Current drug discovery technologies最新文献

{"title":"Bioactive Compounds as a Potential Inhibitor of Biofilm Production: An In silico Study to Identify Natural Hindrance Resources.","authors":"Jai Gupta, Avi Gupta, Debasmita Bhattacharya, Moupriya Nag, Dibyajit Lahiri, Debanjan Mitra","doi":"10.2174/0115701638367145250418033053","DOIUrl":"https://doi.org/10.2174/0115701638367145250418033053","url":null,"abstract":"<p><strong>Background: </strong>Biofilm formation by microorganisms, specifically bacteria, threatens vari-ous fields, including biomedicine and the environment. The development of biofilms has associations with increased resistance to antimicrobial agents and immune responses; it poses a significant threat to human health. ESKAPE pathogens, a group of bacteria known for their multidrug resistance, are particularly adept at biofilm formation. This research explores strategies to combat biofilm-associated infections, with a focus on natural compounds as potential anti-biofilm agents.</p><p><strong>Methods: </strong>The study investigates 23 natural compounds for their druglike properties in fighting against antibiotic-resistant biofilms. These compounds include flavonoids, terpenes, and alkaloids, and exhibit promising bioavailability and usage potential as ligands. Molecular docking analysis em-ploying AutoDock Vina was used to evaluate the binding affinities of these ligands to key biofilm-forming genes and membrane proteins in ESKAPE pathogens.</p><p><strong>Results: </strong>Despite a few violations of a variety of established criteria, the overall safety and efficiency of oral drug reception are maintained, emphasizing their potential for further drug development. The results show specific ligands, such as Baicalin, Apigenin, Azadirachtin, Curcumin, Hyperforin, etc., demonstrating high binding energies against biofilm-associated proteins. This approach aligns with the pursuit of sustainable alternatives to combat biofilm-related infections.</p><p><strong>Conclusion: </strong>Natural compounds like Baicalin, Apigenin, Azadirachtin, Curcumin, Hyperforin not only exhibit broad-spectrum coverage but also show reduced risks of resistance development com-pared to synthetic antibiotics. The integration of natural compounds into multifaceted strategies con-siders the complexities of the biofilm matrix, bacterial diversity, and pathogen characteristics, offer-ing a sustainable approach to address biofilm-associated infections.</p>","PeriodicalId":93962,"journal":{"name":"Current drug discovery technologies","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144063203","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bioactive Flavonoids and Phenolic Acids of Petroselinum Crispum as a Potential Inhibitor of α-amylase: An in silico Evaluation.","authors":"Ishita Biswas, Trishanjan Biswas, Debanjan Mitra","doi":"10.2174/0115701638361734250414033830","DOIUrl":"https://doi.org/10.2174/0115701638361734250414033830","url":null,"abstract":"<p><strong>Background: </strong>Type II diabetes mellitus is treated as one of the detrimental diseases and the drugs used for its treatment often lead to several side effects. Therefore, herbal medication of plant origin with lesser offshoot is a significant concern. Petroselinum crispum is a plant of pharma-ceutical interest. The present work aims to explore the potentiality assessment of flavonoids of Pe-troselinum crispum as an α-amylase inhibitor.</p><p><strong>Methods: </strong>Compounds were extracted from the database and evaluated through drug likeliness prop-erties, ADMET and toxicity assessment. Molecular docking was done to identify the best ligand, and the dynamics simulation study was performed with the leading ligand-protein complex.</p><p><strong>Results: </strong>Amongst the 15 bioactive compounds, apigenin appeared as the best ligand among all the studied compounds. Moreover, drug likeliness, physiochemical characteristics, and ADMET anal-yses revealed that apigenin does not deviate from Lipiniski's rule of five. Non-toxic apigenin showed a satisfactory docking score of -9.5 kcal/mol with human pancreatic α-amylase compared to the ref-erence molecule acarbose. Apigenin- α-amylase complex and apoprotein were subjected to 100ns molecular dynamics simulation to analyze the stability of the docked protein-ligand complex. The values of RMSD, RMSF, Rg, SASA and hydrogen bonding of the screened complexes showed high stability and less fluctuations of the apigenin- α-amylase complex.