International review of neurobiology最新文献_第6页

RNP granules in ALS and neurodegeneration: From multifunctional membraneless organelles to therapeutic opportunities. ALS 和神经变性中的 RNP 颗粒：从多功能无膜细胞器到治疗机会。

International review of neurobiology Pub Date : 2024-01-01 Epub Date: 2024-05-14 DOI: 10.1016/bs.irn.2024.04.009

Tatyana A Shelkovnikova, Guillaume M Hautbergue

{"title":"RNP granules in ALS and neurodegeneration: From multifunctional membraneless organelles to therapeutic opportunities.","authors":"Tatyana A Shelkovnikova, Guillaume M Hautbergue","doi":"10.1016/bs.irn.2024.04.009","DOIUrl":"10.1016/bs.irn.2024.04.009","url":null,"abstract":"Amyotrophic lateral sclerosis (ALS) and related neurodegenerative diseases are characterised by dysfunction of a host of RNA-binding proteins (RBPs) and a severely disrupted RNA metabolism. Recently, RBP-harbouring phase-separated complexes, ribonucleoprotein (RNP) granules, have come into the limelight as \"crucibles\" of neuronal pathology in ALS. RNP granules are indispensable for the multitude of regulatory processes underlying cellular RNA metabolism and serve as critical organisers of cellular biochemistry. Neurons, highly specialised cells, heavily rely on RNP granules for efficient trafficking, signalling and stress responses. Multiple RNP granule components, primarily RBPs such as TDP-43 and FUS, are affected by ALS mutations. However, even in the absence of mutations, RBP proteinopathies represent pathophysiological hallmarks of ALS. Given the high local concentrations of RBPs and RNAs, their weakened or enhanced interactions within RNP granules disrupt their homeostasis. Thus, the physiological process of phase separation and RNP granule formation, vital for maintaining the high-functioning state of neuronal cells, becomes their Achilles heel. Here, we will review the recent literature on the causes and consequences of abnormal RNP granule functioning in ALS and related disorders. In particular, we will summarise the evidence for the network-level dysfunction of RNP granules in these conditions and discuss considerations for therapeutic interventions to target RBPs, RNP granules and their network as a whole.","PeriodicalId":94058,"journal":{"name":"International review of neurobiology","volume":"176 ","pages":"455-479"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141159337","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Therapeutic potential of CBD in Autism Spectrum Disorder. CBD 对自闭症谱系障碍的治疗潜力。

International review of neurobiology Pub Date : 2024-01-01 Epub Date: 2024-06-29 DOI: 10.1016/bs.irn.2024.05.002

João F C Pedrazzi, Lucas Hassib, Frederico R Ferreira, Jaime C Hallak, Elaine Del-Bel, José A Crippa

{"title":"Therapeutic potential of CBD in Autism Spectrum Disorder.","authors":"João F C Pedrazzi, Lucas Hassib, Frederico R Ferreira, Jaime C Hallak, Elaine Del-Bel, José A Crippa","doi":"10.1016/bs.irn.2024.05.002","DOIUrl":"https://doi.org/10.1016/bs.irn.2024.05.002","url":null,"abstract":"Autism Spectrum Disorder (ASD) is a neurodevelopmental condition characterized by persistent deficits in social communication and interaction, as well as restricted and repetitive patterns of behavior. Despite extensive research, effective pharmacological interventions for ASD remain limited. Cannabidiol (CBD), a non-psychotomimetic compound of the Cannabis sativa plant, has potential therapeutic effects on several neurological and psychiatric disorders. CBD interacts with the endocannabinoid system, a complex cell-signaling system that plays a crucial role in regulating various physiological processes, maintaining homeostasis, participating in social and behavioral processing, and neuronal development and maturation with great relevance to ASD. Furthermore, preliminary findings from clinical trials indicate that CBD may have a modulatory effect on specific ASD symptoms and comorbidities in humans. Interestingly, emerging evidence suggests that CBD may influence the gut microbiota, with implications for the bidirectional communication between the gut and the central nervous system. CBD is a safe drug with low induction of side effects. As it has a multi-target pharmacological profile, it becomes a candidate compound for treating the central symptoms and comorbidities of ASD.","PeriodicalId":94058,"journal":{"name":"International review of neurobiology","volume":"177 ","pages":"149-203"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141728488","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Designing and testing treatments for alcohol use disorder. 设计和测试酒精使用障碍的治疗方法。

