Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology最新文献

{"title":"[Clinical efficacy and prognostic factors of pulpotomy combined with fragment reattachment in treating complicated crown-root fractures of maxillary young permanent anterior teeth].","authors":"Xin Yang, Yuanyuan Wang, Chanchan Chen, Guicong Ding, Xinmin Liao, Zhiqing Liao","doi":"10.7518/hxkq.2025.2025130","DOIUrl":"10.7518/hxkq.2025.2025130","url":null,"abstract":"<p><strong>Objectives: </strong>This study aimed to evaluate the clinical efficacy of pulpotomy combined with fragment reattachment in treating complicated crown-root fractures of maxillary young permanent anterior teeth.</p><p><strong>Methods: </strong>A retrospective analysis of 37 cases of complicated crown-root fractures treated at Shenzhen Children's Hospital from January 2019 to December 2023 was conducted. Outcomes such as fragment retention rate, pulp survival rate, root development, and periodontal health were assessed, and the influencing factors were analyzed.</p><p><strong>Results: </strong>The fragment retention rates were 80.9% at 1 year and 69.5% at 2 years. The remaining crown height (cervical half group vs. incisal half group) emerged as a critical predictor of retention (<i>P</i><0.05, hazard ratio=7.45, 95% confidence interval: 1.28-43.48). The pulp survival rate reached 91.6% at 1 year, with no significant influencing factors identified. In cases where the fractured crown retained for over one year, teeth at Nolla stage 8 showed significantly greater root elongation and apical foramen narrowing compared to those at Nolla stage 9 (<i>P</i><0.05), normal periodontal scores were observed in 59.3%.</p><p><strong>Conclusions: </strong>Pulpotomy combined with fragment reattachment effectively preserves pulp vitality and restores dental function and morphology in young permanent anterior teeth. The remaining crown height serves as a key prognostic indicator for fragment retention. This approach also promotes root development and demonstrates favorable clinical outcomes.</p>","PeriodicalId":94028,"journal":{"name":"Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology","volume":"44 2","pages":"188-196"},"PeriodicalIF":0.0,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13047871/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147597011","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Retrospective analysis of localized juvenile spongiotic gingival hyperplasia].","authors":"Yanju Lin, Rongfang Cao, Rui Yao, Jianwei Shang","doi":"10.7518/hxkq.2025.2025176","DOIUrl":"10.7518/hxkq.2025.2025176","url":null,"abstract":"<p><strong>Objectives: </strong>This study aimed to review and summarize the clinical presentation and pathological features of localized juvenile spongiotic gingival hyperplasia (LJSGH) to enhance pediatric dentists' understanding of this condition.</p><p><strong>Methods: </strong>A retrospective analysis was conducted on the clinical and pathological data of patients with LJSGH diagnosed in the Department of Oral Pathology, Tianjin Stomatological Hospital from January 2019 to December 2024.</p><p><strong>Results: </strong>Twelve cases were retrieved, the male-to-female ratio was 1.4∶1, and nine of the cases were children and adolescents (<18 years old). The typical clinical presentation was characterized by erythematous, hyperplastic gingiva exhibiting a papillary or granular appearance. The lesion was predominantly solitary and primarily located on the labial gingiva of the maxillary anterior region. The typical histopathological features were as follows: the superficial epithelium of the lesional area consisted of nonkeratinized stratified squamous epithelium with intercellular edema and spongiosis; irregular elongation of rete ridges; neutrophil infiltration in the superficial epithelial layer; marked vascular dilation and congestion in the subepithelial papillary layer; and a distinct boundary between the lesional epithelium and adjacent normal mucosal epithelium. CK19 exhibited strong positive expression throughout the lesion epithelium. By contrast, only the basal layer showed a strong positive expression in normal gingival tissues.</p><p><strong>Conclusions: </strong>LJSGH exhibits distinctive clinical features, and its diagnosis can be confirmed through histopathological examination. The fin-dings of this study contribute to enhancing pediatric dentists' understanding and recognition of LJSGH.