Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association最新文献_第2页

Ocular Motor Mononeuropathies in Diabetes Mellitus: A Brief Review. 糖尿病的眼部运动性单神经病：简要回顾。

Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association Pub Date : 2025-02-01 Epub Date: 2024-11-07 DOI: 10.1055/a-2463-7075

Dimitrios Pantazopoulos, Evanthia Gouveri, Dimitrios Papazoglou, Nikolaos Papanas

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The Mechanism and Treatment of Cognitive Dysfunction in Diabetes: A Review. 糖尿病认知功能障碍的机制与治疗：综述。

Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association Pub Date : 2025-02-01 Epub Date: 2024-11-21 DOI: 10.1055/a-2480-7826

Yangbo Hou, Zhen Chen, Jiwei Cheng, Guoyi Li, Lu Yin, Jie Gao

{"title":"The Mechanism and Treatment of Cognitive Dysfunction in Diabetes: A Review.","authors":"Yangbo Hou, Zhen Chen, Jiwei Cheng, Guoyi Li, Lu Yin, Jie Gao","doi":"10.1055/a-2480-7826","DOIUrl":"10.1055/a-2480-7826","url":null,"abstract":"Diabetes mellitus (DM) is one of the fastest growing diseases in terms of global incidence and seriously affects cognitive function. The incidence rate of cognitive dysfunction is up to 13% in diabetes patients aged 65-74 years and reaches 24% in those aged >75 years. The mechanisms and treatments of cognitive dysfunction associated with diabetes mellitus are complicated and varied. Previous studies suggest that hyperglycemia mainly contributes to cognitive dysfunction through mechanisms involving inflammation, autophagy, the microbial-gut-brain axis, brain-derived neurotrophic factors, and insulin resistance. Antidiabetic drugs such as metformin, liraglutide, and empagliflozin and other drugs such as fingolimod and melatonin can alleviate diabetes-induced cognitive dysfunction. Self-management, intermittent fasting, and repetitive transverse magnetic stimulation can also ameliorate cognitive impairment. In this review, we discuss the mechanisms linking diabetes mellitus with cognitive dysfunction and propose a potential treatment for cognitive decline associated with diabetes mellitus.","PeriodicalId":94001,"journal":{"name":"Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association","volume":" ","pages":"64-72"},"PeriodicalIF":0.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142690169","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Comparison of Diagnostic Performances of ATA Guidelines, ACR-TIRADS, and EU-TIRADS and Modified K-TIRADS: A Single Center Study of 4238 Thyroid Nodules. ATA指南、ACR-TIRADS、EU-TIRADS及改良K-TIRADS诊断效能比较：4238例甲状腺结节单中心研究

Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association Pub Date : 2025-02-01 Epub Date: 2024-12-09 DOI: 10.1055/a-2498-7952

Mustafa Özdemir, Gamze Türk, Mustafa Bilgili, Ebru Akay, Ali Koç

{"title":"Comparison of Diagnostic Performances of ATA Guidelines, ACR-TIRADS, and EU-TIRADS and Modified K-TIRADS: A Single Center Study of 4238 Thyroid Nodules.","authors":"Mustafa Özdemir, Gamze Türk, Mustafa Bilgili, Ebru Akay, Ali Koç","doi":"10.1055/a-2498-7952","DOIUrl":"10.1055/a-2498-7952","url":null,"abstract":"Several ultrasound-based risk stratification systems (RSSs) have been developed and introduced into clinical practice for managing thyroid nodules. However, there are essential differences among these systems. This study aimed to determine and compare the category-based diagnostic performance of four ultrasound-based risk stratification systems in the detection of thyroid cancer: ACR-TIRADS, ATA, K-TIRADS, and EU-TIRADS.This study included 4238 nodules sampled by fine-needle aspiration biopsy between January 2018 and December 2021. Nodules were classified according to ultrasound imaging features and correlated with biopsy results. The diagnostic success of the risk stratification systems was evaluated and compared.Of the 4238 nodules, 3861 (91.1%) were benign and 376 (8.9%) were malignant. Malignancy was significantly higher in hypoechoic and marked hypoechoic nodules (p=0.001), and solid nodules (p=0.002). For detection of malignancy, areas under the receiving operator characteristics curves were 0.862, 0.850, 0.842, and 0.835 for 2017 ACR-TIRADS, EU-TIRADS, for K-TIRADS, and 2015 American Thyroid Association guidelines, respectively. EU-TIRADS showed the highest sensitivity (91%), whereas ACR-TIRADS had the highest specificity (87%). Compared to other risk stratification systems, ACR-TIRADS resulted in significantly fewer unnecessary biopsies (p=0.009). All RSSs show high diagnostic accuracy and have their own advantages and disadvantages. When selecting an appropriate RSS, the population, the prevalence of the disease, and gender distribution should be considered.","PeriodicalId":94001,"journal":{"name":"Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association","volume":" ","pages":"98-104"},"PeriodicalIF":0.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142803973","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Efficacy of Low-Density Lipoprotein Cholesterol Apheresis in the Treatment of Familial Hypercholesterolemia: Single Center Experience. 低密度脂蛋白胆固醇分离治疗家族性高胆固醇血症的疗效：单中心经验。

Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association Pub Date : 2025-02-01 Epub Date: 2024-12-04 DOI: 10.1055/a-2460-7066

Hulya Hacisahinogullari, Gamze Bilik Oyman, Ummu Mutlu, Senem Dadin, Gulsah Y Yalin, Ozlem Soyluk, Nurdan Gul, Sevgi Kalayoglu Besisik, Ilhan Satman, Kubilay Karsidag, Ayse Kubat Uzum

{"title":"Efficacy of Low-Density Lipoprotein Cholesterol Apheresis in the Treatment of Familial Hypercholesterolemia: Single Center Experience.","authors":"Hulya Hacisahinogullari, Gamze Bilik Oyman, Ummu Mutlu, Senem Dadin, Gulsah Y Yalin, Ozlem Soyluk, Nurdan Gul, Sevgi Kalayoglu Besisik, Ilhan Satman, Kubilay Karsidag, Ayse Kubat Uzum","doi":"10.1055/a-2460-7066","DOIUrl":"10.1055/a-2460-7066","url":null,"abstract":"Purpose: Familial hypercholesterolemia (FH) is a genetic disorder associated with extremely high levels of low-density lipoprotein cholesterol (LDL-C) and increased incidence of cardiovascular disease. We aimed to evaluate the efficacy and long-term outcomes of lipoprotein apheresis (LA) in the treatment of FH.Methods: Cardiovascular events that occurred before and after LA treatment were evaluated by reviewing previous medical records of patients with FH.Results: Thirteen patients (female/male: 8/5) were included in this study. The mean Dutch score was 20±4. All patients were treated with a combination of statin and ezetimibe. Before the onset of LA, 8 patients had a history of coronary artery disease, and the median age at onset of cardiovascular disease (CVD) in these patients was 24 years. At the initiation of LA, the median age was 22 years and the mean LDL-C level was 410±130 mg/dL. The mean duration of LA treatment was 13.9±6.9 years. The mean LDL-C levels before and after the latest three LA treatments were 267±63.4 and 71.5±23.4 mg/dL, respectively. The mean reduction in LDL-C levels after LA was 73±8.2%. De novo cardiovascular events occurred in 10 patients during LA treatment; six of these patients had a known history of CVD before LA. Eight of these patients underwent invasive procedures for therapeutic purposes and the total number of procedures was 12.Conclusion: LA is an effective method of reducing LDL-C levels and an additional treatment option that may slow disease progression in patients with FH who are at high risk of cardiovascular events.","PeriodicalId":94001,"journal":{"name":"Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association","volume":" ","pages":"92-97"},"PeriodicalIF":0.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142782225","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Anxiety and Depression in Polycystic Ovary Syndrome: An Analysis Using the Hospital Anxiety and Depression Scale (HADS) in Women from a Low-Income Country.

Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association Pub Date : 2025-02-01 Epub Date: 2025-01-22 DOI: 10.1055/a-2502-8913

Daiane O Simão, Aline Vanessa M P Santos, Vitória S Vieira, Fernando M Reis, Ana Lúcia Cândido, Fabio V Comim, Jéssica A G Tosatti, Karina B Gomes

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Shwachman-Diamond Syndrome and Diabetes: An Update from the Italian Registry and Review of the Literature. Shwachman-Diamond综合征和糖尿病：来自意大利登记和文献综述的最新信息。

Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association Pub Date : 2025-02-01 Epub Date: 2025-01-15 DOI: 10.1055/a-2460-6977

Antonella Minelli, Emily Pintani, Roberto Valli, Gloria Tridello, Giovanni Porta, Francesca Fioredda, Marco Cipolli, Cesare Danesino

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Endocrine Complications in Hepatic Glycogen Storage Diseases: A Long-term Perspective. 肝糖原贮积症的内分泌并发症：长期展望

Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association Pub Date : 2025-02-01 Epub Date: 2024-10-17 DOI: 10.1055/a-2444-4320

Ja Hye Kim, Yena Lee, Soojin Hwang, Dohyung Kim, Beom Hee Lee, Gu-Hwan Kim, Han-Wook Yoo, Jin-Ho Choi

