Canadian journal of diabetes最新文献

High Prevalence and Common Forms of Maturity-Onset Diabetes of the Young in Greenland.

Canadian journal of diabetes Pub Date : 2025-01-30 DOI: 10.1016/j.jcjd.2025.01.002

Anne Cathrine Baun Thuesen, Marie Balslev Backe, Genís Garcia-Erill, Mikkel Schubert, Kristian Ebbesen Hanghøj, Ida Moltke, Anders Albrechtsen, Niels Grarup, Anette Prior Gjesing, Marit Eika Jørgensen, Torben Hansen, Michael Lynge Pedersen

{"title":"High Prevalence and Common Forms of Maturity-Onset Diabetes of the Young in Greenland.","authors":"Anne Cathrine Baun Thuesen, Marie Balslev Backe, Genís Garcia-Erill, Mikkel Schubert, Kristian Ebbesen Hanghøj, Ida Moltke, Anders Albrechtsen, Niels Grarup, Anette Prior Gjesing, Marit Eika Jørgensen, Torben Hansen, Michael Lynge Pedersen","doi":"10.1016/j.jcjd.2025.01.002","DOIUrl":"https://doi.org/10.1016/j.jcjd.2025.01.002","url":null,"abstract":"Objectives: Population studies have identified common genetic variants contributing substantially to the burden of diabetes in Greenland. However, handling of suspected monogenic diabetes in diabetes clinics in Greenland has not been described. We aimed to describe the referral rate, prevalence, and genetic causes of clinically identified monogenic diabetes in Greenland.Methods: All diabetes patients in Greenland referred for genetic testing due to suspected monogenic diabetes between 2014-2022 were tallied. Targeted short read sequencing and Sanger sequencing of probands and their family members were used to screen for potentially deleterious variants in the Maturity-Onset Diabetes of the Young (MODY) genes GCK, HNF1A, HNF1B, and HNF4A. Clinical data were extracted from the electronic medical records and whole genome sequencing was performed for families with potentially deleterious variants for genetic ancestry analysis.Results: Over the study period, 58 probands were referred for genetic testing, equivalent to 0.1% of the population. Five variants were identified: GCK p.F133L, GCK p.D205E, HNF1A c.1108G>T, HNF1B p.Q182*, HNF4A -178A>G. These variants were found in 11 probands and 19 family members, equivalent to a population prevalence of monogenic diabetes of 0.05%. Local ancestry analysis revealed that all the variants were found exclusively in Inuit haplotypes, despite all individuals being admixed with both Inuit and European genetic ancestry.Conclusions: We show that the rate of referral and prevalence of monogenic diabetes is substantially higher in Greenland than in other populations and that both rare and more common population-specific variants of Inuit genetic ancestry contribute to the high prevalence.","PeriodicalId":93918,"journal":{"name":"Canadian journal of diabetes","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143075698","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Endocrinologists' Acceptability and Implementation of Hemoglobin A1c Targets among Adults with Type 1 Diabetes. 内分泌学家对成人1型糖尿病患者糖化血红蛋白指标的接受度和实施

Canadian journal of diabetes Pub Date : 2025-01-15 DOI: 10.1016/j.jcjd.2024.12.005

Sanchit Kaushal, Patience Fakembe, Ilana J Halperin, Gillian A Hawker, Alanna Weisman