</p>","PeriodicalId":94028,"journal":{"name":"Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology","volume":"44 2","pages":"259-265"},"PeriodicalIF":0.0,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13047890/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147597126","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Clinical symptoms and cone beam computed tomography imaging analysis of patients with temporomandibular joint osteoarthritis with chewing side preference before and after treatment of stabilization splint].","authors":"Xiaoxing Li, Jiazhu Wang, Laiqing Xu, Xinyu Xu, Hongbo Li, Min Hu, Hongchen Liu, Hua Jiang","doi":"10.7518/hxkq.2026.2025360","DOIUrl":"10.7518/hxkq.2026.2025360","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Objectives: &lt;/strong&gt;This study aimed to explore the clinical efficacy of stabilization splint (SS) and the characteristics of cone beam computed tomography (CBCT) imaging changes by analyzing the CBCT images and clinical symptoms of patients with temporomandibular joint osteoarthritis (TMJOA) complicated with chewing side preference before and after treatment with SS. Me⁃thods A retrospective analysis was conducted on 74 TMJOA patients (aged 18-40 years) who visited the Department of Stomatology, First Medical Center, Chinese PLA General Hospital from June 2021 to January 2025. Among them, 31 patients had no chewing side preference (mean age: 29.81±2.99 years), and 43 patients had chewing side preference (mean age: 30.88±5.65 years). The CBCT imaging features and clinical symptoms of the two groups at the initial visit and follow-up (6 months later) were observed and analyzed. SPSS 27.0 software was used for data analysis.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;Comparison of patients without chewing side preference before and after SS treatment: the incidence of pain decreased from 100% to 3.23%, limited mouth opening from 96.77% to 3.23%, and joint noise from 80.65% to 38.71%, with statistically significant differences (&lt;i&gt;P&lt;/i&gt;&lt;0.05). CBCT showed that the ipsilateral posterior joint space and superior joint space increased significantly (&lt;i&gt;P&lt;/i&gt;&lt;0.05), whereas no significant differences were observed in the temporomandibular joint (TMJ) indices between the two sides (&lt;i&gt;P&lt;/i&gt;&gt;0.05). Comparison of patients with chewing side preference before and after SS treatment: the incidence of pain decreased from 100% to 4.65%, limited mouth opening from 88.37% to 2.33%, and joint noise from 79.07% to 39.53%, with statistically significant differences (&lt;i&gt;P&lt;/i&gt;&lt;0.05). CBCT showed that the medial-lateral diameter of the condyle, anterior-posterior diameter of the condyle, intra-articular space, posterior joint space, superior joint space, slope of the articular eminence, and condylar height on the habitual chewing side increased significantly (&lt;i&gt;P&lt;/i&gt;&lt;0.05). Moreover, the medial-lateral diameter of the condyle, anterior-posterior diameter of the condyle, intra-articular space, posterior joint space, and superior joint space on the non-habitual chewing side increased significantly (&lt;i&gt;P&lt;/i&gt;&lt;0.05). The posterior joint space, intra-articular space, and condylar height on the habitual chewing side were significantly larger than those on the non-habitual chewing side (&lt;i&gt;P&lt;/i&gt;&lt;0.05). Comparison between patients with and without chewing side preference after SS treatment: no significant differences were found in pain, limited mouth opening, and joint noise between the two groups (&lt;i&gt;P&lt;/i&gt;&gt;0.05).&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusions: &lt;/strong&gt;SS is effective in treating patients suffering from TMJOA with or without chewing side preference because it can effectively relieve joint pain, significantly improve mouth opening, and reduce the incidence of joint noise to a cer","PeriodicalId":94028,"journal":{"name":"Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology","volume":"44 2","pages":"266-276"},"PeriodicalIF":0.0,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13047861/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147597181","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Comparative analysis of microbial communities in different oral ecological niches of preschool children].","authors":"Jiajia Liu, Yuhui Sun, Juefei Wu, Shuai Tang, Gang Ding","doi":"10.7518/hxkq.2025.2025285","DOIUrl":"10.7518/hxkq.2025.2025285","url":null,"abstract":"<p><strong>Objectives: </strong>This study aims to investigate the structural differences, dominant bacterial genera, and potential functions of microbial communities in different oral ecological niches (dorsal tongue, tooth surface, and buccal mucosa) of preschool children to clarify the influence of local microenvironments on microbial colonization and provide a theoretical basis for the microbiota-targeted regulation of pediatric oral diseases.</p><p><strong>Methods: </strong>A total of 105 plaque samples were collected from the dorsal tongue, tooth surface, and buccal mucosa of 35 healthy preschool children (aged 4-6 years). High-throughput sequencing of the 16S rRNA gene was performed to analyze the microbial community structure and alpha/beta diversity. Principal coordinate analysis, UPGMA clustering, and LEfSe analysis were used to identify niche-specific dominant genera. PICRUSt2 was applied to predict the potential metabolic functional profiles across niches.