Canadian journal of diabetes最新文献

{"title":"A diabetes peer mentorship program for First Nations youth and young adults: An intervention protocol.","authors":"Sahar Fazeli, Jonathan Linton, Paul Linton, Lucy Trapper, Catherine Godin, Helene Porada, Deborah Da Costa, Kaberi Dasgupta, Isabelle Malhame, Claudia Mitchell, Elham Rahme, Julia Elisabeth Von Oettingen, Romina Pace","doi":"10.1016/j.jcjd.2025.07.003","DOIUrl":"https://doi.org/10.1016/j.jcjd.2025.07.003","url":null,"abstract":"<p><p>The rising incidence of type 2 diabetes (T2D) among Indigenous peoples, exacerbated by historical injustices and health inequities, underscores the need for culturally-sensitive health interventions that address both the physiological and psychological burdens of diabetes. This research protocol describes a community-driven initiative aimed at enhancing diabetes management among Indigenous youth and young adults in Canada, leveraging the lived experience and leadership of Indigenous young adults. This project seeks to integrate traditional Indigenous practices with modern health strategies to foster better health outcomes and psychosocial support through peer mentorship. The program, developed and led by an Eeyou Istchee (EI) Cree community member, involves various health-promoting activities including dietary guidance, physical exercise, and traditional land-based practices. These activities are designed to improve self-management of diabetes and to address diabetes distress (DD), a significant factor in diabetes care. Anticipated outcomes include improved psychosocial factors (reduced distress and enhanced resilience) and clinical measures of diabetes management (glycemia, body mass index, blood pressure). The project's methodology combines quantitative assessments of psychological and health outcomes with qualitative feedback from participants, captured through innovative methods like Photovoice to ensure participants' voices and experiences directly inform the intervention's efficacy and adaptability. Overall, this protocol outlines a framework for a scalable, sustainable model of health intervention that respects and revitalizes Indigenous cultural practices and community autonomy. The expected results aim to demonstrate the effectiveness of peer-led and culturally-informed interventions in improving psychological and health outcomes, with the potential to guide similar initiatives in other Indigenous and marginalized communities worldwide.</p>","PeriodicalId":93918,"journal":{"name":"Canadian journal of diabetes","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144755437","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ten-fold Insulin Icodec Overdose: A Case Report.","authors":"Kara Hawker, Justin Morein, Gurleen Gill, Irena Druce","doi":"10.1016/j.jcjd.2025.07.005","DOIUrl":"https://doi.org/10.1016/j.jcjd.2025.07.005","url":null,"abstract":"","PeriodicalId":93918,"journal":{"name":"Canadian journal of diabetes","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144736068","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multidisciplinary Lifestyle Intervention in a Clinical Setting Leads to Remission of Type 2 Diabetes, Prediabetes, and Early Insulin Resistance.","authors":"Christopher Gudas-Cantin, Valérie Dionne, Élise Latour, Karine Lamoureux, Lyne Chevrefils, Chantal Gariepy, Marie-Hélène Morissette C, Lina Mokdad, Juliette Morin, Sarah-Maude Martin, Mathieu Gayda, Florent Besnier, Sara Desmarais, Anil Nigam, Philippe L L'Allier, Véronique Pelletier, Annie Berthiaume, Martin Juneau, Louis Bherer, Josep Iglesies-Grau","doi":"10.1016/j.jcjd.2025.07.004","DOIUrl":"https://doi.org/10.1016/j.jcjd.2025.07.004","url":null,"abstract":"<p><strong>Introduction: </strong>Trials using intensive lifestyle interventions have demonstrated remission of type 2 diabetes mellitus (T2DM), but data on real-world clinical approaches remain limited.</p><p><strong>Methods: </strong>This retrospective analysis evaluates a 12-month clinical remission program for individuals with T2DM (A1C ≥ 6.5%), prediabetes (A1C 5.7%-6.4%), and early insulin resistance (IR, A1C < 5.7%, HOMA-IR ≥ 3). Interventions included six nutrition counseling sessions focused on the Mediterranean diet and a personalized aerobic/resistance training program. Metabolic parameters and body composition (bioimpedance) were assessed at baseline, 3, 6, and 12 months. The primary objective was to evaluate metabolic improvements and remission sustainability at 12 months. Only participants who finished the intervention with complete data were included in this analysis (n=190 of 345 enrolled, 55% of participants).</p><p><strong>Results: </strong>Among 190 participants, mean reductions were: body weight -4.8 kg (95% CI, -5.8 to -3.8; p<0.001), waist circumference -6.3 cm (95% CI, -7.3 to -5.3; p<0.001), and visceral fat -1.0 L (95% CI, -1.3 to -0.7; p<0.001). Participants with T2DM showed a mean A1C reduction of -0.6% (95% CI, -0.9 to -0.3; p<0.001). Sustained remission at 12 months was achieved in 11 (100%) drug-naive T2DM participants, 14 (18%) with prediabetes, 17 (29%) with early IR, and in 1 (2%) T2DM participant on glucose-lowering agents. Glycaemic control (A1C < 6.5%) was achieved in 29 (67%) T2DM participants on glucose-lowering agents, with no participant with prediabetes progressed to T2DM over the 12-month intervention.