Experimental and therapeutic medicine最新文献

{"title":"3D-printed customized semi-restrictive elbow prosthesis for severe pseudoarthritis following comminuted fractures of the distal humerus: A case report and review.","authors":"Bo Zheng, Xiu-Li Zhang, Yu-Xiang Cheng, Ze-Bi He, Peng Li","doi":"10.3892/etm.2026.13154","DOIUrl":"10.3892/etm.2026.13154","url":null,"abstract":"<p><p>Distal humeral fractures are infrequent occurrences in clinical practice and reports of nonunion following comminuted fractures of the distal humerus, particularly those resulting in pseudarthrosis formation and severe pseudoarthritis, are exceedingly rare. This report describes the utilization of a 3D-printed customized semi-restrictive elbow prosthesis as a treatment modality for severe pseudoarthritis following comminuted fractures of the distal humerus. A 51-year-old male presented to the orthopedic outpatient department with a history of left elbow joint pain and restricted movement persisting for >2 decades. Diagnostic imaging, including radiography and computed tomography (CT), revealed traumatic arthritis of the distal left humerus with pseudarthrosis formation. The treatment protocol involved comprehensive preoperative assessments, including electrocardiogram, chest CT, complete blood count, liver and kidney function tests, and coagulation profile. Following the completion of these evaluations, a total elbow joint replacement was performed using a 3D-printed, customized semi-restrictive elbow prosthesis, accompanied by muscle and ligament repair, within the orthopedics department. Postoperatively, the patient's left elbow wound exhibited satisfactory healing, with significant alleviation of pain and marked improvement in joint mobility. The patient was discharged on the 7th day after the operation and is required to have a follow-up checkup every month. This case report underscores the efficacy of employing a 3D-printed, customized semi-restrictive elbow prosthesis in the management of severe arthritis secondary to comminuted fractures of the distal humerus, particularly in cases with pseudarthrosis formation. The approach facilitates precise joint reconstruction and promotes optimal growth of prosthesis, bone, ligaments and tendons, demonstrating favorable clinical outcomes in postoperative functional recovery.</p>","PeriodicalId":94002,"journal":{"name":"Experimental and therapeutic medicine","volume":"31 6","pages":"159"},"PeriodicalIF":2.3,"publicationDate":"2026-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13113258/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147792911","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"α-tocopherol in the prevention of ischemic or hemorrhagic stroke: A meta-analysis.","authors":"Peng Xu, Pengfei Cheng","doi":"10.3892/etm.2026.13153","DOIUrl":"10.3892/etm.2026.13153","url":null,"abstract":"<p><p>Stroke remains a leading cause of disability and mortality worldwide, and the preventive role of antioxidants is of great clinical interest. The present study aimed to clarify the relationship between circulating α-tocopherol and stroke by performing a meta-analysis of prospective studies. The Web of Knowledge, Embase, Scopus, Cochrane Library and PubMed databases were searched through January 2026 for relevant studies. Risk ratios (RRs) and the corresponding 95% confidence intervals (CIs) were extracted to estimate the association of circulating α-tocopherol with stroke risk. In total, six cohort studies involving 104,209 participants and 2,194 events were identified. The results indicated that a high circulating α-tocopherol level was associated with a 22% lower stroke risk (RR, 0.78; 95% CI, 0.70-0.87). Additionally, a higher circulating α-tocopherol level was associated with a reduced stroke risk in the ischemic stroke (RR, 0.80; 95% CI, 0.72-0.90), body mass index >25 (RR, 0.80; 95% CI, 0.72-0.89), physical activity adjusted (RR, 0.69; 95% CI, 0.57-0.84) and physical activity not adjusted (RR, 0.83; 95% CI, 0.73-0.94) subgroups, but not for the hemorrhagic stroke (RR, 0.65; 95% CI, 0.41-1.01) subgroup. Dose-response analysis indicated that each 5 mg/l increment in circulating α-tocopherol was associated with an average 8% lower stroke risk (RR, 0.92; 95% CI, 0.85-0.98). In conclusion, the findings of the present meta-analysis indicates that an increased circulating α-tocopherol level may be related to lower ischemic but not hemorrhagic stroke risk. Notably, while physical activity is a critical determinant of stroke risk, the protective association of α-tocopherol remains significant and is further strengthened after accounting for this factor. This suggests that α-tocopherol may play a vital role in stroke prevention, particularly within the context of active lifestyle management.