Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology最新文献

{"title":"Association analysis between forkhead box E1 gene and non-syndromic cleft lip with or without cleft palate in Han Chinese population.","authors":"Sixuan Jia, Sidi Zhang, Yue You, Jialin Sun, Shijun Duan, Bing Shi, Zhonglin Jia","doi":"10.7518/hxkq.2024.2024110","DOIUrl":"10.7518/hxkq.2024.2024110","url":null,"abstract":"<p><strong>Objectives: </strong>This study aims to explore the association between single nucleotide polymorphisms (SNPs) loci near the haplotype region hg19 chr9:100560865-100660865 of the forkhead box E1 (FOXE1) gene and the occurrence of non-syndromic cleft lip with or without cleft palate (NSCL/P) in western Han Chinese population.</p><p><strong>Methods: </strong>In the first stage, our study recruited 159 NSCL/P patients and performed targeted region sequencing to screen SNPs loci near the haplotype region of the FOXE1 gene associated with NSCL/P. In the second stage, we selected 21 common SNPs and re-enrolled 1 000 non-syndromic cleft lip only (NSCLO) patients, 1 000 non-syndromic cleft palate only (NSCPO) patients, and 1 000 normal controls to verify the association. PLINK software was used to perform Hardy-Weinberg equilibrium (HWE) test. Association analysis for common variants, gene burden analysis for rare mutations, and function prediction of SNPs with non-synonymous mutations were performed using Mutation Taster and other software programs.</p><p><strong>Results: </strong>In the first stage, 126 variants, including 76 single nucleotide variants and 50 insertion-deletions were identified. All the included SNPs confirmed to HWE, and the results of gene burden analysis and prediction of functional harmfulness for rare variants were not statistically significant. Association analysis showed that rs13292899 of the FOXE1 gene was significantly associated with NSCL/P (<i>P</i>=1.85E-27) and was also correlated with NSCLO (<i>P</i>=6.41E-23) and non-syndromic cleft lip with cleft palate (NSCLP) (<i>P</i>=2.36E-15) subtypes. In the validation phase, rs79268293 (<i>P</i>=0.013, <i>P</i>=0.022), rs10983951 (<i>P</i>=0.009 2, <i>P</i>=0.007 6), rs117227387 (<i>P</i>=0.009 2, <i>P</i>=0.007 6), rs3758250 (<i>P</i>=0.009 2, <i>P</i>=0.007 6), and rs116899397 (<i>P</i>=0.009 2, <i>P</i>=0.007 6) were significantly associated with NSCLO and NSCPO; rs13292899 (<i>P</i>=0.008 5), rs74606599 (<i>P</i>=0.008 3), rs143226042 (<i>P</i>=0.008 3), and rs117236550 (<i>P</i>=0.01) were associated with the occurrence of NSCLO; and rs12343182 (<i>P</i>=0.008 7), rs10119760 (<i>P</i>=0.012), rs10113907 (<i>P</i>=0.012), and rs13299924 (<i>P</i>=0.012) were associated with the occurrence of NSCPO.</p><p><strong>Conclusions: </strong>This study found a new susceptible SNP rs13292899 of the FOXE1 gene that is closely associated with NSCL/P and NSCLO subtype and 13 other SNPs associated with NSCLO or NSCPO.</p>","PeriodicalId":94028,"journal":{"name":"Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology","volume":"43 1","pages":"28-36"},"PeriodicalIF":0.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11917515/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143018898","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Three-dimensional finite element feature analysis of the mandible and morphology and position of temporomandibular joint in patients with unilateral and bilateral molar scissor bite.","authors":"Tianhao Chu, Xueying Zhang, Haocheng Wang, Haojie Ma, Yuanyuan Liu","doi":"10.7518/hxkq.2024.2024169","DOIUrl":"10.7518/hxkq.2024.2024169","url":null,"abstract":"<p><strong>Objectives: </strong>The objective of this study is to measuring the morphology and position of bilateral temporomandibular joints in patients with unilateral and bilateral molar scissor bite and simulating the deformation of the mandible during occlusion, in order to provide thesis for the diagnosis of temporomandibular joint disease in patients with unilateral and bilateral molar scissor bite.</p><p><strong>Methods: </strong>This study was a retrospective study. A total of 10 patients with unilateral molar scissor bite (the unilateral molar scissor bite group) and 10 patients with bilateral molar scissor bite (the bilateral molar scissor bite group) were selected as the experimental group, and 20 adult patients with classⅠ of angle classification of similar ages were selected as the control group. All patients underwent cone beam computed tomography scans, by measuring the width of the fossa, height of the fossa, articular eminence inclination, long axis of the condyle, minor axis of the condyle, horizontal angle of the condyle and the space of the temporomandibular joint, compare temporomandibular joint morphology and position. The three-dimensional finite element analysis of the mandible morphology was carried out to evaluate the force and deformation of the mandible by using software to simulate the occlusion of the patients. It was further explored the relationship between the force of the mandible morphology and the possible temporomandibular joint disorder symptoms of the patients.