Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology最新文献

{"title":"[Screening of potential bioactive constituents in wall-broken <i>Ganoderma lucidum</i> spore powder for promoting ulcer healing].","authors":"Juan Liu, Jiaqi Wang, Yuan Li, Yuyi Cong, Xiaobing Guan","doi":"10.7518/hxkq.2026136","DOIUrl":"10.7518/hxkq.2026136","url":null,"abstract":"<p><strong>Objectives: </strong>To screen and validate the activity of potential therapeutic substances in wall-broken <i>Ganoderma lucidum</i> spore powder (BGLSP) for promoting ulcer healing.</p><p><strong>Methods: </strong>The potential active components of BGLSP were screened through network pharmacology combined with molecular docking and verified via the cell counting kit(CCK)-8 assay, cell scratch assay, and a rat oral ulcer model.​.</p><p><strong>Results: </strong>Network pharmacology revealed that 25 compounds in BGLSP exert prohealing effects through multiple targets and pathways. Molecular docking identified seven compounds with strong binding affinity. On the basis of their relative contents in BGLSP, ganoderic acid A (GAA) and ganoderic acid G (GAG) were identified as the key potential active constituents promoting ulcer healing. At low concentrations, GAA and GAG showed no cytotoxicity. GAA promoted the migration of human primary gingival fibroblasts in a concentration-dependent manner, whereas GAG showed a promotive effect only at 2.5 µmol/L. GAA and GAG enhanced collagen deposition and angiogenesis in rat oral ulcers, accelerating healing. GAA demonstrated a good effect at low concentrations in the early stage of ulcer healing but a superior effect at high concentrations in the later stage of ulcer healing, whereas GAG exhibited a concentration-dependent promotive effect. <b>Conclusion​​</b> BGLSP promotes ulcer hea-ling through multicomponent, multitarget, and multipathway synergistic effects. GAA and GAG, as potential active constituents of BGLSP, play important roles in the early hea-ling of oral ulcers.</p>","PeriodicalId":94028,"journal":{"name":"Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology","volume":"44 4","pages":"508-518"},"PeriodicalIF":0.0,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13458852/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148709117","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Correlation between abnormal jaw movement dominated by the lateral pterygoid muscle and symptoms of temporomandibular joint disorder: a retrospective analysis].","authors":"Jinsheng Lin, Dai Wang, Jianzhao Chen, Shan Shen","doi":"10.7518/hxkq.2025294","DOIUrl":"10.7518/hxkq.2025294","url":null,"abstract":"<p><strong>Objectives: </strong>To explore whether the difference in mandibular motor function related to the lateral pterygoid muscle is associated with pain and clicking in the temporomandibular joint based on clinical data.</p><p><strong>Methods: </strong>Outpatient data from January 2022 to August 2025 were collected, and the basic information, joint symptoms, and diagnostic criteria for temporomandibular joint disorder (DC/TMD) of the patients were statistically analyzed. Patients were grouped according to their chief symptoms, and the chi-square test was used to explore whether the chief symptoms were correlated with age and gender. The Mann-Whitney U test was used to examine whether there were differences in lateral movement ability between different genders, and the Kruskal-Wallis H test was used to examine whether there were differences in lateral movement ability between different age groups. Patients were grouped according to whether they had pain, and the Mann-Whitney U test was used to examine whether pain was correlated with lateral movement ability. Binary logistic regression analysis was used to further explore the degree of correlation between joint pain and lateral movement imbalance. Patients were grouped according to different painful sides and relatively restricted sides, and the chi-square test was used to explore the correlation between the two. Multivariate logistic regression analysis was used to further explore the interaction between painful side and relatively restricted side.</p><p><strong>Results: </strong>There was no statistically significant difference between the patient's age, gender, and main symptoms or lateral mobility; there was a statistical difference between the difference in lateral mobility and joint pain; there was a statistical difference between gender and mandibular protrusion ability; relative limitation on one side was a significant predictor of unilateral joint pain, but there was no specific side-specific combination association between the two; there was no statistical correlation between age, gender, and relative limitation on one side and bilateral joint pain.</p><p><strong>Conclusions: </strong>Abnormal lateral movement has clinical significance in the early diagnosis of temporomandibular joint disorder. The gender-specific incidence of temporomandibular joint disorder may be related to the difference in forward movement ability. The bilateral muscle imbalance reflected by lateral movement imbalance should be taken seriously as a risk factor for joint pain.