Ear, nose, & throat journal最新文献

{"title":"Review of Acetazolamide and Novel Medical Paradigms for Idiopathic Intracranial Hypertension Treatment.","authors":"Young Lee, Avraham E Adelman, Alvaro J Mejia-Vergara, Bryce E Buchowicz, Brian C Lobo, Jeb M Justice, Nikita Chapurin","doi":"10.1177/01455613251358629","DOIUrl":"https://doi.org/10.1177/01455613251358629","url":null,"abstract":"<p><strong>Objective: </strong>To summarize recent emerging treatments for idiopathic intracranial hypertension (IIH) as an adjunct to surgical repair of cerebrospinal fluid leak by rhinology and skull base surgeons.</p><p><strong>Data sources: </strong>PubMed and Embase databases.</p><p><strong>Review methods: </strong>A literature review of aforementioned databases was performed on August 23, 2024, to identify studies from the past 5 years of acetazolamide alternatives and on September 16, 2024, for acetazolamide for the medical management of IIH. Data collected from studies included author, publication year, type of evidence, main findings, dosage, reported adverse effects, and medication studied.</p><p><strong>Results: </strong>Ten articles met screening criteria, and medications studied included the following: acetazolamide, topiramate, glucagon-like peptide-1 receptor agonists (GLP-1RAs), and 11-beta hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitors. There were 4 randomized control trials, 1 pilot single-center study, 2 retrospective cohort studies, 1 retrospective case-control study, and 2 murine model basic science studies. There were significant findings supporting the case for increased research into their respective medications with hopeful clinical translation.</p><p><strong>Conclusion: </strong>Topiramate, GLP-1RAs, and 11β-HSD1 inhibitors are promising adjuncts or alternatives to acetazolamide and should be further investigated as effective IIH treatments.</p>","PeriodicalId":93984,"journal":{"name":"Ear, nose, & throat journal","volume":" ","pages":"1455613251358629"},"PeriodicalIF":0.7,"publicationDate":"2025-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144839505","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pre- and Post-Treatment Diffusion-Weighted Imaging Characteristics of Sinonasal Adenoid Cystic Carcinoma.","authors":"Mahlet Worku Molla, Nadieska Caballero, Daniel Thomas Ginat","doi":"10.1177/01455613251356364","DOIUrl":"https://doi.org/10.1177/01455613251356364","url":null,"abstract":"<p><strong>Background: </strong>Sinonasal adenoid cystic carcinoma (ACC) is a rare, aggressive malignancy that commonly involves the nasal cavity and paranasal sinuses, with a propensity for perineural invasion and distant spread. Diffusion-weighted imaging (DWI) is a useful tool for evaluating tumor characteristics and monitoring treatment response. This case series aims to review the pre- and post-treatment diffusion characteristics of sinonasal ACC, focusing on the apparent diffusion coefficient (ADC) values.</p><p><strong>Methods: </strong>A series of 8 cases of sinonasal ACC that underwent pre- and post-treatment magnetic resonance imaging with DWI were retrospectively analyzed. Circular regions of interest were drawn on representative ADC images of the lesions.</p><p><strong>Results: </strong>Pre-treatment mean ADC values ranged from 651 to 1156 × 10^-6 mm²/second, while the post-treatment average ADC values ranged from 1351 to 1879 × 10^-6 mm²/second. Post-treatment changes in ADC values were observed in all cases, demonstrating an increase in ADC, indicative of positive treatment response.</p><p><strong>Conclusion: </strong>This case series suggests that DWI could serve as a non-invasive imaging tool for evaluating post-treatment response of sinonasal ADC. Post-treatment changes in ADC potentially correlate with treatment response and disease progression. Hence, DWI could play a supplemental role in monitoring therapy, highlighting its potential in guiding clinical management decisions for patients with sinonasal ACC.