Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association最新文献_第10页

Valproic Acid Initiates Transdifferentiation of the Human Ductal Adenocarcinoma Cell-line Panc-1 Into α-Like Cells. 丙戊酸启动人导管腺癌细胞系Panc-1向α样细胞的转分化。

Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association Pub Date : 2022-04-21 DOI: 10.1055/a-1750-9190

S. F. Petry, Naga Deepa Kandula, S. Günther, Christian S. M. Helker, U. Schagdarsurengin, T. Linn

{"title":"Valproic Acid Initiates Transdifferentiation of the Human Ductal Adenocarcinoma Cell-line Panc-1 Into α-Like Cells.","authors":"S. F. Petry, Naga Deepa Kandula, S. Günther, Christian S. M. Helker, U. Schagdarsurengin, T. Linn","doi":"10.1055/a-1750-9190","DOIUrl":"https://doi.org/10.1055/a-1750-9190","url":null,"abstract":"Non-mesenchymal pancreatic cells are a potential source for cell replacement. Their transdifferentiation can be achieved by triggering epigenetic remodeling through e. g. post-translational modification of histones. Valproic acid, a branched-chain saturated fatty acid with histone deacetylase inhibitor activity, was linked to the expression of key transcription factors of pancreatic lineage in epithelial cells and insulin transcription. However, the potential of valproic acid to cause cellular reprogramming is not fully understood. To shed further light on it we employed next-generation RNA sequencing, real-time PCR, and protein analyses by ELISA and western blot, to assess the impact of valproic acid on transcriptome and function of Panc-1-cells. Our results indicate that valproic acid has a significant impact on the cell cycle, cell adhesion, histone H3 acetylation, and metabolic pathways as well as the initiation of epithelial-mesenchymal transition through acetylation of histone H3 resulting in α-cell-like characteristics. We conclude that human epithelial pancreatic cells can be transdifferentiated into cells with endocrine properties through epigenetic regulation by valproic acid favoring an α-cell-like phenotype.","PeriodicalId":94001,"journal":{"name":"Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association","volume":"12 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87102633","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Definition, Classification and Diagnosis of Diabetes Mellitus. 糖尿病的定义、分类与诊断。

Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association Pub Date : 2022-04-21 DOI: 10.1055/a-1624-2897

Erwin Schleicher, Christian Gerdes, A. Petersmann, D. Müller-Wieland, U. Müller, G. Freckmann, L. Heinemann, M. Nauck, R. Landgraf

引用次数: 14

Diabetes and Fatty Liver. 糖尿病和脂肪肝。

Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association Pub Date : 2022-04-01 DOI: 10.1055/a-1624-3541

N. Stefan, M. Roden

引用次数: 0

Glucose Measurement and Control in Patients with Type 1 or Type 2 Diabetes. 1型或2型糖尿病患者的血糖测量和控制

Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association Pub Date : 2022-03-31 DOI: 10.1055/a-1624-3282

Sandra Schlüter, D. Deiss, B. Gehr, K. Lange, S. von Sengbusch, A. Thomas, R. Ziegler, G. Freckmann

引用次数: 2

Adjustment of Anti-Hyperglycaemic Agents During Bowel Preparation for Colonoscopy in Patients with Diabetes. 糖尿病患者结肠镜检查肠准备期间抗高血糖药物的调整。

Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association Pub Date : 2022-03-31 DOI: 10.1055/a-1782-9389

K. Müssig, H. Adamek

{"title":"Adjustment of Anti-Hyperglycaemic Agents During Bowel Preparation for Colonoscopy in Patients with Diabetes.","authors":"K. Müssig, H. Adamek","doi":"10.1055/a-1782-9389","DOIUrl":"https://doi.org/10.1055/a-1782-9389","url":null,"abstract":"OBJECTIVE\u0000Due to the growing diabetes pandemic, the number of colonoscopies performed in patients with diabetes is steadily rising. However, recommendations on adjustments of anti-hyperglycaemic agents (AHG) during bowel preparation for colonoscopy are limited.\u0000\u0000\u0000METHODS\u0000A total of nine articles were revealed on a PubMed search using the search terms \"diabetes\" and \"colonoscopy\", \"sigmoidoscopy\", \"endoscopy\", \"endoscopic intervention\", \"endoscopic invasive diagnostics\", \"endoscopic surgery\", or \"diabetes care in the hospital\" and manual screening of the references of the articles reporting on AHG adjustment during bowel preparation.\u0000\u0000\u0000RESULTS\u0000Regular glucose measurements and the opportunity to contact the diabetes team were commonly advised. Recommendations also agreed that all oral AHG and short-acting insulin should be omitted when patients are on clear fluids. Recent studies suggest discontinuation of sodium-glucose cotransporter-2 (SGLT2) inhibitors even three days before the colonoscopy. In contrast, recommendations differed regarding adjustment of basal insulin depending on diabetes type and time point in relation to the intervention.\u0000\u0000\u0000CONCLUSIONS\u0000While discontinuation of oral AHG and short-acting insulin during bowel preparation for colonoscopy is generally accepted, recommendations on the adaptation of basal insulin follow different approaches.","PeriodicalId":94001,"journal":{"name":"Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association","volume":"126 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91473300","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Family Structure is Associated with Mental Health and Attention Deficit (Hyperactivity) Disorders in Adolescents with Type 1 Diabetes. 家庭结构与1型糖尿病青少年心理健康和注意缺陷(多动)障碍相关

Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association Pub Date : 2022-03-31 DOI: 10.1055/a-1729-7972

C. Baechle, A. Stahl-Pehe, K. Castillo, R. Holl, J. Rosenbauer

{"title":"Family Structure is Associated with Mental Health and Attention Deficit (Hyperactivity) Disorders in Adolescents with Type 1 Diabetes.","authors":"C. Baechle, A. Stahl-Pehe, K. Castillo, R. Holl, J. Rosenbauer","doi":"10.1055/a-1729-7972","DOIUrl":"https://doi.org/10.1055/a-1729-7972","url":null,"abstract":"OBJECTIVE\u0000To analyze the cross-sectional associations of family structure with mental health and attention deficit (hyperactivity) disorders (AD(H)D) in 11- to 17-year-old adolescents with early-onset type 1 diabetes participating in one of three baseline surveys as part of an ongoing cohort study.\u0000\u0000\u0000METHODS\u0000Parents (n=1,631) completed the Strengths and Difficulties Questionnaire to screen for their child's mental health and answered questions about their child's diagnosis of AD(H)D. Associations between mental health or AD(H)D and family structure were analyzed using multivariable logistic regression analyses adjusted for various personal and diabetes-related variables.\u0000\u0000\u0000RESULTS\u0000Compared to adolescents living with both parents, adolescents living with one parent and his/her partner had 2.35 (95% confidence interval 1.32; 4.21) higher odds of abnormal screening result and 2.08 (1.09; 3.95) higher odds of a borderline screening result while adolescents living with a single parent had 1.84 (1.07; 3.17)/1.08 (0.53; 2.21) higher odds of abnormal/borderline screening results. The odds ratios for diagnosed attention deficit (hyperactivity) disorder were 2.17 (0.98; 4.84) for adolescents living with one parent and his/her partner and 1.27 (0.54; 3.01) for those living with a single parent vs. both parents.\u0000\u0000\u0000CONCLUSIONS\u0000Our results indicate higher odds of mental health problems and AD(H)D in adolescents with type 1 diabetes who do not live with both parents; this finding was most pronounced in individuals living with one parent and his/her partner vs. both parents. Longitudinal studies are needed to verify our results and elucidate the underlying mechanisms.","PeriodicalId":94001,"journal":{"name":"Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association","volume":"46 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84064542","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Position Paper on Lipid Therapy in Patients with Diabetes Mellitus. 糖尿病患者脂质治疗的立场文件。

Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association Pub Date : 2022-03-31 DOI: 10.1055/a-1624-3572

K. Parhofer, A. Birkenfeld, W. Krone, M. Lehrke, N. Marx, M. Merkel, K. Schütt, A. Zirlik, D. Müller-Wieland

引用次数: 0

Diabetes Mellitus and the Heart. 糖尿病与心脏。

Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association Pub Date : 2022-03-31 DOI: 10.1055/a-1624-3593

K. Schütt, T. Forst, A. Birkenfeld, A. Zirlik, D. Müller-Wieland, N. Marx

引用次数: 1

Dietary recommendations for persons with type 2 diabetes mellitus. 2型糖尿病患者的饮食建议。

Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association Pub Date : 2022-03-31 DOI: 10.1055/a-1624-5095

T. Skurk, A. Bosy-Westphal, A. Grünerbel, S. Kabisch, W. Keuthage, P. Kronsbein, K. Müssig, A. Pfeiffer, M. Simon, A. Tombek, K. Weber, Diana Rubin

引用次数: 5

What is the Role of Thyroid Hormone Receptor Alpha 2 (TRα2) in Human Physiology? 甲状腺激素受体α2 (TRα2)在人体生理中的作用是什么?

Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association Pub Date : 2022-03-07 DOI: 10.1055/a-1716-7980

Sarah Paisdzior, Marc Schuelke, H. Krude

引用次数: 4