Deutsche medizinische Wochenschrift (1946)最新文献_第7页

[Outpatient palliative care for non-oncological diseases]. [非肿瘤疾病的门诊姑息治疗]。

Deutsche medizinische Wochenschrift (1946) Pub Date : 2025-07-01 Epub Date: 2025-06-25 DOI: 10.1055/a-2436-7791

Paul Wiesheu, Ulrich Grabenhorst, Johannes Maximilian Just

引用次数: 0

[Genetic Causes of Heart Failure in Adults]. [成人心力衰竭的遗传原因]。

Deutsche medizinische Wochenschrift (1946) Pub Date : 2025-07-01 Epub Date: 2025-06-25 DOI: 10.1055/a-2304-7182

Brenda Gerull

引用次数: 0

[Basic knowledge of drug pain therapy in the palliative situation]. 【姑息情况下药物疼痛治疗的基本知识】。

Deutsche medizinische Wochenschrift (1946) Pub Date : 2025-07-01 Epub Date: 2025-06-25 DOI: 10.1055/a-2544-4239

Sascha Weber, Angelika Lampert, Julia C Stingl, Vera Peuckmann-Post, Sonja Hiddemann, Frank Elsner, Irene Neuner, Roman Rolke

{"title":"[Basic knowledge of drug pain therapy in the palliative situation].","authors":"Sascha Weber, Angelika Lampert, Julia C Stingl, Vera Peuckmann-Post, Sonja Hiddemann, Frank Elsner, Irene Neuner, Roman Rolke","doi":"10.1055/a-2544-4239","DOIUrl":"https://doi.org/10.1055/a-2544-4239","url":null,"abstract":"This review provides an overview of the basic knowledge of drug pain therapy in the palliative situation. Pain is one of the main symptoms in 60 to 90% of cancer patients. Pain also develops with neurological and other diseases that occur in end-of-life situations. To address this symptom, a holistic strategy is required that encompasses all physical, psychological, social, and spiritual aspects of the multi-dimensional pain experience (\"total pain\" concept).Drug treatment for cancer pain has been based on a stepwise approach for many years, starting with non-opioid analgesics, followed by moderate and strong opioids. In contrast, today's pain management is determined more by the actual intensity of this aversive event.The pain assessment should be tailored to identify a nociceptive vs. a neuropathic pain component that needs to be challenged by the most appropriate drug therapies. Non-opioid analgesics are ideal substances for relieving nociceptive pain. Antidepressants and anticonvulsants reduce the intensity of new neuropathic pain. Opioids are suitable for all types of pain, but are restricted to a second-line choice. Among all opioids are Tilidine and Tramadol prodrugs, which only relieve pain after activation in the liver. Drug-drug interactions may also block this activation. Rapid release opioids should be used for break-through cancer pain. Transdermal opioid applications are recommended in case of swallowing disorders, but usually not to initiate pain control. An opioid change can be performed if side effects such as hallucinations for the selected opioid are more pronounced than the pain reduction.","PeriodicalId":93975,"journal":{"name":"Deutsche medizinische Wochenschrift (1946)","volume":"150 14","pages":"817-825"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144499899","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Antithrombotic therapy for polyvascular atherosclerosis]. [多血管粥样硬化的抗血栓治疗]。

Deutsche medizinische Wochenschrift (1946) Pub Date : 2025-06-01 Epub Date: 2025-05-28 DOI: 10.1055/a-2359-4422

Christine Espinola-Klein

引用次数: 0

[Polyvascular atherosclerosis]. (Polyvascular动脉粥样硬化)。

Deutsche medizinische Wochenschrift (1946) Pub Date : 2025-06-01 Epub Date: 2025-05-28 DOI: 10.1055/a-2359-4339

Christine Espinola-Klein

引用次数: 0

[Bronchiectasis disease]. (支气管扩张疾病)。

Deutsche medizinische Wochenschrift (1946) Pub Date : 2025-06-01 Epub Date: 2025-05-19 DOI: 10.1055/a-2145-7495

Judith Smith, Michael Dreher

{"title":"[Bronchiectasis disease].","authors":"Judith Smith, Michael Dreher","doi":"10.1055/a-2145-7495","DOIUrl":"10.1055/a-2145-7495","url":null,"abstract":"Bronchiectasis is a worldwide inflammatory disease with different epidemiology and heterogenous etiology. The disease burden is high for patients and economic costs can be immense. So far there are no special disease modifying drugs available for patients with bronchiectasis other than cystic fibrosis. With rising numbers of newly diagnosed patients (prevalence 120/100000 in Germany) due to different reasons (idiopathic, postinfectious, genetic, asthma, COPD etc.) the awareness for this once called orphan disease should rise - not only among pulmonologists but also among general care practitioners. This article focuses on diagnostic algorithms and multimodal treatment options based on the latest studies and the recently published German bronchiectasis guideline from May 2024. It outlines what general care practitioners can do for their patients, what they should consider when treating an exacerbation and that special surveillance of these patients is needed in centers with expertise in this disease due to its complexity. With upcoming treatment options just as disease modifying drugs like DDP-1 inhibitors or inhaled antibiotics one can expect a change in disease treatment and outcome. Therefore, it is more and more important to raise awareness for bronchiectasis starting at the very basis when patients present at their general care practitioner with recurring productive cough, exacerbations, and further cardinal symptoms of bronchiectasis disease.","PeriodicalId":93975,"journal":{"name":"Deutsche medizinische Wochenschrift (1946)","volume":"150 12","pages":"703-712"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144103366","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Geriatric Assessment in the Hospital - An Overview of Clinical Guidelines]. [医院的老年评估-临床指南概述]。