</p>","PeriodicalId":93984,"journal":{"name":"Ear, nose, & throat journal","volume":" ","pages":"1455613251356364"},"PeriodicalIF":0.7,"publicationDate":"2025-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144823456","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply to the Comments on \"Reconstruction of a Large Oncologic Defect Involving the Lower Eyelid and Infraorbital Cheek Using the MSTAFI Flap\".","authors":"Chao Lian, Xue-Lei Li, Xiao-Jun Liu","doi":"10.1177/01455613251364609","DOIUrl":"https://doi.org/10.1177/01455613251364609","url":null,"abstract":"","PeriodicalId":93984,"journal":{"name":"Ear, nose, & throat journal","volume":" ","pages":"1455613251364609"},"PeriodicalIF":0.7,"publicationDate":"2025-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144823457","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ewing's Sarcoma of the Tongue in a 17-Year-Old Female Patient: A Unique Case Report.","authors":"Elias Edward Lahham, Jamal Al-Sa'ed, Mayar Karaki, Mohammad Fatayer, Mahmoud Ramahi, Jalal Qawasmeh, Khadra Salami, Hani Saleh","doi":"10.1177/01455613251367188","DOIUrl":"https://doi.org/10.1177/01455613251367188","url":null,"abstract":"<p><p>Ewing's sarcoma (ES), the second most common primary bone cancer in adolescents, predominantly affects males with a peak incidence at 15 years of age. While extraskeletal presentations are rare, tongue involvement is uncommon, with few cases reported globally. ES typically manifests as a firm swelling, often asymptomatic or accompanied by mild discomfort, and is managed primarily with chemotherapy or surgery. In this report, we present a rare case of a 17-year-old female with extraskeletal ES presenting as progressive swelling on the left side of the tongue. The patient responded impressively to chemotherapy, then was given radiation therapy with complete resolution of the disease. This case highlights the diagnostic and therapeutic challenges of managing such an unusual presentation, contributing valuable insights to the literature, and guiding future care for similar cases.</p>","PeriodicalId":93984,"journal":{"name":"Ear, nose, & throat journal","volume":" ","pages":"1455613251367188"},"PeriodicalIF":0.7,"publicationDate":"2025-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144823455","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Rise and Fall of Radium Adenoid Ablation.","authors":"Robert Duncheskie, Glenn Isaacson","doi":"10.1177/01455613251366042","DOIUrl":"https://doi.org/10.1177/01455613251366042","url":null,"abstract":"","PeriodicalId":93984,"journal":{"name":"Ear, nose, & throat journal","volume":" ","pages":"1455613251366042"},"PeriodicalIF":0.7,"publicationDate":"2025-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144805406","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Temporal Lobe Abscess Secondary to Chronic Otitis Media: Evaluation and Management in a Medical Complex Patient.","authors":"Tyler J Ostrowski, Erica L Greiner, Lara K Reichert","doi":"10.1177/01455613251357421","DOIUrl":"https://doi.org/10.1177/01455613251357421","url":null,"abstract":"<p><p>Chronic otitis media is a persistent middle ear infection caused by various well-described bacteria that, in rare cases, can lead to severe complications including intracranial infections such as brain abscesses and meningitis. We present a case of a 42-year-old female with a complicated medical history including chronic otitis media, who developed a brain abscess and meningitis following the spread of the infection. The patient initially presented with altered mental status and concerns for acute intracranial processes were confounded by her significant polysubstance use history. Further work up revealed bacteremia. Imaging revealed middle ear effusions with skull base dehiscence and a large brain abscess in the temporal lobe. Workup revealed a diagnosis of viral and bacterial meningitis via blood, and CSF cultures from both cerebrospinal fluid and ear discharge confirmed the presence of <i>Streptococcus pneumoniae</i> with Epstein-Barr Virus (EBV) DNA in the CSF. The patient was treated with intravenous antibiotics, surgical drainage of the abscess, and supportive care, leading to clinical improvement and eventual discharge from the hospital against medical advice. This case highlights the potential for chronic otitis media to result in life-threatening intracranial infections, underscoring the importance of early detection, high clinical suspicion despite patient confounding medical factors, and aggressive management in cases of advanced disease.