</p>","PeriodicalId":94002,"journal":{"name":"Experimental and therapeutic medicine","volume":"31 6","pages":"158"},"PeriodicalIF":2.3,"publicationDate":"2026-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13113213/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147792991","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preliminary study on symptoms and signs of patients with laryngopharyngeal reflux disease infected with <i>Helicobacter pylori</i>.","authors":"Haixiang Zhang, Huanhuan Dang, Xin Wang, Yuxiang Zhao, Jinping Wang","doi":"10.3892/etm.2026.13152","DOIUrl":"10.3892/etm.2026.13152","url":null,"abstract":"<p><p>The aim of the present study was to investigate the symptoms and signs of laryngopharyngeal reflux disease (LPRD) in patients infected with <i>Helicobacter pylori</i> (HP) and provide a clinical reference for the treatment of such patients. From January 2023 to October 2024, HP tests were performed on 97 outpatients who received a diagnosis of LPRD at the Department of Otolaryngology, Shaanxi Provincial People's Hospital, among whom 60 patients were HP-positive and 37 patients were HP-negative. The symptom and sign scores of the patients who were HP-positive and HP-negative were statistically compared. After treatment, the symptom scores of patients who were HP-positive (treated with anti-HP quadruple therapy) and patients who were HP-negative (treated with acid suppression therapy) were analysed. The results showed that significant differences in dysphagia symptoms (P<i>=</i>0.038) and vocal cord oedema signs (P<i>=</i>0.026) were observed between patients who were HP-positive and HP-negative. After treatment, the total Reflux Symptom Index (RSI) scores were significantly decreased in both groups (HP-positive group, Z=6.733, P<0.001; HP-negative group, Z=4.546, P<0.001). Moreover, the improvement in RSI scores was significantly greater in the HP-positive group compared with in the HP-negative group (Z=-4.12; P<i><</i>0.001). In conclusion, after being infected with HP, the symptoms of dysphagia and the signs of vocal cord oedema in LPRD increase significantly; therefore, HP infection may exacerbate the severity of LPRD.</p>","PeriodicalId":94002,"journal":{"name":"Experimental and therapeutic medicine","volume":"31 6","pages":"157"},"PeriodicalIF":2.3,"publicationDate":"2026-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13112339/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147792993","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Factors affecting central sensitization inventory score before surgery for distal radius fractures.","authors":"Shoichiro Ishii, Kiyohito Naito, Norizumi Imazu, Takamaru Suzuki, Kenjiro Kawamura, So Kawakita, Tatsuki Itoh, Muneaki Ishijima","doi":"10.3892/etm.2026.13157","DOIUrl":"10.3892/etm.2026.13157","url":null,"abstract":"<p><p>Volar locking plate fixation enables early postoperative return to daily activities. However, from the patient's perspective, undergoing surgery can pose substantial challenges. In particular, the perioperative period is considered a time of high psychological stress. The central sensitization inventory (CSI) score is an assessment tool for psychosocial factors in pain. In the present study, the utility of CSI scores for assessing the psychosocial factors influencing patients' status before surgery for distal radius fracture (DRF) were evaluated. This study included 22 patients who underwent volar locking plate fixation of DRF. Before surgery, data on sex, side of injury, fracture type, age, interval (in days) from injury to evaluation, numerical rating scale (NRS), Quick Disabilities of the Arm, Shoulder and Hand (Q-DASH) score and CSI score were collected. We analyzed the relationship between each evaluation item and CSI score. There were no significant associations between CSI score and sex (P=0.389), side of injury (P=0.774), fracture type (P=0.063), interval from injury to evaluation (P=0.529, r=-0.142) and Q-DASH score (P=0.385, r=0.195). On the other hand, significant associations between CSI score and age (P=0.049, r=0.424) and NRS (P=0.003, r=0.607) were found. CSI scores were significantly associated with age and NRS before volar locking plate fixation for DRF. Mental stress management and nociceptive pain relief for elderly patients may be useful in preoperative patient care.</p>","PeriodicalId":94002,"journal":{"name":"Experimental and therapeutic medicine","volume":"31 6","pages":"162"},"PeriodicalIF":2.3,"publicationDate":"2026-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13113204/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147793051","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy analysis of percutaneous cannulated paravertebral approach for microscopic resection of intraspinal schwannomas: A case series.","authors":"Shaobo Yang, Nianhua Wang","doi":"10.3892/etm.2026.13155","DOIUrl":"10.3892/etm.2026.13155","url":null,"abstract":"<p><p>The present study aimed to describe the surgical technique and to evaluate the clinical feasibility of a percutaneous cannulated paravertebral approach for microscopic resection of intraspinal schwannomas. A retrospective case series analysis was conducted using clinical data from six patients treated between January 2019 and December 2021. Demographic characteristics, clinical presentation, tumor location, operative parameters and follow-up outcomes were reviewed and descriptive statistical analysis was performed. The mean operative time was 130.8±32.9 min (range, 100-190 min), the mean intraoperative blood loss was 60±32.2 ml (range, 30-100 ml) and the mean length of hospital stay was 10.5±2.0 days (range, 8-12 days). In the present small cohort gross total resection was confirmed on postoperative imaging. During a follow-up period of 38-60 months, subjective improvement in presenting symptoms was reported, with no radiological evidence of tumor recurrence or clinically apparent spinal instability. As a consequence, the percutaneous cannulated paravertebral approach may be technically feasible in selected patients with small, single-level intraspinal schwannomas.