芍药属:芍药属植物:药理和临床特性的靶向信号通路及基本机制综述》。

Atefeh Jalali, Fereshteh Jafari, Shima Behnamrad, Mohammad M Zarshenas, Xiuxin Zhang, Ali Kashkooe
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引用次数: 0

摘要

简介芍药科只有芍药属,被认为是开花植物的主要类群。芍药科草本植物的一些传统和药理应用已被描述。本文旨在确定芍药属最常用草药的药理活性,重点研究其潜在的作用机制和信号传导途径,为进一步深入研究芍药的药用资源提供见解:方法:通过 PubMed 和 Scopus 数据库对 1995 年 1 月 1 日至 2024 年 5 月 15 日期间的 "芍药属 "关键词进行检索。只提取了与药理学、药剂学和毒理学相关的论文。随后讨论了芍药可能具有的药理活性及其作用机制和信号传导途径:根据我们的研究,只有 15 种芍药的药理应用得到了充分评估。Paeonia lactiflora Pall.、Paeonia suffruticosa Andrews 和 Paeonia emodi Royle 是最常见的芍药植物,它们在现代药理学研究中引起了越来越多的关注。芍药具有多种药理作用,如消炎、抗过敏、抗癌、抗菌、保护心血管、美容护肤、清除自由基、保肝和抗溃疡、抗糖尿病、肌肉骨骼和神经保护作用,可作为危重病人的替代疗法:在芍药的应用中,抗炎和抗氧化活性至关重要,因为其他大多数药理作用都归功于它们。换言之,核因子(NF)-κB 和核因子红细胞 2 相关因子 2(Nrf2)可被视为参与芍药药理活性的最重要信号通路。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The Genus Paeonia: A Review of the Targeted Signaling Pathways and Underlying Mechanisms of Pharmacological and Clinical Properties.

Introduction: The Paeoniaceae family contains only the Paeonia genus and is considered the major group of flowering plants. Several traditional and pharmacological applications of Paeoniaceae herbs have been described. The current paper aimed to determine the pharmacological activities of the most prevalent herbs from the genus Paeonia by focusing on the underlying mechanism of action and signaling pathways to provide insight for further in-depth research on the medicinal resources of Paeonia.

Method: The "Paeoniaceae" keyword was searched from 1st January 1995 to 15th May 2024 through the PubMed and Scopus databases. Only papers related to pharmacology, pharmaceutics, and toxicology were extracted. The possible pharmacological activity of the Paeonia plants underlying their mechanism of action and signaling pathways was subsequently discussed.

Results: Following our venture, only 15 Paeonia herbs were adequately evaluated for their pharmacological applications. Paeonia lactiflora Pall., Paeonia suffruticosa Andrews, and Paeonia emodi Royle are among the most prevalent Paeonia plants that have attracted increased amounts of attention in modern pharmacological studies. Paeonia herbs possess various pharmacological applications, such as anti-inflammatory, anti-allergic, anticancer, antimicrobial, cardiovascular protective, cosmetic and skincare, radical scavenging, hepatoprotective and anti-ulcerative, anti-diabetic, musculoskeletal, and neuroprotective effects, and can be used as alternative therapies under critical medical conditions.

Conclusion: Among the applications of Paeonia herbs, anti-inflammatory and antioxidant activities are critical, as most of the other pharmacological effects are attributed to them. In other words, nuclear factor (NF)-κB and nuclear factor erythroid 2-related factor 2 (Nrf2) can be considered the most important signaling pathways involved in the pharmacological activity of Paeonia herbs.

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