IF 8.7

JACS Au Pub Date : 2025-08-25 eCollection Date: 2025-09-22 DOI: 10.1021/jacsau.5c00475

Ayokunle A Lekuti, Vanessa Y C Li, Ayden Malekjahani, Sara Ahmed, Stefan M Mladjenovic, Marshall G G Macduff, Warren C W Chan

{"title":"Designing Nanoparticle Surfaces with DNA Barcodes for Accurate In Vivo Quantification.","authors":"Ayokunle A Lekuti, Vanessa Y C Li, Ayden Malekjahani, Sara Ahmed, Stefan M Mladjenovic, Marshall G G Macduff, Warren C W Chan","doi":"10.1021/jacsau.5c00475","DOIUrl":"10.1021/jacsau.5c00475","url":null,"abstract":"DNA barcoding is a common method for identifying the biodistribution of nanoparticles. DNA barcodes are typically encapsulated within nanoparticles to ensure accurate measurements by next-generation sequencing. This method limits the types of nanoparticles that can be screened. DNA can also be coated on nanoparticle surfaces. However, it is unclear whether surface-coated DNA can be used as barcodes because they can degrade, making the identification and quantification of nanoparticle designs challenging. Here, we developed strategies to reduce DNA degradation on nanoparticle surfaces, allowing surface-based DNA barcodes for biodistribution applications. We demonstrate that nanoparticle size, DNA density, and polymer length and density are essential design parameters for accurately identifying and quantifying nanoparticles in vivo. We found that chemical modification of DNA and shielding using neutral polymers reduce DNA degradation. We validated that surface barcoding can determine the in vivo distribution of nanoparticles. Our findings pave the way for the use of surface-based DNA barcodes for in vivo screening of nanoparticle formulations for targeted applications.","PeriodicalId":94060,"journal":{"name":"JACS Au","volume":"5 9","pages":"4211-4223"},"PeriodicalIF":8.7,"publicationDate":"2025-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12458034/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145152356","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Light-Sensitive Ion Channel Delivery System for Ion-Interference Tumor Therapy. 用于离子干涉肿瘤治疗的光敏离子通道输送系统。

IF 8.7

JACS Au Pub Date : 2025-08-23 eCollection Date: 2025-09-22 DOI: 10.1021/jacsau.5c00762

Yueyue Lu, Yuxin Wu, Canhong Zhu, Tianlong Zhang, Yanting Wu, Lulu Xi, Xianze Huang, Tengfei Yan, Junqiu Liu

{"title":"Light-Sensitive Ion Channel Delivery System for Ion-Interference Tumor Therapy.","authors":"Yueyue Lu, Yuxin Wu, Canhong Zhu, Tianlong Zhang, Yanting Wu, Lulu Xi, Xianze Huang, Tengfei Yan, Junqiu Liu","doi":"10.1021/jacsau.5c00762","DOIUrl":"10.1021/jacsau.5c00762","url":null,"abstract":"Artificial ion channels have shown great potential applications in tumor treatment by disrupting ion homeostasis across cancer cell membranes. Herein, we report a de novo-designed ion channel delivery system (ICDS) based on light-sensitive nanocapsules that can induce cell apoptosis via interfering with ion homeostasis of subcellular membranes of tumors. The nanocapsules were self-assembled by the host-guest complex of azobenzene-modified quinoline helix (an artificial proton channel) and α-cyclodextrin, which can easily enter tumor cells by an endocytic effect and release proton channels under ultraviolet (UV) light irradiation. The artificial proton channels further neutralize the acidic organelles (such as lysosomes), deplete the mitochondrial membrane potential, elevate reactive oxygen species (ROS) levels, and eventually induce the apoptosis of cancer cells. As far as we know, this is the first example of an ion-interference antitumor strategy by an ion channel delivery system that may offer novel therapeutic directions for artificial ion channels.","PeriodicalId":94060,"journal":{"name":"JACS Au","volume":"5 9","pages":"4439-4448"},"PeriodicalIF":8.7,"publicationDate":"2025-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12458000/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145152412","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Single Photocatalytic Hydrosilylation of Alkenes for the Synthesis of Bis(silyl) and Silaboryl Alkanes. 单光催化硅烷氢化反应合成双（硅基）和硅硼基烷烃。

