Current drug discovery technologies最新文献_第8页

Envisioning Clinical Management of Breast Cancer: a Comprehensive Review. 展望乳腺癌的临床治疗：全面综述》。

Current drug discovery technologies Pub Date : 2025-01-01 DOI: 10.2174/0115701638300812240417055802

Shubhashree Das, Gurudutta Pattnaik, Sovan Pattanaik, Bikash Ranjan Jena, Bhabani Sankar Satapathy, Ayushi Pradhan

{"title":"Envisioning Clinical Management of Breast Cancer: a Comprehensive Review.","authors":"Shubhashree Das, Gurudutta Pattnaik, Sovan Pattanaik, Bikash Ranjan Jena, Bhabani Sankar Satapathy, Ayushi Pradhan","doi":"10.2174/0115701638300812240417055802","DOIUrl":"10.2174/0115701638300812240417055802","url":null,"abstract":"Background: Background: Coming to the edge of disease manufacturing in the twenty-- first-century, breast cancer occupies a terrifying scenario in the globe, especially in adult women. Its curiosity endeavours remarkable advances made during the past decennaries for cancer treatment and diagnosis.Objective: It accounts for the fifth leading cause of transience, killing approximately 570,000 people per annum. To reduce the prognosis of clinical oncological development with the application of a new chemical entity, some of the critical challenges, like active pharmaceutical ingredients with high chemical resistance, extreme side effects, and high treatment costs are some of the limitations in the curbing aspects of breast melanoma.Methods: In cancer research, hence, the development of drugs that are safe, efficient, and cost-effective remains a 'Holy Grail' that may be considered as a boon to target the malignant tissues with novel therapeutics devices.Results: Through the findings on overcoming the drawbacks of traditional methods, researchers have given special attention to cancer-preventive and theranostic approaches based on some novel drug delivery systems.Conclusion: The present study forecasts the wide-ranging modern applications, and on developing some novel liposomal drug delivery therapy against breast cancer.","PeriodicalId":93962,"journal":{"name":"Current drug discovery technologies","volume":" ","pages":"e290424229495"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140862590","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

In-silico Studies, Design, and Synthesis of Pyrimidine-linked Benzothiazoles for its Anticonvulsant Potential. 嘧啶连接的苯并噻唑的抗惊厥潜力的硅内研究、设计和合成。

Current drug discovery technologies Pub Date : 2025-01-01 DOI: 10.2174/0115701638299019240418055933

Amol Kale, Rajendra Kakde, Smita Pawar, Rutuja Thombare, Dhanashree Zope, Ishwar Kakde

{"title":"In-silico Studies, Design, and Synthesis of Pyrimidine-linked Benzothiazoles for its Anticonvulsant Potential.","authors":"Amol Kale, Rajendra Kakde, Smita Pawar, Rutuja Thombare, Dhanashree Zope, Ishwar Kakde","doi":"10.2174/0115701638299019240418055933","DOIUrl":"10.2174/0115701638299019240418055933","url":null,"abstract":"Background: The objective of the study was to design and synthesize a series of N-(6-substituted- 1, 3-benzothiazole-2-yl)-2-{[6-(3-substitutedphenyl)-5-cyano-2-sulfanylpyrimidine-4-yl)]amino} acetamide derivatives BPD (1-15) that contains key pharmacophores required for anticonvulsant action.Methods: The titled compounds (BPD 1-15) were synthesized by reacting 2-substituted-N-(6-chlorobenzo[ d]thiazol-2-yl)acetamide with 4-amino-6-(4-substituted phenyl)-2-mercapto pyrimidine 5-carbonitrile in the presence of potassium carbonate and dry acetone. The synthesized compounds BPD (1-15) were assessed in vivo by the maximum electric shock (MES) test and the subcutaneous pentylenetetrazol (scPTZ) test in mice. The neurotoxicity test was performed by the rotarod test. A molecular docking study of title compounds with a sodium channel receptor (PDB ID: 1BYY) was carried out using the SP Docking protocol of the Glide module of the Maestro. Pharmacophore modeling was used to qualitatively identify the chemical characteristics for ligand binding and their spatial configurations in the 3D space of the active site.Result: Among the studied compounds, BPD-15 and BPD-5 compounds showed significant action in both the MES and scPTZ models, with no neurotoxicity. BPD-15 & BPD-5 were relatively safe in acute toxicity testing. Compounds BPD-15 and BPD-5 showed good dock scores of -6.434 and -6.191, respectively.Conclusion: Thus, the compounds BPD-15 and BPD-5 have shown a considerable affinity towards the sodium channel as compared to the standard drug Riluzole. Compound BPD-14 showed good drug compatibility, and compounds BPD-1, BPD-2, BPD-11, BPD-12, BPD-13, BPD-14, BPD-15 showed good ADME values.","PeriodicalId":93962,"journal":{"name":"Current drug discovery technologies","volume":" ","pages":"e070524229730"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140878164","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Potential Role of Benzoic Acid and its Synthetic Derivatives to Alleviate Cancer: An Up-to-Date Review. 苯甲酸及其合成衍生物在缓解癌症方面的潜在作用：最新综述。

