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Calcified Tissue Research最新文献

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Effect of 1,25-dihydroxycholecalciferol on adenosine 3',5'-cyclic monophosphate production in calvaria of mice. 1,25-二羟基胆骨化醇对小鼠颅骨3′，5′-环单磷酸腺苷生成的影响。
Calcified Tissue Research Pub Date : 1978-08-18 DOI: 10.1007/BF02010773
U Gebauer, H Fleisch
{"title":"Effect of 1,25-dihydroxycholecalciferol on adenosine 3',5'-cyclic monophosphate production in calvaria of mice.","authors":"U Gebauer,&nbsp;H Fleisch","doi":"10.1007/BF02010773","DOIUrl":"https://doi.org/10.1007/BF02010773","url":null,"abstract":"<p><p>1,25-dihydroxycholecalciferol (1,25-(OH)2D3), added at doses which stimulate bone resorption in the system used, did not increase adenosine 3',5'-cyclic monophosphate (cAMP) production in vitro in mouse calvaria incubated for up to 48 h. Thus 1,25-(OH)2D3 does not appear to stimulate bone resorption through involvement of an increased cAMP production.</p>","PeriodicalId":9389,"journal":{"name":"Calcified Tissue Research","volume":"25 3","pages":"223-5"},"PeriodicalIF":0.0,"publicationDate":"1978-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/BF02010773","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11428542","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Histogenesis of bone cells. 骨细胞的组织发生。
Calcified Tissue Research Pub Date : 1978-08-18 DOI: 10.1007/BF02010770
M Owen
{"title":"Histogenesis of bone cells.","authors":"M Owen","doi":"10.1007/BF02010770","DOIUrl":"https://doi.org/10.1007/BF02010770","url":null,"abstract":"","PeriodicalId":9389,"journal":{"name":"Calcified Tissue Research","volume":"25 3","pages":"205-7"},"PeriodicalIF":0.0,"publicationDate":"1978-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/BF02010770","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11911061","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 45
The morphology of bone mineral crystals. 骨矿物晶体的形态
Calcified Tissue Research Pub Date : 1978-08-18 DOI: 10.1007/BF02010772
S A Jackson, A G Cartwright, D Lewis
{"title":"The morphology of bone mineral crystals.","authors":"S A Jackson,&nbsp;A G Cartwright,&nbsp;D Lewis","doi":"10.1007/BF02010772","DOIUrl":"https://doi.org/10.1007/BF02010772","url":null,"abstract":"<p><p>Electron microscopical observations of the size and shape of bone mineral crystallites have not been in complete agreement with X-ray diffraction findings. The two prevalent viewpoints consider bone mineral crystals to be either rod, or plate like in habit. There appears to be agreement that the smallest dimension of the crystals is about 5 nm, but there is discrepancy in the reported c-axial lengths. The method of dark field imaging is used to obtain a quantitative measurement of the c-axial length distribution in rabbit, ox and human bone: mean c-axial lengths 32.6 nm, 36.2 nm and 32.4 nm, respectively, show no significant difference at the 5% level to the mean c-axial length measured by X-ray line broadening. Both bright and dark field images strongly suggest that bone mineral has a plate like form. Reasons for past discrepancies are discussed.</p>","PeriodicalId":9389,"journal":{"name":"Calcified Tissue Research","volume":"25 3","pages":"217-22"},"PeriodicalIF":0.0,"publicationDate":"1978-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/BF02010772","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11911062","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 79
A bone resorbing substance from bovine serum albumin (brA). 从牛血清白蛋白(brA)中提取的骨吸收物质。
Calcified Tissue Research Pub Date : 1978-08-18 DOI: 10.1007/BF02010775
P H Stern, J C Miller, S F Chen, D J Kahn
{"title":"A bone resorbing substance from bovine serum albumin (brA).","authors":"P H Stern,&nbsp;J C Miller,&nbsp;S F Chen,&nbsp;D J Kahn","doi":"10.1007/BF02010775","DOIUrl":"https://doi.org/10.1007/BF02010775","url":null,"abstract":"","PeriodicalId":9389,"journal":{"name":"Calcified Tissue Research","volume":"25 3","pages":"233-40"},"PeriodicalIF":0.0,"publicationDate":"1978-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/BF02010775","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11911064","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Bone mineral turnover in a patient with osteogenesis imperfecta estimated by fluoride excretion. 通过氟化物排泄估计成骨不全患者的骨矿物质转换。
Calcified Tissue Research Pub Date : 1978-08-18 DOI: 10.1007/BF02010782
