Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology最新文献

{"title":"[Case of concurrent second branchial cleft cyst and diffuse large B-cell lymphoma].","authors":"Xianyong Liu, Fang Wang, Legang Sun, Zhang Cao, Yong Yang, Honghai Fu","doi":"10.7518/hxkq.2025382","DOIUrl":"10.7518/hxkq.2025382","url":null,"abstract":"<p><p>Second branchial cleft cyst and lymphoma are two common types of neck masses. The etiology, clinical manifestations, imaging findings, treatment options, and prognosis of these two entities differ. Clinically, the occurrence of both lesions at the same anatomical site is rare. Herein, we report a case of concurrent second branchial cleft cyst and diffuse large B-cell lymphoma in the same anatomical region. The final diagnosis was confirmed by clinical features, ima-ging findings, and ultrasound-guided biopsy. The patient received the R-CHOP (rituximab, cyclophosphamide, doxorubicin, vincristine and prednisone) chemotherapy regimen combined with surgical resection and finally achieved patholo-gical complete response with a favorable prognosis. This case report aims to provide a reference for the diagnosis and treatment of similar cases.</p>","PeriodicalId":94028,"journal":{"name":"Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology","volume":"44 3","pages":"454-460"},"PeriodicalIF":0.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13268868/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148260870","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Expression of Rho-related BTB domain-containing protein 1 in tongue squamous cell carcinoma and its effect on cell proliferation, invasion, and migration].","authors":"Yu Shao, Yingju Wang, Wenyuan Yu, Yong Xu, Jin Xu, Xia Wang, Zhenggang Chen","doi":"10.7518/hxkq.2026.2025345","DOIUrl":"10.7518/hxkq.2026.2025345","url":null,"abstract":"<p><strong>Objectives: </strong>This study explored the expression of Rho-related BTB domain-containing protein 1 (Rho-BTB1) in tongue squamous cell carcinoma (TSCC) cells; its effects on TSCC cell proliferation, invasion, and migration; and the underlying molecular mechanisms.</p><p><strong>Methods: </strong>RhoBTB1 expression in TSCC was analyzed by querying a bioinformatics online database. Forty-five cases of primary TSCC lesions resected during oral and maxillofacial surgery from December 2024 to August 2025 were selected. Immunohistochemistry and Western blot were used to detect RhoBTB1 expression in TSCC tissues and adjacent tissues. Two kinds of TSCC cell lines, CAL-27 and SCC-25, were selected for <i>in vitro</i> experiments. The overexpression plasmid vector and small interfering RNA were designed on the basis of the RhoBTB1 gene sequence. TSCC cells were transiently transfected, and the transfection efficiency was evaluated by real-time quantitative polymerase chain reaction. The proliferation, invasion, migration, and apoptosis of TSCC cells were evaluated by CCK-8 assay, Transwell cell invasion assay, cell scratch assay, and flow cytometry respectively. The expression levels of RhoBTB1, Rho-related protein kinase 1 (ROCK1), phosphatase and tensin homologue (PTEN), phosphorylated phosphatase and tensin homologue (p-PTEN), protein kinase B (AKT), and phosphorylated protein kinase B (p-AKT) were analyzed by Western blot. SPSS 22.0 and GraphPad Pri 8.0 were used to analyze the experimental data.</p><p><strong>Results: </strong>RhoBTB1 expression in TSCC tissues was significantly lower than that in adjacent tissues (<i>P</i><0.05). RhoBTB1 overexpression significantly inhibited the proliferation, invasion, and migration of TSCC cells, promoted their apoptosis, down-regulated ROCK1/p-AKT, and up-regulated p-PTEN (<i>P</i><0.05); no significant difference in expression was observed between PTEN and AKT (<i>P</i>>0.05). Knockdown of RhoBTB1 yielded opposing effects, with the upregulation of ROCK1 and p-AKT and the downregulation of p-PTEN (<i>P</i><0.05). No significant differences were observed in the expression levels of PTEN and AKT (<i>P</i>>0.05).</p><p><strong>Conclusions: </strong>RhoBTB1 is lowly expressed in TSCC and may inhibit its malignant phenotype by negatively regulating the ROCK1/PTEN/AKT pathway, suggesting its potential as an oncogene and therapeutic target.</p>","PeriodicalId":94028,"journal":{"name":"Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology","volume":"44 3","pages":"422-436"},"PeriodicalIF":0.