</p><p><strong>Conclusions: </strong>This 12-month clinical program integrating nutrition counseling and personalized exercise significantly improved metabolic parameters and body composition. Sustained remission of T2DM was achieved in 11 drug-naive participants who completed the intervention, with no progression of prediabetes to T2DM.</p>","PeriodicalId":93918,"journal":{"name":"Canadian journal of diabetes","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144736067","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In The Eye Of Controversy: A Deeper Look Into The Impact Of Glucagon-Like Peptide 1 Receptor Agonists (GLP1RA) on Diabetic Retinopathy and Non-arteritic anterior ischemic optic neuropathy (NAION).","authors":"Nadia Nadeem, Raghad Mazin Al Issa, Asnin Shah, Rahaf Wardeh, Fauzia Rashid, Elamin Ibrahim Abdelgadir, Alaaeldin Bashier","doi":"10.1016/j.jcjd.2025.07.002","DOIUrl":"https://doi.org/10.1016/j.jcjd.2025.07.002","url":null,"abstract":"<p><strong>Introduction: </strong>Glucagon-like peptide 1 receptor agonists (GLP1RA), a relatively new class of drugs, are widely used in treating type 2 diabetes mellitus and obesity. Maintaining long-term glycemic control lowers the risk of development and progression of diabetic retinopathy. However, recent literature has raised concerns about transient worsening of the condition with GLP1RA use.</p><p><strong>Aim: </strong>This review aims to evaluate the association between GLP1RA and retinopathy in patients with diabetes mellitus. We also analyzed the available evidence on the potential association between Semaglutide therapy and non-arteritic anterior ischemic optic neuropathy (NAION).</p><p><strong>Materials and methods: </strong>The review consists of relevant publications, including metanalysis, randomized control trials, and post-hoc analysis, including outcomes of in vitro and in vivo research. Article search was conducted using several databases, including the WorldCat Discovery service provided by Al Maktoum Medical Library, PubMed, and Google Scholar.</p><p><strong>Conclusion: </strong>Preclinical studies hint at possible protective effects on the retina, but a more complex picture is presented by clinical evidence. While there have been cases of retinopathy development following GLP1RA use, this might be due to a swift reduction in HbA1C levels rather than the drug's mechanism of action itself. Evidence linking Semaglutide to NAION remains inconclusive and limited by methodological constraints. Large-scale studies with robust design are warranted to elucidate the potential association and to guide clinical practice.</p>","PeriodicalId":93918,"journal":{"name":"Canadian journal of diabetes","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144719263","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"\"Letter to the Editor: The association between insulin regimen and the risk of severe hypoglycemia and mortality in adults with type 2 diabetes. A large population-based retrospective cohort study\".","authors":"Noor Un Nisa, Syeda Sana-E-Zehra Naqvi","doi":"10.1016/j.jcjd.2025.07.001","DOIUrl":"https://doi.org/10.1016/j.jcjd.2025.07.001","url":null,"abstract":"","PeriodicalId":93918,"journal":{"name":"Canadian journal of diabetes","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144710303","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Blood characteristics of patients with type 2 diabetes and response of their peripheral blood mononuclear cells to inhibitors of the NLRP3-inflammasome and caspase-1.","authors":"Joyce de Paula Souza, Justus S Fischer, Karine Jeanneau, Cyril Allard, Eline Angevaare, Dominik Aschenbrenner, Ursula Bodendorf, Benjamin Demarco, John S Gounarides, Saskia Killmer, Jiri Kovarik, Sabina Pfister, Hong Yin, Vithushan Ratnarasa, Marianne Bo Ni-Schnetzler, Matthias Hepprich, Daniel T Meier, Grazyna Wieczorek, Marc Y Donath","doi":"10.1016/j.jcjd.2025.06.008","DOIUrl":"https://doi.org/10.1016/j.jcjd.2025.06.008","url":null,"abstract":"<p><p>Obesity and aging are associated with increased activity of the innate immune system. This chronic systemic inflammation contributes to the development of type 2 diabetes and long-term complications and is partly driven by the activation of the NLRP3 inflammasome. We conducted a comparative analysis of clinical parameters, non-esterified fatty acid (NEFA) profiles, immune cell subsets, and inflammatory responses of peripheral blood mononuclear cells obtained from both healthy individuals and those diagnosed with type 2 diabetes. Plasma NEFA profiling revealed a dysregulation in patients with type 2 diabetes, indicating potential modulation of immune cell responses by lipids, along with leukocytosis, elevated serum levels of inflammatory cytokines, the inflammasome-related protein ASC, IL-1RA, and IL-18BPa. Surprisingly, functional assessments demonstrated comparable NLRP3 inflammasome activity in peripheral blood mononuclear cells (PBMCs) from both groups, suggesting that systemic inflammation in type 2 diabetes is driven by elevated leucocyte numbers or resident tissue macrophages. Treatment of PBMCs with NLRP3 and caspase-1 inhibitors attenuated the release of pro-inflammatory cytokines ex vivo. Therefore, inhibition of inflammasome activation emerges as a promising therapeutic strategy for management of diabetes-related complications.