Canadian journal of diabetes最新文献_第2页

Blood characteristics of patients with type 2 diabetes and response of their peripheral blood mononuclear cells to inhibitors of the NLRP3-inflammasome and caspase-1. 2型糖尿病患者的血液特征及其外周血单个核细胞对nlrp3炎性体和caspase-1抑制剂的反应

Canadian journal of diabetes Pub Date : 2025-07-10 DOI: 10.1016/j.jcjd.2025.06.008

Joyce de Paula Souza, Justus S Fischer, Karine Jeanneau, Cyril Allard, Eline Angevaare, Dominik Aschenbrenner, Ursula Bodendorf, Benjamin Demarco, John S Gounarides, Saskia Killmer, Jiri Kovarik, Sabina Pfister, Hong Yin, Vithushan Ratnarasa, Marianne Bo Ni-Schnetzler, Matthias Hepprich, Daniel T Meier, Grazyna Wieczorek, Marc Y Donath

{"title":"Blood characteristics of patients with type 2 diabetes and response of their peripheral blood mononuclear cells to inhibitors of the NLRP3-inflammasome and caspase-1.","authors":"Joyce de Paula Souza, Justus S Fischer, Karine Jeanneau, Cyril Allard, Eline Angevaare, Dominik Aschenbrenner, Ursula Bodendorf, Benjamin Demarco, John S Gounarides, Saskia Killmer, Jiri Kovarik, Sabina Pfister, Hong Yin, Vithushan Ratnarasa, Marianne Bo Ni-Schnetzler, Matthias Hepprich, Daniel T Meier, Grazyna Wieczorek, Marc Y Donath","doi":"10.1016/j.jcjd.2025.06.008","DOIUrl":"https://doi.org/10.1016/j.jcjd.2025.06.008","url":null,"abstract":"Obesity and aging are associated with increased activity of the innate immune system. This chronic systemic inflammation contributes to the development of type 2 diabetes and long-term complications and is partly driven by the activation of the NLRP3 inflammasome. We conducted a comparative analysis of clinical parameters, non-esterified fatty acid (NEFA) profiles, immune cell subsets, and inflammatory responses of peripheral blood mononuclear cells obtained from both healthy individuals and those diagnosed with type 2 diabetes. Plasma NEFA profiling revealed a dysregulation in patients with type 2 diabetes, indicating potential modulation of immune cell responses by lipids, along with leukocytosis, elevated serum levels of inflammatory cytokines, the inflammasome-related protein ASC, IL-1RA, and IL-18BPa. Surprisingly, functional assessments demonstrated comparable NLRP3 inflammasome activity in peripheral blood mononuclear cells (PBMCs) from both groups, suggesting that systemic inflammation in type 2 diabetes is driven by elevated leucocyte numbers or resident tissue macrophages. Treatment of PBMCs with NLRP3 and caspase-1 inhibitors attenuated the release of pro-inflammatory cytokines ex vivo. Therefore, inhibition of inflammasome activation emerges as a promising therapeutic strategy for management of diabetes-related complications.","PeriodicalId":93918,"journal":{"name":"Canadian journal of diabetes","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144621588","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Patient perspectives of the operationalization of adult patient-centered care at the Primary Care Diabetes Support Program, London, Ontario: A Qualitative Descriptive Study. 在安大略省伦敦的初级保健糖尿病支持项目中，以患者为中心的成人护理的操作化：一项定性描述性研究。

Canadian journal of diabetes Pub Date : 2025-07-04 DOI: 10.1016/j.jcjd.2025.06.007

Gillian Young, Anika Garg, Dana Ryan, Leslie Meredith, Stewart Harris, Sonja M Reichert, Lindsay Hedden, Maria Mathews