</p>","PeriodicalId":93984,"journal":{"name":"Ear, nose, & throat journal","volume":" ","pages":"1455613251357421"},"PeriodicalIF":0.7,"publicationDate":"2025-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144801304","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Radiofrequency Ablation of Inferior Turbinates With Posterior Nasal Nerve Neurolysis for Refractory Rhinitis Medicamentosa.","authors":"Jyun-Yi Liao, Yi-Li Hwang, Ting-Yu Shih, Han-Lo Teng, Chien-Yu Huang","doi":"10.1177/01455613251364615","DOIUrl":"https://doi.org/10.1177/01455613251364615","url":null,"abstract":"<p><strong>Objective: </strong>To explore the effectiveness of surgical intervention in treating refractory rhinitis medicamentosa (RM) and determine whether laser posterior nasal neurolysis improves outcomes.</p><p><strong>Method: </strong>This is a retrospective cohort study from February 2023 to June 2025, which enrolled patients with RM refractory to medical treatment who received either radiofrequency ablation turbinate reduction (RF) alone or combined RF ablation with laser posterior nasal nerve neurolysis (RPN3).</p><p><strong>Results: </strong>The study included 37 patients with refractory RM (RF group = 9, RPN3 group = 28). During the 12-month follow-up, 35 patients (94.6%) withdrew from nasal constrictors successfully. For the entire cohort, the baseline reflective total nasal symptom score was 6.6 ± 2.9, decreasing to 1.5 ± 2.1 during the 12-month follow-up (<i>P</i> < .001). The baseline nasal obstruction symptom evaluation score was 13.3 ± 4.7, decreasing to 1.6 ± 2.7 during the 12-month follow-up (<i>P</i> < .001). The RF group showed significant improvement in congestion (<i>P</i>-value < .001), rhinorrhea, and sneezing (<i>P</i>-value < .05) but not in itching during the 12-month follow-up. The RPN3 group showed significant improvement in all subscores from the 1st to 12th month follow-up (<i>P</i> < .001).</p><p><strong>Conclusions: </strong>Surgical intervention successfully eliminated nasal decongestant dependency in patients with RM while improving their quality of life. The RPN3 procedure, which combines laser posterior nasal nerve treatment, may offer additional benefits by providing enhanced control of nasal itching and achieving earlier response in rhinorrhea and sneezing control.</p><p><strong>Level of evidence: </strong>III.</p>","PeriodicalId":93984,"journal":{"name":"Ear, nose, & throat journal","volume":" ","pages":"1455613251364615"},"PeriodicalIF":0.7,"publicationDate":"2025-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144777412","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Data-Driven Analysis of Short- and Long-Term Outcomes of Simulation, Nasal Hump Reduction, and Rasping in Open Rhinoplasty for Nasal Dorsum Correction.","authors":"Fuat Bulut, Faruk Bulut","doi":"10.1177/01455613251334450","DOIUrl":"10.1177/01455613251334450","url":null,"abstract":"<p><strong>Purpose: </strong>This study aims to highlight the significance of performing simulations, nasal hump reduction, and rasping in open-technique rhinoplasty for the nasal dorsum. The research utilizes data science methodologies for a thorough examination of the collected survey data.</p><p><strong>Methods: </strong>A comprehensive survey comprising 29 questions was presented to surgeons participating in the Eastern Trakya ENT Association Training Meetings-I. This survey, specifically designed to investigate the nuances of open and closed rhinoplasty approaches to nasal dorsum intervention, collected responses from 132 physicians. The collected dataset was thoroughly reviewed and analyzed. The responses were not only graphically represented but also transformed into a dataset primed for data science analysis. Significant results were derived using both association rule-mining algorithms from machine learning and basic statistical analysis.</p><p><strong>Results: </strong>The raw data underwent thorough analysis using fundamental statistical methods and association rules within the field of data science. The discerned data patterns revealed significant insights into the behavioral tendencies and approaches adopted by physicians in rhinoplasty. The survey analysis emphasized the widespread acceptance of the open technique for nasal dorsum procedures, even though it may not be the preferred choice for all rhinoplasty cases. A notable 74.6% of rhinoplasty surgeons employing the open technique indicated that the primary long-term challenge during nasal dorsum interventions was irregularity. In addition, among the 132 participating surgeons, 25.8% were found to frequently engage in facial plastic surgery, while 55.4% reported abstaining from simulations. Notably, rhinoplasty surgeons who opted out of simulations, despite exclusively applying the open technique, reported encountering irregularities and requiring more adjustments.