IF 8.7

JACS Au Pub Date : 2025-08-22 eCollection Date: 2025-09-22 DOI: 10.1021/jacsau.5c00831

Yuki Nagashima, Mone Suzuki, Asuha Shimose, Ryo Arai, Ken Tanaka, Masanobu Uchiyama

{"title":"Single Photocatalytic Hydrosilylation of Alkenes for the Synthesis of Bis(silyl) and Silaboryl Alkanes.","authors":"Yuki Nagashima, Mone Suzuki, Asuha Shimose, Ryo Arai, Ken Tanaka, Masanobu Uchiyama","doi":"10.1021/jacsau.5c00831","DOIUrl":"10.1021/jacsau.5c00831","url":null,"abstract":"Bis-(silyl) and silaboryl alkanes are of interest as bioactive compounds and highly functionalized synthetic building blocks, but conventional hydrosilylation reactions lack generality and/or selectivity for synthesizing multielement-containing alkanes. Here, we present a versatile photoactivated hydrosilylation reaction of silicon- or boron-containing alkenes using silylborane as a silyl radical source to construct bis-(silyl) or silaboryl alkanes. This method employs a single phenothiazine-based photocatalyst and does not require conventional transition-metal or hydrogen-atom-transfer (HAT) catalysts or cocatalysts. Consequently, it has high generality, including alkenes bearing acid/base-sensitive groups, and provides high chemo-/regio-selectivity, overcoming the limitations of existing methods. This methodology also enables cyclizative functionalization of dienes and arylsilylation of boryl alkenes, and we show that the obtained multielement-containing alkanes are useful synthetic building blocks. Mechanistic studies uncovered a novel photoactivation mechanism, in which the phenothiazine catalyst directly facilitates Si-B bond cleavage in the triplet state, in contrast to conventional redox or HAT mechanisms, enabling radical hydrosilylation with a broad scope of alkenes.","PeriodicalId":94060,"journal":{"name":"JACS Au","volume":"5 9","pages":"4481-4490"},"PeriodicalIF":8.7,"publicationDate":"2025-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12458007/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145152450","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Chemoselective Modification of Reducing 2‑Acetamido Sugars Enables Facile Functionalization of Diverse Peptidoglycan Fragments Derived from the Gut Microbiota. 2 -乙酰氨基糖的化学选择性修饰使来自肠道微生物群的多种肽聚糖片段容易功能化。

IF 8.7

JACS Au Pub Date : 2025-08-21 eCollection Date: 2025-09-22 DOI: 10.1021/jacsau.5c00790

Christopher Adamson, Evan Wei Long Ng, Allan Wee Ren Ng, Shiliu Feng, Yuan Qiao

{"title":"Chemoselective Modification of Reducing 2‑Acetamido Sugars Enables Facile Functionalization of Diverse Peptidoglycan Fragments Derived from the Gut Microbiota.","authors":"Christopher Adamson, Evan Wei Long Ng, Allan Wee Ren Ng, Shiliu Feng, Yuan Qiao","doi":"10.1021/jacsau.5c00790","DOIUrl":"10.1021/jacsau.5c00790","url":null,"abstract":"Gut microbiota-derived peptidoglycan fragments (PGNs) are key signaling molecules in microbiota-host crosstalk. Efficient strategies to functionalize natural, unprotected PGN molecules are highly desirable for advancing the biological studies of PGNs. In this work, we developed a facile chemoselective strategy to derivatize the anomeric C1 position of reducing 2-acetamido sugars, a characteristic shared by most PGNs that contain reducing N-acetylmuramic acid. Upon treatment with imidazole-dithiocarbamate-azide (IDA), we showed that natural reducing 2-acetamido PGNs are readily converted to oxazoline intermediates under aqueous conditions. Serendipitously, we discovered that simply freeze-drying the reaction mixture promotes glycosidation of the oxazoline glycosyl donor, leading to PGN-DTC-azide products with high stereoselectivity and yields. Importantly, our chemoselective azidation strategy shows a broad substrate scope, including diverse gut microbiota-derived PGNs, such as muropeptides and natural oligosaccharides. The azido moiety in PGN-DTC-azides serves as a versatile handle for further functionalization, leading to fluorescent or photo-cross-linking PGN probes that maintain the immunological activities of natural PGNs. Importantly, we demonstrate the successful generation of the IgG1 monoclonal antibody 7F8 in mice, which specifically recognizes GlcNAc-MurNAc-DTC-azide as its antigen. Together, we present a simple and unprecedented chemoselective modification of reducing 2-acetamido sugars in unprotected forms via simple freeze-drying, offering attractive tools for studying gut microbiota-derived PGNs and other carbohydrates.","PeriodicalId":94060,"journal":{"name":"JACS Au","volume":"5 9","pages":"4449-4458"},"PeriodicalIF":8.7,"publicationDate":"2025-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12457995/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145152416","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Modular Access to Quaternary α‑Cyano Carbonyl Compounds via NiH Catalysis. 通过NiH催化获得季α -氰基羰基化合物的模块化途径。