</p><p><strong>Results: </strong>Intergroup comparisons for the unilateral molar scissor bite group and left sides of the other groups revealed that the superior articular space in the group with unilateral molar scissor bite was shorter than that in the control group (<i>P</i><0.05); the long axis of the condyle in the unilateral and bilateral molar scissor bite group were both shorter than that of the control group (<i>P</i><0.05); among which the unilateral group was larger than the bilateral group, and the minor axis of the condyle in bilateral molar scissor bite group was smaller than in the control group (<i>P</i><0.05), and the unilateral and bilateral condylar groups were larger than the control group (<i>P</i><0.05); and the condylar horizontal angle in the unilateral and bilateral groups were larger than that in the control group (<i>P</i><0.05). The normal sides of the unilateral molar scissor bite group and right sides of the other groups had smaller superior articular space than the control group (<i>P</i><0.05); and the condylar long-axis in bilateral group was smaller than the control group (<i>P</i><0.05); and the normal side of the condylar short-axis unilateral group was larger than that of the bilateral condylar group. Three-dimensional finite element analysis: the condyle of patients with molar scissor bite was a concentrated area of deformation during the bite of the mandible, when the first molar occlusion of the scissors bite si","PeriodicalId":94028,"journal":{"name":"Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology","volume":"43 1","pages":"114-125"},"PeriodicalIF":0.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11917508/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143018608","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical study on deciduous fused teeth and inherited permanent teeth.","authors":"Fenfang Qiu, Shan Meng, Yangyang Chong, Xiaoli Song","doi":"10.7518/hxkq.2024.2024304","DOIUrl":"10.7518/hxkq.2024.2024304","url":null,"abstract":"<p><strong>Objectives: </strong>This study aimed to investigate the clinical characteristics of deciduous fused teeth and their inherited permanent-tooth performance type by using panoramic radiographs.</p><p><strong>Methods: </strong>A total of 14 404 panoramic radiographs of 3- to 6-year-old children with deciduous dentition were collected from January 2023 to July 2024. The incidence of deciduous fused teeth was observed, and the abnormality of permanent teeth was recorded. SPSS 24.0 software was used for statistical analysis.</p><p><strong>Results: </strong>The incidence of deciduous fused teeth was 3.06% (441/14 404). The order of dental position was as follows: mandibular deciduous incisors and cusp teeth fused (58.18%) > mandibular deciduous central and lateral incisors fused (30.91%) > maxillary deciduous central and lateral incisors fused (8.89%) > deciduous incisors and supernumerary teeth fused (2.02%). Deciduous fused teeth were found in 226 boys and 215 girls, with no significant difference between the sexes (<i>P</i>>0.05). We observed one pair (87.76%, 387/441) and two pairs (12.24%, 54/441) of fused teeth (54/441), respectively. A total of 287 pairs of fusion teeth on the right side more than 208 pairs on the left side, and the difference between them was statistically significant (<i>P</i><0.01). More fusion teeth existed in mandibular deciduous teeth (443 pairs) than in maxillary ones (54 pairs), and the difference between them was statistically significant (<i>P</i><0.01). More unilateral deciduous teeth (387 subjects) were found than bilateral ones (54 subjects), and the difference between them was statistically significant (<i>P</i><0.01). Three types of deciduous fused teeth with inherited permanent teeth were observed as follows: 1) 49.49% (245/495) of inherited permanent teeth was absent, 2) 46.67% (231/495) of inherited permanent teeth was not absent, and 3) the number of fused permanent teeth accounted for 3.84% (19/495).</p><p><strong>Conclusions: </strong>The incidence of deciduous fused teeth was 3.06%, mostly occurring in the lower anterior teeth region, with no gender difference. One pair of fused teeth is commonly observed, more often on the right than the left. These fusions occur more frequently in the mandible than the maxillary, and unilateral cases are more common than bilateral ones. Deciduous fused teeth had a certain impact on inherited permanent teeth. Pediatric dentists should pay attention to and closely observe whether any abnormality exists in the permanent dentition for early detection to prevent the harm caused by deciduous fused teeth.</p>","PeriodicalId":94028,"journal":{"name":"Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology","volume":"43 1","pages":"92-97"},"PeriodicalIF":0.