Current problems in diagnostic radiology最新文献

{"title":"Neurointerventional publication metrics by rank, specialty and gender: The impact of academic age and mega-authorship.","authors":"Estelle Schurink, Mahla Radmard, Philippe Gailloud, David M Yousem","doi":"10.1067/j.cpradiol.2026.09.008","DOIUrl":"https://doi.org/10.1067/j.cpradiol.2026.09.008","url":null,"abstract":"<p><strong>Background: </strong>Bibliometric measures are used to compare neurointerventional faculty trained in neurosurgery, radiology and neurology, but the comparability of citation-weighted metrics across these pathways is not established.</p><p><strong>Objective: </strong>To provide national bibliometric data for academic neurointerventional faculty and to determine whether academic age and mega-authored research distort cross-specialty comparison.</p><p><strong>Methods: </strong>Cross-sectional study of 423 neurointerventional faculty at 148 institutions. Scopus data were retrieved in July 2026. Academic age was defined as 2026 minus year of first publication. Specialties were compared unadjusted, adjusted for academic-age tertile, and in multivariable models exploring academic age, rank and gender. Mega-authored publications (>25 authors) were identified and models refitted excluding them.</p><p><strong>Results: </strong>Median academic age differed by specialty (radiology 24, neurosurgery 20, neurology 18 years; p < 0.001). Output rose steeply with rank (median publications 34, 70 and 160; p < 0.001), which accounted for more variance than academic age. Unadjusted, specialties were indistinguishable on citations (p = 0.698) and h-index (p = 0.177); after age adjustment both differed (p = 0.005, p = 0.028) in favor of neurosurgery over radiology with differences concentrated among assistant professors. Mega-authored publications accounted for a median 44.9% of citations in neurology, 10.6% in neurosurgery and 4.7% in radiology (p < 0.001); excluding them abolished neurology's adjusted citation advantage. Women (9.5%) recorded fewer last-author publications after adjustment (0.68, 95% CI 0.51-0.90).</p><p><strong>Conclusions: </strong>Citation-weighted bibliometrics are not comparable across neurointerventional faculty. Academic age and mega-authorship each independently distort them, and both must be accounted for before h-index or citation counts are used in career assessment.</p>","PeriodicalId":93969,"journal":{"name":"Current problems in diagnostic radiology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149120629","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Radiation dose knowledge and imaging referral practices among emergency department clinicians: implications for justification and radiation safety.","authors":"Hossein Nadri, Marziyeh Tahmasbi","doi":"10.1067/j.cpradiol.2026.09.009","DOIUrl":"https://doi.org/10.1067/j.cpradiol.2026.09.009","url":null,"abstract":"<p><strong>Introduction: </strong>Emergency department clinicians often request imaging under time pressure, making radiation dose knowledge important for appropriate imaging referral and justification. This study evaluated radiation dose knowledge, self-perceived knowledge, educational background, and radiation protection-related imaging referral practices among emergency clinicians.</p><p><strong>Methods: </strong>In this cross-sectional study, medical interns, residents, general practitioners, and specialist physicians completed a structured questionnaire assessing radiation-related education, self-perceived knowledge, objective knowledge of radiation dose and related health risks, and radiation protection-related imaging referral practices. Data were analyzed using nonparametric tests and Spearman's rank correlation in SPSS version 25. Bonferroni-adjusted significance thresholds were applied to subgroup comparisons and correlations.</p><p><strong>Results: </strong>Among 90 participants, 27.8% had received formal radiation-related education. Mean scores were 3.29 ± 1.27 for self-perceived knowledge (range, 2-10), 5.70 ± 2.05 for objective knowledge (range, 0-11), and 8.59 ± 2.24 for referral practice (range, 3-15). Objective knowledge was not significantly correlated with referral practice (ρ = -0.095, p = 0.375), and self-perceived knowledge was not significantly correlated with referral practice (ρ = 0.126, p = 0.238) or objective knowledge (ρ = 0.025, p = 0.812). Objective knowledge differed across employment-status categories (p != 0.007) and remained significant after adjustment for multiple comparisons.</p><p><strong>Conclusion: </strong>Emergency department clinicians showed room for improvement in radiation-related knowledge and reported imaging referral practices. No significant associations among objective knowledge, self-perceived knowledge, and referral-practice scores were demonstrated in this sample. Clinically integrated, longitudinal radiation safety education may support imaging justification, referral decision-making, risk communication, and patient safety.