</p><p><strong>Conclusion: </strong>This finding suggests apigenin as alternative therapeutics in treating diabetes mellitus by targeting the enzyme α-amylase which can be used for in vitro cross-validation studies. This study is the first documentation of the antidiabetic potentiality of the flavonoid compounds of Petroselinum crispum through in silico investigation.</p>","PeriodicalId":93962,"journal":{"name":"Current drug discovery technologies","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144033023","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Techniques and Strategies for Engineering Vaccine Adjuvants: A Comprehensive Review.","authors":"Suman Sharma, Rajani Chauhan, Qumar Negar, Pragya Sharma","doi":"10.2174/0115701638351666250405070745","DOIUrl":"https://doi.org/10.2174/0115701638351666250405070745","url":null,"abstract":"<p><p>Vaccines are biological products used to prevent diseases and ailments caused by viruses, bacteria, and fungi. Vaccine adjuvants increase the potency of the vaccine. The vaccine adjuvants like gold nanoparticle, silver nanoparticle, Lentinan-calcium carbonate microsphere, Aluminium nano metal-organic framework, Poly[di(carboxylatomethylphenoxy)phosphazene] macromolecule, Lignin nanoparticle, Nanostructured hydroxy phosphate synthesized by Chemical and Biosynthesis and their evaluation method have been discussed. Evaluations for physical parameters like particle size and biological evaluation to find out the potency of adjuvants have been discussed. The adjuvant synthesis discussed is a potential method for improvement of the marketed vaccine.</p>","PeriodicalId":93962,"journal":{"name":"Current drug discovery technologies","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144060465","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Design of Potent Telomerase Inhibitors Using Ligand-based Approaches and Molecular Dynamics Simulations Studies.","authors":"Shalini Bajaj, Manikanta Murahari, Mayur Yc","doi":"10.2174/0115701638352883250414054348","DOIUrl":"https://doi.org/10.2174/0115701638352883250414054348","url":null,"abstract":"<p><strong>Background: </strong>Telomerase is a well-recognised and a promising target for cancer therapy. In this study, we selected ligand-based approaches to design telomerase inhibitors for the develop-ment of potent anticancer agents for future cancer therapy.</p><p><strong>Methods: </strong>To investigate the chemical characteristics required for telomerase inhibitory activity, a ligand-based pharmacophore model of oxadiazole derivatives reported from the available literature was generated using the Schrodinger phase tool. This selected pharmacophore hypothesis is validated by screening a dataset of reported oxadiazole derivatives. The pharmacophore model was selected for virtual screening using ZINCPharmer against the ZINC database. The ZINC database molecules with pharmacophore features similar to the selected pharmacophore model and good fitness score were taken for molecular docking studies. With the pkCSM and SwissADME tools we predicted the pharmacokinetic and toxicity of top ten ZINC database compounds based on docking score, binding interactions and identified two in-silico potential compounds with good absorption, distribution, me-tabolism, and less toxicity. Then both the hit molecules were exposed to molecular dynamic simula-tion integrated with MM-PBSA binding free energy calculations using GROMACS tools.</p><p><strong>Results: </strong>The generated pharmacophore model displayed five features, two hydrophobic and three aro-matic rings. The MM-PBSA calculations exhibited that the free binding energy of selected protein-lig-and complexes were found stable and stabilized with non-polar and van-der walls free energies.</p><p><strong>Conclusion: </strong>Our study suggests that ZINC82107047 and ZINC8839196 can be used as hit molecules for future biological screening and for discovery of safe and potent drugs as telomerase inhibitors for cancer therapy.