Current drug discovery technologies Pub Date : 2025-01-01 DOI: 10.2174/0115701638311865240904054111

Arvind Kumar, Yoonus Kunju Thajuddin Koya Kamal, Arun K Mishra, Mhaveer Singh, Harpreet Singh, Niranjan Kaushik, Amrita Mishra

{"title":"Potential Role of Benzoic Acid and its Synthetic Derivatives to Alleviate Cancer: An Up-to-Date Review.","authors":"Arvind Kumar, Yoonus Kunju Thajuddin Koya Kamal, Arun K Mishra, Mhaveer Singh, Harpreet Singh, Niranjan Kaushik, Amrita Mishra","doi":"10.2174/0115701638311865240904054111","DOIUrl":"10.2174/0115701638311865240904054111","url":null,"abstract":"Unregulated cell division is one of the main causes of cancer. These cancerous cells negatively impact nearby healthy cells. Cancer can occur anywhere in the body. Normal cell division occurs when cells grow, reproduce, and divide as the body needs. As a normal cascade of cell growth and division, when the cells get damaged, they undergo death, and normal cells develop. However, sometimes, this process is not followed, and abnormal or damaged cells start to grow and multiply several times more than normal. This particular process may form the basis of cancer. There is a research gap in terms of identifying personalized synthetic anticancer therapy, which may be based on individual patient characteristics with an aim to optimize treatment efficacy and minimize adverse effects. While searching for new bioactive compounds, it has been observed that organic molecules with benzoic acid (BA) moiety possess significant anticancer potential. Several works of literature reported the use of BA from natural or synthetic sources to synthesize bioactive chemicals. It has been observed that several natural products also contain BA moiety, and the presence of this moiety is considered responsible for several important biological activities. Therefore, in order to chemically synthesize a wide variety of potent biologically active compounds, benzoic acid as a basic moiety in the form of a scaffold can be employed. Other synthetic compounds with BA scaffolds include furosemide, tetracaine, and bumetanide. The current article aims to focus on past and present work done on BA derivatives and to emphasize the molecular pathways involved in cancer treatment. The future prospects for research in this area are encouraging as researchers are striving to advance synthetic BA derivatives. This could possibly contribute to more efficient treatments and better results for cancer patients.","PeriodicalId":93962,"journal":{"name":"Current drug discovery technologies","volume":" ","pages":"e15701638311865"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142396227","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

In-silico Approach to Combat Methicillin-resistant Staphylococcus aureus: Targeting RelP Protein with Inhibitor Peptide to Mitigate Drug Resistance. 对抗耐甲氧西林金黄色葡萄球菌的计算机方法：用抑制剂肽靶向RelP蛋白以减轻耐药性。

Current drug discovery technologies Pub Date : 2025-01-01 DOI: 10.2174/0115701638337060250121154347

Priyanka Sinoliya, Pooran Singh Solanki, Ravi Ranjan Kumar Niraj, Vinay Sharma

{"title":"In-silico Approach to Combat Methicillin-resistant Staphylococcus aureus: Targeting RelP Protein with Inhibitor Peptide to Mitigate Drug Resistance.","authors":"Priyanka Sinoliya, Pooran Singh Solanki, Ravi Ranjan Kumar Niraj, Vinay Sharma","doi":"10.2174/0115701638337060250121154347","DOIUrl":"10.2174/0115701638337060250121154347","url":null,"abstract":"Introduction: Methicillin-resistant Staphylococcus aureus (MRSA), known for its resistance to multiple antibiotics, has emerged as a major global health concern. It facilitates biofilm formation under stressful conditions by catalyzing the synthesis of alarmones (p)ppGpp and ppGpp. These alarmones on accumulation lead to biofilm formation and cause resistance towards antibiotics.Methods: This condition has prompted the exploration of various novel approaches and methodologies to combat MRSA infections. Among these, peptide therapeutics stand out as a promising nextgeneration treatment option. In this study, ninety antimicrobial peptides were sourced from the antimicrobial peptide database and the other sixty-one peptide sequences were designed using the Pepdraw server. These peptide sequences were screened out using different in-silico tools. The proteinpeptide molecular interaction was studied using a molecular docking and molecular dynamic simulation technique.Results and discussion: Out of 151 peptide sequences, Pantocin wh-1 emerged as the most promising drug candidate. Both molecular interaction studies and molecular dynamics simulations demonstrated positive results.Conclusion: Peptide therapeutics is a novel approach researchers are presently exploring as it provides prompt significant results and promotes a new insight towards dealing with conditions like MDR. Pantocin wh-1 is a peptide drug currently listed as an accessible anti-tuberculosis peptide, and this study suggests the repurposing of this drug as a viable treatment option for MRSA infections.","PeriodicalId":93962,"journal":{"name":"Current drug discovery technologies","volume":" ","pages":"e15701638337060"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143416552","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Comprehensive Review on Immunoregulatory Effects of Phytochemicals. 植物化学物质免疫调节作用研究综述