IF 8.7

JACS Au Pub Date : 2025-08-21 eCollection Date: 2025-09-22 DOI: 10.1021/jacsau.5c00835

Yoonho Lee, Yujin Jung, Seonhwa Choo, Kwangmin Shin

{"title":"Modular Access to Quaternary α‑Cyano Carbonyl Compounds via NiH Catalysis.","authors":"Yoonho Lee, Yujin Jung, Seonhwa Choo, Kwangmin Shin","doi":"10.1021/jacsau.5c00835","DOIUrl":"10.1021/jacsau.5c00835","url":null,"abstract":"Quaternary α-cyano carbonyl compounds are an important class of molecules in organic synthesis due to their versatility as precursors to essential building blocks and their potential applications in pharmaceutical synthesis. Despite the importance of these sterically congested and highly functionalized structures, the development of a general and practical synthetic platform remains a persistent challenge. Herein, we report a nickel-hydride-catalyzed hydrofunctionalization of α,β-unsaturated nitriles with acyl fluorides as well as their carbamoyl and formyl derivatives. This synthetic protocol enables the modular synthesis of a diverse range of quaternary α-cyano carbonyl compounds, including ketones, amides, and esters, under mild conditions and without the need for an external ligand. Combined DFT and experimental mechanistic studies reveal that the present NiH catalysis proceeds via regioselective hydrometalation, followed by the formation of a nickel-keteneiminate intermediate through rearrangement and subsequent nucleophilic substitution reaction between the nickel-keteneiminate and the carbonyl fluorides.","PeriodicalId":94060,"journal":{"name":"JACS Au","volume":"5 9","pages":"4506-4518"},"PeriodicalIF":8.7,"publicationDate":"2025-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12458049/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145152337","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

IF 8.7

JACS Au Pub Date : 2025-08-21 eCollection Date: 2025-09-22 DOI: 10.1021/jacsau.5c00733

Huan-Xiang Zhou

{"title":"Correlated Segments of Intrinsically Disordered Proteins as Drivers of Homotypic Phase Separation.","authors":"Huan-Xiang Zhou","doi":"10.1021/jacsau.5c00733","DOIUrl":"10.1021/jacsau.5c00733","url":null,"abstract":"Many studies have suggested that amino acid composition, not their positions along the sequence, is the determinant of phase separation of intrinsically disordered proteins (IDPs). In particular, aromatic amino acids and Arg have been identified as major drivers. Here I underscore the importance of the positions of amino acids along the sequence in phase separation. Specifically, clusters of interaction-prone amino acids, including Trp and Arg, along the sequence form correlated segments, and these correlated segments, rather than individual residues, drive the phase separation of many IDPs. Correlated segments manifest themselves as stretches of residues that span major peaks in the backbone 15N NMR transverse relaxation rates and can be predicted by a sequence-based method called SeqDYN (https://zhougroup-uic.github.io/SeqDYNidp/). Interchain interactions between individual residues may be too transient, but those between correlated segments involve multiple residues can provide the strengths required for phase separation. Indeed, sequence motifs revealed by NMR and other techniques as important for phase separation frequently map to SeqDYN-predicted correlated segments. These include residues G624-R626, G638-R640, and R660-Q666 of CAPRIN1, residues R21-G30 of LAF-1, and residues Q9-P21 of FUS. SeqDYN presents a sequence-based method for identifying motifs that drive phase separation of IDPs.","PeriodicalId":94060,"journal":{"name":"JACS Au","volume":"5 9","pages":"4361-4369"},"PeriodicalIF":8.7,"publicationDate":"2025-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12458045/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145152431","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ionic Reactant Orientation Inhibits Ion-Neutral Reactions at Low Temperatures. 离子反应物取向在低温下抑制离子中性反应。

