Novel Approaches for the Enhancement of Bioavailability of Drugs: An Updated Review.

Jyoshna Rani Dash, Gurudutta Pattnaik, Himansu Bhusan Samal, Gangadhar Pradhan, Choudhury Pratyush Kumar Baral, Biswajit Behera, Biswakanth Kar
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Abstract

In medicine, bioavailability is the percentage of a drug that enters the bloodstream and can be used to treat a patient. It has proven challenging throughout time to develop techniques that allow oral administration of most drugs, regardless of their properties, to achieve therapeutic systemic availability. This will be an impressive feat, considering that over 90% of pharmaceuticals are known to have limitations on their oral bioavailability. Improving bioavailability is crucial for optimizing the efficacy and safety of drugs. This review covers a wide range of techniques, including physical, chemical, and formulation approaches, highlighting their mechanisms, advantages, and limitations. Inhibitions of efflux pumps, inhibition of presystemic metabolism, and innovative drug delivery systems that capitalize on the gastrointestinal regionality of medicines are some of the new techniques that have drawn increased interest. Nanotechnology in pharmaceuticals is also being used in this field. We have collected the literature data from 2009 to 2024 using Science Direct, PubMed/Medline, Scopus, and Google Scholar.

提高药物生物利用度的新方法:最新综述。
在医学中,生物利用度是指进入血液并可用于治疗病人的药物比例。事实证明,无论药物的特性如何,要想开发出让大多数药物的口服给药达到治疗性全身可用性的技术,始终是一项挑战。考虑到已知 90% 以上的药物在口服生物利用度方面存在限制,这将是一项了不起的成就。提高生物利用度对于优化药物的疗效和安全性至关重要。本综述涵盖各种技术,包括物理、化学和制剂方法,重点介绍其机制、优势和局限性。抑制外排泵、抑制系统前代谢以及利用药物的胃肠道区域性的创新给药系统等新技术引起了越来越多的关注。纳米制药技术也被应用于这一领域。我们利用 Science Direct、PubMed/Medline、Scopus 和 Google Scholar 收集了 2009 年至 2024 年的文献数据。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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