Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association最新文献

{"title":"Effects of thyroid hormones on muscle and bone in mice.","authors":"Akihito Nishikawa, Naoyuki Kawao, Yuya Mizukami, Ryota Kishigami, Koji Goto, Hiroshi Kaji","doi":"10.1055/a-2937-4838","DOIUrl":"https://doi.org/10.1055/a-2937-4838","url":null,"abstract":"<p><strong>Abstract: </strong>BACKGROUND: : The significance of muscle-bone interactions in bone metabolism and the pathophysiology of osteoporosis has been recognized. However, the effects of thyroid hormones on muscle-bone interactions remain unclear.</p><p><strong>Abstract: </strong>METHODS:: We herein investigated the effects of hyperthyroidism on muscle and bone by administering L-thyroxin to male mice for 4 weeks.</p><p><strong>Abstract: </strong>RESULTS:: A micro-computed tomography analysis showed that the administration of L-thyroxin significantly decreased trabecular bone mineral density, bone volume/tissue volume, trabecular number, trabecular thickness, and connectivity density at the femurs of mice and slightly reduced cortical thickness. However, the administration of L-thyroxin did not affect muscle mass in the lower limbs, tissue weights of the soleus and gastrocnemius muscles, or grip strength. Among the myokines examined, the administration of L-thyroxin significantly decreased the messenger RNA level of follistatin in the soleus muscle and simple regression analyses showed a positive correlation between follistatin levels and bone volume/tissue volume; however, it did not affect serum follistatin levels.</p><p><strong>Abstract: </strong>CONCLUSIONS:: The present results suggest that hyperthyroidism induced by the administration of L-thyroxin caused trabecular-dominant osteopenia without reducing muscle mass or grip strength in mice. The direct effects of thyroid hormones on bone, but not muscle-bone interactions, may be crucial for hyperthyroidism-induced osteoporosis.</p>","PeriodicalId":94001,"journal":{"name":"Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2026-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148852119","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cardiovascular Outcomes, Hospitalization, and Mortality following Amiodarone-Induced Thyrotoxicosis.","authors":"Irene Serrano, Pedro Iglesias, Juan J Díez","doi":"10.1055/a-2937-4553","DOIUrl":"https://doi.org/10.1055/a-2937-4553","url":null,"abstract":"<p><strong>Context: </strong>Amiodarone-induced thyrotoxicosis is a recognized adverse effect of amiodarone therapy. However, its long-term effects on cardiovascular morbidity, hospitalization, and mortality remain insufficiently characterized.</p><p><strong>Objective: </strong>The objective of this study is to evaluate the incidence of cardiovascular events, hospitalizations, and all-cause mortality following amiodarone-induced thyrotoxicosis and to assess their association with clinical, biochemical, and therapeutic parameters.</p><p><strong>Methods: </strong>A retrospective cohort study was conducted including 113 adult patients diagnosed with amiodarone-induced thyrotoxicosis and followed at a tertiary endocrinology center between 2008 and 2024. Clinical and biochemical characteristics, therapeutic interventions, cardiovascular events, hospital admissions, and mortality were recorded. The event-free survival was evaluated using Kaplan-Meier curves, and predictors of outcomes were assessed using Cox proportional hazard regression models.</p><p><strong>Results: </strong>Fifty patients (44.2%) were classified as amiodarone-induced thyrotoxicosis type 1 and 63 patients (55.8%) as amiodarone-induced thyrotoxicosis type 2. Over a median follow-up of 52 months, 42.5% experienced at least one cardiovascular event, 38.0% required hospitalization, and 33.6% died. Serum free thyroxine levels at diagnosis were significantly higher in patients who developed cardiovascular events (hazard ratio: 2.6; 95% confidence interval: 1.9-3.7 vs. hazard ratio: 2.3; 95% confidence interval: 1.6-3.4 ng/dL; <i>p</i>=0.042). Kaplan-Meier analysis showed reduced survival in older patients (<i>p</i><0.001). In the multivariate model, age at diagnosis was the only independent predictor of mortality (hazard ratio=1.06; 95% confidence interval: 1.02-1.10; <i>p</i>=0.001). Neither amiodarone-induced thyrotoxicosis type nor treatment intensity were significantly associated with cardiovascular outcomes, hospitalization, or survival.</p><p><strong>Conclusions: </strong>Amiodarone-induced thyrotoxicosis is associated with substantial long-term clinical burden. In unadjusted analysis, elevated free thyroxine levels were associated with cardiovascular events, although this association did not reach significance after multivariate adjustment. Age at amiodarone-induced thyrotoxicosis diagnosis was the only independent predictor of mortality. Amiodarone-induced thyrotoxicosis type and treatment intensity did not significantly influence outcomes.