{"title":"Endocrinologists' Acceptability and Implementation of Hemoglobin A1c Targets among Adults with Type 1 Diabetes.","authors":"Sanchit Kaushal, Patience Fakembe, Ilana J Halperin, Gillian A Hawker, Alanna Weisman","doi":"10.1016/j.jcjd.2024.12.005","DOIUrl":"https://doi.org/10.1016/j.jcjd.2024.12.005","url":null,"abstract":"Aims: Attainment of the A1C target of ≤7.0% is consistently low among those living with type 1 diabetes (T1D). We evaluated endocrinologists' acceptability and implementation of A1C targets.Methods: All 309 adult endocrinologists in Ontario were invited to complete an online questionnaire between October 31, 2023 and Jan 16, 2024. The questionnaire consisted of four sections: 1) Acceptability of the A1C target of ≤7.0%, evaluated by agreement with statements pertaining to the seven domains of the Theoretical Framework of Acceptability (TFA); 2) Endocrinologists' perceptions of patient attainment of A1C targets, frequency of setting and discussing A1c targets, common targets used, and open-ended questions regarding A1C targets; 3) Influence of patient characteristics on selecting individualized A1C targets different from 7.0%; and 4) Respondent characteristics.Results: 148 endocrinologists (48%) completed the questionnaire. Endocrinologists agreed that the A1C target of ≤7.0% is important (87% agreed or strongly agreed) and the correct threshold (75% agreed or strongly agreed). However, endocrinologists over-estimated A1C target attainment among their own patients, and recognized the A1C target of <7.0% may be unrealistic for patients, difficult to achieve, and could cause patient distress. Patients' psychosocial characteristics (such as mental health disorders) and use of technologies (such as continuous glucose monitors and automated insulin delivery systems) emerged as important yet previously under-emphasized factors when selecting individualized A1C targets.Conclusions: Endocrinologists endorsed the A1C target of ≤7.0%, yet simultaneously expressed concerns regarding its feasibility. Future studies should evaluate how this discrepancy might impact physician discussions and counselling regarding A1C targets.","PeriodicalId":93918,"journal":{"name":"Canadian journal of diabetes","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143018327","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

"Critical Insights on Promoting Self-Management in Adults with Type 2 Diabetes: Development and Validation of the Glucose Monitoring Impact Scale." “促进成人2型糖尿病患者自我管理的关键见解：血糖监测影响量表的开发和验证。”

Canadian journal of diabetes Pub Date : 2025-01-13 DOI: 10.1016/j.jcjd.2024.12.007

Saad Khan, Fatima Naveed, Ayesha Khan, Rizwan Ahmad, Faraz Arshad

引用次数: 0

Describing a Transition to Adult Type 1 Diabetes Care Model at the McGill University Health Centre. 描述在麦吉尔大学健康中心过渡到成人1型糖尿病护理模式。

Canadian journal of diabetes Pub Date : 2024-12-26 DOI: 10.1016/j.jcjd.2024.12.001

Samantha Jacobson, Isabella Albanese, Jonathan-Raphaël Stetco, Natasha Garfield

{"title":"Describing a Transition to Adult Type 1 Diabetes Care Model at the McGill University Health Centre.","authors":"Samantha Jacobson, Isabella Albanese, Jonathan-Raphaël Stetco, Natasha Garfield","doi":"10.1016/j.jcjd.2024.12.001","DOIUrl":"https://doi.org/10.1016/j.jcjd.2024.12.001","url":null,"abstract":"Aims: To describe a type 1 diabetes melllitus (T1DM) transition care model by assessing clinic attendance, glycemic management, and diabetes-related hospitalizations.Methods: This is a descriptive longitudinal single-center study of patients with T1DM aged 18 to 25 referred to our transition clinic from 2012 to 2021 (N=179).Results: Our data analysis demonstrates an average clinic attendance rate of 79% and mean time between last pediatric and first adult visit of 6.9 months ± 5.8. HbA1c at last pediatric visit, first and last transition visit were 8.92 ± 1.84%, 9.03 ± 1.84%, and 8.47 ± 1.74%, respectively. There was no change of frequency of diabetes-related hospitalizations after transfer to transition clinic.Conclusion: Youth attending our transition clinic had high clinic attendance and improved glycemic management at their last transition visit compared to the last pediatric visit without an increase in diabetes-related hospitalizations. This highlights the potential importance of comprehensive support in addressing psychosocial and lifestyle challenges during the critical transition period from pediatric to adult care.","PeriodicalId":93918,"journal":{"name":"Canadian journal of diabetes","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142901230","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Impact of Resistance Training and Diabetes Education on Physical Functioning, Frailty Status, and Glycemia in Older Adults with Short- and Long-Duration Type 2 Diabetes: A Secondary Analysis of the Band-Frail Study. 抗阻训练和糖尿病教育对患有短期和长期2型糖尿病的老年人身体功能、虚弱状态和血糖的影响：对band -脆弱研究的二次分析