</p>","PeriodicalId":93918,"journal":{"name":"Canadian journal of diabetes","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144621588","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Patient perspectives of the operationalization of adult patient-centered care at the Primary Care Diabetes Support Program, London, Ontario: A Qualitative Descriptive Study.","authors":"Gillian Young, Anika Garg, Dana Ryan, Leslie Meredith, Stewart Harris, Sonja M Reichert, Lindsay Hedden, Maria Mathews","doi":"10.1016/j.jcjd.2025.06.007","DOIUrl":"https://doi.org/10.1016/j.jcjd.2025.06.007","url":null,"abstract":"<p><strong>Background: </strong>Patient-centered care is a hallmark of family medicine, and patient-centered care for diabetes has been associated with better outcomes. The Primary Care Diabetes Support Program (PCDSP) in London, Ontario, uses a patient-centered model of care and targets three groups of patients at high risk for diabetes complications: 1) medically complex, 2) socially complex, and 3) those without a primary care provider. We describe, from the patient's perspectives, how the PCDSP operationalizes patient-centered care.</p><p><strong>Approach: </strong>Using maximum variation sampling, we recruited and interviewed 17 patients regarding their experiences with the PCDSP. We asked patients about the PCDSP's approach to care and its impact on their diabetes management and overall health. We coded interview transcripts using an inductive thematic analysis approach.</p><p><strong>Results: </strong>We identified eight attributes of PCDSP care that aligned with the principles of patient-centered of care: 1) reassurance, 2) education, 3) whole person care, 4) individualized care, 5) high accessibility, 6) co-ordinated care, 7) integration of new technologies, and 8) ownership of care. Participants emphasized that they felt the care they received from the PCDSP was tailored to their individual needs, accessible, coordinated care with other providers, and gave them access to new medications and technologies as well as the latest research on diabetes care.</p><p><strong>Conclusions: </strong>Findings highlight that the PCDSP approach is more holistic than existing patient-centered care models for diabetes described in the literature, which focus on education and skills to improve self-management. The attributes identified are mutually reinforcing, and our findings reflect longitudinal, high-quality primary care approach through the PCDSP.</p>","PeriodicalId":93918,"journal":{"name":"Canadian journal of diabetes","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144577241","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"\"Letter to the Editor: {Do Provincial Formulary Restrictions Explain Differential Uptake of Sodium-Glucose Co-Transporter-2 Inhibitors in Adults with Diabetes and Cardiovascular Disease in Canada? A Retrospective Cohort Study of Pharmacy Claims}\".","authors":"Muhammad Tabish, Hamna Khan, Muhammad Naveed","doi":"10.1016/j.jcjd.2025.06.006","DOIUrl":"https://doi.org/10.1016/j.jcjd.2025.06.006","url":null,"abstract":"","PeriodicalId":93918,"journal":{"name":"Canadian journal of diabetes","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144562270","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"\"Letter to the Editor: Hypertension Treatment and Control in Canadians with Diabetes.\"","authors":"Krishna Jaipal, Sanjana Bebu Punshi, Mehak Kumari Bansari","doi":"10.1016/j.jcjd.2025.06.004","DOIUrl":"https://doi.org/10.1016/j.jcjd.2025.06.004","url":null,"abstract":"","PeriodicalId":93918,"journal":{"name":"Canadian journal of diabetes","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144512851","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter to the Editor: Association between circulating vitamin C concentrations and risk of diabetes mellitus: dual evidence from NHANES database and Mendelian randomization analysis.","authors":"Masashi Hasebe, Chen-Yang Su","doi":"10.1016/j.jcjd.2025.06.005","DOIUrl":"https://doi.org/10.1016/j.jcjd.2025.06.005","url":null,"abstract":"","PeriodicalId":93918,"journal":{"name":"Canadian journal of diabetes","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144509993","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}