Deutsche medizinische Wochenschrift (1946) Pub Date : 2025-06-01 Epub Date: 2025-05-19 DOI: 10.1055/a-2353-0680

Barbara Kumlehn, Simone Brefka, Filippo Maria Verri, Michael Denkinger

{"title":"[Geriatric Assessment in the Hospital - An Overview of Clinical Guidelines].","authors":"Barbara Kumlehn, Simone Brefka, Filippo Maria Verri, Michael Denkinger","doi":"10.1055/a-2353-0680","DOIUrl":"10.1055/a-2353-0680","url":null,"abstract":"According to forecasts, 27 % of the German population will be aged 65 or over by 2050. Age-associated multimorbidity, functional impairment and need for care have a considerable impact on the healthcare system. A comprehensive geriatric assessment (CGA) is therefore essential to identify health risks at an early stage and make targeted treatment decisions. Numerous studies prove effectiveness of CGA regarding relevant clinical outcomes. In Germany, an S3 guideline with recommendations on CGA in hospitalised patients was published in 2024. There is also an S1 guideline with recommendations on assessment tools. Internationally, the UK, the Netherlands and Italy have published corresponding recommendations. In oncology, two guidelines recommend the systematic integration of CGA before starting cancer treatment. Guidelines emphasise the multidimensional and interprofessional implementation of CGA using standardised, validated instruments. In acute geriatrics, CGA has established as an integral part of care. Focussed screening is recommended in the emergency department. Orthogeriatric co-management has been shown to be associated with lower mortality and improved treatment outcomes. In oncology, CGA is becoming increasingly important for customising treatment. Prognostic tools such as the multidimensional prognostic index (MPI) enable targeted risk stratification. The implementation of CGA is hampered by limited time resources, staff shortages and inconsistent billing modalities. Clear recommendations on the selection of suitable assessment tools could improve utilisation and integration in the future. New technologies such as artificial intelligence and digital applications offer promising approaches for increasing efficiency. The development of a European guideline could help to establish CGA in various care structures.","PeriodicalId":93975,"journal":{"name":"Deutsche medizinische Wochenschrift (1946)","volume":"150 12","pages":"675-681"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144103369","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[GLP-1 agonists - new kid on the block in nephrology]. [GLP-1激动剂——肾脏病学领域的新产品]。

Deutsche medizinische Wochenschrift (1946) Pub Date : 2025-06-01 Epub Date: 2025-05-19 DOI: 10.1055/a-2420-6176

Leonie Kraft, Moritz Schanz, Jörg Latus

引用次数: 0

[Polyvascular Atherosclerosis: prevalence and prognosis]. 【多血管粥样硬化：患病率和预后】。

Deutsche medizinische Wochenschrift (1946) Pub Date : 2025-06-01 Epub Date: 2025-05-28 DOI: 10.1055/a-2360-7551

Jörn Fredrik Dopheide, Mathias Kaspar

引用次数: 0

[Health Effects of Wildfires]. [野火对健康的影响]。

Deutsche medizinische Wochenschrift (1946) Pub Date : 2025-06-01 Epub Date: 2025-05-28 DOI: 10.1055/a-2542-8711

Thomas Münzel, Andreas Daiber

{"title":"[Health Effects of Wildfires].","authors":"Thomas Münzel, Andreas Daiber","doi":"10.1055/a-2542-8711","DOIUrl":"10.1055/a-2542-8711","url":null,"abstract":"The increasing frequency and intensity of wildfires, exacerbated by climate change, pose a significant threat to both the environment and human health. In addition to destroying ecosystems, these fires cause severe air pollution, particularly through fine particulate matter (PM2.5, diameter ≤ 2.5 µm), which can be transported over long distances. A recent example are the wildfires in Canada, whose smoke enveloped New York City in dense smog. Fine particulate matter increases the risk of cardiovascular and respiratory diseases, especially among vulnerable groups such as children, pregnant women, individuals with preexisting conditions, and the elderly. Globally, emissions from wildfires are linked to hundreds of thousands of premature deaths annually. Protective measures such as early warning systems, air filtration systems, and the use of masks can help reduce exposure. However, knowledge gaps remain, particularly regarding the specific components of pollutants and their interactions with environmental factors. Long-term research is essential to better understand the health impacts and to develop targeted prevention strategies. Wildfires underscore the urgent need for global climate protection measures and innovative approaches to public health preparedness.","PeriodicalId":93975,"journal":{"name":"Deutsche medizinische Wochenschrift (1946)","volume":"150 13","pages":"772-779"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144176148","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0