</p>","PeriodicalId":93969,"journal":{"name":"Current problems in diagnostic radiology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149066909","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessing the effectiveness of spaced repetition learning in radiology medical education.","authors":"John Wang, Justin Waldman, Jacob Budnitz, Taylor B Harrison, Catherine S W Albin, Brent D Weinberg","doi":"10.1067/j.cpradiol.2026.09.007","DOIUrl":"https://doi.org/10.1067/j.cpradiol.2026.09.007","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate the educational impact of an image-rich, case-based neuroradiology spaced repetition (Anki) flashcard deck on neuroradiology knowledge and image interpretation confidence among third-year medical students during their Neurology clerkship.</p><p><strong>Materials and methods: </strong>In this pilot, prospective observational cohort study, third-year medical students across four consecutive four-week Neurology clerkship cohorts completed pre- and post-clerkship surveys and a 10-question neuroradiology assessment. A 59-card Anki deck (89.8% image-based) aligned with clerkship and USMLE Step 2 objectives was provided to all students in each cohort. Anki deck use was voluntary, and students were categorized as \"users\" or \"non-users\".Outcomes included changes in test scores, perceived confidence, and specialty interest. Anki usage was quantified by total review count. Paired t-tests and Spearman rank correlations were performed to evaluate associations between Anki usage and outcomes.</p><p><strong>Results: </strong>Twelve students completed paired surveys (7 users, 5 non-users). Overall perceived confidence increased significantly across all participants (p < 0.0001), with greater gains among Anki users compared with non-users (3.29 ± 1.38 vs 1.40 ± 0.55; p = 0.011). Neuroradiology test scores improved overall for the combined cohort (p = 0.026), without significant between-group differences. Anki usage was strongly associated with improvement in confidence (Spearman ρ = 0.79, p = 0.002), but not with test score change. Users rated the deck favorably (mean 6.43/10), and the majority of users recommended the deck to other students.</p><p><strong>Conclusion: </strong>In this pilot study, an image-rich neuroradiology Anki deck implemented during the Neurology clerkship was associated with greater improvements in perceived, self-reported image interpretation confidence, though not with objective knowledge test performance, and was well received by students. Given the small sample size and voluntary, non-randomized design, these preliminary findings warrant confirmation in larger studies before definitiveconclusions about educational value are drawn.</p>","PeriodicalId":93969,"journal":{"name":"Current problems in diagnostic radiology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149066831","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of iodinated contrast shortage on repeat CT imaging and ED spending: a retrospective analysis.","authors":"Eline M van den Broek-Altenburg, Jamie S Benson, Kristen K DeStigter, Dmitriy Akselrod","doi":"10.1067/j.cpradiol.2026.09.006","DOIUrl":"https://doi.org/10.1067/j.cpradiol.2026.09.006","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the impact of an iodinated contrast media (ICM) shortage on repeat CT imaging, length of stay (LOS), and total healthcare spending in a mid-sized academic medical center, focusing on abdominal/pelvis CT.</p><p><strong>Methods: </strong>Retrospective cohort analysis of electronic health records from August 1, 2021 to February 15, 2023. Four shortage phases were defined: Pre-Shortage, Wash-In, Rationing, and Post-Shortage. The primary exposure was receipt of CT with contrast vs. CT without contrast at initial imaging. Outcomes included number of follow-up scans per patient, LOS, and total costs within two months after initial imaging. Multivariable models adjusted for age, sex, comorbidities, and ED presentation characteristics to estimate associations between initial contrast status and subsequent imaging, LOS, and costs.</p><p><strong>Results: </strong>Among 12,232 CT encounters, 38-55% of initial scans occurred without contrast during shortage phases. The proportion of patients requiring multiple follow-up scans increased in the shortage periods, with a notable rise during Rationing. Median LOS was longer for patients who had non-contrast initial CT compared with contrast-enhanced CT in the same period. Total peri-imaging costs rose in shortage phases, driven largely by additional imaging and extended LOS. After return to baseline supply, follow-up imaging and LOS metrics approached pre-shortage levels, yet costs remained elevated in the short term.