{"title":"Endocrine Complications in Hepatic Glycogen Storage Diseases: A Long-term Perspective.","authors":"Ja Hye Kim, Yena Lee, Soojin Hwang, Dohyung Kim, Beom Hee Lee, Gu-Hwan Kim, Han-Wook Yoo, Jin-Ho Choi","doi":"10.1055/a-2444-4320","DOIUrl":"10.1055/a-2444-4320","url":null,"abstract":"Patients with a hepatic type of glycogen storage diseases (GSDs) can manifest endocrine features such as hypoglycemia, dyslipidemia, or osteoporosis. This study aimed to investigate the long-term endocrine consequences in patients with hepatic GSDs.This study included 64 patients from 52 families with hepatic GSDs including GSD type Ia (41 patients from 37 families), Ib (3 unrelated), III (8 from 6 families), IV (1 patient), and IX (11 from 5 families). All patients were genetically confirmed. Clinical and endocrine findings were retrospectively analyzed.The median age at diagnosis and current age were 2.4 years (range, 0.1-42.4 years) and 17.6 years (range, 1.0-47.8 years), respectively. The mean height SDS at diagnosis was -3.5±1.4, and short stature was observed in 35.6% of patients. Patients diagnosed after the age of 3.4 years exhibited a high risk of short stature (OR=36.1; P-value<0.001). Among 33 patients who reached the final height, 23 (69.7%) showed delayed puberty. Hypertriglyceridemia was observed in 46 patients (71.9%), whereas 25 patients (39%) had elevated low-density lipoprotein cholesterol levels during the follow-up period. Among 24 patients who underwent dual-energy X-ray absorptiometry, 22 showed a low bone mineral density Z-score of -3.0±1.3 at the L-spine.This study described the long-term endocrine consequences in patients with hepatic GSDs. Pediatric endocrinologists should be aware of the presenting features and long-term endocrine sequelae of GSDs to provide proper management and decrease its morbidities.","PeriodicalId":94001,"journal":{"name":"Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association","volume":" ","pages":"83-91"},"PeriodicalIF":0.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142484052","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Can Salivary Cortisol be Used in Diagnosing Adrenal Insufficiency During the Acute and Subacute Phases of Traumatic Brain Injury? 唾液皮质醇能否用于诊断脑外伤急性期和亚急性期的肾上腺功能不全？

Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association Pub Date : 2025-01-01 Epub Date: 2024-10-17 DOI: 10.1055/a-2444-4386

Emre Urhan, Gulsah Elbuken, Zuleyha Karaca, Kursad Unluhizarci, Mustafa Kula, Ahmed Selcuklu, Fahrettin Kelestimur

{"title":"Can Salivary Cortisol be Used in Diagnosing Adrenal Insufficiency During the Acute and Subacute Phases of Traumatic Brain Injury?","authors":"Emre Urhan, Gulsah Elbuken, Zuleyha Karaca, Kursad Unluhizarci, Mustafa Kula, Ahmed Selcuklu, Fahrettin Kelestimur","doi":"10.1055/a-2444-4386","DOIUrl":"10.1055/a-2444-4386","url":null,"abstract":"Introduction: The diagnosis of adrenal insufficiency (AI) related to traumatic brain injury (TBI) remains a challenge. We investigated the basal and low-dose adrenocorticotropic hormone (ACTH)-stimulated serum cortisol and salivary cortisol (SaC) levels and the diagnostic utility of SaC levels during 28 days following TBI.Materials and methods: Blood samples were collected for basal levels [sequentially from day 1 (D1) to D7 and on D28)] and for peak serum cortisol and SaC responses to the low-dose ACTH stimulation test (on D1, D7, and D28). After the patient enrollment period was completed, patients were retrospectively categorized as AI or AS (adrenal sufficiency) for each day separately, based on a basal serum cortisol cut-off level of 11 µg/dL, and data analysis was performed between the groups.Results: Thirty-seven patients and 40 healthy controls were included. Median basal serum cortisol levels were higher in patients on D1 but were similar on other days. Median basal SaC levels were higher in patients on D1 and D2 but were similar on other days. Median peak serum cortisol and SaC levels were similar on D1 but were lower in patients on D7 and D28. Median basal SaC levels were higher in the AS group than in the AI group on all days.Discussion and conclusions: When evaluating AI during the course of TBI, the cut-off for basal SaC levels is 0.5-0.6 µg/dL throughout the first week, except for 1.38 µg/dL on D2. SaC levels may serve as a surrogate marker for accurately reflecting circulating glucocorticoid activity.","PeriodicalId":94001,"journal":{"name":"Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association","volume":" ","pages":"25-33"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142484051","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Acknowledgment to the Reviewers.

Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association Pub Date : 2025-01-01 Epub Date: 2025-01-16 DOI: 10.1055/a-2497-8322

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ECED Best Paper Award - Honouring outstanding clinical-experimental work in the past two years. ECED最佳论文奖-表扬过去两年杰出的临床实验工作。

Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association Pub Date : 2025-01-01 Epub Date: 2025-01-16 DOI: 10.1055/a-2501-3043

Karsten Müssig

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