</p>","PeriodicalId":93962,"journal":{"name":"Current drug discovery technologies","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144032147","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Darunavir: A Versatile Protease Inhibitor against Microbial Infections.","authors":"Mridul Singh Sengar, Kalpana Rahate, Megha Verma","doi":"10.2174/0115701638336144250331174407","DOIUrl":"https://doi.org/10.2174/0115701638336144250331174407","url":null,"abstract":"<p><p>Microbial infections continue to pose significant threats to global health, necessitating the development of innovative therapeutic strategies. One promising avenue is the use of protease inhib-itors, with darunavir (DRV) emerging as a potent candidate in the field. Designed to combat re-sistance to standard HIV therapy, DRV is a second-generation protease inhibitor. Regarding micro-bial infections, this study sheds light on the internal processes behind the impact of DRV within cells. Novel protease inhibitor DRV targets essential proteolytic enzymes that are essential for microbial survival and growth in order to achieve its antimicrobial actions. By interfering with the proteolytic digestion of important microbial proteins, its inhibitory effect prevents infectious particles from being assembled and maturing. DRV is a viable treatment option for microbial infections as its selective suppression reduces the possibility of off-target consequences. DRV efficiently penetrates the intra-cellular milieu of host cells, where it prevents the proteolytic cleavage of vital viral and bacterial proteins, hence combating pathogenic infections. Microbial infections may be treated in a variety of ways using DRV as it disrupts the cycle of pathogen reproduction. The present review explores the molecular principles behind the effectiveness of DRV against microbial infections, emphasizing the drug's ability to fight a wide range of pathogens. The comprehension of the intracellular activity of DRV is promising for the creation of novel treatment approaches, providing encouragement in the continuous fight against microbial diseases.</p>","PeriodicalId":93962,"journal":{"name":"Current drug discovery technologies","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144003649","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anti-Cancer Potential of Scopoletin Derivatives Across Diverse Cancer Cell Lines: A Comprehensive Review.","authors":"Manvi Karayat, Niranjan Kaushik, Deepika Paliwal, Sachin Chaudhary","doi":"10.2174/0115701638379522250412162643","DOIUrl":"https://doi.org/10.2174/0115701638379522250412162643","url":null,"abstract":"<p><p>Scopoletin, a naturally occurring coumarin derivative, has garnered significant attention for its diverse pharmacological properties, including potent anticancer activity. This review provides a comprehensive examination of scopoletin's anticancer effects across a wide range of tumor cell lines. The paper explores its modulation of apoptotic pathways, inhibition concentration (IC50) of cancer cell proliferation, and suppression of metastasis and angiogenesis. Additionally, the review discusses the role of scopoletin in regulating oxidative stress, inflammation, and cell cycle arrest in cancer cells. A detailed analysis of in vitro and in vivo studies highlights its efficacy, specificity, and potential for synergistic effects when used in combination with conventional chemotherapeutics. Hence, this comprehensive review aims to provide a foundation for future research and development of scopoletin as a promising anticancer agent.</p>","PeriodicalId":93962,"journal":{"name":"Current drug discovery technologies","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144061080","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Superfoods in Drug Discovery: Nutrient Profiles and their Emerging Health Benefits.","authors":"Ravi Kumar Mittal, Vikram Sharma, Gaurav Krishna","doi":"10.2174/0115701638355532250408095114","DOIUrl":"https://doi.org/10.2174/0115701638355532250408095114","url":null,"abstract":"<p><strong>Objective: </strong>This extensive review aims to cover the health and nutritional benefits of su-perfoods. It also discusses the macro- and micronutrients of amla, maca, jackfruit, Brazil nuts, and goji berries. Additionally, we explore the potential of superfoods to protect against chronic diseases, including diabetes, cardiovascular disease, cognitive decline, and cancer.</p><p><strong>Methods: </strong>A comprehensive investigation was carried out to find published literature using Web of Science, PubMed, and Scopus. In addition to Boolean operators (AND, OR), keywords such as \"su-perfood,\" \"bioactive compounds,\" \"functional foods,\" and \"health benefits\" were integrated. Super-foods, their bioactive ingredients, and potential health benefits based on preclinical or clinical data were the subject of permitted research. Research on isolated or synthesized substances unrelated to superfoods, articles without experimental data, and non-peer-reviewed databases were excluded.