Canadian journal of diabetes最新文献_第2页

Trends in gestational diabetes in Manitoba from 1981 - 2019: A descriptive study with geospatial mapping. 1981年至2019年马尼托巴省妊娠糖尿病趋势：一项地理空间测绘的描述性研究

Canadian journal of diabetes Pub Date : 2024-11-29 DOI: 10.1016/j.jcjd.2024.11.005

Nicole Brunton, Kevin Friesen, Jennifer M Yamamoto, Heather J Prior, Jonathan McGavock

{"title":"Trends in gestational diabetes in Manitoba from 1981 - 2019: A descriptive study with geospatial mapping.","authors":"Nicole Brunton, Kevin Friesen, Jennifer M Yamamoto, Heather J Prior, Jonathan McGavock","doi":"10.1016/j.jcjd.2024.11.005","DOIUrl":"https://doi.org/10.1016/j.jcjd.2024.11.005","url":null,"abstract":"Background: There is little information describing trends in gestational diabetes incidence within sub-groups that often experience health inequities.Methods: We leveraged provincial administrative health data to describe trends in gestational diabetes incidence between 1981-2019, stratified by sub-populations based on age, urbanicity, and neighbourhood-level average household income. We calculated yearly incidence across sub-groups and annual percent change in incidence to assess trends over time. Geospatial mapping was used to visualize changes by neighbourhood cluster.Results: Gestational diabetes incidence increased from 1.3% to 8.6% between 1981 and 2019, with an upward inflection occurring around 2010. The annual percent change (APC) between 1981-2009, prior to the inflection point, was 1.9% (95% CI: 1.4-2.5%) and was 11.7% (95% CI: 8.9-14.7%) post inflection - from 2010-2019. After 2010, gestational diabetes incidence increased most among urban residents (APC= 18.1%; 95%CI: 13.9-22.5), among those >35 years (APC = 12.0%; 95% CI: 8.4-15.7%), and among individuals in the highest SES group (APC = 14.8%; 95% CI: 9.4-20.4%).Geospatial mapping showed that incidence increased more in neighbourhoods with the highest proportion of recent immigrants to Canada.Conclusion: Incidence of gestational diabetes increased six-fold in Manitoba over the last 20 years, particularly among those with high SES and higher age. Further research is required to clarify the role of screening practices in the trends observed here.","PeriodicalId":93918,"journal":{"name":"Canadian journal of diabetes","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142775268","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cardiovascular and Respiratory Measures in Adults With Early-onset Type 2 Diabetes Mellitus Compared With Matched Controls. 与匹配对照组相比，早期 2 型糖尿病患者的心血管和呼吸系统指标。

Canadian journal of diabetes Pub Date : 2024-11-23 DOI: 10.1016/j.jcjd.2024.11.003

Phillip A Munoz, David S Celermajer, Yu Gu, Sue Bradley, Jencia Wong, Maria I Constantino, Sue McLennan, Edmund M T Lau, Jennifer A Alison, Alison R Harmer

{"title":"Cardiovascular and Respiratory Measures in Adults With Early-onset Type 2 Diabetes Mellitus Compared With Matched Controls.","authors":"Phillip A Munoz, David S Celermajer, Yu Gu, Sue Bradley, Jencia Wong, Maria I Constantino, Sue McLennan, Edmund M T Lau, Jennifer A Alison, Alison R Harmer","doi":"10.1016/j.jcjd.2024.11.003","DOIUrl":"10.1016/j.jcjd.2024.11.003","url":null,"abstract":"Objectives: The aim of the study was to compare cardiac and respiratory function at rest in participants with early-onset type 2 diabetes and a control group without diabetes, matched for age, sex, and body mass index (BMI).Methods: This study included 18 participants with early-onset type 2 diabetes (12 men and 6 women, age 34.9±6 years, diabetes duration 3.1±3.0 years) and 14 control participants without diabetes, matched for age, sex, and BMI (9 men and 5 women, age 32.9±5.2 years). Participants underwent resting echocardiography and pulmonary function tests. Fasting blood samples were analyzed for glycated hemoglobin, glucose, C-reactive protein, insulin, free fatty acids, and N-terminal pro-B-type natriuretic peptide.Results: Significant differences between groups were observed in left ventricular diastolic function at rest. Compared with controls, the group with early-onset type 2 diabetes had lower E/A (ratio between early [E] and late [A] ventricular filling velocity) (p=0.002), higher E/e' (representing left ventricular filling pressure) (p=0.017), lower e' (early myocardial relaxation velocity) (p<0.001), and lower diffusing capacity of the lung for carbon monoxide (p=0.003).Conclusions: Subclinical left ventricular diastolic dysfunction and lower lung diffusing capacity were detected in participants with early-onset type 2 diabetes when compared with matched controls.","PeriodicalId":93918,"journal":{"name":"Canadian journal of diabetes","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-11-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142712074","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The First Nations Community Experiences With the SOAR Research Program: Improving Type 2 Diabetes Prevention and Management. 原住民社区对 SOAR 研究计划的体验：改善 2 型糖尿病的预防和管理。

