Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association最新文献_第2页

The Trigeminal Nerve in Diabetes Mellitus: A Brief Narrative Review. 三叉神经与糖尿病的关系：简要回顾。

Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association Pub Date : 2025-04-24 DOI: 10.1055/a-2552-8692

Dimitrios Pantazopoulos, Evanthia Gouveri, Dimitrios Papazoglou, Nikolaos Papanas

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Diagnosis, Therapy and Follow-Up of Type 1 Diabetes Mellitus in Children and Adolescents. 儿童和青少年1型糖尿病的诊断、治疗和随访。

Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association Pub Date : 2025-04-01 Epub Date: 2025-05-06 DOI: 10.1055/a-2490-5096

Martin Holder, Clemens Kamrath, Karin Lange, Sebastian Kummer, Ralph Ziegler

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Diabetes Mellitus at an Elderly Age. 老年糖尿病。

Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association Pub Date : 2025-04-01 Epub Date: 2025-05-06 DOI: 10.1055/a-2500-0428

Andrej Zeyfang, Jürgen Wernecke, Anke Bahrmann

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Nutritional Recommendations for People with Type 1 Diabetes Mellitus. 1型糖尿病患者的营养建议

Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association Pub Date : 2025-04-01 Epub Date: 2025-05-06 DOI: 10.1055/a-2500-0477

Diana Rubin, Anja Bosy-Westphal, Stefan Kabisch, Peter Kronsbein, Karsten Müssig, Marie-Christine Simon, Astrid Tombek, Katharina S Weber, Thomas Skurk

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Diabetes and Pregnancy. 糖尿病和怀孕。

Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association Pub Date : 2025-04-01 Epub Date: 2025-05-06 DOI: 10.1055/a-2499-9780

Michael Hummel, Martin Füchtenbusch, Wilgard Battefeld, Christoph Bührer, Tanja Groten, Thomas Haak, Franz Kainer, Alexandra Kautzky-Willer, Andreas Lechner, Thomas Meissner, Christine Nagel-Reuper, Ute Margaretha Schäfer-Graf, Thorsten Siegmund

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Digitalization in Diabetology. 糖尿病学中的数字化。

Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association Pub Date : 2025-04-01 Epub Date: 2025-05-06 DOI: 10.1055/a-2490-5192

Susanne Reger-Tan, Angelika Deml, Manuel Ickrath, Jens Kröger, Bernhard Kulzer, Friedhelm Petry, Nikolaus Scheper, Oliver Schubert-Olesen, Peter Schwarz, Dietrich Tews, Marlo Verket, Sabrina Vite, Tobias Wiesner, Dirk Müller-Wieland

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Nephropathy in Diabetes. 糖尿病肾病。

Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association Pub Date : 2025-04-01 Epub Date: 2025-05-06 DOI: 10.1055/a-2500-1124

Ludwig Merker, Thomas Ebert, Erwin Schleicher, Berend Isermann, Martina Guthoff

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Morin attenuates ferroptosis via activation of the SIRT1/p53/SLC7A11 signaling pathway to alleviate diabetic cardiomyopathy in vivo. 在体内，马桑素通过激活SIRT1/p53/SLC7A11信号通路减轻铁下垂，从而减轻糖尿病性心肌病。

Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association Pub Date : 2025-03-12 DOI: 10.1055/a-2557-4592

Qingmei Wang, Xuanguo Zhang, Li Xi

{"title":"Morin attenuates ferroptosis via activation of the SIRT1/p53/SLC7A11 signaling pathway to alleviate diabetic cardiomyopathy in vivo.","authors":"Qingmei Wang, Xuanguo Zhang, Li Xi","doi":"10.1055/a-2557-4592","DOIUrl":"https://doi.org/10.1055/a-2557-4592","url":null,"abstract":"Diabetic cardiomyopathy (DCM) is a serious complication in patients with diabetes, which still lacks adequate therapy. Ferroptosis has recently been emphasized as a main contributor to the development of DCM. Hence, the current study aimed to assess the effects of morin, a well-known phytochemical, on the DCM. In this regard, DCM in Wistar rats was induced by streptozotocin (STZ). After treatment of animals with a dose of 25, 50, and 100 mg/kg of morin orally for 60 days, Sirtuin 1 (SIRT1), p53, solute carrier family 7 member 11 (SLC7A11), and glutathione peroxidase 4 (GPX4) in gene and protein levels in cardiac tissue were measured. Moreover, determination of redox status (GSH, SOD, CAT, and MDA) and inflammatory markers (IL-6, IL-1, and TNF-) in the cardiac tissue was performed and the levels of glucolipid profile, iron profile, and cardiac markers (troponin T and CK-MB) were assessed. The findings demonstrated that the administration of morin restored glucolipid and iron profiles, improved hypertension and cardiac hypertrophy, and suppressed inflammatory responses (p-value<0.001). Moreover, morin at a dose of 100 mg/kg/day was able to increase the levels of SLC7A11, SIRT1, GSH, SOD, CAT, and GPX4 while decreasing the cardiac levels of p53 and MDA (p-value<0.05). In conclusion, the findings suggest morin could alleviate DCM probably through modulation of ferroptosis via the SIRT1/p53/SLC7A11 signaling pathway activation and suppression of oxidative stress and inflammation.","PeriodicalId":94001,"journal":{"name":"Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143618006","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Patient-Reported Outcome Measures in Patients with Diabetes Mellitus: Findings from the Diabetes Landeck Cohort. 糖尿病患者报告的结果测量：来自糖尿病Landeck队列的发现。

Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association Pub Date : 2025-03-01 Epub Date: 2025-01-20 DOI: 10.1055/a-2496-2062

Veronika Haslwanter, Lára R Hallson, Ursula Rochau, Uwe Siebert, Hans Robert Schönherr, Wilhelm Oberaigner

{"title":"Patient-Reported Outcome Measures in Patients with Diabetes Mellitus: Findings from the Diabetes Landeck Cohort.","authors":"Veronika Haslwanter, Lára R Hallson, Ursula Rochau, Uwe Siebert, Hans Robert Schönherr, Wilhelm Oberaigner","doi":"10.1055/a-2496-2062","DOIUrl":"10.1055/a-2496-2062","url":null,"abstract":"Introduction: Maintaining and optimizing quality of life (QoL) is a central issue and one of the most important goals in therapy for patients with chronic diseases, such as diabetes mellitus (DM). Despite its importance, there is little data on the QoL of patients with DM in Austria. The objective of this study was to extend an established population-based cohort, the Diabetes-Landeck cohort, by including patient-reported outcomes.Methods: We performed a survey on quality of life (QoL) and treatment satisfaction in patients from the Diabetes-Landeck cohort using the EQ-5D-5L, the problem areas in diabetes survey (PAID), and the diabetes treatment satisfaction questionnaire (DTSQ). Mean sum scores were calculated and compared between patient characteristic subgroups.Results: In total 58 patients were recruited, with a mean age of 63 years and a mean hemoglobin A1c (HbA1c) of 7.1%. The mean sum score of EQ-5D-5L was 92 (SD=10.6), and that of DTSQ and PAID were 32.2 (SD=6.6) and 10.8 (SD=11.6), respectively. Patients with obesity (body mass index ≥ 30 kg/m2) showed a statistically significant decreased mean sum score of EQ-5D-5L and a statistically significant increased mean sum score of DTSQ. Patients with HbA1c ≥7.5% showed a statistically significant decreased mean sum score of DTSQ.Conclusion: We observed patient-reported outcomes significantly associated with obesity and HbA1c, which could be used for targeted patient monitoring. Limited by small sample size and questions in generalizability, we strongly suggest the rollout of a larger study.","PeriodicalId":94001,"journal":{"name":"Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association","volume":" ","pages":"139-145"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143018772","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Metrnl Ameliorates Ferroptosis in Model of Diabetic Foot Ulcer Through the Inhibition of Mitochondrial Damage via LKB1/AMPK Signaling. Metrnl通过LKB1/AMPK信号抑制线粒体损伤改善糖尿病足溃疡模型中的铁下垂

Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association Pub Date : 2025-03-01 Epub Date: 2025-03-12 DOI: 10.1055/a-2502-8712

Xiangjian Meng, Zhichen Pu, Junjun He, Qin Li, Ying Xie

{"title":"Metrnl Ameliorates Ferroptosis in Model of Diabetic Foot Ulcer Through the Inhibition of Mitochondrial Damage via LKB1/AMPK Signaling.","authors":"Xiangjian Meng, Zhichen Pu, Junjun He, Qin Li, Ying Xie","doi":"10.1055/a-2502-8712","DOIUrl":"10.1055/a-2502-8712","url":null,"abstract":"Diabetic foot ulcer (DFU) represents a severe complication of diabetes, mainly caused by peripheral vascular occlusion and infection, presenting significant clinical challenges in treatment and potentially resulting in gangrene, amputation, or even fatality. This study aimed to investigate the involvement and underlying mechanisms of Meteorin-like (Metrnl) in the pathogenic process of DFU. Mice underwent diabetes induction by streptozotocin, while human umbilical vein endothelial cells (HUVECs) were exposed to 5.5, 10, 20 or 40 mM glucose. HUVECs were transfected with negative or Metrnl or si-nc or si-Metrnl plasmids via Lipofectamine 2000. The expression of Metrnl was down-regulated in both patients and the murine model of DFU. Elevated glucose levels diminished Metrnl through enhanced Metrnl ubiquitination. The suppression of Metrnl exacerbated foot ulcer in the mouse model of DFU. Metrnl alleviated oxidative stress and ferroptosis in the DFU model by inhibiting mitochondrial damage. Metrnl induced liver kinase B1 (LKB1)/AMP-activated protein kinase (AMPK) signaling in the DFU model. LKB1 attenuated the effects of Metrnl on oxidative stress and ferroptosis in the DFU model. The data cumulatively demonstrate that Metrnl ameliorates ferroptosis in the DFU model by inhibiting mitochondrial damage via LKB1/AMPK signaling, suggesting that targeting Metrnl may emerge as a potential preventive approach against ferroptosis of DFU or other diabetes.","PeriodicalId":94001,"journal":{"name":"Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association","volume":"133 3","pages":"120-132"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143618030","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0