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13268861/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148260868","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Chinese introduction to the Preferred Reporting Items for Randomized Trials in Endodontics 2020 checklist].","authors":"Xiao Pang, Chang Liu, Xinxin Cui, Jiyuan Liu, Liao Wang, Jian Pan","doi":"10.7518/hxkq.2025.2025193","DOIUrl":"10.7518/hxkq.2025.2025193","url":null,"abstract":"<p><p>Randomized controlled trial (RCT) represent a type of study design wherein research subjects are randomly allocated to different groups to receive various interventions, allowing for the comparison of result differences and minimizing bias to the greatest extent possible. They are the primary source of evidence in evidence-based dentistry. Recently, an international team of dental experts has published the Preferred Reporting Items for Randomized Trials in Endodontics (PRIRATE) 2020 checklist, a set of guidelines aimed at enhancing the quality of design and reporting of RCTs contextualized to dentistry. We provide a detailed interpretation of the key items of the PRIRATE checklist, supplemented with specific examples, to promote the reporting of RCTs in China.</p>","PeriodicalId":94028,"journal":{"name":"Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology","volume":"44 3","pages":"400-410"},"PeriodicalIF":0.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13268871/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148260942","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Effect of pioglitazone on periodontitis-related renal injury in mice and its relationship with Klotho].","authors":"Yaqi Shang, Mengting Hu, Zhenzhen Che, Xinchan Liu, Yu Deng, Weixian Yu","doi":"10.7518/hxkq.2025.2025286","DOIUrl":"10.7518/hxkq.2025.2025286","url":null,"abstract":"<p><strong>Objectives: </strong>This study aims to examine the protective effect of the peroxisome proliferator-activated receptor gamma (PPAR-γ) agonist pioglitazone on renal injury linked to periodontitis in mice and to preliminarily explore the relationship between this effect and Klotho.</p><p><strong>Methods: </strong>A total of 24 eight-week-old C57 mice were randomly assigned to three groups: control (C), periodontitis (P), and pioglitazone treatment (P+Pio). Silk ligation was employed to induce experimental periodontitis around the maxillary second molars, and pioglitazone was administered through oral gavage. After eight weeks, the mice were euthanized. The maxillae were subjected to Micro-CT scanning. Periodontal and kidney tissues underwent hematoxylin and eosin, periodic acid-Schiff, and Masson's trichrome staining. Renal ultrastructure was observed using transmission electron microscopy (TEM), and malondialdehyde (MDA), superoxide dismutase (SOD), and glutathione (GSH) were measured. The levels of renal reactive oxygen species (ROS) were assessed through MitoSOX red fluorescence staining. Serum concentrations of creatinine (Cre), blood urea nitrogen (BUN), and albumin (Alb) were evaluated, in addition to urinary protein levels. The gene and protein expression levels of PPAR-γ, Klotho, phosphatidylinositol 3-kinase (PI3K), and serine/threonine kinase (AKT) were determined using quantitative reverse transcription polymerase chain reaction (qRT-PCR) and immunohistochemistry (IHC).</p><p><strong>Results: </strong>Micro-CT and periodontal histological analysis indicated substantial alveolar bone loss and heightened periodontal pocket depth in the second molar region of the P group relative to the C group. The P+Pio group exhibited reduced effects, compared with the P group. Histological examination of renal tissue and TEM revealed pathological damage in the P group. Pathological damage was alleviated in the P+Pio group. Biochemical assays and MitoSOX staining indicated that the P group demonstrated lower levels of SOD and GSH levels than the C group and increased MDA and ROS levels. Compared with the P group, the P+Pio group exhibited elevated levels of SOD and GSH and reduced levels of MDA and ROS. No notable differences were detected in Cre, BUN, and Alb levels across the groups. qRT-PCR and IHC revealed a reduction in PPAR-γ and Klotho expression levels in the renal tissues and an increase in PI3K and AKT expression levels in the P group compared with the C group. In the P+Pio group, the expression levels of PPAR-γ and Klotho were elevated relative to those of the P group, whereas expression levels of PI3K and AKT were decreased.</p><p><strong>Conclusions: </strong>Pioglitazone can alleviate renal damage associated with periodontitis in mice, and its effect may be related to the upregulation of Klotho expression.