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11917516/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143018907","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation and analysis of efficacy in bisphosphonate treatment of chronic nonbacterial osteomyelitis.","authors":"Dandan Li, Zhujun Yu, Cheng Nie, Zixin Zou, Jianli Wang","doi":"10.7518/hxkq.2024.2024241","DOIUrl":"10.7518/hxkq.2024.2024241","url":null,"abstract":"<p><strong>Objectives: </strong>This study aimed to analyze the influence of drug factors on the efficacy of bisphosphonate for chronic nonbacterial osteomyelitis to provide a reference for clinical treatment and promote clinical rational drug use by evaluation of effectiveness and safety of bisphosphonate treatment of chronic nonbacterial osteomyelitis.</p><p><strong>Methods: </strong>Literature on the treatment of chronic nonbacterial osteomyelitis by using bisphosphonate was collected and analyzed from PubMed, Medline, Embase, Cochrane, ISI Web of Knowledge, CNKI, VIP, and Wanfang databases.</p><p><strong>Results: </strong>A total of 489 cases were collected, with an average complete response rate of clinical presentation, laboratory tests and imaging findings of 80.37%, 80.56% and 79.22%, respectively. Except for opadronate, risedronate, ibandronate, pamidronate, alendronate, neidronate and zoledronate showed good efficacy, and the average complete response rates were 100%, 100%, 81.64%, 87.50%, 69.23% and 69.23%, respectively.The study found that in the pamidronate group, the average complete response rate of 0.5-1 mg/kg (maximum single dose≤60 mg) subgroup and the frequency of administration once every 3 months subgroup were better than other subgroups.</p><p><strong>Conclusions: </strong>Bisphosphonate could be used to treat chronic nonbacterial osteomyelitis, which of efficacy were affected by different drug types, dose and frequency of administration. The optimal dose and frequency of administration of pamidronate were 0.5-1 mg/kg (maximum single dose≤60 mg) and once every 3 months, respectively.</p>","PeriodicalId":94028,"journal":{"name":"Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology","volume":"43 1","pages":"98-105"},"PeriodicalIF":0.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11917513/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143018928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Non-static Stafne bone cavity: a case report.","authors":"Pingfan Wu, Linlin Chen","doi":"10.7518/hxkq.2024.2024228","DOIUrl":"10.7518/hxkq.2024.2024228","url":null,"abstract":"<p><p>Stafne bone cavity, also known as static bone cavity, is a rare bony defect on the lingual side of the mandible. It rarely shows progressive changes, and requires only follow-up bservation. This article described a case of progressive enlargement of a Stafne bone cavity and analyzed the causes of its progress by reviewing relevant literature.</p>","PeriodicalId":94028,"journal":{"name":"Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology","volume":"43 1","pages":"140-143"},"PeriodicalIF":0.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11917505/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143017728","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hierarchical evolution of bone biomimicry and osteo-coagulo-immunomodulation induced by the size of biological hydroxyapatite.","authors":"Jieyun Xu, Yuan Zhao, Haozhou Liu, Jingyuan Yin, Zetao Chen","doi":"10.7518/hxkq.2024.2024315","DOIUrl":"10.7518/hxkq.2024.2024315","url":null,"abstract":"<p><p>Biological hydroxyapatite (BHA) is widely used in the treatment of clinical bone defects due to its good biocompatibility and osteoconductivity. The clinical application of mateiral size is based on the principle of bone defect area adaptation, which contributes to diversity of BHA sizes. However, different sizes correspond to different hierarchical levels of bone biomimicry. As the size changes, the bone biomimicry hierarchy evolves accordingly and influences the process of bone repair and regeneration through osteo-coagulo-immunomodulation, leading to unstable bone graft outcomes. Therefore, this paper reviews the size effect of clinical BHA, analyzes the multilevel structure of natural bone, proposes the evolution of bone biomimetic hierarchy triggered by the size of BHA, and further analyzes the size-media-ted osteo-coagulo-immunomodulation. Based on the hierarchical levels of bone and its osteo-coagulo-immunomodulation effect, we provide a new understanding of the biological principle of the size effect of biomaterials and a theoretical basis for the basic research and clinical application of different size BHA materials.