</p>","PeriodicalId":94002,"journal":{"name":"Experimental and therapeutic medicine","volume":"31 6","pages":"160"},"PeriodicalIF":2.3,"publicationDate":"2026-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13113274/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147792967","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Systemic immune-inflammation index and neutrophil-to-lymphocyte ratio predict treatment responses in elderly patients with profound sudden deafness.","authors":"Chong Li, Huili Wu, Hongxia Cui, Yue Li, Zhiming Sun, Siqi Haoliu, Xinfa Wei","doi":"10.3892/etm.2026.13156","DOIUrl":"10.3892/etm.2026.13156","url":null,"abstract":"<p><p>The aim of the present study was to evaluate the potential role of the neutrophil-to-lymphocyte ratio (NLR) and the systemic immune-inflammation index (SII) in predicting hearing recovery among elderly patients with profound sudden sensorineural hearing loss (SSNHL) following steroid treatment. The present retrospective study analyzed data from 186 elderly patients with profound SSNHL. Clinical characteristics and laboratory parameters were assessed to identify independent predictors of hearing outcomes using logistic regression and receiver operating characteristic (ROC) analyses. Baseline characteristics were generally comparable across groups; however, NLR, SII, total bilirubin (TBIL) and C-reactive protein (CRP) were significantly elevated in the non-recovery group (P<0.001). Multivariate logistic regression analysis further demonstrated that elevated NLR and SII were independent risk factors for poor hearing recovery; notably, increased CRP and TBIL levels were also independently associated with a higher likelihood of no recovery. ROC analysis demonstrated that both the NLR [area under the curve (AUC)=0.809] and SII (AUC=0.862) possessed a strong discriminatory ability for identifying non-recovery. In an exploratory analysis, the combined use of CRP, TBIL, SII and NLR achieved the highest predictive performance for distinguishing no recovery from complete recovery, with an AUC of 0.951 (95% CI, 0.907-0.996; P<0.001). Overall, elevated NLR and SII were independent predictors of poor hearing recovery in elderly patients with profound SSNHL. These readily available inflammatory markers may serve as useful prognostic tools for outcome stratification in clinical practice.</p>","PeriodicalId":94002,"journal":{"name":"Experimental and therapeutic medicine","volume":"31 6","pages":"161"},"PeriodicalIF":2.3,"publicationDate":"2026-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13113199/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147792980","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of low-benefit subgroups in breast-conserving surgery: Implications for clinical decision-making (Review).","authors":"Weicheng Lin, Lan Luo, Guiping Guo, Huan Lin","doi":"10.3892/etm.2026.13150","DOIUrl":"10.3892/etm.2026.13150","url":null,"abstract":"<p><p>Breast-conserving surgery (BCS) with radiotherapy is a standard treatment for early-stage breast cancer, offering survival outcomes equivalent to mastectomy while preserving breast appearance and improving quality of life. However, BCS suitability and effectiveness vary notably among patients due to differences in age, comorbidities, tumor biology, breast anatomy and psychosocial factors. Through a systematic review, the present study identified six patient subgroups that may derive limited benefit from BCS followed by radiotherapy. These constituted the elderly with multiple comorbidities, those with ductal carcinoma <i>in situ</i>, premenopausal women with aggressive tumor subtypes, patients with cardiac contraindications to radiotherapy, individuals at high risk of poor cosmetic outcomes and those with socioeconomic constraints. For these patients, alternative procedures such as mastectomy with immediate reconstruction may provide improved oncologic or functional results. The present analysis highlights the importance of a personalized, risk-adapted approach to surgical decision-making in breast cancer. By integrating clinical, pathological and sociodemographic variables, the present study supports treatment strategies that are not only valid within oncology but also aligned with the functional needs and psychological well-being of patients.