</p><p><strong>Results: </strong>Spatial hete-rogeneity in microbial composition and structure was observed across the three oral niches. Species richness was significantly higher on the tooth surface and buccal mucosa than on the dorsal tongue. The dominant phyla included Firmicutes, Actinobacteria, Proteobacteria, Bacteroidetes, Fusobacteria, and Patescibacteria. At the genus level, Actinomyces and Corynebacterium were enriched on the tooth surface, Veillonella was enriched on the dorsal tongue, and Streptococcus was predominant on the buccal mucosa. Beta diversity and clustering analyses confirmed distinct microbial community structures among the niches. LEfSe analysis identified several niche-specific genera. PICRUSt2 functional prediction revealed significant differences in amino acid metabolism, carbohydrate metabolism, cell motility, translation, signal transduction, immune system, infectious disea-ses, and membrane transport (<i>P</i><0.05).</p><p><strong>Conclusions: </strong>The dorsal tongue, tooth surface, and buccal mucosa in preschool children harbor distinct microbial communities with different taxonomic composition, diversity, and functional potential. The findings suggest that local microenvironmental factors shape oral microbiota and may contribute to the early onset of oral diseases. This study provides foundational data and theoretical insights for early microbiome-based risk assessment and personalized oral health interventions in children.</p>","PeriodicalId":94028,"journal":{"name":"Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology","volume":"44 2","pages":"197-205"},"PeriodicalIF":0.0,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13047870/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147597130","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Dihydroartemisinin inhibits the progression of oral squamous cell carcinoma].","authors":"Tianyu Shan, Jiajia Liu, Tangjun Liu, Dandan Sun, Xinwei Wang, Yunxia Liu","doi":"10.7518/hxkq.2026.2025163","DOIUrl":"10.7518/hxkq.2026.2025163","url":null,"abstract":"<p><strong>Objectives: </strong>This study aimed to explore the impact of dihydroartemisinin (DHA) on cell proliferation, migration, and invasion in oral squamous cell carcinoma (OSCC). Our findings offer a theoretical foundation for advancing the research and development of novel therapeutic agents for OSCC.</p><p><strong>Methods: </strong>Bioinformatics analysis was conducted using the cancer genome database to classify OSCC patients based on the presence or absence of extracapsular spread and metastasis in tumor tissues, and to compare the differences in survival rates among different OSCC cell lines. The cell proliferation of different OSCC cell lines treated with different DHA concentrations was detected by CCK-8 cytoto-xicity assay, and the optimal drug concentration was screened. The CCK-8 cytotoxicity assay was used to detect the cell proliferation of different OSCC cell lines (CAL27, HN30, and SCC9) after treatment with different concentrations of DHA, and to screen out the optimal drug concentration. The effects of DHA on the proliferation of OSCC cells were detected by CCK-8 cell proliferation assay and cell cloning assay. The effect of DHA on the migration and invasion ability of tumor cells was detected by scratch test and Transwell test. A nude mouse subcutaneous tumor model was constructed to study the effects of DHA on OSCC tumor tissues and major organ.</p><p><strong>Results: </strong>Bioinforma-tics analysis showed that the survival rate of patients with extracapsular spread and metastasis in tumor tissues was lower than that of patients without such phenomena (<i>P</i><0.05). According to CCK-8 cytotoxicity results, the maximum safe concentrations for different OSCC cell lines CAL27, HN30, and SCC9 were 20, 10, and 5 μmol/L, respectively. Proliferation and cloning experiments of CCK-8 cells showed that DHA could inhibit the proliferation of three squamous cell lines (<i>P</i><0.05). Scratch test and Transwell test showed that the migration and invasion levels of CAL27, HN30, and SCC9 cells were significantly decreased under DHA treatment (<i>P</i><0.05). <i>In vivo</i> experiments showed that the growth rate of tumor tissue significantly decreased after DHA treatment (<i>P</i><0.05).</p><p><strong>Conclusions: </strong>DHA exhibits significant inhibitory effects on the proliferation, migration, and invasion of various OSCC cells and growth of tumor tissues.