{"title":"Patient perspectives of the operationalization of adult patient-centered care at the Primary Care Diabetes Support Program, London, Ontario: A Qualitative Descriptive Study.","authors":"Gillian Young, Anika Garg, Dana Ryan, Leslie Meredith, Stewart Harris, Sonja M Reichert, Lindsay Hedden, Maria Mathews","doi":"10.1016/j.jcjd.2025.06.007","DOIUrl":"https://doi.org/10.1016/j.jcjd.2025.06.007","url":null,"abstract":"Background: Patient-centered care is a hallmark of family medicine, and patient-centered care for diabetes has been associated with better outcomes. The Primary Care Diabetes Support Program (PCDSP) in London, Ontario, uses a patient-centered model of care and targets three groups of patients at high risk for diabetes complications: 1) medically complex, 2) socially complex, and 3) those without a primary care provider. We describe, from the patient's perspectives, how the PCDSP operationalizes patient-centered care.Approach: Using maximum variation sampling, we recruited and interviewed 17 patients regarding their experiences with the PCDSP. We asked patients about the PCDSP's approach to care and its impact on their diabetes management and overall health. We coded interview transcripts using an inductive thematic analysis approach.Results: We identified eight attributes of PCDSP care that aligned with the principles of patient-centered of care: 1) reassurance, 2) education, 3) whole person care, 4) individualized care, 5) high accessibility, 6) co-ordinated care, 7) integration of new technologies, and 8) ownership of care. Participants emphasized that they felt the care they received from the PCDSP was tailored to their individual needs, accessible, coordinated care with other providers, and gave them access to new medications and technologies as well as the latest research on diabetes care.Conclusions: Findings highlight that the PCDSP approach is more holistic than existing patient-centered care models for diabetes described in the literature, which focus on education and skills to improve self-management. The attributes identified are mutually reinforcing, and our findings reflect longitudinal, high-quality primary care approach through the PCDSP.","PeriodicalId":93918,"journal":{"name":"Canadian journal of diabetes","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144577241","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

"Letter to the Editor: {Do Provincial Formulary Restrictions Explain Differential Uptake of Sodium-Glucose Co-Transporter-2 Inhibitors in Adults with Diabetes and Cardiovascular Disease in Canada? A Retrospective Cohort Study of Pharmacy Claims}". 致编辑的信：{各省处方限制是否解释了加拿大成人糖尿病和心血管疾病患者钠-葡萄糖共转运蛋白-2抑制剂的不同摄取？《药品索赔的回顾性队列研究》。

Canadian journal of diabetes Pub Date : 2025-07-01 DOI: 10.1016/j.jcjd.2025.06.006

Muhammad Tabish, Hamna Khan, Muhammad Naveed

引用次数: 0

"Letter to the Editor: Hypertension Treatment and Control in Canadians with Diabetes." “致编辑的信：加拿大糖尿病患者的高血压治疗和控制。”

Canadian journal of diabetes Pub Date : 2025-06-25 DOI: 10.1016/j.jcjd.2025.06.004

Krishna Jaipal, Sanjana Bebu Punshi, Mehak Kumari Bansari

引用次数: 0

Letter to the Editor: Association between circulating vitamin C concentrations and risk of diabetes mellitus: dual evidence from NHANES database and Mendelian randomization analysis. 致编辑的信：循环维生素C浓度与糖尿病风险之间的关系：来自NHANES数据库和孟德尔随机化分析的双重证据。

Canadian journal of diabetes Pub Date : 2025-06-24 DOI: 10.1016/j.jcjd.2025.06.005

Masashi Hasebe, Chen-Yang Su

引用次数: 0

"Letter to the Editor: Virtual vs. In-Person Care in Gestational Diabetes Management: A Retrospective Cohort Analysis". 致编辑的信：妊娠糖尿病管理中的虚拟与面对面护理：回顾性队列分析。

Canadian journal of diabetes Pub Date : 2025-06-13 DOI: 10.1016/j.jcjd.2025.06.003

Shorrem Naeem, Zainab Arif

引用次数: 0

Impact of an Audit and Feedback-based Intervention on Preparation of Adolescents for Transition to Adult Type 1 Diabetes Care: A Multi-Center Quasi-Experimental Study. 基于审计和反馈的干预对青少年向成人1型糖尿病护理过渡准备的影响：一项多中心准实验研究

Canadian journal of diabetes Pub Date : 2025-06-10 DOI: 10.1016/j.jcjd.2025.06.002

Syed Zain Ahmad, Noah Ivers, Ian Zenlea, Baiju R Shah, Peter C Austin, Cheril Clarson, Jennifer Harrington, Alanna Landry, Geetha Mukerji, Zubin Punthakee, Mark R Palmert, Janet Parsons, Mikayla Sonnenberg, Rayzel Shulman

