><p>We evaluated the effect of infrared thermography (IRT) on the clinical assessment of bacterial and viral pharyngitis and its impact on the predictive value of the McIsaac score algorithm for streptococcal pharyngitis in children. We also investigated if IRT could distinguish between bacterial and viral pharyngitis. The study included children aged 2-17 years presenting with sore throat and fever over 38°C from November 1, 2021, to April 30, 2022. Of the 76 assessed children, 16 were excluded due to missing data or technical issues, leaving 60 children (32 males, 28 females) divided into three groups: Group A with streptococcal pharyngitis (N = 30), viral pharyngitis (N = 16), and healthy controls (N = 14). McIsaac score and IRT imaging showed a 90% positive predictive value for streptococcal pharyngitis. While IRT alone could not distinguish between bacterial and viral infections, it significantly increased the predictive value when combined with the McIsaac score.</p>","PeriodicalId":94068,"journal":{"name":"Journal of biophotonics","volume":" ","pages":"e202400219"},"PeriodicalIF":0.0,"publicationDate":"2024-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142484173","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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