</p>","PeriodicalId":94028,"journal":{"name":"Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology","volume":"44 4","pages":"586-593"},"PeriodicalIF":0.0,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13458845/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148708992","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Technical specification and consensus on routine oral health examinations for adults].","authors":"","doi":"10.7518/hxkq.2025509","DOIUrl":"10.7518/hxkq.2025509","url":null,"abstract":"<p><p>China has a large number of patients but a low rate of medical advice-seeking in oral diseases, leading to difficulties in the prevention and treatment of oral diseases. This situation calls for basic oral health examinations, which would increase the public awareness of oral health and fundamentally enhance the effectiveness of comprehensive prevention and control of oral diseases. As a risk-driven primary care service, oral health examination achieves early war-ning, comorbidity management, and resource optimization through standardized protocols. This program enables the early detection and diagnosis of oral diseases, facilitating timely intervention and improving the oral health status of the public. To standardize the flowchart of oral health examinations and ensure the technical results of the examinations conducted by different examination institutions, this study forms an expert consensus on the technical specification of routine oral health examinations for adults. This consensus, which includes oral examination items, oral examination elements, management of abnormal results and follow-up dental cares, provides standardized guidelines for dentists and dental medical institutions, the keystones in the development of prevention and control network for oral diseases, to conduct routine oral health examinations.</p>","PeriodicalId":94028,"journal":{"name":"Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology","volume":"44 4","pages":"550-560"},"PeriodicalIF":0.0,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13458883/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148709103","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Preface to the column: advances in oral medicine].","authors":"Jianli Wang","doi":"10.7518/hxkq.20260002","DOIUrl":"10.7518/hxkq.20260002","url":null,"abstract":"","PeriodicalId":94028,"journal":{"name":"Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology","volume":"44 4","pages":"461"},"PeriodicalIF":0.0,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13458853/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148709129","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Interpretation of the American Dental Association practice guidelines for the management of acute dental pain with pharmacotherapy (2023-2024) and its clinical implications for China].","authors":"Dianhong Zhao, Liguang Zheng","doi":"10.7518/hxkq.2026172","DOIUrl":"10.7518/hxkq.2026172","url":null,"abstract":"<p><p>Acute toothache is a common dental emergency. In 2023 and 2024, the American Dental Association successively issued evidence‑based clinical practice guidelines for the pharmacologic management of acute dental pain in children, adolescents, adults, and older adults, establishing a new system that prioritizes nonsteroidal anti‑inflammatory drugs, strictly limits opioids, and implements age‑specific precise management. This article systematically interprets the evidence‑based foundation and age‑specific medication regimens of the guidelines. By integrating relevant Chinese diagnostic and treatment standards, expert consensuses, and the National Essential Medicines List, it explores localized implementation pathways from the perspectives of drug accessibility, prescribing habits, policy alignment, and primary healthcare resource allocation. It proposes age‑stratified analgesic regimens suitable for China and provides actionable recommendations for evidence‑based training, multidisciplinary collaboration, patient education, and pharmaceutical supervision. This article aims to provide Chinese dentists with a decision‑making reference for the pharmacological treatment of acute toothache that incorporates the latest international evidence and local realities, thereby promoting standardized and scientific acute oral pain management in China.</p>","PeriodicalId":94028,"journal":{"name":"Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology","volume":"44 4","pages":"462-471"},"PeriodicalIF":0.0,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13458855/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148709100","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Characteristics of adverse drug reaction in 403 cases from a specialty stomatology hospital].","authors":"Jiao Yue, Bin Feng, Jing Huang, Yanfei Ma, Xiaojuan Xue, Yihuan Liu, Yao Lin, Shuibing Liu","doi":"10.7518/hxkq.2026074","DOIUrl":"10.7518/hxkq.2026074","url":null,"abstract":"<p><strong>Objectives: </strong>To analyze the characteristics of adverse drug reaction (ADR) in a specialized stomatology hospital and thus provide references for clinical rational drug use and risk management.</p><p><strong>Methods: </strong>A total of 403 ADR cases reported to the military ADR monitoring system by the School of Stomatology, The Fourth Military Medical University from January 2022 to December 2025 were collected. Descriptive statistical and Pareto chart analyses were conducted by using Excel 2019.