{"title":"Impact of an Audit and Feedback-based Intervention on Preparation of Adolescents for Transition to Adult Type 1 Diabetes Care: A Multi-Center Quasi-Experimental Study.","authors":"Syed Zain Ahmad, Noah Ivers, Ian Zenlea, Baiju R Shah, Peter C Austin, Cheril Clarson, Jennifer Harrington, Alanna Landry, Geetha Mukerji, Zubin Punthakee, Mark R Palmert, Janet Parsons, Mikayla Sonnenberg, Rayzel Shulman","doi":"10.1016/j.jcjd.2025.06.002","DOIUrl":"https://doi.org/10.1016/j.jcjd.2025.06.002","url":null,"abstract":"Introduction: Adolescents and young adults (AYA) often report feeling poorly prepared and dissatisfied with the process of transitioning from pediatric to adult type 1 diabetes (T1D) care. We aimed to examine the impact of Bridging the Gap (BTG), an audit and feedback-based intervention, on transition care.Methods: This is a secondary analysis of survey data collected during a multi-center, quasi-experimental pre-post study comparing self-reported completion of important transition activities and preparedness in AYA with T1D between study periods. AYA who had their final pediatric visit in the first and second study years were in the early- and late-implementation cohorts respectively. BTG was conducted in five pediatric diabetes centres within the Ontario Pediatric Diabetes Network in Ontario, Canada from June 1, 2019 to September 30, 2021. Poisson and Logistic regression models were used to examine differences in the completion of transition activities reported to be important and transition preparedness between time periods.Results: Survey data from 116/144 (81%) and 73/113 (65%) participants in the early and late cohorts were analyzed. The mean number of important transition activities completed was 13% lower in the late cohort (adjusted rate ratio 0.87; 95% confidence interval 0.76-0.99, p=0.03). In the early cohort, 10.3% of participants reported completing all transition care activities which they felt were important compared to 4.1% in the late cohort.Conclusions: The intervention did not improve the completion of important transition care activities, although this may have been related to the effects of the pandemic on transition care.","PeriodicalId":93918,"journal":{"name":"Canadian journal of diabetes","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144287584","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Pilot Study of the Feasibility and Acceptability of a Patient Navigator in a Pediatric Type 1 Diabetes Clinic. 儿童1型糖尿病门诊患者导航员的可行性和可接受性的初步研究。

Canadian journal of diabetes Pub Date : 2025-06-10 DOI: 10.1016/j.jcjd.2025.05.011

Elise Schlissel Tremblay, Ashley B Tartarilla, Kali McCollister, Mia Umali, Melicia Y Whitley, Julia Ainsworth, Patrice Melvin, Lori M Laffel, Valerie L Ward

{"title":"A Pilot Study of the Feasibility and Acceptability of a Patient Navigator in a Pediatric Type 1 Diabetes Clinic.","authors":"Elise Schlissel Tremblay, Ashley B Tartarilla, Kali McCollister, Mia Umali, Melicia Y Whitley, Julia Ainsworth, Patrice Melvin, Lori M Laffel, Valerie L Ward","doi":"10.1016/j.jcjd.2025.05.011","DOIUrl":"https://doi.org/10.1016/j.jcjd.2025.05.011","url":null,"abstract":"Objective: To assess the feasibility and acceptability of a patient navigator (PN) in a pediatric type 1 diabetes (T1D) clinic.Methods: Pilot prospective cohort intervention study from 2022-2024 of pediatric endocrinology patients with T1D ≥1 year duration with hemoglobin A1c ≥9.0%. Participants met with a PN over six months of clinic visits including pre- and post-clinic visits to establish both clinical and non-clinical needs and follow up goals. A subset of families completed semi-structured interviews following the 6-month intervention to characterize their experiences during the study.Results: Of 118 eligible patients, 27 youth of diverse backgrounds and their caregivers enrolled; 17 completed the study. Five or more distinct needs or goals were identified by at least 50% of families prior to as well as after clinic visits. Health-related social needs/concerns were identified at ∼20% of PN and clinic visits. Following the 6-month study, 3 main themes emerged during the interviews: appreciation for the added value of a PN to support diabetes visits, recognition and gratitude for the efficiency of PN contacts, and a preference to personalize the PN intervention to family needs.Discussion: This pilot study demonstrated a high level of need among families of youth with T1D with suboptimal glycemic control; however, challenges with recruitment and retention demonstrated the importance of tailoring of the PN intervention to family priorities.Conclusions: Further study is required to optimize the impact of a PN in pediatric T1D clinics, potentially implemented at the time of diagnosis when there is need for greater support.","PeriodicalId":93918,"journal":{"name":"Canadian journal of diabetes","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144287572","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Do Provincial Formulary Restrictions Explain Differential Uptake of Sodium-Glucose Co-Transporter-2 Inhibitors in Adults with Diabetes and Cardiovascular Disease in Canada? A Retrospective Cohort Study of Pharmacy Claims. 省级处方限制是否解释了加拿大成人糖尿病和心血管疾病患者钠-葡萄糖共转运蛋白-2抑制剂的不同摄取？药品索赔的回顾性队列研究。