Current drug discovery technologies Pub Date : 2025-01-01 DOI: 10.2174/0115701638326442241118053543

Shikha Sharma, Utkarsh Sharma, Neha Dangi, Mukesh K Gupta, Anurag Agrawal, Suraj N Mali, Bimal Krishan Banik

{"title":"A Comprehensive Review on Immunoregulatory Effects of Phytochemicals.","authors":"Shikha Sharma, Utkarsh Sharma, Neha Dangi, Mukesh K Gupta, Anurag Agrawal, Suraj N Mali, Bimal Krishan Banik","doi":"10.2174/0115701638326442241118053543","DOIUrl":"10.2174/0115701638326442241118053543","url":null,"abstract":"An efficient immune system in the host body plays a crucial role in the preservation of normal biological and immune reactions and processes, as well as the intrinsic environment. This is because the immune system is responsible for fighting off foreign invaders. A healthy immune system strengthens the body's defense against infections, illnesses, and other unwelcome pathogens, thereby reducing the risk of allergic reactions and autoimmune diseases. Innate immune cells and acquired immune system components interact in a corrective fashion to produce optimal immune responses. In recent years, researchers have begun to focus on the immune system as a potential primary target of toxicity from chemical, pharmacological, and environmental exposure. Sex, age, stress, malnutrition, alcohol, genetic variability, lifestyles, environmental pollutants, and chemotherapy are just a few of the many elements that might modify the host's immunological responses. The production, amplification, attenuation, or suppression of immunological responses are all examples of immunomodulation. There are a wide variety of synthetic and traditional treatments available, and many of them cause major side effects and develop pathogenic resistance very quickly. Natural substances called phytochemicals play a crucial role in regulating the body's immune system. Risk factors for immune response changes are discussed, as is the immunomodulatory action of phytochemicals like glycosides, alkaloids, phenolic acids, flavonoids, saponins, tannins, sterols, and steroids.","PeriodicalId":93962,"journal":{"name":"Current drug discovery technologies","volume":" ","pages":"e15701638326442"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142775856","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Drug Discovery Potential of Insect-derived Compounds: A Review. 昆虫衍生化合物的药物发现潜力：综述。

Current drug discovery technologies Pub Date : 2025-01-01 DOI: 10.2174/0115701638294753240422134722

Nafiur Rahman, Arpita Gope, Jayeeta Khanrah, Anjali Rawani

{"title":"Drug Discovery Potential of Insect-derived Compounds: A Review.","authors":"Nafiur Rahman, Arpita Gope, Jayeeta Khanrah, Anjali Rawani","doi":"10.2174/0115701638294753240422134722","DOIUrl":"10.2174/0115701638294753240422134722","url":null,"abstract":"Insects are the most numerous and diverse collection of organisms on earth. Around the world, human societies have utilised insects and the materials derived from them as medical resources. These arthropods use chemistry, like all other species. According to their survival needs, they make adaptations, including protecting themselves from infection as well as predation, being able to connect with a social life, and carrying out generations with survivability in the environment. The main focus of the study of chemical ecology is the abundance of chemical compounds found in arthropods that are used for these ecological adaptations. This thorough analysis summarises the huge potential for finding new natural compounds with medical benefits from the Arthropods. Insects and their derivatives have a wide range of uses, and their \"raw products\" have made significant strides in a wide range of industries, including pharmaceuticals, tissue engineering, dentistry, plant and agricultural science, veterinary medicine, cosmetics, and cosmeceuticals, food, and nutraceuticals, among others. Bioactive components derived from insects are emerging as potential therapeutic sources that are beneficial against a variety of disorders. Insects, which have a huge variety of species, are an intriguing and potential source of low molecular biologically active natural compounds that are either produced by the insect itself or by accompanying microbes. The present review work collated the updates of insect-derived compounds, the use of insects worldwide, and drug discovery potential of insect derivatives.","PeriodicalId":93962,"journal":{"name":"Current drug discovery technologies","volume":" ","pages":"e300424229557"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140859363","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Tecelra Approval: A Breakthrough in Synovial Sarcoma Therapy. 泰克拉的批准：滑膜肉瘤治疗的突破。