</p><p><strong>Discussion: </strong>The ICM shortage and associated rationing protocols substantially changed contrast use. Contrary to our initial hypothesis, adjusted repeat imaging was lower during rationing than during the pre- and post-shortage periods. When repeat imaging occurred, it was associated with longer outpatient and inpatient LOS. Contrast use and repeat imaging were also associated with differences in billed charges. These findings highlight the importance of evaluating both imaging utilization and downstream resource use during future ICM disruptions.</p>","PeriodicalId":93969,"journal":{"name":"Current problems in diagnostic radiology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149077167","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The value of machine learning inference to predict multidisciplinary discussion diagnosis of interstitial lung diseases.","authors":"Eduardo J Mortani Barbosa, Yohan Kim, Justin Shanahan, Alex Rupsee","doi":"10.1067/j.cpradiol.2026.09.002","DOIUrl":"https://doi.org/10.1067/j.cpradiol.2026.09.002","url":null,"abstract":"<p><strong>Objectives: </strong>Multidisciplinary discussion (MDD) is the reference standard for diagnosing interstitial lung diseases (ILD), however, it requires considerable expertise, and up to 25% of patients remain unclassifiable. We evaluated whether machine learning (ML) models trained on multimodal data can accurately replicate MDD consensus ILD diagnoses.</p><p><strong>Materials & methods: </strong>We retrospectively identified 428 patients with ILD confirmed by MDD consensus at a tertiary academic center from 2010 to 2021. Using comprehensive clinical and radiological data, we trained and cross-validated multiple ML models for three classifications: (1) three-level: connective tissue disease associated ILD (CTD-ILD), usual interstitial pneumonia (UIP), or unclassifiable; (2) UIP/IPF versus all other, and (3) unclassifiable versus all other. Logistic regression, random forest, and neural networks ML models were trained with five-fold cross-validation. Performance was compared via area under the curve (AUC) with 95% confidence intervals.</p><p><strong>Results: </strong>MDD diagnoses were UIP/IPF in 131 patients (30.6%), CTD-ILD in 130 (30.4%), and unclassifiable ILD in 167 (39.0%). Clinical variables and CT imaging features were more predictive than PFTs. ML models achieved AUC values ranging from 0.66 to 0.92. For UIP/IPF vs. other, the neural network reached an AUC of 0.88. Notably, the Lasso regression model exhibited high specificity (0.966), suggesting utility as a high-confidence \"rule-in\" AI tool.</p><p><strong>Conclusion: </strong>ML classification closely approximated MDD diagnoses of ILD, especially for UIP/IPF, relying primarily on clinical and CT imaging features, even without pathology information, allowing expert-level diagnostic performance where MDD resources are not available.</p>","PeriodicalId":93969,"journal":{"name":"Current problems in diagnostic radiology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149003011","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Beyond tubal patency: A pictorial review of the imaging spectrum of hysterosalpingography.","authors":"Loganathan Muthusamy, Shabana Rasheed, Tian Kai Woon, Thida Win","doi":"10.1067/j.cpradiol.2026.09.004","DOIUrl":"https://doi.org/10.1067/j.cpradiol.2026.09.004","url":null,"abstract":"<p><p>Hysterosalpingography (HSG) remains a widely utilized fluoroscopic examination in the evaluation of female infertility, primarily for assessing fallopian tube patency. Despite the increasing use of ultrasound and magnetic resonance imaging for comprehensive pelvic assessment, HSG continues to serve as a first-line investigation due to its accessibility, cost-effectiveness, and ability to provide real-time functional evaluation of contrast passage through the reproductive tract. However, the diagnostic value of HSG extends beyond the simple determination of tubal patency. A systematic and structured interpretation enables assessment of the uterine cavity, fallopian tube morphology, cervical canal, and peritoneal contrast dynamics, allowing detection of a broad spectrum of abnormalities. These include proximal and distal tubal obstruction, hydrosalpinx, salpingitis isthmica nodosa, intrauterine adhesions, endometrial polyps, congenital uterine anomalies, and peritubal adhesions. Equally important is the recognition of normal variants, technical artifacts, and physiological pitfalls, which may mimic pathology and lead to misinterpretation. This pictorial review illustrates the imaging spectrum of HSG beyond tubal patency, emphasizing pattern-based interpretation, key radiological features, and clinically relevant considerations to optimize diagnostic yield and guide further management in infertility evaluation.