</p>","PeriodicalId":94028,"journal":{"name":"Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology","volume":"44 2","pages":"224-231"},"PeriodicalIF":0.0,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13047856/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147597176","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Surgical robot-assisted submandibular gland excision through retroauricular hairline approach: three case reports].","authors":"Shaofei Ma, Jialu He, Chang Cao, Xiaoyi Wang, Chunjie Li, Guiquan Zhu","doi":"10.7518/hxkq.2026.2025190","DOIUrl":"10.7518/hxkq.2026.2025190","url":null,"abstract":"<p><p>Conventional submandibular gland resection is typically performed via a lateral cervical open approach, which inevitably leaves a visible scar. As a leading advancement in minimally invasive techniques, robotic-assisted surgery shows significant potential for clinical application. To date, only a limited number of robot-assisted submandibular gland resections have been reported globally, and most were conducted using the Da Vinci Surgical System. No cases involving a domestically developed Chinese robotic system have been documented in either domestic or international lite-rature. Using nearly 100 cases of endoscopic submandibular gland resection through retroauricular hairline approach as basis, we successfully performed three cases of submandibular gland resection with the assistance of a domestically developed multi-arm universal surgical robot. All procedures were completed without intraoperative conversion. Postoperative recovery was uneventful, with no complications including facial nerve palsy, tongue numbness, or impaired tongue mobility. The incisions were well concealed, achieving satisfactory aesthetic outcomes. This preliminary study demonstrates the feasibility of utilizing a Chinese-developed robotic system for submandibular gland resection.</p>","PeriodicalId":94028,"journal":{"name":"Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology","volume":"44 2","pages":"286-292"},"PeriodicalIF":0.0,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13047885/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147597145","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Three-dimensional finite element analysis of the cantilever fixed bridge restoration for mandibular central incisors supported by narrow-diameter implants].","authors":"Xinxin Zhou, Yanshuo Gong, Wei Peng, Gang Fu","doi":"10.7518/hxkq.2026.2025342","DOIUrl":"10.7518/hxkq.2026.2025342","url":null,"abstract":"<p><strong>Objectives: </strong>To investigate the biomechanical behavior of three distinct types of narrow-diameter implants (NDIs) supporting a single-cantilever fixed bridge for mandibular central incisors using three-dimensional finite element analysis.</p><p><strong>Methods: </strong>Three commonly used NDIs were selected: group Z1, Osstem one-piece implant with a dia-meter of 2.5 mm; group Z2, Anthogy Morse taper connected two-piece implant with a diameter of 2.8 mm; group Z3, Nobel Active screw-retained two-piece implant with a diameter of 3.0 mm. The three-dimensional finite-element model of cantilever fixed bridge supported by NDIs was constructed using finite element software. Vertical loads of 65 and 130 N and 45° oblique load were applied. von Mises stress of the implants and metal components, principal stress of the bone tissue, and stress distribution cloud map were calculated and analyzed.</p><p><strong>Results: </strong>Under vertical load, only Z3 group implant reached a von Mises stress peak of 1 004.5 MPa at a load of 130 N, exceeding the material's yield strength. Under the 45° oblique load, the von Mises stress peaks of all three groups of NDIs excee-ded the material's yield strength. The stress cloud map revealed that the implant neck and surrounding bone tissue were the stress concentration areas.</p><p><strong>Conclusions: </strong>All three NDIs groups proved theoretically feasible under a 65 N axial load, with this study delineating the biomechanical safety boundary and highlighting the important risks posed by excessive or oblique loading.</p>","PeriodicalId":94028,"journal":{"name":"Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology","volume":"44 2","pages":"251-258"},"PeriodicalIF":0.0,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13047853/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147597194","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Removal of a high-translucency zirconia crown with Er:YAG laser: a case report].","authors":"Jingyi Huo, Xinyuan Zhang, Wudi Jing, Jizhi Zhao, Haitao Dong","doi":"10.7518/hxkq.2025.2025297","DOIUrl":"10.7518/hxkq.2025.2025297","url":null,"abstract":"<p><p>The removal of a full crown typically requires considerable chairside time, and the interface between zirconia and resin cement in zirconia restoration is difficult to discern. A high-speed dental handpiece may damage residual dental tissue, thereby affecting the final outcome. The article presents a case after a restoration involving a fiber post, resin core, and zirconia full crown. For esthetic purposes, the removal of the full crown is necessary. An Er:YAG laser was used to completely remove the intact crown, which was then used as temporary restoration. A satisfactory esthetic result was attained after the final restoration. The case suggests that crown extraction with an Er:YAG laser is a safe and effective technique.