</p>","PeriodicalId":94028,"journal":{"name":"Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology","volume":"42 6","pages":"706-715"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11669920/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142752684","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical study of the effect of the metal precrown restoration in the first deciduous molar on the composite resin filling in the second deciduous molar.","authors":"Chunxian Wang, Yu Zhang","doi":"10.7518/hxkq.2024.2024189","DOIUrl":"10.7518/hxkq.2024.2024189","url":null,"abstract":"<p><strong>Objectives: </strong>The effect of metal precrown restoration of distal proximal maxillofacial caries in the first deciduous molar on the composite resin filling of mesio-adjacent maxillofacial caries in the second deciduous molar was investigated.</p><p><strong>Methods: </strong>A total of 80 children aged 4-8 who visited our clinic were selected, and 120 teeth were examined. Two consecutive deciduous molars in one jaw were considered a single case when the distal proximal maxillary surface of the first deciduous molar and the mesial proximal maxillary surface of the second deciduous molar simultaneously had caries. The teeth were randomly divided into two groups: group A (68 cases), in which the first and second molars were repaired with composite resin, and group B (52 cases), in which the first deciduous molar was repaired with metal precrown after composite resin filling and the second deciduous molar was filled with composite resin. The two groups were compared in terms of the success rate of composite resin filling in the second deciduous molar.</p><p><strong>Results: </strong>At 3 months, no significant difference (<i>P</i>>0.05) was found between groups A (92.65%) and B (96.15%). At 6 months, no significant difference (<i>P</i>>0.05) was observed between groups A (89.71%) and B (94.23%). At 12 months, statistically significant difference (<i>P</i><0.05) was found between groups A (73.53%) and B (88.46%); At 24 months, statistically significant difference (<i>P</i><0.05) was found between groups A (66.18%) and B (86.54%).</p><p><strong>Conclusions: </strong>Compared with composite resin filling of the first deciduous molar, the metal precrown restoration of the first deciduous molar can improve the success rate of composite resin filling of the second deciduous molar.</p>","PeriodicalId":94028,"journal":{"name":"Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology","volume":"42 6","pages":"773-777"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11669937/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142752629","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Construction and verification of prediction model for postoperative hypokalemia in patients with oral cancer.","authors":"Guangman Wang, Xiaoqin Bi, Xiaoxue Tang","doi":"10.7518/hxkq.2024.2024130","DOIUrl":"10.7518/hxkq.2024.2024130","url":null,"abstract":"<p><strong>Objectives: </strong>This study aimed to explore the risk factors of postoperative hypokalemia in patients with oral cancer and to provide a basis for preventing and controlling postoperative hypokalemia.</p><p><strong>Methods: </strong>We included 366 patients undergoing oral cancer surgery in the Department of Head and Neck Oncology, West China Hospital of Stomatology, Sichuan University from January 2022 to August 2022. Univariate and multivariate analyses were used to determine the risk factors of postoperative hypokalemia. The receiver operation characteristic (ROC) curve was used to quantify the effectiveness of the factors. A nomogram of the risk factors for postoperative hypokalemia in oral cancer patients was developed and validated.</p><p><strong>Results: </strong>A total of 224 patients (61.20%) had postoperative hypokalemia, the lowest serum potassium level (3.50±0.35) mmol/L on the 4th day after surgery, and the highest incidence of hypokalemia (54.68%). Variables with <i>P</i><0.05 in the univariate analysis were quantified by ROC curve followed by multivariate logistic regression analysis. Results showed an independent correlation with postoperative hypokalemia as follows: preoperative serum potassium<3.87 mmol/L (<i>P</i>=0.008), preoperative serum calcium<2.31 mmol/L (<i>P</i>=0.033), preoperative PNI<49.16 (<i>P</i>=0.032), postoperative drainage volume>264.25 mL (<i>P</i>=0.002). The above variables were constructed into a postoperative hypokalemia risk nomogram and verified, and a good degree of fit was found.</p><p><strong>Conclusions: </strong>The independent risk factors for postoperative hypokalemia in patients with oral cancer were as follows: preoperative serum potassium<3.87 mmol/L, preoperative serum calcium<2.31 mmol/L, preoperative PNI<49.16, and postoperative drainage volume>264.25 mL. Clinical attention should be paid to managing the above high-risk patients. Preventive potassium supplementation should be performed as soon as possible to reduce hypokalemia occurrence.