Canadian journal of diabetes Pub Date : 2025-06-10 DOI: 10.1016/j.jcjd.2025.06.001

Darren Lau, Douglas C Dover, Hena Qureshi, Roseanne O Yeung, Dean Eurich, Peter Senior, Sonia Butalia, Padma Kaul

{"title":"Do Provincial Formulary Restrictions Explain Differential Uptake of Sodium-Glucose Co-Transporter-2 Inhibitors in Adults with Diabetes and Cardiovascular Disease in Canada? A Retrospective Cohort Study of Pharmacy Claims.","authors":"Darren Lau, Douglas C Dover, Hena Qureshi, Roseanne O Yeung, Dean Eurich, Peter Senior, Sonia Butalia, Padma Kaul","doi":"10.1016/j.jcjd.2025.06.001","DOIUrl":"https://doi.org/10.1016/j.jcjd.2025.06.001","url":null,"abstract":"Background: Ontario listed SGLT-2 inhibitors (SGLT2i) as regular public drug benefits for adults age ≥ 65, while other Canadian provinces providing benefits for SGLT2i implemented special authorization restrictions. We hypothesized that special authorization led to lower SGLT2i use among older adults with diabetes and cardiovascular disease (CVD) in other provinces (Alberta, Manitoba, New Brunswick, and Saskatchewan), compared to Ontario.Methods: Retrospective cohort study of adults with diabetes and CVD, age ≥ 65 years, discharged from hospital April 1, 2016 to March 31, 2019, in five Canadian provinces. Data were obtained from a national discharge database linked with public pharmacy claims. We followed individuals from discharge until March 31, 2019 for SGLT2i uptake. We also examined SGLT2i discontinuation and sulfonylurea uptake as control outcomes. Fine-Gray hazard models were adjusted for comorbidities and area-level socio-demographics.Results: Of 161,249 individuals (average age 78 years, 42% female, median follow-up 1.8 years), 68% were from Ontario, and 32% were from other provinces. Cumulative SGLT2i uptake at 6 months was 2.2% in Ontario vs 0.7% in other provinces, with adjusted hazard ratio [aHR] = 2.72, 95% CI [2.56-2.94], p < 0.001). Ontario residents had similar SGLT2i discontinuation or sulfonylurea uptake compared to other provinces. Other predictors of SGLT2i uptake were identified.Conclusions: There was an interprovincial disparity in SGLT2i uptake in older adults with diabetes and cardiovascular disease, in whom SGLT2i are now indicated for cardio-kidney benefit. Special authorization restrictions should be flexibly and rapidly re-assessed and revised as new evidence of clinical benefits become available.","PeriodicalId":93918,"journal":{"name":"Canadian journal of diabetes","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144287573","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Response to the Letter to the Editor: Temporal Trends in the Rates of Foot Complications and Lower Extremity Amputation Related to Type 1 and Type 2 Diabetes in Adults in Selected Canadian Provinces. 致编辑的回复：在加拿大选定的省份中，与1型和2型糖尿病相关的成人足部并发症和下肢截肢率的时间趋势。

IF 2.6

Canadian journal of diabetes Pub Date : 2025-06-03 DOI: 10.1016/j.jcjd.2025.05.010

Angela Y Kim, James Hanley, Rebecca Fuhrer, Charles de Mestral

引用次数: 0