</p><p><strong>Conclusion: </strong>Rhinoplasty surgeons who do not use simulations in open nasal dorsum approaches reported facing irregularities and performing more revisions. Furthermore, they noted encountering irregularities in both the short and long term following nasal hump reduction and rasping procedures.</p>","PeriodicalId":93984,"journal":{"name":"Ear, nose, & throat journal","volume":" ","pages":"NP497-NP509"},"PeriodicalIF":0.0,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144047248","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Laryngopharyngeal Reflux in Otolaryngology-Head and Neck Surgery Clinic: An Epidemiological Survey.","authors":"Yuanyuan Wang, Qixu Liang, Jian Luo, Hongbin Miao, Gang Qin, Yilin Bao","doi":"10.1177/01455613241301601","DOIUrl":"10.1177/01455613241301601","url":null,"abstract":"<p><p><b>Background and Objectives:</b> Laryngopharyngeal reflux disease (LPRD) has been implicated in the etiology of many laryngeal disorders and is also closely related to the occurrence and progression of a variety of throat diseases, including chronic cough, leukoplakia of the larynx, dysphonia, and even laryngeal tumors. LPRD can significantly reduce the quality of life of patients and cause substantial medical and economic burdens to the society. Reflux Symptom Index (RSI), a self-administered 9-item outcomes instrument for laryngopharyngeal reflux (LPR), has been widely used to screen for LPRD, but there is a lack of feasibility studies on the use of RSI for LPRD screening and alternative diagnostic tools in otolaryngology-head and neck surgery (OHNS) clinics. To study the incidence, clinical characteristics, diagnostic status, and influencing factors of LPRD at OHNS clinics, RSI as an alternative diagnostic tool has also been studied. LPRD was defined as RSI > 13. <b>Methods:</b> Systematic collection of data by the RSI questionnaire was used to identify patients in the outpatient clinic suffering from LPRD; in addition, the personal history of participants was collected. Follow-up observation was carried out for 6 months for patients with suspected LPRD (RSI > 13), including whether they were treated with standardized anti-reflux therapy, and the questionnaire based on RSI was completed again after treatment. <b>Results:</b> The LPRD rate was 7.92% (94/1187) in this survey. The proportions of LPRD patients with smoking history (vs no smoking) and alcohol consumption history (vs. no alcohol consumption) were significantly higher (<i>χ</i>² values: 7.025 and 4.562, and <i>P</i> values: .008 and .033; respectively). Smoking significantly increased the risk of LPRD (OR: 2.140, 95% CI: 1.058-4.331, <i>P</i> = .034). Among patients with LPRD positive, the incidence of \"foreign body sensation in the throat\" (symptom 8) score equal to 5 was the highest (19.15%). The severity of \"excess mucus in the throat or postnasal drip\" (symptom 3) contributed mostly to the total RSI score in patients with LPRD (<i>r</i> = .409, <i>P</i> < .001). ROC curve analysis showed that RSI ≥ 14 had a sensitivity of 72.9% and a specificity of 71.4% for the diagnosis of LPRD, with AUC = 0.797 (95% CI: 0.577-0.884, <i>P</i> < .001). <b>Conclusions:</b> The incidence of LPRD was high in patients we examined in OHNS clinics. We recommend that RSI can be used by otolaryngologists as a reliable tool for screening and diagnosing LPRD in OHNS clinics, which is beneficial for clinical practice.</p>","PeriodicalId":93984,"journal":{"name":"Ear, nose, & throat journal","volume":" ","pages":"NP510-NP517"},"PeriodicalIF":0.0,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142684046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rare Presentation of Monkeypox: Initial Tonsillitis Symptoms Leading to Diagnostic Challenges.","authors":"Chien-Wei Huang, Jyun-Yi Liao, Sheng-Chiao Lin","doi":"10.1177/01455613241260769","DOIUrl":"10.1177/01455613241260769","url":null,"abstract":"","PeriodicalId":93984,"journal":{"name":"Ear, nose, & throat journal","volume":" ","pages":"475-477"},"PeriodicalIF":0.0,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141263498","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}