Canadian journal of diabetes Pub Date : 2024-12-26 DOI: 10.1016/j.jcjd.2024.12.002

Amy M Thomson, Isaac C Cull, Logan E Peskett, Danielle R Bouchard, Martin Sénéchal

{"title":"The Impact of Resistance Training and Diabetes Education on Physical Functioning, Frailty Status, and Glycemia in Older Adults with Short- and Long-Duration Type 2 Diabetes: A Secondary Analysis of the Band-Frail Study.","authors":"Amy M Thomson, Isaac C Cull, Logan E Peskett, Danielle R Bouchard, Martin Sénéchal","doi":"10.1016/j.jcjd.2024.12.002","DOIUrl":"https://doi.org/10.1016/j.jcjd.2024.12.002","url":null,"abstract":"Background: Diabetes duration is an underappreciated risk factor in type 2 diabetes (T2DM) management that can increase the risk of complications and potentially decrease the effectiveness of lifestyle interventions. However, whether T2DM duration impacts the efficacy of an elastic band resistance training intervention for older adults living with comorbid T2DM and frailty is unclear.Objective: This analysis aimed to investigate the impact of a 16-week elastic band resistance training and diabetes education intervention on physical functioning, glycemia, and frailty in older adults of different T2DM durations.Methods: This secondary analysis of the Band-Frail Study includes 130 adults (>65 years) living with T2DM and pre-frailty/frailty who completed 16 weeks of elastic band resistance training and diabetes education. Participants were categorized as 1) short-duration T2DM (<10 years) and 2) long-duration T2DM (>10 years). Outcome measures included physical functioning (Short Physical Performance Battery), glycemia (A1c), and frailty (Fried's Frailty scale).Results: Participants in both the short- and long-duration T2DM groups improved in physical functioning and frailty status post-intervention (p <0.05). The long-duration group improved A1c significantly more than the short-duration group (p =0.03).Conclusion: Our findings suggest that older adults, irrespective of T2DM duration, improve physical functioning and frailty status after 16 weeks of elastic band resistance training and diabetes education, and that longer-duration T2DM is associated with greater improvements in A1c.","PeriodicalId":93918,"journal":{"name":"Canadian journal of diabetes","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142901234","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Possible drug-interaction between elexacaftor-tezacaftor-ivacaftor and repaglinide in an adult with cystic fibrosis-related diabetes. 在囊性纤维化相关性糖尿病成人患者中，elexafor - tezacafor -ivacaftor与瑞格列奈之间可能的药物相互作用。

Canadian journal of diabetes Pub Date : 2024-12-26 DOI: 10.1016/j.jcjd.2024.12.003

Mirna Gerges, Meredith Chiasson, Carly Nichols, Nancy Morrison, Barna De

引用次数: 0

Switching From Open-source to Commercial Advanced Automated Insulin Delivery System: Glucose Management and Patient Perspective in an Adult Living With Type 1 Diabetes. 从开源到商业化先进自动化胰岛素输送系统的转换：1型糖尿病成人患者的血糖管理和患者观点

Canadian journal of diabetes Pub Date : 2024-12-24 DOI: 10.1016/j.jcjd.2024.12.004

Maha Lebbar, Anne Bonhoure, Rémi Rabasa-Lhoret, Zekai Wu

引用次数: 0

Pharmacologic Glycemic Management of Type 2 Diabetes in Adults-2024 Update: An Opportunity Lost to Move Beyond First-Line Metformin. 成人2型糖尿病的药理学血糖管理-2024更新：失去了一线二甲双胍之外的机会。

Canadian journal of diabetes Pub Date : 2024-12-03 DOI: 10.1016/j.jcjd.2024.11.007

Jill Trinacty, Ronald M Goldenberg

引用次数: 0

Are Diabetes Prevention Programs Reaching Those Most at Risk? A Scoping Review. 糖尿病预防项目对高危人群有效吗？范围审查。

Canadian journal of diabetes Pub Date : 2024-11-29 DOI: 10.1016/j.jcjd.2024.11.006