</p><p><strong>Results: </strong>ADR reports were predominantly submitted by pharmacists (91.32%). The proportion of male patients was slightly higher than that of females (53.35% vs. 46.65%). Patients aged 41-60 years accounted for the highest proportion (37.72%) of cases. Intravenous administration was the most common route (60.79%). The main drug categories causing ADR were anti-infective (31.02%), antineoplastic (28.78%), and immune system (18.36%) agents. ADR primarily involved the digestive system (32.75%), skin, and appendages (29.53%). Three new ADR cases and 10 severe ADR cases, with all cases involving multiple drug categories, were reported.</p><p><strong>Conclusions: </strong>ADR in specialized stomatology hospitals exhibit certain specialty-specific characteristics, and high-risk drugs predominate. Although the incidence of severe ADR is low, enhanced monitoring is still required. Establishing an ADR early warning system for stomatology hospitals, promoting multidisciplinary collaboration, and improving clinical medication safety are recommended.</p>","PeriodicalId":94028,"journal":{"name":"Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology","volume":"44 4","pages":"499-507"},"PeriodicalIF":0.0,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13458885/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148709020","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Preparation of B@PH/GM-V hydrogel microspheres and their antioxidant and osteogenesis-promoting effects].","authors":"Yankun Feng, Yuanrong Liu, Mi Shen, Junli Sun, Binwei Liu, Zhenzhen Lin, Cancan Lu, Jincai Guo","doi":"10.7518/hxkq.2026139","DOIUrl":"10.7518/hxkq.2026139","url":null,"abstract":"<p><strong>Objectives: </strong>This study constructed bone morphogenetic protein 2-loaded polydopamine heparin nanoparticles (B@PH NPs) and vanillin methacrylate (VMA)-grafted GelMA hydrogel microspheres (B@PH/GM-V) and evaluated their physicochemical properties and regulatory effects on osteogenic differentiation under oxidative stress.</p><p><strong>Methods: </strong>B@PH NPs were prepared through oxidative self-polymerization, and B@PH/GM-V microspheres were fabricated via microfluidic technology. The materials were characterized by using scanning electron microscope, Fourier transform infrared spectrometer (FTIR), and energy-dispersive X-ray spectroscopy (EDS). Swelling, degradation, and drug release behaviors were evaluated. Biocompatibility was assessed through the CCK-8 assay and live/dead staining by using MC3T3-E1 cells. Intracellular reactive oxygen species (ROS) levels were detected with 2',7'-dichlorodihydrofluorescein diacetate (DCFH-DA) probes, and osteogenic differentiation capacity was evaluated through alkaline phosphatase and alizarin red S staining.</p><p><strong>Results: </strong>The average diameters of B@PH NPs and B@PH/GM-V microspheres were approximately 288.2 nm and 499.1 μm, respectively. FTIR and EDS confirmed successful modification with heparin and VMA. B@PH NPs showed favorable sustained release performance. B@PH/GM-V exhibited good biocompatibility, significantly reduced the ROS levels induced by lipopolysaccharide and H₂O₂, and promoted the differentiation and mineralization of MC3T3-E1 cells.</p><p><strong>Conclusions: </strong>B@PH/GM-V hydrogel microspheres possess good biocompatibility, antioxidant activity, and osteogenic effects, showing promising potential for periodontitis-related alveolar bone regeneration.</p>","PeriodicalId":94028,"journal":{"name":"Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology","volume":"44 4","pages":"519-529"},"PeriodicalIF":0.0,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13458851/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148709167","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Oral mucosal administration].","authors":"Tiannan Liu, Jiang Liu, Hang Zhao","doi":"10.7518/hxkq.2026143","DOIUrl":"10.7518/hxkq.2026143","url":null,"abstract":"<p><p>Oral mucosal administration (OMA) can circumvent hepatic first-pass metabolism and avoid gastrointestinal degradation while offering advantages, such as a rapid onset of action, noninvasiveness, and convenience, positioning it as an important complementary and alternative route to conventional oral and parenteral administration. How-ever, the dynamic and moist environment of the oral cavity leads to inadequate formulation adhesion, substantial drug permeation barriers across the mucosa, and suboptimal controlled-release precision. These limitations have driven the development of oral mucosal drug delivery systems (OMDDSs). This paper systematically summarizes the structural and physiological characteristics of the oral mucosa and dissects the core advantages and major challenges of OMA. It further comments on the research progress and application status of various OMDDSs, including tablets, nanoparticles, hydrogels, patches/films, and microneedles, as well as their clinical application in the management of local oral diseases and systemic disorders. Finally, it discusses future directions, such as artificial intelligence-assisted design, breakthroughs in macromolecular delivery, standardized evaluation systems, and theranostic integration, to provide theoretical references and innovative insights for the rational design and clinical translation of novel OMDDSs.