</p><p><strong>Results: </strong>Our research reveals that superfoods include health-promoting phytochemicals, carotenoids, flavonoids, and polyphenols. They may prevent diseases like diabetes, cardiovascular disease, cancer, and obesity. In conclusion, superfoods improve health and wellness in numerous ways.</p><p><strong>Conclusion: </strong>Superfoods prevent chronic illnesses and improve health. This review discusses the nu-tritional content and health advantages of superfoods, which may encourage their consumption. More research is needed to promote global health and wellness using superfoods.</p>","PeriodicalId":93962,"journal":{"name":"Current drug discovery technologies","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144061714","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Structure-based Virtual Screening and Hit Identification of Novel designed Quinazolin-4(3H)-one Derivatives as Antitubercular Agent Against targets Polyketide Synthase 13 and DNA gyrase of Mycobacterium tuberculosis.","authors":"Revathi G, Sowmiya P, Girija K","doi":"10.2174/0115701638362095250402180030","DOIUrl":"https://doi.org/10.2174/0115701638362095250402180030","url":null,"abstract":"<p><strong>Background: </strong>After COVID-19, tuberculosis remained the world's second most infectious fatal disease in 2022, with about 410 million people developing MDR TB, according to WHO. The fast increase of MDR and XDR-TB has posed a significant clinical problem in tuberculosis treatment. Bedaquiline, the first FDA-approved medicine for MDR-TB treatment, has caused cardiotoxicity and hepatotoxicity due to high lipophilicity or hERG potassium channel blockage throughout the last four decades. To overcome medication resistance and toxicity, there is an urgent need to create innovative drugs with improved efficacy against specific enzymes.</p><p><strong>Methods: </strong>The work focused on the biological importance of the Quinazoline pharmacophore scaf-fold, and it involved the virtual screening and development of 180 novel Quinazoline derivatives in order to find potential hit candidates against molecular dual targets (Pks-13 esterase and DNA gy-rase). Based on docking scores lower than (-7.5, -7.6 kcal/mol) of the standard compound, 80 drug molecules were screened using AUTODOCK vina and filtered by ADMET profile. The top five HIT compounds developed with good binding interactions, acceptable ADME features that obeys the Lipinski Rule of Five, and no toxicity produced as compared to standard bedaquiline were chosen.</p><p><strong>Results: </strong>Docking scores showed that compound RBSI64 had a substantial binding affinity against dual targets (-11.6, -8.2 kcal/mol) than Bedaquiline (-7.5, -7.6 kcal/mol). MD simulation at 100 ns was carried out to investigate the protein's dynamic behaviour with the standard and ligand complex.</p><p><strong>Conclusion: </strong>The results indicated that RBSI64 could be a useful template for developing MDR and XDR-TB inhibitors. The current study contributes to the identification of promising antitubercular candidates against targeted enzymes.</p>","PeriodicalId":93962,"journal":{"name":"Current drug discovery technologies","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144059970","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effective Integration of Artificial Intelligence and Blockchain Technologies for Empowerment of Drug Discovery and Development.","authors":"Virendra S Gomase, Devendra L Visokar, Vitthal V Chopade","doi":"10.2174/0115701638361312250402125556","DOIUrl":"https://doi.org/10.2174/0115701638361312250402125556","url":null,"abstract":"<p><p>The effective integration of blockchain technology and artificial intelligence (AI) has the potential to change healthcare management. Two cutting-edge developments in the healthcare indus-try are blockchain and artificial intelligence. Blockchain, an open network for information sharing and permission, is being used in e-Health to apply artificial intelligence models. Healthcare workers will be able to view patient medical records on the blockchain. Artificial intelligence (AI) makes use of a wide range of suggested algorithms, decision-making power, and vast amounts of