</p>","PeriodicalId":93969,"journal":{"name":"Current problems in diagnostic radiology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148957656","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-term outcomes and reinterventions following uterine artery embolization for the treatment of uterine leiomyomata.","authors":"Alexis M Medema, Robert J French, Andrea Gorodezky, Nicole C Zanolli, Brendan Cline, Waleska Pabon-Ramos, Jonathan G Martin","doi":"10.1067/j.cpradiol.2026.09.001","DOIUrl":"https://doi.org/10.1067/j.cpradiol.2026.09.001","url":null,"abstract":"<p><strong>Purpose: </strong>Uterine artery embolization (UAE) is a minimally invasive treatment for symptomatic uterine fibroids, but long-term data on subsequent reintervention and effects on ovarian function remain limited. This study quantifies the frequency and timing of gynecologic reintervention at five to thirteen years following UAE.</p><p><strong>Methods: </strong>This is a single-institution retrospective cohort of 199 patients with MRI-confirmed symptomatic fibroids who underwent UAE between January 2013 and December 2018. Demographics, symptomology, procedural details, and follow-up data were collected by chart review. Cumulative procedural reintervention was estimated using Kaplan-Meier analysis with censoring at the date of last clinical contact. A multivariable Cox proportional hazards model was used to calculate risk factors for requiring reintervention.</p><p><strong>Results: </strong>At least five-year follow-up information was available for 184 patients (92.5%). Of 175 survey respondents, 132 (75.4%) reported significant symptom improvement at least two years following embolization. Sixty-one patients (33.2%) required additional medical (32, 17.4%) and/or procedural (34, 18.5%) intervention, with hysterectomy the most common subsequent procedure (29, 15.8%). The Kaplan-Meier 10-year cumulative incidence of any secondary procedure was 19.4% (95% CI 13.1-25.3), with younger age at embolization significantly associated with reintervention (HR 0.91, 95% CI 0.86-0.97, p = 0.003).</p><p><strong>Conclusion: </strong>UAE provides durable symptom relief with a low periprocedural complication rate. Procedural reintervention is required in approximately one in five patients over a decade with no clear high-risk window but with younger age at embolization independently associated with reintervention.</p>","PeriodicalId":93969,"journal":{"name":"Current problems in diagnostic radiology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148946339","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"AI in medical imaging: Practical vision-language model prompt engineering for radiologists.","authors":"Tianpei Yang, Daniel Stahlhoven, Hyun Soo Ko","doi":"10.1067/j.cpradiol.2026.08.011","DOIUrl":"https://doi.org/10.1067/j.cpradiol.2026.08.011","url":null,"abstract":"<p><p>The progressive advancement of generative artificial intelligence and in particular vision-language models (VLM) has led to its adoption and integration in radiology. Prompting, the process of providing instructional and contextual information (input) to the model, serves as a critical interaction influencing the quality and clinical usefulness of the output. This article provides an overview of the core prompting principles, provides practical examples of radiological application, and discusses limitations of VLMs relevant to clinical practice and education.</p>","PeriodicalId":93969,"journal":{"name":"Current problems in diagnostic radiology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148922387","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ultrafast breast MRI to differentiate between molecular subtypes of breast cancer: a systematic review and meta-analysis.","authors":"Hanna Terhaar, Brittany Duck, Priyanka Mitta, Ryan Rauch, Stefanie Woodard","doi":"10.1067/j.cpradiol.2026.08.010","DOIUrl":"https://doi.org/10.1067/j.cpradiol.2026.08.010","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Background: &lt;/strong&gt;Ultrafast dynamic contrast-enhanced MRI (UF-MRI) offers high temporal resolution and early kinetic information that may extend beyond lesion discrimination to molecular subtype differentiation in breast cancer. Conventional MRI has been more extensively studied, but whether UF-MRI provides comparable or superior diagnostic accuracy remains unclear.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Objective: &lt;/strong&gt;To systematically review and synthesize the evidence on the diagnostic accuracy of UF-MRI in differentiating breast cancer molecular subtypes with pooled estimates of sensitivity, specificity, diagnostic odds ratio (DOR), and key kinetic parameters.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Evidence acquisition: &lt;/strong&gt;A systematic search of PubMed, Scopus, and Embase through 2025 identified studies reporting UF-MRI performance stratified by subtype (Luminal, HER2-enriched, TNBC) in both screening and diagnostic extent-of-disease (EOD) breast MRI populations. Data extraction included study characteristics, diagnostic outcomes, and kinetic parameters (time to enhancement, TTE, and maximum slope, MaxSlope). Meta-analyses were performed using random-effects models to account for between-study heterogeneity with heterogeneity assessed by I². Meta-regression examined covariates including scanner vendor, sequence type, and reader.