</p>","PeriodicalId":94002,"journal":{"name":"Experimental and therapeutic medicine","volume":"31 6","pages":"155"},"PeriodicalIF":2.3,"publicationDate":"2026-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13112341/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147792879","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Autophagy-epithelial-mesenchymal transition crosstalk in acute respiratory distress syndrome: Mechanistic insights and therapeutic perspectives (Review).","authors":"Yue Zhang, Hongzhi He, Chufan Dong, Qing Guo, Jiuwen Tan, Yonggui Yang, Zhuangbo Guo, Rui Zhang","doi":"10.3892/etm.2026.13151","DOIUrl":"10.3892/etm.2026.13151","url":null,"abstract":"<p><p>Acute respiratory distress syndrome (ARDS) is a life-threatening pulmonary disorder frequently encountered in intensive care units, characterized by diffuse alveolar damage, intense inflammatory infiltration and progressive fibrotic remodeling. Among the mechanisms driving fibrosis, the epithelial-mesenchymal transition (EMT) has gained increasing recognition as a key contributor to the generation of fibroblasts and extracellular matrix deposition. Autophagy, a tightly regulated intracellular degradation and recycling process, serves a context-dependent role in EMT regulation and lung injury. While basal autophagy supports pulmonary cellular homeostasis, dysregulated or excessive autophagy may exacerbate tissue injury and maladaptive repair. The literature has previously highlighted both classical macroautophagy and selective autophagy pathways, including mitophagy, endoplasmic reticulum-selective autophagy and ferritinophagy, as modulators of EMT dynamics and fibrotic outcomes. However, the mechanistic associations between specific autophagy subtypes and EMT in ARDS remain poorly defined and occasionally contradictory. In the present review, current evidence on autophagy-EMT crosstalk in ARDS is critically appraised, conceptual gaps and controversies are identified and further potential mechanistic frameworks and research priorities are summarized. Such investigation may help inform the rational targeting of autophagy pathways in future ARDS therapies.</p>","PeriodicalId":94002,"journal":{"name":"Experimental and therapeutic medicine","volume":"31 6","pages":"156"},"PeriodicalIF":2.3,"publicationDate":"2026-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13112342/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147792885","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Plexiform fibromyxoma of the lesser curvature of the stomach in a 16-year-old adolescent: A case report and literature review.","authors":"Zhenhua Fu, Peiyao Tao, Da Sun, Xiang Chen","doi":"10.3892/etm.2026.13149","DOIUrl":"10.3892/etm.2026.13149","url":null,"abstract":"<p><p>Gastric plexiform fibromyxoma (PF) is a rare mesenchymal tumor, with ~150 cases reported worldwide, predominantly occurring in the gastric antrum of adults. The present study describes a case of isolated PF in the lesser curvature of the stomach in a 16-year-old male patient. As confirmed by various multi-dimensional analyses of clinical, imaging and pathological data, the unique features of the case included its adolescent onset (only 12 cases of patients ≤18 years old have been reported globally) and the solitary localization in the lesser curvature of the stomach, with no previously documented cases. The patient presented with abdominal pain. A computed tomography scan revealed a solid intramural gastric mass with progressive enhancement. Postoperative pathology combined with immunohistochemistry (vimentin⁺, smooth muscle actin partially⁺, CD10⁺ and CD117/discovered on GIST-1^-) confirmed the diagnosis. No recurrence was observed during the 12-month follow-up. The present case expands the clinical spectrum of PF and emphasizes the value of multimodal diagnosis for tumors in rare locations.</p>","PeriodicalId":94002,"journal":{"name":"Experimental and therapeutic medicine","volume":"31 6","pages":"154"},"PeriodicalIF":2.3,"publicationDate":"2026-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13112363/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147792969","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retroperitoneal ovarian venous hemangioma: A case report.","authors":"Jie Tian, Hong Hu, Siyi Chen, Junping Li","doi":"10.3892/etm.2026.13148","DOIUrl":"10.3892/etm.2026.13148","url":null,"abstract":"<p><p>Retroperitoneal venous hemangioma is a rare vascular malformation. The present study reports a unique case of a 68-year-old female with a retroperitoneal ovarian venous hemangioma that was surgically resected. Computed tomography and magnetic resonance imaging showed a retroperitoneal mass anterior to the left kidney. Enhanced imaging revealed a close relationship between the mass and surrounding vessels, suggesting a retroperitoneal vascular neoplasm. Histopathological examination of the tissue after complete surgical resection confirmed the diagnosis of a retroperitoneal ovarian venous hemangioma. This case provides crucial insights for clinicians to enhance their understanding of ovarian venous hemangioma through the integration of multimodal imaging characteristics and pathological evidence, thereby contributing to the reduction of misdiagnosis in clinical practice.</p>","PeriodicalId":94002,"journal":{"name":"Experimental and therapeutic medicine","volume":"31 6","pages":"153"},"PeriodicalIF":2.3,"publicationDate":"2026-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13112364/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147792953","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}