data. Health care services can be made more decentralized, transparent, safe, and impenetrable with the use of blockchain technology. AI needs cryptographic records to be stored, and blockchain makes this pos-sible. Applications of artificial intelligence in healthcare management include chatbots for diagnosis and treatment, predictive analytics, personalized medicine, and more. Blockchain technology has ap-plications in supply chain management, clinical trial management, interoperability, and data security and integrity in healthcare management. A more effective, safe, and patient-centered healthcare eco-system can be created by integrating blockchain technology and artificial intelligence (AI) into healthcare management. It can encourage the development of a wide range of applications in radiol-ogy, cancer treatment, cardiology, dermatology, and fundoscopy that may save patients' lives.</p>","PeriodicalId":93962,"journal":{"name":"Current drug discovery technologies","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144046060","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In Silico Development and Characterization of Nisoldipine Analogues for Enhanced Solubility and Therapeutic Potential in the Treatment of Angina Pectoris.","authors":"Pavankumar Krosuri, Mothilal Mohan","doi":"10.2174/0115701638359244250411045740","DOIUrl":"https://doi.org/10.2174/0115701638359244250411045740","url":null,"abstract":"<p><strong>Background: </strong>Angina pectoris, a common cardiovascular condition, necessitates the de-velopment of effective therapeutic agents. Nisoldipine, a calcium channel blocker, and its analogues have shown potential in treating this condition. However, the optimization of these compounds for enhanced therapeutic efficacy remains a critical challenge.</p><p><strong>Objective: </strong>This study aimed to investigate the therapeutic potential of Nisoldipine analogues through in silico analysis, with the goal of identifying lead compounds for the treatment of angina pectoris and optimizing their formulation for improved solubility and drug release.</p><p><strong>Methods: </strong>Eighteen Nisoldipine derivatives were screened using in silico techniques, including mo-lecular docking, SWISS ADME analysis, and molecular dynamics (MD) simulations. The top candi-date, ZINC26826387, was identified and further analyzed. A comprehensive gene set analysis was performed using OMIM, GeneCards, and STITCH databases to identify target hub genes associated with angina pectoris. PPI network analysis and CytoHubba ranking were used to prioritize key genes for further study. Additionally, the lead compound was optimized through nanoparticle formulation, and the resulting nanoparticle tablets were characterized for solubility, dissolution, particle size, en-trapment efficiency, and zeta potential. ANOVA was used to analyze the characterization data.</p><p><strong>Results: </strong>ZINC26826387 emerged as the most promising Nisoldipine analogue, exhibiting superior solubility, absence of AMES toxicity, strong molecular docking interaction with the target protein (docking score of -8.0 kcal/mol), and favourable pharmacokinetic properties. MD simulation con-firmed the stability of the ligand-receptor complex. The study also identified 88 target hub genes associated with angina pectoris, with PTGS2 prioritized as a key gene. The nanoparticle formulation of ZINC26826387 significantly enhanced solubility by 2.53-fold compared to the unformulated com-pound. The optimized nanoparticle tablets achieved a 98.53% drug release within 30 minutes, with an average particle size of 50 nm, entrapment efficiency of 98.89%, and zeta potential of -52 mV, indicating good stability and uniformity.</p><p><strong>Conclusion: </strong>The study demonstrates the therapeutic potential of ZINC26826387, a Nisoldipine ana-logue, through its enhanced solubility and reduced Crystallinity. The lead compound was made into Nanoparticles using Pluronic F407 as carrier. These nanoparticles were further formulated to oral disintegrating tablets for rapid drug release, good stability compared to conventional tablets. These findings suggest that ZINC26826387 could be a promising candidate for the treatment of angina pec-toris.</p>","PeriodicalId":93962,"journal":{"name":"Current drug discovery technologies","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144061009","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}