Canadian journal of diabetes Pub Date : 2024-11-12 DOI: 10.1016/j.jcjd.2024.11.001

Melanie Dissanayake, Romina Pace, Stewart Harris

{"title":"The First Nations Community Experiences With the SOAR Research Program: Improving Type 2 Diabetes Prevention and Management.","authors":"Melanie Dissanayake, Romina Pace, Stewart Harris","doi":"10.1016/j.jcjd.2024.11.001","DOIUrl":"10.1016/j.jcjd.2024.11.001","url":null,"abstract":"Objectives: Indigenous peoples in Canada are considered the highest risk populations for type 2 diabetes mellitus (T2DM). Quality improvement (QI) strategies may be considered effective interventions for improving T2DM health outcomes. The purpose of this study was to understand experiences associated with implementation of the SOAR QI program to improve prevention and management of T2DM.Methods: A qualitative study was conducted, and in-depth, semistructured interviews were held with QI team members and key contacts, in person and through videoconference with 2 First Nations communities. Interviews were audio-recorded and transcribed for data analysis.Results: Ten interviews were conducted and emerging themes from the data analysis were organized into 2 categories: facilitators and barriers. Four subthemes were identified. Two subthemes emerged under the category of facilitators (cultural relevance and partnership building) and 2 subthemes emerged under the category of barriers (workload burden, role ambiguity).Conclusions: This study highlights the necessity of implementing diabetes QI strategies that foster cultural sensitivity and provide opportunities for partnership building to strengthen community relationships. We also highlight the importance of diminishing role ambiguity, and increased workload burdens, which can hinder the successful implementation of QI programs long term. Our findings can be used to improve future adaptations of SOAR and other diabetes First Nations-focussed QI strategies, to benefit Indigenous people in acquiring optimal outcomes relative to T2DM care. Findings can also inform the design, practices, and policies of such QI interventions in support of the spread and sustainability of the intervention long term.","PeriodicalId":93918,"journal":{"name":"Canadian journal of diabetes","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142634530","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Concomitant Detection of Serum Activating Transcription Factor 4 Levels and Mean Amplitude of Glycemic Excursion Is Helpful to Predict Osteoporosis in Adult Patients With Type 2 Diabetes Mellitus. 同时检测血清 ATF4 水平和 MAGE 有助于预测 2 型糖尿病患者骨质疏松症的发生。

Canadian journal of diabetes Pub Date : 2024-11-09 DOI: 10.1016/j.jcjd.2024.11.002

Jing Zhang, Wei Huang

{"title":"Concomitant Detection of Serum Activating Transcription Factor 4 Levels and Mean Amplitude of Glycemic Excursion Is Helpful to Predict Osteoporosis in Adult Patients With Type 2 Diabetes Mellitus.","authors":"Jing Zhang, Wei Huang","doi":"10.1016/j.jcjd.2024.11.002","DOIUrl":"10.1016/j.jcjd.2024.11.002","url":null,"abstract":"Objectives: Activating transcription factor 4 (ATF4) and mean amplitude of glycemic excursion (MAGE) have been implicated in the pathogenesis of osteoporosis (OP) and type 2 diabetes mellitus (T2DM). In this retrospective cohort study we assessed the predictive value of serum ATF4 and MAGE for occurrence of OP in patients with T2DM.Methods: A total of 162 patients with T2DM were assigned to T2DM or T2DM+OP groups. All participants underwent serum ATF4 level detection and 72-hour blood glucose monitoring (MAGE measurement). The correlations of ATF4 and MAGE with glucose and bone metabolism indicators and bone mineral density (BMD) were analyzed. A multivariate logistic regression model was developed to evaluate the correlations of ATF4 and MAGE with T2DM-associated OP. The diagnostic performance of concomitant detection of ATF4 and MAGE was assessed based on area under the receiver-operating characteristic (AUC) curve.Results: Patients with T2DM with OP had higher serum ATF4 levels and MAGE than patients with T2DM only. ATF4 and MAGE correlated positively with fasting insulin, glycated hemoglobin, homeostatic model for insulin resistance assessment, beta-C-terminal crosslinking telopeptide of type I collagen, and tartrate-resistant acid phosphatase-5b, but negatively with bone alkaline phosphatase, serum procollagen type I N-propeptide, procollagen type I carboxy-terminal propeptide, and BMD. Elevated levels of ATF4 and MAGE were independent risk factors, but increased BMD at the hip, femoral neck, and lumbar spine was a protective factor for patients with T2DM with OP. More importantly, the AUC of concomitant ATF4 and MAGE was considerably higher than that of ATF4 or MAGE alone.Conclusion: Concomitant detection of ATF4 and MAGE may aid in predicting the occurrence of OP in patients with T2DM.","PeriodicalId":93918,"journal":{"name":"Canadian journal of diabetes","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-11-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142634528","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Glucagon-like Peptide-1 Receptor Agonist Use in Hospital: A Multicentre Observational Study. 医院中胰高血糖素样肽 1 受体激动剂的使用：一项多中心观察研究。