</p>","PeriodicalId":94001,"journal":{"name":"Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2026-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148820788","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Interpretation of 5'-Adenosine Monophosphate-Activated Protein Kinase Signaling and Translational Considerations in High-Methionine Diet Models: A Comment on the Study by Jiang et al.","authors":"Fariha Shahid Tanveer, Muhammad Hassan Saeed","doi":"10.1055/a-2937-4296","DOIUrl":"https://doi.org/10.1055/a-2937-4296","url":null,"abstract":"","PeriodicalId":94001,"journal":{"name":"Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2026-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148803541","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"DDG [German Diabetes Society] Position Paper on Type 1 Diabetes Screening.","authors":"Oliver Blankenstein, Carolin Daniel, Andreas Fritsche, Stephan Goelz, Thomas Haak, Georg F Hoffmann, Andrea Icks, Beate Karges, Giovanni Maio, Damon Mohebbi, Andreas Neu, Matthias Schulze, Baptist Gallwitz","doi":"10.1055/a-2896-1245","DOIUrl":"10.1055/a-2896-1245","url":null,"abstract":"","PeriodicalId":94001,"journal":{"name":"Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2026-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148803577","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of Gallbladder Function in Patients with Type 2 Diabetes Using Three-Dimensional Ultrasound.","authors":"Tæraneh Jouleh, Ingrid Kvåle Nordaas, Spiros Kotopoulis, Georg Gjorgji Dimcevski, Erling Tjora, Sondre Vatne Meling, Odd Helge Gilja, Eirik Wigtil Søfteland","doi":"10.1055/a-2886-2833","DOIUrl":"10.1055/a-2886-2833","url":null,"abstract":"<p><strong>Aims: </strong>Symptoms related to gastrointestinal autonomic neuropathy, which can involve gallbladder, are prevalent in patients with diabetes. We hypothesize that diabetes duration may impact gallbladder volume and motility. This study aims to explore relationships between gallbladder volume parameters and diabetes duration in individuals with type 2 diabetes compared with non-diabetic controls. Autonomic neuropathy will also be explored.</p><p><strong>Methods: </strong>In this cross-sectional observational case-control study, matched individuals with longstanding type 2 diabetes, early type 2 diabetes, and non-diabetic controls were included. Gallbladder motility was investigated by gallbladder volume changes measured by three-dimensional ultrasound. Gallbladder volumes were collected at predefined time intervals before and after an intake of a standardized high-fat meal. Autonomic neuropathy was evaluated by cardiovascular (Vagus) and sudomotor (Sudoscan) testing.</p><p><strong>Results: </strong>Sixty-one adults were included in the final analysis, of which 18 adults had longstanding type 2 diabetes, 15 adults had early type 2 diabetes, and 28 adults were non-diabetic controls. Subjects with longstanding type 2 diabetes had significantly higher fasting gallbladder volume and ejection volume compared to the controls (<i>p</i>=0.020 and <i>p</i>=0.019, respectively). No other significant differences in gallbladder motility were observed. Only five participants had autonomic neuropathy.</p><p><strong>Conclusions: </strong>Specific gallbladder volumes and motility parameters were associated with diabetes duration. Associations between gallbladder motility and autonomic neuropathy could not be analyzed.</p>","PeriodicalId":94001,"journal":{"name":"Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association","volume":" ","pages":"264-270"},"PeriodicalIF":1.7,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148159462","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diabetes and Metabolic Dysfunction-Associated Steatotic Liver Disease.","authors":"Norbert Stefan, Michael Roden","doi":"10.1055/a-2766-3214","DOIUrl":"10.1055/a-2766-3214","url":null,"abstract":"","PeriodicalId":94001,"journal":{"name":"Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association","volume":" ","pages":"239-244"},"PeriodicalIF":1.7,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147824959","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sudomotor Dysfunction in Fibrocalculous Pancreatic Diabetes: Clinical Insights From Electrochemical Skin Conductance Testing.","authors":"Gautham Kolla, Channabasappa Shivaprasad, Ramdas Barure, Amit Goel","doi":"10.1055/a-2866-8646","DOIUrl":"10.1055/a-2866-8646","url":null,"abstract":"<p><strong>Background: </strong>Fibrocalculous pancreatic diabetes is a unique form of diabetes prevalent in tropical regions, characterized by chronic calcific pancreatitis and a high burden of diabetic complications. Sudomotor dysfunction remains underexplored in this population.</p><p><strong>Aim: </strong>To determine the prevalence and clinical determinants of sudomotor dysfunction in individuals with fibrocalculous pancreatic diabetes.</p><p><strong>Methods: </strong>In this cross-sectional study, 90 patients with fibrocalculous pancreatic diabetes were evaluated at a tertiary care endocrinology centre. Sudomotor function was assessed using electrochemical skin conductance. Large fiber neuropathy was evaluated using vibration perception threshold testing and nerve conduction studies. Agreement between modalities was assessed using Cohen's kappa, and logistic regression was used to identify the predictors of sudomotor dysfunction.</p><p><strong>Results: </strong>Sudomotor dysfunction was present in 43.3% of patients, compared with abnormalities in vibration perception threshold (17.8%) and nerve conduction studies (21.1%). Agreement between electrochemical skin conductance and large fiber measures was fair to moderate (<i>κ</i>=0.39-0.47), while the vibration perception threshold and nerve conduction studies showed substantial concordance (<i>κ</i>=0.61). In multivariable analysis, increasing age (odds ratio: 1.08; 95% confidence interval: 1.00-1.16) and longer duration of diabetes (odds ratio: 1.26; 95% confidence interval: 1.07-1.49) were independently associated with sudomotor dysfunction.