</p>","PeriodicalId":94028,"journal":{"name":"Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology","volume":"44 4","pages":"472-485"},"PeriodicalIF":0.0,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13458848/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148709097","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Analysis of dental caries characteristics and influencing factors based on structural equation modeling among primary and secondary school students in Hunan Province].","authors":"Jialin Wan, Yaqing Tan, Lixi Qin, Kexin Li, Jiayou Luo, Miyang Luo, Fei Wang","doi":"10.7518/hxkq.2025277","DOIUrl":"10.7518/hxkq.2025277","url":null,"abstract":"<p><strong>Objectives: </strong>This study explores the differences in the characteristics and influencing factors of dental ca-ries in primary and secondary school students in Hunan Province, aiming to prevent and control dental caries.</p><p><strong>Methods: </strong>The multistage stratified cluster random sampling method was used to select 265 985 primary and secondary school students across Hunan. Participants completed a nationally standardized questionnaire and underwent physical examinations. Statistical description was used to analyze caries characteristics, and structural equation modeling was used to analyze influencing factors.</p><p><strong>Results: </strong>The caries prevalence rate of primary school students was 69.60%, and the decayed, missing, filled teeth (DMFT) index was 3.05±3.30; for secondary school students, the figures were 54.30% and 1.73±2.31, respectively. Structural equation modeling revealed that caries risk in primary and secondary school students was influenced by demographic characteristics (<i>β</i>=0.384 and -0.025), school-based prevention and control (<i>β</i>=0.033 and -0.067), dietary behavior habits (<i>β</i>=0.043 and 0.032), and family size (<i>β</i>=0.024 and 0.009). In secondary school students, psychological factors were additionally associated with caries risk (<i>β</i>=0.024).</p><p><strong>Conclusions: </strong>Dental caries prevalence and mean DMFT are high among primary and secondary students in Hunan, associated with demographic characteristics, school prevention policies, dietary and hygiene ha-bits, and household size. Targeted interventions addressing these factors are essential for preventing and controlling dental caries and promoting oral health among students.</p>","PeriodicalId":94028,"journal":{"name":"Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology","volume":"44 4","pages":"605-613"},"PeriodicalIF":0.0,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13458850/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148708987","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Medication adherence and its influencing factors in patients with oral lichen planus].","authors":"Ling Lü, Xiaoying Li, Jiongke Wang, Ning Xiao, Wanxin Sun, Hongtao Zhang, Mingjia Hu, Jia Li, Jing He","doi":"10.7518/hxkq.2025431","DOIUrl":"10.7518/hxkq.2025431","url":null,"abstract":"<p><strong>Objectives: </strong>To investigate the current medi-cation adherence status and analyze its influencing factors in patients with oral lichen planus (OLP) and thus provide a reference for developing interventions to improve medication adherence in this population.</p><p><strong>Methods: </strong>A cross-sectional survey was conducted among patients with OLP who attended the Department of Oral Medicine, West China Hospital of Stomatology, Sichuan University, between February 2023 and September 2024. Data were collected by using a general information questionnaire, a patient medication questionnaire, and the Morisky medication adherence scale (MMAS-8). Univariate analysis was first performed, and variables with <i>P</i><0.1 were included in a multiple linear regression model to adjust for interactions and potential confounding effects, assessing the effect of demographic characteristics, disease status, disease cognition, and medication behavior on medication adherence.</p><p><strong>Results: </strong>A total of 388 patients with OLP were included. The mean MMAS-8 score was 5.37, with a median of 5.75 (Q₁, Q₃: 4.00, 7.00). Medication adherence was categorized as low (MMAS-8<6) in 202 patients (52.1%), medium (6≤MMAS-8<8) in 147 patients (37.9%), and high (MMAS-8=8) in 39 patients (10.1%). Univariate analysis and multiple regression model adjustment revealed that educational level and anxiety related to long-term medication were independent negative influen-cing factors for medication adherence. By contrast, awareness of the drug abuse harm and the experience of adverse drug reactions were independent positive influencing factors.</p><p><strong>Conclusions: </strong>Medication adherence among patients with OLP is generally suboptimal. A high educational level and medication-related anxiety are risk factors for low adherence, whereas sufficient awareness of the harm of drug abuse and the actual experience of adverse drug reactions are associa-ted with good adherence. This situation suggests that differentiated patient education and increased attention to psychological intervention during treatment are necessary in clinical practice to improve medication adherence in patients OLP specifically.</p>","PeriodicalId":94028,"journal":{"name":"Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology","volume":"44 4","pages":"540-549"},"PeriodicalIF":0.0,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13458878/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148709089","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}