Canadian journal of diabetes Pub Date : 2024-10-30 DOI: 10.1016/j.jcjd.2024.10.011

Prachi Ray, Jason A Moggridge, Alanna Weisman, Mina Tadrous, Daniel J Drucker, Bruce A Perkins, Michael Fralick

{"title":"Glucagon-like Peptide-1 Receptor Agonist Use in Hospital: A Multicentre Observational Study.","authors":"Prachi Ray, Jason A Moggridge, Alanna Weisman, Mina Tadrous, Daniel J Drucker, Bruce A Perkins, Michael Fralick","doi":"10.1016/j.jcjd.2024.10.011","DOIUrl":"10.1016/j.jcjd.2024.10.011","url":null,"abstract":"Background: Glucagon-like peptide-1 receptor agonists (GLP-1RAs) are effective medications for type 2 diabetes mellitus (T2DM) and obesity, yet their uptake among patients most likely to benefit has been slow.Methods: We conducted a cross-sectional analysis of medication exposure in adults hospitalized at 16 hospitals in Ontario, Canada, between 2015 and 2022. We estimated the proportions of those with T2DM, obesity, and cardiovascular disease. We identified the frequency of GLP-1RA use and conducted multivariable logistic regression to identify factors associated with their use.Results: Across 1,278,863 hospitalizations, 396,084 (31%) patients had T2DM and approximately 327,844 (26%) had obesity. GLP-1RA use (n=1,274) was low among those with a diagnosis of T2DM (0.3%) or obesity (0.7%), despite a high prevalence of cardiovascular disease (36%). In contrast, the use of diabetes medications lacking cardiovascular benefit was high during inpatient hospitalizations related to diabetes: 60% (n=236,612) received insulin and 14% (n=54,885) received a sulfonylurea. Apart from T2DM (odds ratio [OR]=29.6, 95% confidence interval [CI] 23.5 to 37.2), characteristics associated with greater odds of receiving a GLP-1RA were seen in those 50 to 70 years of age (OR=1.71, 95% CI 1.38 to 2.11) compared with those <50 years of age, glycated hemoglobin >9% (OR=1.83, 95% CI 1.36 to 2.47) compared with <6.5%, and highest income quintile (OR=1.73, 95% CI 1.45 to 2.07) compared with lowest income quintile.Conclusion: Knowledge translation interventions are needed to address the low adoption of GLP-1RA among hospitalized patients with T2DM and obesity, who are the most likely to benefit from this treatment.","PeriodicalId":93918,"journal":{"name":"Canadian journal of diabetes","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142565315","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Proactive, Legal, and Ethical Approach to the Management of People Living With Diabetes Treated With Insulin Pumps Who Lack Capacity Yet Decline Care During Hospitalization. 对使用胰岛素泵治疗的糖尿病患者在住院期间因缺乏行为能力而拒绝接受治疗的情况，采取积极主动、合法和合乎道德的管理方法。

Canadian journal of diabetes Pub Date : 2024-10-22 DOI: 10.1016/j.jcjd.2024.10.010

Bridie Hamilton, Lisa-Marie Williams, Gurleen Gill, Maya Liepert, Juanita Wilzer, Ali Ladak, Elisabeth Oliviero, Annie Garon-Mailer, Cathy J Sun

引用次数: 0

Reassessing the Burden of Food Insecurity in Youth and Young Adults With Youth-onset Diabetes: The Importance of Marginal Food Security. 重新评估青少年糖尿病患者的粮食不安全负担：边缘粮食安全的重要性。