</p>","PeriodicalId":94028,"journal":{"name":"Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology","volume":"42 6","pages":"778-786"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11669922/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142752631","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Role of fatty acid metabolism-related genes in periodontitis based on machine learning and bioinformatics analysis.","authors":"Yuxiang Chen, Anna Zhao, Haoran Yang, Xia Yang, Tingting Cheng, Xianqi Rao, Ziliang Li","doi":"10.7518/hxkq.2024.2024214","DOIUrl":"10.7518/hxkq.2024.2024214","url":null,"abstract":"<p><strong>Objectives: </strong>This study aims to investigate the role of genes related to fatty acid metabolism in periodontitis through machine learning and bioinformatics methods.</p><p><strong>Methods: </strong>Periodontitis datasets GSE10334 and GSE-16134 were downloaded from the GEO database, and the fatty acid metabolism-related gene sets were obtained from the GeneCards database. Differentially expressed fatty acid metabolism-related genes (DEFAMRGs) in periodontitis were screened using the \"limma\" R package. Functional enrichment and pathway analyses were conducted. Recursive Feature Elimination, Least Absolute Shrinkage and Selection Operator, and Boruta algorithm were used to determine hub DEFAMRGs and construct diagnostic models with internal and external validation. Subtypes of periodontitis related to hub DEFAMRGs were constructed using consistency clustering analysis. CIBERSORT was used to analyze immune cell infiltration in gingival tissues and explore the correlation between hub DEFAMRGs and immune cells.</p><p><strong>Results: </strong>A total of 113 periodontitis DEFAMRGs were screened out as a result. The enrichment analysis results indicate that DEFAMRGs are mainly associated with immune inflammatory responses and immune cell chemotaxis.Finally, 8 hub DEFAMRGs (BTG2, CXCL12, FABP4, CLDN10, PPBP, RGS1, LGALSL, and RIF1) were identified and a diagnostic model (AUC=0.967) was constructed, based on which periodontitis was divided into two subtypes. In addition, there is a significant correlation between hub DEFAMRGs and different immune cell populations, with mast cells and dendritic cells showing higher correlation.</p><p><strong>Conclusions: </strong>This study provides new insights and ideas for the occurrence and development mechanism of periodontitis and proposes a diagnostic model based on hub DEFAMRGs to provide new directions for diagnosis and treatment.</p>","PeriodicalId":94028,"journal":{"name":"Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology","volume":"42 6","pages":"735-747"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11669931/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142752717","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of symmetrical bone repair of nasal alar base on nasal deformity after unilateral cleft lip surgery.","authors":"Jiaqi Jian, Bingshuai Jing, Chao Yang, Bing Shi, Chenghao Li","doi":"10.7518/hxkq.2024.2024074","DOIUrl":"10.7518/hxkq.2024.2024074","url":null,"abstract":"<p><strong>Objectives: </strong>This study aimed to compare the impacts of undertaking symmetrical bone repair of the nasal alar base combined with nasolabial deformity repair versus nasolabial deformity repair alone on the improvement in nasal deformity of patients with unilateral cleft lip and alveolar cleft.</p><p><strong>Methods: </strong>Fifty patients presenting with unilateral cleft lip and alveolar cleft were evaluated. Among them, 20 underwent nasolabial deformity repair solely (non-bone grafting group), whereas 30 patients received bone repair in conjunction with nasolabial deformity repair (bone-repair group). Preoperative measurements and one-year follow-up results were assessed through photographic anthropometric analysis. According to the Farkas anthropometric standard, the nasal anatomic landmarks were located, and 10 nostril indicators were measured. The operative effects of two groups were compared.</p><p><strong>Results: </strong>In contrast to the non-bone-grafting group, the nasal deformity of patients in the bone-repair group demonstrated significant improvement one year post-operation. The symmetry parameters of the nasal columella more closely approximated 1, the columella deviation angle more closely approached 90°, and the sub-alare inclination angle and the inclination angle of the nasal alar were smaller (<i>P</i><0.05).</p><p><strong>Conclusions: </strong>The accomplishment of symmetrical bone repair of the nasal alar base is conducive to enhancing nasal deformity after cleft-lip surgery in patients with unilateral cleft lip and alveolar cleft. This strategy has a positive influence on nasal symmetry, the morphology of the nasal alar, and nasal base deformity.</p>","PeriodicalId":94028,"journal":{"name":"Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology","volume":"42 6","pages":"748-754"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11669919/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142752681","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}