Potential Role of Benzoic Acid and its Synthetic Derivatives to Alleviate Cancer: An Up-to-Date Review.

Arvind Kumar, Kamal Yt, Arun K Mishra, Mhaveer Singh, Harpreet Singh, Niranjan Kaushik, Amrita Mishra
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Abstract

Unregulated cell division is one of the main causes of cancer. These cancerous cells negatively impact nearby healthy cells. Cancer can occur anywhere in the body. Normal cell division occurs when cells grow, reproduce, and divide as the body needs. As a normal cascade of cell growth and division, when the cells get damaged, they undergo death, and normal cells develop. However, sometimes, this process is not followed, and abnormal or damaged cells start to grow and multiply several times more than normal. This particular process may form the basis of cancer. There is a research gap in terms of identifying personalized synthetic anticancer therapy, which may be based on individual patient characteristics with an aim to optimize treatment efficacy and minimize adverse effects. While searching for new bioactive compounds, it has been observed that organic molecules with benzoic acid (BA) moiety possess significant anticancer potential. Several works of literature reported the use of BA from natural or synthetic sources to synthesize bioactive chemicals. It has been observed that several natural products also contain BA moiety, and the presence of this moiety is considered responsible for several important biological activities. Therefore, in order to chemically synthesize a wide variety of potent biologically active compounds, benzoic acid as a basic moiety in the form of a scaffold can be employed. Other synthetic compounds with BA scaffolds include furosemide, tetracaine, and bumetanide. The current article aims to focus on past and present work done on BA derivatives and to emphasize the molecular pathways involved in cancer treatment. The future prospects for research in this area are encouraging as researchers are striving to advance synthetic BA derivatives. This could possibly contribute to more efficient treatments and better results for cancer patients.

苯甲酸及其合成衍生物在缓解癌症方面的潜在作用:最新综述。
不规则的细胞分裂是导致癌症的主要原因之一。这些癌细胞会对附近的健康细胞产生负面影响。癌症可发生在身体的任何部位。正常的细胞分裂是指细胞根据身体需要生长、繁殖和分裂。作为细胞生长和分裂的正常级联,当细胞受损时,它们就会死亡,正常细胞就会发育。然而,有时这一过程并没有得到遵守,异常或受损的细胞开始比正常细胞多几倍地生长和繁殖。这一特殊过程可能是癌症的基础。在确定个性化合成抗癌疗法方面还存在研究空白,这种疗法可以根据患者的个体特征来确定,目的是优化疗效,减少不良反应。在寻找新的生物活性化合物的过程中,人们发现带有苯甲酸(BA)分子的有机分子具有显著的抗癌潜力。一些文献报道了利用天然或合成来源的苯甲酸合成生物活性化学物质的情况。据观察,一些天然产品也含有 BA 分子,而这一分子的存在被认为是多种重要生物活性的原因。因此,为了化学合成多种具有生物活性的强效化合物,可以采用苯甲酸作为支架形式的基本分子。其他具有 BA 支架的合成化合物包括呋塞米、四卡因和布美他尼。本文旨在重点介绍过去和现在有关 BA 衍生物的工作,并强调癌症治疗所涉及的分子途径。由于研究人员正在努力推进合成 BA 衍生物,该领域未来的研究前景令人鼓舞。这有可能为癌症患者带来更有效的治疗和更好的疗效。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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