Canadian journal of diabetes Pub Date : 2024-10-17 DOI: 10.1016/j.jcjd.2024.10.006

Angela D Liese, Emmanuel F Julceus, Andrea D Brown, Catherine Pihoker, Edward A Frongillo, Katherine A Sauder, Faisal S Malik, Anna Bellatorre, Beth A Reboussin, Jason A Mendoza

{"title":"Reassessing the Burden of Food Insecurity in Youth and Young Adults With Youth-onset Diabetes: The Importance of Marginal Food Security.","authors":"Angela D Liese, Emmanuel F Julceus, Andrea D Brown, Catherine Pihoker, Edward A Frongillo, Katherine A Sauder, Faisal S Malik, Anna Bellatorre, Beth A Reboussin, Jason A Mendoza","doi":"10.1016/j.jcjd.2024.10.006","DOIUrl":"10.1016/j.jcjd.2024.10.006","url":null,"abstract":"Introduction: Whereas marginal food insecurity has been recognized as important in Canadian food security policy, the category of marginal food security (MFS) is often ignored in US food security research.Methods: Prevalence of FI was estimated according to the conventional and an alternate classification of MFS with food insecurity among 938 youth and young adults (YYA) with youth-onset type 1 diabetes (T1D) and 156 with youth-onset of type 2 diabetes (T2D) from the SEARCH Food Security Cohort Study (2018-2021). Multivariable regression was used to estimate the association of MFS and conventionally defined food insecurity (FI) ascertained with diabetes-related outcomes, including acute diabetes complications, health care utilization, and diabetes self-management among YYA with T1D.Results: MFS affected 10% of participants with T1D diabetes and 20% of participants with T2D. Classifying MFS with FI increased FI prevalence from 18.0% to 27.8% in participants with T1D and 34.6% to 55.1% in participants with T2D. Compared to T1D with high food security, YYA with T1D who were FI had higher odds hypoglycemia (2.1, 95% CI 1.2 to 3.6) and ketoacidosis (1.6, 95% CI 1.0 to 2.6), but no association was seen in MFS. The FI group also had higher odds of emergency department use and hospitalization (2.3, 95% CI 1.5 to 3.4; 2.4, 95% CI 1.5 to 3.9) and lower odds of technology use and checking glucose (0.6, 95% CI 0.4 to 0.9; 0.3, 95% CI 0.1 to 0.6). The MFS group exhibited associations of similar directions.Discussion and conclusion: Health care providers should consider care of patients with T1D and MFS the same way they care for patients with FI.","PeriodicalId":93918,"journal":{"name":"Canadian journal of diabetes","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142483054","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cystic Fibrosis Related Diabetes: a first Canadian Clinical Practice guideline. 囊性纤维化相关糖尿病：第一份加拿大临床实践指南。

Canadian journal of diabetes Pub Date : 2024-09-09 DOI: 10.1016/j.jcjd.2024.09.001

A Coriati, Kj Potter, J Gilmour, Gy Lam, C Nichols, Lc Lands, M-A Doyle, V Boudreau, L Alexandre-Heymann, Ml McKinney, D Sherifali, P Senior, R Rabasa-Lhoret

引用次数: 0

LONG-TERM EXPOSURE TO KETOGENIC DIET INDUCES NAFLD IN APOE DEFICIENT MICE: A ROLE FOR GUT MICROBIOTA ALTERATIONS AND TOLL-LIKE RECEPTOR 5 长期暴露于生酮饮食诱导apoe缺乏小鼠nafld:肠道微生物群改变和toll样受体5的作用

Canadian journal of diabetes Pub Date : 2023-11-01 DOI: 10.1016/j.jcjd.2023.10.252

A. Abdualkader, S. Mourad, H. Mechchate, R. Al Batran

引用次数: 0

SEX DIFFERENCES IN THE PRESENTATION, TREATMENT AND OUTCOMES OF PATIENTS WITH HOMOZYGOUS FAMILIAL HYPERCHOLESTEREMIA 纯合子家族性高胆固醇血症患者的表现、治疗和结局的性别差异

Canadian journal of diabetes Pub Date : 2023-11-01 DOI: 10.1016/j.jcjd.2023.10.358

Z. Al-Baldawi, L. Brown, I. Ruel, A. Baass, J. Bergeron, L. Cermakova, P. Couture, D. Gaudet, G. Francis, R. Hegele, I. Iatan, G. Mancini, B. McCrindle, M. Sherman, J. Genest, L. Brunham

引用次数: 0