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Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association最新文献

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Diabetes and Fatty Liver. 糖尿病与脂肪肝
Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association Pub Date : 2024-03-01 Epub Date: 2024-02-07 DOI: 10.1055/a-2166-6824
Norbert Stefan, Michael Roden
{"title":"Diabetes and Fatty Liver.","authors":"Norbert Stefan, Michael Roden","doi":"10.1055/a-2166-6824","DOIUrl":"10.1055/a-2166-6824","url":null,"abstract":"","PeriodicalId":94001,"journal":{"name":"Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139704267","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
FGF19 Promotes the Proliferation and Insulin Secretion from Human Pancreatic β Cells Via the IRS1/GLUT4 Pathway. FGF19通过IRS1/GLUT4途径促进人胰腺β细胞的增殖和胰岛素分泌
Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association Pub Date : 2024-03-01 Epub Date: 2024-03-21 DOI: 10.1055/a-2250-7830
Ting Zeng, Xi Tang, Xiaosu Bai, Haiyan Xiong
{"title":"FGF19 Promotes the Proliferation and Insulin Secretion from Human Pancreatic β Cells Via the IRS1/GLUT4 Pathway.","authors":"Ting Zeng, Xi Tang, Xiaosu Bai, Haiyan Xiong","doi":"10.1055/a-2250-7830","DOIUrl":"10.1055/a-2250-7830","url":null,"abstract":"<p><strong>Background: </strong>Type 2 diabetes mellitus (T2DM) is a commonly observed complication associated with obesity. The effect of fibroblast growth factor 19 (FGF19), a promising therapeutic agent for metabolic disorders, on pancreatic β cells in obesity-associated T2DM remains poorly understood.</p><p><strong>Methods: </strong>Human pancreatic β cells were cultured with high glucose (HG) and palmitic acid (PA), followed by treatment with FGF19. The cell proliferation, apoptosis, and insulin secretion were evaluated by CCK-8, qRT-PCR, ELISA, flow cytometry, and western blotting. The expression of the insulin receptor substrate (IRS)/glucose transporter (GLUT) pathway was evaluated. The interaction between FGF19 and IRS1 was predicted using the STRING database and verified by co-immunoprecipitation and immunofluorescence. The regulatory effects of the IRS1/GLUT4 pathway on human pancreatic β cells were assessed by overexpressing IRS1 and silencing IRS1 and GLUT4.</p><p><strong>Results: </strong>HG+PA treatment reduced the human pancreatic β cell proliferation and insulin secretion and promoted cell apoptosis. However, FGF19 treatment restored these alterations and significantly increased the expressions of IRS1, GLUT1, and GLUT4 in the IRS/GLUT pathway. Furthermore, FGF19 and IRS1 were found to interact. IRS1 overexpression partially promoted the proliferation of pancreatic β cells and insulin secretion through GLUT4. Additionally, the silencing of IRS1 or GLUT4 attenuated the therapeutic effects of FGF19.</p><p><strong>Conclusion: </strong>In conclusion, FGF19 partly promoted the proliferation and insulin secretion of human pancreatic β cells and inhibited apoptosis by upregulating the IRS1/GLUT4 pathway. These findings establish a theoretical framework for the clinical utilization of FGF19 in the treatment of obesity-associated T2DM.</p>","PeriodicalId":94001,"journal":{"name":"Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140186731","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Therapy for Type 1 Diabetes. 治疗 1 型糖尿病。
Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association Pub Date : 2024-03-01 Epub Date: 2024-02-16 DOI: 10.1055/a-2166-6695
Thomas Haak, Stefan Gölz, Andreas Fritsche, Martin Füchtenbusch, Thorsten Siegmund, Elisabeth Schnellbächer, Harald H Klein, Til Uebel, Diana Droßel
{"title":"Therapy for Type 1 Diabetes.","authors":"Thomas Haak, Stefan Gölz, Andreas Fritsche, Martin Füchtenbusch, Thorsten Siegmund, Elisabeth Schnellbächer, Harald H Klein, Til Uebel, Diana Droßel","doi":"10.1055/a-2166-6695","DOIUrl":"10.1055/a-2166-6695","url":null,"abstract":"","PeriodicalId":94001,"journal":{"name":"Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139747888","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Definition, Classification, Diagnosis and Differential Diagnosis of Diabetes Mellitus: Update 2023. 糖尿病的定义、分类、诊断和鉴别诊断：2023 年更新。
Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association Pub Date : 2024-03-01 Epub Date: 2024-02-20 DOI: 10.1055/a-2166-6643
Stefan Pleus, Andrea Tytko, Rüdiger Landgraf, Lutz Heinemann, Christoph Werner, Dirk Müller-Wieland, Anette-Gabriele Ziegler, Ulrich A Müller, Guido Freckmann, Helmut Kleinwechter, Erwin Schleicher, Matthias Nauck, Astrid Petersmann
{"title":"Definition, Classification, Diagnosis and Differential Diagnosis of Diabetes Mellitus: Update 2023.","authors":"Stefan Pleus, Andrea Tytko, Rüdiger Landgraf, Lutz Heinemann, Christoph Werner, Dirk Müller-Wieland, Anette-Gabriele Ziegler, Ulrich A Müller, Guido Freckmann, Helmut Kleinwechter, Erwin Schleicher, Matthias Nauck, Astrid Petersmann","doi":"10.1055/a-2166-6643","DOIUrl":"10.1055/a-2166-6643","url":null,"abstract":"","PeriodicalId":94001,"journal":{"name":"Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139914326","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Correction: Definition, Classification, Diagnosis and Differential Diagnosis of Diabetes Mellitus: Update 2023. 更正：糖尿病的定义、分类、诊断和鉴别诊断：2023 年更新。
Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association Pub Date : 2024-03-01 Epub Date: 2024-03-14 DOI: 10.1055/a-2277-1648
Stefan Pleus, Andrea Tytko, Rüdiger Landgraf, Lutz Heinemann, Christoph Werner, Dirk Müller-Wieland, Anette-Gabriele Ziegler, Ulrich A Müller, Guido Freckmann, Helmut Kleinwechter, Erwin Schleicher, Matthias Nauck, Astrid Petersmann
{"title":"Correction: Definition, Classification, Diagnosis and Differential Diagnosis of Diabetes Mellitus: Update 2023.","authors":"Stefan Pleus, Andrea Tytko, Rüdiger Landgraf, Lutz Heinemann, Christoph Werner, Dirk Müller-Wieland, Anette-Gabriele Ziegler, Ulrich A Müller, Guido Freckmann, Helmut Kleinwechter, Erwin Schleicher, Matthias Nauck, Astrid Petersmann","doi":"10.1055/a-2277-1648","DOIUrl":"10.1055/a-2277-1648","url":null,"abstract":"","PeriodicalId":94001,"journal":{"name":"Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140133598","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Diabetes Mellitus and the Heart. 糖尿病与心脏
Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association Pub Date : 2024-02-01 Epub Date: 2024-01-23 DOI: 10.1055/a-2166-6885
Katharina Schütt, Thomas Forst, Andreas L Birkenfeld, Andreas Zirlik, Dirk Müller-Wieland, Nikolaus Marx
{"title":"Diabetes Mellitus and the Heart.","authors":"Katharina Schütt, Thomas Forst, Andreas L Birkenfeld, Andreas Zirlik, Dirk Müller-Wieland, Nikolaus Marx","doi":"10.1055/a-2166-6885","DOIUrl":"10.1055/a-2166-6885","url":null,"abstract":"","PeriodicalId":94001,"journal":{"name":"Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139543852","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Bilirubin Down-Regulates Oxidative Stress and Fibroblast Growth Factor 23 Expression in UMR106 Osteoblast-Like Cells. 胆红素下调 UMR106 类成骨细胞的氧化应激和成纤维细胞生长因子 23 的表达
Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association Pub Date : 2024-02-01 Epub Date: 2024-02-19 DOI: 10.1055/a-2237-8863
Steffen Rausch, Katharina Hammerschmidt, Martina Feger, Libor Vítek, Michael Föller
{"title":"Bilirubin Down-Regulates Oxidative Stress and Fibroblast Growth Factor 23 Expression in UMR106 Osteoblast-Like Cells.","authors":"Steffen Rausch, Katharina Hammerschmidt, Martina Feger, Libor Vítek, Michael Föller","doi":"10.1055/a-2237-8863","DOIUrl":"10.1055/a-2237-8863","url":null,"abstract":"<p><strong>Introduction: </strong>Fibroblast growth factor 23 (FGF23) is a major regulator of phosphate and vitamin D metabolism in the kidney, and its higher levels in plasma are associated with poorer outcomes in kidney and cardiovascular diseases. It is produced by bone cells upon enhanced oxidative stress and inhibits renal phosphate reabsorption and calcitriol (active form of vitamin D) production. Bilirubin, the final product of the heme catabolic pathway in the vascular bed, has versatile biological functions, including antioxidant and anti-inflammatory effects. This study explored whether bilirubin alters FGF23 production.