IF 8.7

JACS Au Pub Date : 2025-08-21 eCollection Date: 2025-09-22 DOI: 10.1021/jacsau.5c00613

Yongxu Peng, Junlong Li, Zongao Song, Mengyang Li, Yue Xiao, Xin Wang, Tao Wang, Yurun Xie, Jun Li, Tiangang Yang

{"title":"Ionic Reactant Orientation Inhibits Ion-Neutral Reactions at Low Temperatures.","authors":"Yongxu Peng, Junlong Li, Zongao Song, Mengyang Li, Yue Xiao, Xin Wang, Tao Wang, Yurun Xie, Jun Li, Tiangang Yang","doi":"10.1021/jacsau.5c00613","DOIUrl":"10.1021/jacsau.5c00613","url":null,"abstract":"Barrierless ion-molecule reactions are critical to interstellar chemistry, particularly at low temperatures. Their rate coefficients are often estimated using classical capture theory, which neglects the spatial orientation of molecular ions. Here, we investigate the reaction between sympathetically cooled BeD+ and O2 using a linear quadrupole ion trap combined with a high-resolution time-of-flight mass spectrometer. Isotopic substitution confirms BeOD+ and O were the only products. The measured rate coefficient, k = (5.4 ± 1.2) × 10-11 cm3/s at the collision energy of 97 K (E/kB), is approximately 15 times lower than that predicted by the classical capture model. Master equation modeling based on electronic structure calculations up to CCSDT-(Q) accurately reproduces the experiment. Unlike the point-charge approximation in capture theory, our results show that reactivity is strongly constrained by the steric requirements of the ionic reactant: only a small subset of orientations between reactants leads to a low-energy barrier that allows the reaction to proceed at low temperatures. These findings underscore the necessity to include steric effects in capture models for accurate predictions.","PeriodicalId":94060,"journal":{"name":"JACS Au","volume":"5 9","pages":"4260-4267"},"PeriodicalIF":8.7,"publicationDate":"2025-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12458013/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145152376","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dynamic Single-Atom Catalysts on Gallium To Overcome the Scaling Relationship Limit: AIMD Screening for CO₂ Reduction and Hydrogen Evolution Reactions. 克服结垢关系限制的动态镓单原子催化剂：二氧化碳还原和析氢反应的AIMD筛选。

IF 8.7

JACS Au Pub Date : 2025-08-20 eCollection Date: 2025-09-22 DOI: 10.1021/jacsau.5c00823