</p><p><strong>Conclusions: </strong>Sudomotor dysfunction assessed by electrochemical skin conductance was common in fibrocalculous pancreatic diabetes and detected more frequently than abnormalities on vibration perception threshold or nerve conduction studies. Electrochemical skin conductance may serve as a practical adjunctive tool for evaluating sudomotor dysfunction in this population, although longitudinal studies are needed to clarify its clinical significance.</p>","PeriodicalId":94001,"journal":{"name":"Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association","volume":" ","pages":"257-262"},"PeriodicalIF":1.7,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147936332","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nutritional Recommendations for the Prevention of Type 2 Diabetes Mellitus.","authors":"Thomas Skurk, Arthur Grünerbel, Sandra Hummel, Stefan Kabisch, Winfried Keuthage, André Kleinridders, Karsten Müssig, Helmut Nussbaumer, Diana Rubin, Marie-Christine Simon, Astrid Tombek, Katharina S Weber","doi":"10.1055/a-2766-3137","DOIUrl":"10.1055/a-2766-3137","url":null,"abstract":"","PeriodicalId":94001,"journal":{"name":"Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association","volume":" ","pages":"246-255"},"PeriodicalIF":1.7,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148240890","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Position Paper of the German Diabetes Association, German Society of Angiology and Vascular Medicine, German Society for Vascular Surgery and Vascular Medicine and German Society for Interventional Radiology and Minimally Invasive Therapy on the Diagnosis and Treatment of Peripheral Arterial Occlusive Disease in Diabetes Mellitus.","authors":"Kilian Rittig, Farzin Adili, Markus Zähringer, Nasser M Malyar, Ulrich Rother, Bernd Balletshofer, Hui J Qiu, Peter Reimer, Holger Lawall","doi":"10.1055/a-2766-4074","DOIUrl":"https://doi.org/10.1055/a-2766-4074","url":null,"abstract":"","PeriodicalId":94001,"journal":{"name":"Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2026-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148623412","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Possible Role of Anti-Glutamic Acid Decarboxylase Antibody Levels in the Development of Celiac Disease in Children with Type 1 Diabetes.","authors":"Abdulkerim Elmas, Nesibe Kübra Göl, Nurten Özkan Zarif, Mustafa Akçam","doi":"10.1055/a-2916-3044","DOIUrl":"https://doi.org/10.1055/a-2916-3044","url":null,"abstract":"<p><strong>Abstract: </strong>OBJECTIVE : This study evaluated whether metabolic status and diabetes-related autoantibody levels at the time of type 1 diabetes diagnosis are associated with subsequent celiac disease in children.</p><p><strong>Abstract: </strong>METHODS : This retrospective matched case-control study included children diagnosed with type 1 diabetes between 2015 and 2025. Twenty-two children who developed celiac disease during follow-up were compared with 44 age- and sex-matched children with type 1 diabetes who did not develop celiac disease. Celiac disease was diagnosed based on serology and duodenal histopathology. Baseline acid-base status, C-peptide, glycated hemoglobin, and diabetes-related autoantibodies were analyzed.</p><p><strong>Abstract: </strong>RESULTS : Among 238 children with newly diagnosed type 1 diabetes, 22 children (9.2%) developed celiac disease. These children were compared with 44 age- and sex-matched children with type 1 diabetes who did not develop celiac disease. The median interval from diabetes diagnosis to celiac disease diagnosis was 8.5 months. Celiac disease was diagnosed within the first year in 59.2%, within the first 2 years in 86.3%, and within the first 3 years in 95.4% of affected children. Baseline acid-base status and C-peptide levels did not differ between groups. Anti-glutamic acid decarboxylase levels were higher in children who later developed celiac disease. Using a cut-off value of 66.5 IU/mL, anti-glutamic acid decarboxylase positivity was associated with increased odds of celiac disease development. This association remained significant in exploratory multivariable analysis after adjustment for anti-insulin antibody, islet cell antibody, and C-peptide levels.</p><p><strong>Abstract: </strong>CONCLUSIONS : Baseline acid-base status and C-peptide levels were not associated with subsequent celiac disease in children with type 1 diabetes. Anti-glutamic acid decarboxylase≥66.5 IU/mL remained independently associated with subsequent celiac disease after exploratory adjustment for other diabetes-related autoimmune markers and C-peptide levels. Given the limited sample size and retrospective design, this finding should be considered hypothesis-generating and requires validation in larger prospective cohorts. Regular serological screening for celiac disease after the diagnosis of type 1 diabetes remains essential, regardless of baseline autoantibody status.</p>","PeriodicalId":94001,"journal":{"name":"Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2026-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148623377","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}