</p>","PeriodicalId":94028,"journal":{"name":"Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology","volume":"44 3","pages":"411-421"},"PeriodicalIF":0.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13268856/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148260920","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Selection of indications for apical microsurgery in different types of affected teeth].","authors":"Zuhua Wang, Yifujie Chen","doi":"10.7518/hxkq.2026087","DOIUrl":"10.7518/hxkq.2026087","url":null,"abstract":"<p><p>As dental technology advances, apical microsurgery has emerged as a vital therapeutic approach for preserving natural teeth following unsuccessful root canal treatment or nonsurgical endodontic retreatment. Its clinical application is becoming increasingly widespread, but the careful selection of surgical indications is crucial for ensuring treatment efficacy and improving the prognosis of affected teeth. This paper synthesizes existing research and clinical experience to outline core assessment criteria for surgical selection, thereby providing a reference framework for clinicians to standardize the conduct of apical microsurgery and optimize treatment decision-making.</p>","PeriodicalId":94028,"journal":{"name":"Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology","volume":"44 3","pages":"311-318"},"PeriodicalIF":0.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13268867/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148260933","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Expert consensus in Southwest China on the application of botulinum toxin type A in upper and mid-facial aesthetics].","authors":"","doi":"10.7518/hxkq.2026021","DOIUrl":"10.7518/hxkq.2026021","url":null,"abstract":"<p><p>This consensus systematically addresses the unique facial anatomical and aging characteristics of the population in Southwest China and systematically proposes an individualized injection protocol for botulinum toxin type A (BONT/A) for upper and mid-face aesthetic treatments. The protocol was tailored to the skeletal and muscular features of this regional group and incorporates precise injection techniques, dosage recommendations, and depth guidance for key upper facial areas, such as forehead lines, glabellar lines, crow's feet, nasal wrinkles, and temporalis muscle. In addition, it outlines peri‑injection assessment procedures, combined treatment strategies, and the management of adverse reactions. The aims are to provide clinicians with standardized operational guidance that aligns with regional characteristics and to enhance the safety, precision, and aesthetic outcomes of treatment.</p>","PeriodicalId":94028,"journal":{"name":"Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology","volume":"44 3","pages":"378-391"},"PeriodicalIF":0.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13268860/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148260892","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Effectiveness and cost-effectiveness of risk-based topical fluoride intervention on early childhood caries in Jiangnan District, Nanning City].","authors":"Yiling Jiang, Yuyan Li, Yishan Zhang, Fanghong Liu, Ling Li, Sicheng Deng, Yu Qin, Jinmei Yu, Rongmin Qiu","doi":"10.7518/hxkq.2025150","DOIUrl":"10.7518/hxkq.2025150","url":null,"abstract":"<p><strong>Objectives: </strong>This study aims to evaluate the clinical effectiveness and cost-effectiveness of personalized topical fluoride intervention guided by the modified caries-risk assessment tool for preschool children (PSC-MCAT) for preschool children in Jiangnan District of Nanning City and to provide evidence to support the implementation of community-based graded oral health interventions for preschooler children.</p><p><strong>Methods: </strong>A total of 198 three-year-old children from Jiangnan District, Nanning City, were recruited and randomly assigned to a test or control group. Baseline data were collected through questionnaires and oral examinations. The test group received personalized topical fluoride treatments based on caries risk levels determined using the PSC-MCAT, whereas the control group received standard fluoride varnish application every six months. After 1.5 years of follow-up, the incidence of new caries and changes in mean dmft increment were analyzed. Cost-effectiveness analysis was conducted to assess economic benefits, and sensitivity analysis was performed to evaluate result stability.