</p><p><strong>Methods: </strong>Experiments were performed using UMR106 osteoblast-like cells. <i>Fgf23</i> transcript levels were determined by quantitative real-time polymerase chain reaction, C-terminal and intact FGF23 protein levels were determined by enzyme-linked immunosorbent assay, and cellular oxidative stress was assessed by CellROX assay.</p><p><strong>Results: </strong>Unconjugated bilirubin down-regulated <i>Fgf23</i> gene transcription and FGF23 protein abundance; these effects were paralleled by lower cellular oxidative stress levels. Also, conjugated bilirubin reduced <i>Fgf23</i> mRNA abundance.</p><p><strong>Conclusion: </strong>Bilirubin down-regulates FGF23 production in UMR106 cells, an effect likely to be dependent on the reduction of cellular oxidative stress.</p>","PeriodicalId":94001,"journal":{"name":"Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139907080","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Nutritional Recommendations for the Prevention of Type 2 Diabetes Mellitus. 预防 2 型糖尿病的营养建议。
Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association Pub Date : 2024-02-01 Epub Date: 2024-01-17 DOI: 10.1055/a-2166-6943
Thomas Skurk, Arthur Grünerbel, Sandra Hummel, Stefan Kabisch, Winfried Keuthage, Karsten Müssig, Helmut Nussbaumer, Diana Rubin, Marie-Christine Simon, Astrid Tombek, Katharina S Weber
{"title":"Nutritional Recommendations for the Prevention of Type 2 Diabetes Mellitus.","authors":"Thomas Skurk, Arthur Grünerbel, Sandra Hummel, Stefan Kabisch, Winfried Keuthage, Karsten Müssig, Helmut Nussbaumer, Diana Rubin, Marie-Christine Simon, Astrid Tombek, Katharina S Weber","doi":"10.1055/a-2166-6943","DOIUrl":"10.1055/a-2166-6943","url":null,"abstract":"","PeriodicalId":94001,"journal":{"name":"Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139486326","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Correction: Nutritional Recommendations for the Prevention of Type 2 Diabetes Mellitus. 更正：预防 2 型糖尿病的营养建议。
Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association Pub Date : 2024-02-01 Epub Date: 2024-06-03 DOI: 10.1055/a-2323-4254
Thomas Skurk, Arthur Grünerbel, Sandra Hummel, Stefan Kabisch, Winfried Keuthage, Karsten Müssig, Helmut Nussbaumer, Diana Rubin, Marie-Christine Simon, Astrid Tombek, Katharina S Weber
{"title":"Correction: Nutritional Recommendations for the Prevention of Type 2 Diabetes Mellitus.","authors":"Thomas Skurk, Arthur Grünerbel, Sandra Hummel, Stefan Kabisch, Winfried Keuthage, Karsten Müssig, Helmut Nussbaumer, Diana Rubin, Marie-Christine Simon, Astrid Tombek, Katharina S Weber","doi":"10.1055/a-2323-4254","DOIUrl":"https://doi.org/10.1055/a-2323-4254","url":null,"abstract":"","PeriodicalId":94001,"journal":{"name":"Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141238707","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Position Paper on Lipid Therapy in Patients with Diabetes Mellitus. 关于糖尿病患者血脂治疗的立场文件。
Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association Pub Date : 2024-02-01 Epub Date: 2024-01-15 DOI: 10.1055/a-2166-6859
Klaus G Parhofer, Andreas L Birkenfeld, Wilhelm Krone, Michael Lehrke, Nikolaus Marx, Martin Merkel, Katharina S Schütt, Andreas Zirlik, Dirk Müller-Wieland
{"title":"Position Paper on Lipid Therapy in Patients with Diabetes Mellitus.","authors":"Klaus G Parhofer, Andreas L Birkenfeld, Wilhelm Krone, Michael Lehrke, Nikolaus Marx, Martin Merkel, Katharina S Schütt, Andreas Zirlik, Dirk Müller-Wieland","doi":"10.1055/a-2166-6859","DOIUrl":"10.1055/a-2166-6859","url":null,"abstract":"","PeriodicalId":94001,"journal":{"name":"Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139472783","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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