Current drug discovery technologies Pub Date : 2025-01-01 DOI: 10.2174/0115701638357969250131102049

Dinesh Kumar, Rajni Tanwar, Raj Kamal, Debanjan Mukherjee

引用次数: 0

Phytophenols as Promoieties for Prodrug Design. 植物酚作为原药设计的促进剂。

Current drug discovery technologies Pub Date : 2025-01-01 DOI: 10.2174/0115701638282895240523091552

Bharat V Dhokchawle, Punit S Mishra, Renny J Daniel

引用次数: 0

Liquisolid Technique for Solubility Enhancement of Poorly Soluble Drug - A Brief Review. 用于提高难溶性药物溶解度的 Liquisolid 技术--简要回顾。

Current drug discovery technologies Pub Date : 2025-01-01 DOI: 10.2174/0115701638318659240923074614

Amaresh Prusty, Bikash Ranjan Jena, Vivek Barik, Piyali Khamkat, Bhakti Bhusan Barik

{"title":"Liquisolid Technique for Solubility Enhancement of Poorly Soluble Drug - A Brief Review.","authors":"Amaresh Prusty, Bikash Ranjan Jena, Vivek Barik, Piyali Khamkat, Bhakti Bhusan Barik","doi":"10.2174/0115701638318659240923074614","DOIUrl":"10.2174/0115701638318659240923074614","url":null,"abstract":"Most of the newly discovered drug candidates are lipophilic and poorly water-soluble, making it a significant challenge for the pharmaceutical industry to formulate suitable drug delivery systems. This review gives insight into an overview of the liquisolid technique (LST) and summarizes the progress of its various applications in drug delivery. This novel technique involves converting liquid drugs or drugs in a liquid state (such as solutions, suspensions, or emulsions) into dry, nonadherent, free-flowing, and readily compressible powder mixtures by blending or spraying a liquid dispersion onto specific powder carriers and coating materials. In Liquisolid systems, the liquid medication is absorbed into the interior framework of carriers. Once the carrier's interior is saturated with liquid medication, a liquid layer forms on the surface of the carrier particles, which is instantly adsorbed by the fine coating material. As a result, a dry, free-flowing, and compressible powder mixture is formed. Compared to other solubility enhancement techniques, s.a. micronization, inclusion complexation, microencapsulation, nanosuspension, and self-nano emulsions, LST is relatively simple to prepare and may offer a cost-effective solution to enhance the solubility of poorly water-soluble drugs enhancing its bioavailability in drug formulation and delivery.","PeriodicalId":93962,"journal":{"name":"Current drug discovery technologies","volume":" ","pages":"e15701638318659"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142396226","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Comprehensive Investigation: Developing the Pharmaceutical Industry through Artificial Intelligence. 全面调查：通过人工智能发展制药业。

Current drug discovery technologies Pub Date : 2025-01-01 DOI: 10.2174/0115701638313233240830132804

Deepak Jain, Phool Chandra, Zeeshan Ali, Nishat Fatma, Hafsa Khan

{"title":"A Comprehensive Investigation: Developing the Pharmaceutical Industry through Artificial Intelligence.","authors":"Deepak Jain, Phool Chandra, Zeeshan Ali, Nishat Fatma, Hafsa Khan","doi":"10.2174/0115701638313233240830132804","DOIUrl":"10.2174/0115701638313233240830132804","url":null,"abstract":"AI's rise has affected many aspects of civilization. Pharmaceutical businesses have been hit hard. This review paper highlights AI's benefits for disease detection, clinical trials, medicine development, and productivity in the pharmaceutical industry. Pharmaceutical companies have built specialized systems to help doctors diagnose and monitor medication remediation. Pharmaceutical businesses are utilizing AI for machine learning to imitate human analytical processes for more accurate and insightful data. AI has many benefits for the pharmaceutical business. Data analysis can address previously insoluble problems due to improved precision. AI boosts productivity, lowers expenses, and enhances tasks. AI insights enhance understanding of user behavior, market performance, and clinical trial success. AI helps identify patients during clinical trials and improves antiviral detection to ensure efficacy, safety, cost-effectiveness, and seamless pharmaceutical procedures. The pharmaceutical industry emphasizes AI in R&D, drug discovery, diagnostics, sickness prevention, epidemic forecasting, remote access, manufacturing, and marketing. Artificial intelligence has transformed medication development and discovery by analyzing vast datasets, discovering complicated patterns, and forecasting efficacy. Pharmaceutical companies like Novartis, AstraZeneca, and Verge Genomics are utilizing AI for drug feature prediction, neurological evaluation, therapy development, pulmonary and hypertension recognition, low-cost medication production, and disease diagnosis.","PeriodicalId":93962,"journal":{"name":"Current drug discovery technologies","volume":" ","pages":"e15701638313233"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142142110","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0