</p><p><strong>Results: </strong>After 1.5 years, the test group demonstrated significantly lower caries incidence (50.9%) and △dmft (1.42±1.90) compared with the control group (68.9%, 2.74±2.92) (<i>P</i><0.05). Cost-effectiveness analysis indicated that the incremental cost to prevent one new case of caries in the test group was 559.66 yuan, which was lower than the willingness-to-pay threshold (626.77 yuan). The cost per prevented caries lesion was 153.80 yuan, which was lower than the direct treatment cost of 200.5 yuan per lesion. Sensitivity analysis indicated a 99.8% probability that the intervention is cost-effective at a willingness-to-pay of 626.77 yuan per person.</p><p><strong>Conclusions: </strong>The PSC-MCAT tool is effective and cost-effective for caries risk assessment and may serve as a practical framework for caries prevention.</p>","PeriodicalId":94028,"journal":{"name":"Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology","volume":"44 3","pages":"437-447"},"PeriodicalIF":0.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13268853/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148260925","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Current status and prospects of minimally invasive surgical treatment for anterior disc displacement without reduction in temporomandibular joint].","authors":"Rong Ren, Pinyin Cao, Nan Jiang","doi":"10.7518/hxkq.2025354","DOIUrl":"10.7518/hxkq.2025354","url":null,"abstract":"<p><p>Anterior disc displacement without reduction (ADDwoR) is the most common type of temporomandibular disorders (TMDs). Surgical intervention remains one of the most important treatment modalities for this condition. With the increasing adoption of minimally invasive surgery (MIS) concepts in oral and maxillofacial surgery, implementing MIS principles in the surgical management of ADDwoR has become crucial. This article traces the evolution of minimally invasive temporomandibular joint surgery, summarizes the current status of MIS applications in ADDwoR, and discusses future directions. It aims to provide a reference for further promoting and implementing MIS concepts in the treatment of TMDs.</p>","PeriodicalId":94028,"journal":{"name":"Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology","volume":"44 3","pages":"392-399"},"PeriodicalIF":0.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13268858/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148260944","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Application and prospect of digital technology in endodontic microsurgery].","authors":"Rui Zhang, Liuyan Meng","doi":"10.7518/hxkq.2026054","DOIUrl":"10.7518/hxkq.2026054","url":null,"abstract":"<p><p>The application of endodontic microsurgery in complex cases is often limited by difficulties in apex localization due to complex anatomical structures. The introduction of digital technologies has provided a novel approach to address this challenge. This article reviews the operational workflows, clinical application points, accuracy, key influencing factors, and clinical application considerations of static navigation, dynamic navigation, and robotic system assistance in endodontic microsurgery. Clinical cases are presented to demonstrate the successful application of digital technologies in managing complex endodontic microsurgeries, providing references for clinicians performing such cases. Furthermore, the future direction of digital technologies in endodontic microsurgery toward intelligence, standardization, and minimally invasive development is discussed.</p>","PeriodicalId":94028,"journal":{"name":"Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology","volume":"44 3","pages":"349-359"},"PeriodicalIF":0.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13268866/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148260860","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Preface to the column: cognition and practice of endodontic microsurgery].","authors":"Dingming Huang, Xiaoyan Wang, Zhengwei Huang, Ling Ye","doi":"10.7518/hxkq.20260001","DOIUrl":"10.7518/hxkq.20260001","url":null,"abstract":"","PeriodicalId":94028,"journal":{"name":"Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology","volume":"44 3","pages":"299-301"},"PeriodicalIF":0.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13268857/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148260880","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}