Mohsen Tamtaji, William A Goddard, Ziyang Hu, Shuguang Chen, GuanHua Chen

{"title":"Dynamic Single-Atom Catalysts on Gallium To Overcome the Scaling Relationship Limit: AIMD Screening for CO2 Reduction and Hydrogen Evolution Reactions.","authors":"Mohsen Tamtaji, William A Goddard, Ziyang Hu, Shuguang Chen, GuanHua Chen","doi":"10.1021/jacsau.5c00823","DOIUrl":"10.1021/jacsau.5c00823","url":null,"abstract":"Extensive research has been conducted on single-atom catalysts (SACs) for a range of electrochemical reactions. However, static SACs suffer from scaling relationship limits, which hinder their further development. In this work, we introduce the idea of dynamic SACs supported on Gallium for the hydrogen evolution reaction (HER) and the CO2 reduction reaction (CO2RR). We utilized AIMD and DFT calculations to systematically conduct high-throughput screening on s-, p-, d-, and f-block elements supported by Gallium denoted as M-SAC@Ga. We found that among all the understudied catalysts, Re-, Pt-, Pd-, Rh-, Ir-, Au-, Ag-, Ru-, Tc-, Ni-, Cu-, Os-, Hg-, and Ge-SAC@Ga possess thermodynamic and electrochemical stabilities. In addition: Ni-SAC@Ga leads to CO2RR overpotentials of 0.28, 0.28, 0.69, and 0.92 V, respectively, toward CHOOH, CO, CH3OH, and CH4 formation. Low overpotentials and mitigation of scaling relationship limits are primarily due to the atomic intelligence (the ability to guide reactions) and dynamic coordination changes of SACs, seen through DFT and AIMD calculations. Analyzing the phonon-induced fluctuations in total energies suggests a standard deviation of up to 0.26 V in the calculated overpotentials. Additionally, the dephasing time for these dynamic systems is below 5 fs, a crucial factor affecting the modeling of catalytic behavior. Feature importance analysis suggests that the d-electron numbers serve as the universal descriptors for these catalysts. This study offers a comprehensive insight into the discovery of cutting-edge electrocatalysts and beyond by applying the concept of dynamic SACs.","PeriodicalId":94060,"journal":{"name":"JACS Au","volume":"5 9","pages":"4459-4471"},"PeriodicalIF":8.7,"publicationDate":"2025-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12458042/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145152386","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Asymmetrically Steering Excited-State Reaction Channels for Ambient N ₂ Catalytic Oxidation. 环境氮催化氧化的不对称导向激发态反应通道。

IF 8.7

JACS Au Pub Date : 2025-08-20 eCollection Date: 2025-09-22 DOI: 10.1021/jacsau.5c00767

Jiabao Lv, Pu Guo, Shanzhi Liu, Yaqi Peng, Lujie Liu, Jian Wu, Xiaodong Li, Zhifu Qi, Songqiang Zhu, Liang Wang, Angjian Wu, Jianping Xiao, Jianhua Yan

{"title":"Asymmetrically Steering Excited-State Reaction Channels for Ambient N 2 Catalytic Oxidation.","authors":"Jiabao Lv, Pu Guo, Shanzhi Liu, Yaqi Peng, Lujie Liu, Jian Wu, Xiaodong Li, Zhifu Qi, Songqiang Zhu, Liang Wang, Angjian Wu, Jianping Xiao, Jianhua Yan","doi":"10.1021/jacsau.5c00767","DOIUrl":"10.1021/jacsau.5c00767","url":null,"abstract":"Precise control of catalytic reactions in the excited state is challenging, as the highly reactive chemical environment strengthens both forward and reverse reactions simultaneously. Here, we propose a strategy to asymmetrically regulate the reaction channels via the physical mixing of the model catalyst Co3O4/Al2O3 with 13X zeolite, enabling efficient plasma-driven N2 oxidation with minimized reverse reaction kinetics. In situ characterization combined with molecular dynamics simulations reveals that the diffusion of the product NO is selectively accelerated through Na+-mediated transport channels. This promotes NO turnover on octahedral Co3+ active sites, thereby unidirectionally shifting the reaction equilibrium. Thus, we demonstrate N2 oxidation performance under ambient conditions that surpasses the efficiency of thermochemical conversion at 1,800 K, achieving more than a 3-fold improvement in the N2 conversion rate compared to the conventional plasma-catalysis system. This work provides an approach to orderly modulate heterogeneous catalytic reactions in the excited state.","PeriodicalId":94060,"journal":{"name":"JACS Au","volume":"5 9","pages":"4398-4407"},"PeriodicalIF":8.7,"publicationDate":"2025-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12457990/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145152339","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Emerging Research on Gene Delivery to the Nucleus via DNA Origami. 通过DNA折纸将基因传递到细胞核的新研究。

IF 8.7

JACS Au Pub Date : 2025-08-19 eCollection Date: 2025-09-22 DOI: 10.1021/jacsau.5c00737

Sierra Sterling, Yin Wei, Gaurav Arya, Carlos Castro, Yonggang Ke

引用次数: 0

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