International review of neurobiology Pub Date : 2024-01-01 Epub Date: 2024-03-08 DOI: 10.1016/bs.irn.2024.02.004

Katie Witkiewitz, Felicia R Tuchman

引用次数: 0

Executive dysfunction and cognitive decline, a non-motor symptom of Parkinson's disease captured in animal models. 在动物模型中捕捉帕金森病的非运动症状--执行功能障碍和认知能力下降。

International review of neurobiology Pub Date : 2024-01-01 Epub Date: 2023-12-28 DOI: 10.1016/bs.irn.2023.12.001

Mahmoud M Iravani, Mohammed Shoaib

引用次数: 0

Macro and micro-sleep dysfunctions as translational biomarkers for Parkinson's disease. 作为帕金森病转化生物标志物的宏观和微观睡眠功能障碍。

International review of neurobiology Pub Date : 2024-01-01 Epub Date: 2023-12-01 DOI: 10.1016/bs.irn.2023.08.008

Marcelo M S Lima, Adriano D S Targa, Gustavo Z Dos Santos Lima, Clarissa F Cavarsan, Pablo Torterolo

{"title":"Macro and micro-sleep dysfunctions as translational biomarkers for Parkinson's disease.","authors":"Marcelo M S Lima, Adriano D S Targa, Gustavo Z Dos Santos Lima, Clarissa F Cavarsan, Pablo Torterolo","doi":"10.1016/bs.irn.2023.08.008","DOIUrl":"10.1016/bs.irn.2023.08.008","url":null,"abstract":"Sleep disturbances are highly prevalent among patients with Parkinson's disease (PD) and often appear from the early-phase disease or prodromal stages. In this chapter, we will discuss the current evidence addressing the links between sleep dysfunctions in PD, focusing most closely on those data from animal and mathematical/computational models, as well as in human-based studies that explore the electrophysiological and molecular mechanisms by which PD and sleep may be intertwined, whether as predictors or consequences of the disease. It is possible to clearly state that leucine-rich repeat kinase 2 gene (LRRK2) is significantly related to alterations in sleep architecture, particularly affecting rapid eye movement (REM) sleep and non-REM sleep, thus impacting sleep quality. Also, decreases in gamma power, observed after dopaminergic lesions, correlates negatively with the degree of injury, which brings other levels of understanding the impacts of the disease. Besides, abnormal synchronized oscillations among basal ganglia nuclei can be detrimental for information processing considering both motor and sleep-related processes. Altogether, despite clear advances in the field, it is still difficult to definitely establish a comprehensive understanding of causality among all the sleep dysfunctions with the disease itself. Although, certainly, the search for biomarkers is helping in shortening this road towards a better and faster diagnosis, as well as looking for more efficient treatments.","PeriodicalId":94058,"journal":{"name":"International review of neurobiology","volume":"174 ","pages":"187-209"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139716767","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Animal models for studying therapeutic targets and treatments for alcohol use disorder. 研究酒精使用障碍治疗目标和治疗方法的动物模型。

International review of neurobiology Pub Date : 2024-01-01 Epub Date: 2024-10-24 DOI: 10.1016/bs.irn.2024.08.004

Cristiane Aparecida Favoretto, Thamires Righi, Gustavo Juliate Damaceno Fernandes, Natalia Bonetti Bertagna, Ben Tagami Rodolpho, Nilma do Rocio Lara de Lima Janisset, Caio Jovita-Farias, Giovanna Victória Lopes Costa, Alexia Dos Anjos-Santos, Fernando Bezerra Romualdo da Silva, Rodrigo Molini Leão, Fábio Cardoso Cruz