</p>","PeriodicalId":94028,"journal":{"name":"Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology","volume":"44 2","pages":"293-298"},"PeriodicalIF":0.0,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13047862/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147597098","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Contrast-enhanced CT-based habitat radiomics for analyzing the predictive capability for oral squamous cell carcinoma].","authors":"Qilin Liu, Zhuang Liang, Shuwen Yang, Hui Dong","doi":"10.7518/hxkq.2026.2025211","DOIUrl":"10.7518/hxkq.2026.2025211","url":null,"abstract":"<p><strong>Objectives: </strong>By comparing deep learning and habitat analysis models based on contrast-enhanced CT (CECT), this study explores a novel approach to predict cervical lymph node metastasis and pathological subtypes in oral squamous cell cancer (OSCC).</p><p><strong>Methods: </strong>CECT images from patients diagnosed with OSCC by paraffin pathology were retrospectively collected. A total of 107 patients underwent primary lesion resection and cervical lymph node dissection. Region-of-interest images under CECT were divided into three regions using K-means clustering, and feature selection was performed through a fully connected neural network to construct a habitat analysis model. A clinical model was constructed using nine clinical features, including age, gender, and tumor location. With pathological subtypes and lymph node metastasis (LNM) as study endpoints, the predictive capabilities of the clinical model, deep learning model, habitat analysis model, and combined clinical + habitat model were compared using confusion matrices and receiver operating characteristic (ROC) curve.</p><p><strong>Results: </strong>The habitat-clinical combined model exhibits superior predictive performance: in the prediction of lymph node metastasis, the area under the receiver operating characteristic curve (AUC) reaches 0.97. In the prediction of pathological typing, the AUC values are 1.00 for well-differentiated type, 0.94 for moderately differentiated type, and 1.00 for poorly differentiated type. This combined model outperforms the standalone clinical and habitat models in predicting pathological typing and lymph node metastasis.</p><p><strong>Conclusions: </strong>The habitat-clinical integrated model exhibits superior predictive efficacy in evaluating LNM and pathological classification in oral carcinoma.</p>","PeriodicalId":94028,"journal":{"name":"Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology","volume":"44 2","pages":"277-285"},"PeriodicalIF":0.0,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13047860/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147597115","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Oral homeostasis imbalance under hypoxia].","authors":"Yifan Xu, Songling Wang, Jian Zhou","doi":"10.7518/hxkq.2026.2025427","DOIUrl":"10.7518/hxkq.2026.2025427","url":null,"abstract":"<p><p>Hypoxia disrupts oral homeostasis through multiple interconnected pathways, including interference with tooth germ development, impairment of salivary gland function and salivary buffering capacity, compromise of the oral mucosal barrier, imbalance in jawbone and alveolar bone remodeling, and alterations in the diversity and functionality of the oral microbiome. These disturbances collectively contribute to the onset and progression of oral diseases. Moreover, disruption of oral homeostasis may, in turn, affect systemic homeostasis, increasing the risk of disorders in other organ systems through mechanisms involving inflammatory mediator release and microbial translocation. Here, we systematically review the effects and underlying mechanisms of hypoxia exposure on oral homeostasis, and further explore the interconnections between hypoxia-induced oral dysregulation and systemic homeostatic imbalance. This review aims to provide a comprehensive understanding of the regulatory networks linking oral and systemic homeostasis under hypoxia, thereby offering potential insights for maintaining homeostatic balance.</p>","PeriodicalId":94028,"journal":{"name":"Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology","volume":"44 2","pages":"215-223"},"PeriodicalIF":0.0,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13047857/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147597166","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}