Cara E Johnston, Megan M MacPherson, Mary E Jung

{"title":"Are Diabetes Prevention Programs Reaching Those Most at Risk? A Scoping Review.","authors":"Cara E Johnston, Megan M MacPherson, Mary E Jung","doi":"10.1016/j.jcjd.2024.11.006","DOIUrl":"10.1016/j.jcjd.2024.11.006","url":null,"abstract":"Objectives: Previous reviews have highlighted the efficacy of lifestyle diabetes prevention programs (DPPs) in decreasing type 2 diabetes (T2D) risk, but the participating populations were predominantly white. This is concerning as ethnically diverse populations are disproportionately affected by T2D. The objective of this scoping review was to: 1) summarize existing tailored DPPs and 2) provide recommendations for future program implementation to improve access and reach for diverse populations.Methods: This work represents a subanalysis of a larger scoping review synthesizing DPPs. Several databases were searched for studies relating to T2D risk and lifestyle programs. Study characteristics were systematically extracted using the Template for Intervention Description and Replication checklist.Results: Of 25,110 screened publications, 351 (220 programs) were included in the larger review. Only 29% (64 programs) of the 220 programs were identified as specifically serving ethnically diverse populations and were included in this subanalysis. An updated search was run that identified an additional 10 publications (10 programs). Over a third (35%) of programs reported strategies used to tailor their intervention to the target population; of those that reported, 62% tailored the content of the intervention to be culturally appropriate and relevant as well as accommodate the geographic and cultural context.Conclusions: Based on recruitment, tailoring, and provision strategies used in DPPs targeting specific underresourced populations, this review provides recommendations on how future program developers can increase access and reach, improving individual- and population-level health outcomes via T2D reduction in those at highest risk.","PeriodicalId":93918,"journal":{"name":"Canadian journal of diabetes","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142774841","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

How to Improve Attendance for Diabetic Retinopathy Screening: Ideas and Perspectives From People With Type 2 Diabetes and Health-care Professionals. 如何提高糖尿病视网膜病变筛查的出勤率？来自2型糖尿病患者和医疗保健专业人员的想法和观点。

Canadian journal of diabetes Pub Date : 2024-11-29 DOI: 10.1016/j.jcjd.2024.11.004

Gabriela B Petersen, Lene E Joensen, Jette K Kristensen, Henrik Vorum, Stine Byberg, Mia V Fangel, Bryan Cleal

{"title":"How to Improve Attendance for Diabetic Retinopathy Screening: Ideas and Perspectives From People With Type 2 Diabetes and Health-care Professionals.","authors":"Gabriela B Petersen, Lene E Joensen, Jette K Kristensen, Henrik Vorum, Stine Byberg, Mia V Fangel, Bryan Cleal","doi":"10.1016/j.jcjd.2024.11.004","DOIUrl":"10.1016/j.jcjd.2024.11.004","url":null,"abstract":"Objectives: Our aim in this study was to identify how to improve diabetic retinopathy screening from the perspectives of people with type 2 diabetes and health-care professionals and to elicit their thoughts on initiatives to increase attendance.Methods: A total of 38 semistructured interviews were conducted with people with type 2 diabetes (n=20), general practitioners (n=10), and ophthalmic staff (n=8). The interviews examined ideas for improving screening and elicited feedback on 3 initiatives: getting a fixed appointment; same-day screening; and outsourcing screening to general practice, including the use of artificial intelligence (AI). Data analysis was guided by content analysis approaches.Results: Ideas for improving screening were centred around reducing the inconvenience of attendance, making appointment scheduling easier, and improving health-care professionals' communication. Participants recognized the potential benefits of the initiatives but expressed important reservations to consider. Concerns included the following: that a fixed appointment would cause less active patient involvement and negatively affect attendance; that same-day screening may result in loss of patient-provider communication; that people with type 2 diabetes may be uneasy with having the screening performed outside the eye clinic; and that health-care professionals were concerned about the finances, validity, and examination quality associated with outsourcing screening and using AI.Conclusions: Participants' thoughts on how to improve diabetic retinopathy screening should be seen as starting points for potential future interventions. Although outsourcing screening and the use of AI have gained traction, our study indicates that the target population has reservations that are important to consider in future development and implementation of such strategies.","PeriodicalId":93918,"journal":{"name":"Canadian journal of diabetes","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142775267","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0