{"title":"Animal models for studying therapeutic targets and treatments for alcohol use disorder.","authors":"Cristiane Aparecida Favoretto, Thamires Righi, Gustavo Juliate Damaceno Fernandes, Natalia Bonetti Bertagna, Ben Tagami Rodolpho, Nilma do Rocio Lara de Lima Janisset, Caio Jovita-Farias, Giovanna Victória Lopes Costa, Alexia Dos Anjos-Santos, Fernando Bezerra Romualdo da Silva, Rodrigo Molini Leão, Fábio Cardoso Cruz","doi":"10.1016/bs.irn.2024.08.004","DOIUrl":"https://doi.org/10.1016/bs.irn.2024.08.004","url":null,"abstract":"Over the decades, preclinical models have been developed and refined to investigate the rewarding effects of addictive substances and the neurobiological underpinnings of alcohol and other drug use disorders. This chapter delves into the methodological foundations, advantages, and limitations of leading animal models used to study alcohol use disorders (AUDs). Some models focus on the early stages of alcohol use and abuse. For instance, conditioned place preference assesses associative learning between a specific context and the effects of the drug, while locomotor sensitization measures increased locomotor activity following repeated drug exposure. In contrast, contingent models such as operant and non-operant alcohol self-administration protocols gauge voluntary intake, preference, motivation, and seeking behavior for alcohol solutions among experimental subjects. Additionally, we discuss the chronic intermittent alcohol vapor model, extensively utilized to induce a phenotype resembling dependence through non-contingent inhalation of alcohol vapor, resulting in elevated blood alcohol concentrations. Given the focus on pharmacological treatments for AUDs, we explore how different animal models can be employed to evaluate potential therapies and extrapolate findings to alcohol-related behaviors in humans. This chapter aims to provide readers with a comprehensive understanding of various animal models for AUDs, aiding in the interpretation of preclinical studies and the selection of suitable models for future research endeavors.","PeriodicalId":94058,"journal":{"name":"International review of neurobiology","volume":"178 ","pages":"355-381"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142635017","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neuroanatomy of the nociceptive system: From nociceptors to brain networks. 痛觉系统的神经解剖学：从痛觉感受器到大脑网络。

International review of neurobiology Pub Date : 2024-01-01 Epub Date: 2024-11-04 DOI: 10.1016/bs.irn.2024.10.008

Julian C Motzkin, Allan I Basbaum, Andrew J Crowther

引用次数: 0

From use of omics to systems biology: Identifying therapeutic targets for amyotrophic lateral sclerosis. 从使用 omics 到系统生物学：确定肌萎缩性脊髓侧索硬化症的治疗目标。

International review of neurobiology Pub Date : 2024-01-01 Epub Date: 2024-05-22 DOI: 10.1016/bs.irn.2024.02.001

Lydia Castelli, Rosario Vasta, Scott P Allen, Rachel Waller, Adriano Chiò, Bryan J Traynor, Janine Kirby

{"title":"From use of omics to systems biology: Identifying therapeutic targets for amyotrophic lateral sclerosis.","authors":"Lydia Castelli, Rosario Vasta, Scott P Allen, Rachel Waller, Adriano Chiò, Bryan J Traynor, Janine Kirby","doi":"10.1016/bs.irn.2024.02.001","DOIUrl":"10.1016/bs.irn.2024.02.001","url":null,"abstract":"Amyotrophic lateral sclerosis (ALS) is a heterogeneous progressive neurodegenerative disorder with available treatments such as riluzole and edaravone extending survival by an average of 3-6 months. The lack of highly effective, widely available therapies reflects the complexity of ALS. Omics technologies, including genomics, transcriptomic and proteomics have contributed to the identification of biological pathways dysregulated and targeted by therapeutic strategies in preclinical and clinical trials. Integrating clinical, environmental and neuroimaging information with omics data and applying a systems biology approach can further improve our understanding of the disease with the potential to stratify patients and provide more personalised medicine. This chapter will review the omics technologies that contribute to a systems biology approach and how these components have assisted in identifying therapeutic targets. Current strategies, including the use of genetic screening and biosampling in clinical trials, as well as the future application of additional technological advances, will also be discussed.","PeriodicalId":94058,"journal":{"name":"International review of neurobiology","volume":"176 ","pages":"209-268"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141159329","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

New developments in pre-clinical models of ALS to guide translation. 肌萎缩性脊髓侧索硬化症临床前模型的新进展，为转化提供指导。

International review of neurobiology Pub Date : 2024-01-01 Epub Date: 2024-04-23 DOI: 10.1016/bs.irn.2024.04.008

Lenja De Cock, Valérie Bercier, Ludo Van Den Bosch

引用次数: 0

The role of glial cells in amyotrophic lateral sclerosis. 神经胶质细胞在肌萎缩性脊髓侧索硬化症中的作用。

International review of neurobiology Pub Date : 2024-01-01 Epub Date: 2024-05-20 DOI: 10.1016/bs.irn.2024.04.005

Virenkumar A Pandya, Rickie Patani

引用次数: 0