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Evidence synthesis: &lt;/strong&gt;Nine studies including 1,371 lesions met inclusion criteria. Luminal cancers showed the highest pooled accuracy (sensitivity 0.90, 95% CI: 0.81-0.95; specificity 0.79, 95% CI: 0.65-0.89; DOR 25.80, 95% CI: 10.15-65.59; area under the curve [AUC] 0.87, 95% CI: 0.81-0.92), followed by HER2-enriched (sensitivity 0.85, 95% CI: 0.68-0.94; specificity 0.67, 95% CI: 0.10-0.97; DOR 15.03, 95% CI: 7.72-29.28; AUC 0.81, 95% CI: 0.69-0.89) and TNBC (sensitivity 0.82, 95% CI: 0.74-0.88; specificity 0.72, 95% CI: 0.69-0.75; DOR 10.09, 95% CI: 6.44-15.82, AUC 0.81, 95% CI: 0.72-0.85). Meta-regression identified scanner vendor and sequence type as contributors to heterogeneity. TTE was shortest for TNBC (7.86 s, 95% CI: 4.85-10.86) compared with HER2-enriched (9.67 s, 95% CI: 7.01-12.33) and Luminal (9.78 s, 95% CI: 8.00-11.56). MaxSlope showed extreme heterogeneity with poor reproducibility, precluding reliable interpretation of pooled estimates.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusion: &lt;/strong&gt;UF-MRI demonstrates subtype-specific diagnostic performance for differentiating breast cancer molecular subtypes, with the strongest discriminatory accuracy in Luminal tumors and diagnostic accuracy patterns and kinetic parameters aligned with known differences in enhancement behavior across subtypes, high sensitivity but modest specificity in TNBC, and more variable performance in HER2-enriched cancers. Time to enhancement (TTE) appears to be a reliable and interpretable kinetic marker, whereas maximum slope (MaxSlope) shows extreme heterogeneity and limited reproducibility, restricting its clinical utility.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Clinical impac","PeriodicalId":93969,"journal":{"name":"Current problems in diagnostic radiology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148922398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Radiologically detectable microcalcifications in histopathologically confirmed ductal carcinoma in situ: The impact of cohort composition on reported prevalence.","authors":"Ahmet Veysel Polat, İrem Ceren Koç, Ali Özçağlayan, Yurdanur Süllü, Fatih Uzunkaya, Ayfer Kamalı Polat","doi":"10.1067/j.cpradiol.2026.08.009","DOIUrl":"https://doi.org/10.1067/j.cpradiol.2026.08.009","url":null,"abstract":"<p><strong>Purpose: </strong>This study aimed to determine the prevalence of radiologically detectable microcalcifications in histopathologically confirmed ductal carcinoma in situ (DCIS) using specimen radiography and to evaluate clinicopathologic factors associated with their presence.</p><p><strong>Methods: </strong>A total of 1201 consecutive patients who underwent wire-guided localization for non-palpable breast lesions were retrospectively identified. Patients without histopathologically confirmed DCIS, those without specimen radiographs, and those who had received neoadjuvant systemic therapy were excluded. The final cohort included 100 patients with histopathologically confirmed DCIS. Specimen radiographs were retrospectively reviewed for radiologically detectable microcalcifications, and associations with clinicopathologic variables were analyzed using univariate and multivariable analyses.</p><p><strong>Results: </strong>Radiologically detectable microcalcifications were identified in 48% of DCIS cases. Subgroup analysis demonstrated marked differences according to cohort composition, with microcalcifications present in 95.8% of pure DCIS cases compared with 32.9% of non-pure cases (p < 0.001). In multivariable analysis, cohort composition and high-grade DCIS remained independently associated with radiologically detectable microcalcifications, whereas necrosis, ER status, and PR status were not independently significant after adjustment. Seventy percent of the cohort had coexisting invasive ductal carcinoma.</p><p><strong>Conclusion: </strong>A substantial proportion of histopathologically confirmed DCIS cases may lack radiologically detectable microcalcifications. These findings suggest that reported calcification prevalence in DCIS may be strongly influenced by cohort composition and study design, particularly differences between screening-enriched and surgically treated populations. Accordingly, the absence of calcifications does not exclude DCIS, and DCIS should remain a diagnostic consideration when suspicious imaging findings other than microcalcifications are present. Complementary multimodality imaging may be helpful in selected patients with suspicious non-calcified imaging findings, reflecting the broader imaging spectrum of DCIS. Further prospective multicenter studies are needed to validate these observations.</p>","PeriodicalId":93969,"journal":{"name":"Current problems in diagnostic radiology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148883135","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}