G B Forbes, D R Taves, F A Smith, R W Kilpper
{"title":"Bone mineral turnover in a patient with osteogenesis imperfecta estimated by fluoride excretion.","authors":"G B Forbes,&nbsp;D R Taves,&nbsp;F A Smith,&nbsp;R W Kilpper","doi":"10.1007/BF02010782","DOIUrl":"https://doi.org/10.1007/BF02010782","url":null,"abstract":"<p><p>A child with severe osteogenesis imperfecta was treated with NaF for 8 years, at the end of which time his iliac bone contained 29 mg F/g Ca. Urine F was assayed at intervals for 4.5 years after discontinuing treatment. After the first few days the decline in urinary F excretion can be described by a two component exponential function, with half-times of 5.4 months (10%) and 8.9 years (90%). The latter half-time value is of the same order of magnitude as those observed for F and other \"bone-seeking\" elements in normal subjects, which suggests that the turnover rate of bone mineral is normal in this disease. Three methods for estimating the attained body F burden at the end of NaF treatment--namely, metabolic balance, bone biopsy, and integration of the exponential function--yielded comparable values.</p>","PeriodicalId":9389,"journal":{"name":"Calcified Tissue Research","volume":"25 3","pages":"283-7"},"PeriodicalIF":0.0,"publicationDate":"1978-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/BF02010782","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11910015","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 5
A quantitative study of the structure of trabecular bone in man, rhesus monkey, beagle and miniature pig. 人、恒河猴、小猎犬和小型猪小梁骨结构的定量研究。
Calcified Tissue Research Pub Date : 1978-08-18 DOI: 10.1007/BF02010781
A H Beddoe
{"title":"A quantitative study of the structure of trabecular bone in man, rhesus monkey, beagle and miniature pig.","authors":"A H Beddoe","doi":"10.1007/BF02010781","DOIUrl":"https://doi.org/10.1007/BF02010781","url":null,"abstract":"","PeriodicalId":9389,"journal":{"name":"Calcified Tissue Research","volume":"25 3","pages":"273-81"},"PeriodicalIF":0.0,"publicationDate":"1978-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/BF02010781","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11911070","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 16
Philippe Bordier, M.D., 1927--1977. Philippe Bordier，医学博士，1927-1977年。
Calcified Tissue Research Pub Date : 1978-08-18 DOI: 10.1007/BF02010783
F Bronner
{"title":"Philippe Bordier, M.D., 1927--1977.","authors":"F Bronner","doi":"10.1007/BF02010783","DOIUrl":"https://doi.org/10.1007/BF02010783","url":null,"abstract":"","PeriodicalId":9389,"journal":{"name":"Calcified Tissue Research","volume":"25 3","pages":"289"},"PeriodicalIF":0.0,"publicationDate":"1978-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/BF02010783","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11570560","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Changes in organic matrix of bone and of bone and blood ATP in rats fed rachitogenic diets. 鼠源性饲料对骨有机基质及骨和血三磷酸腺苷的影响。
Calcified Tissue Research Pub Date : 1978-08-18 DOI: 10.1007/BF02010776
K C Hong, R L Cruess
{"title":"Changes in organic matrix of bone and of bone and blood ATP in rats fed rachitogenic diets.","authors":"K C Hong,&nbsp;R L Cruess","doi":"10.1007/BF02010776","DOIUrl":"https://doi.org/10.1007/BF02010776","url":null,"abstract":"<p><p>Vitamin D deficient and phosphate deficient states were produced in young rats by the use of synthetic diets. Whole blood ATP, serum calcium and phosphorus and the ash, phospholipid, hexosamine and hydroxyproline contents of metaphyseal bones of control and rachitic rats were measured after 4 weeks on the diets. There was a decrease in whole blood ATP and serum phosphorus of the rachitic rats, and in the contents of ash, phospholipid and hexosamine of the rachitic metaphyses, while the hydroxyproline contents of the rachitic bones were higher than those of the controls. Subcutaneous injection of ATP or inorganic phosphate in rats, fed a low phosphate diet deficient in vitamin D, caused an increase in serum phosphorus and blood ATP levels and in metaphyseal ash contents. It is suggested that some of the metabolic disturbances in rickets are due to alteration in ATP production.</p>","PeriodicalId":9389,"journal":{"name":"Calcified Tissue Research","volume":"25 3","pages":"241-4"},"PeriodicalIF":0.0,"publicationDate":"1978-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/BF02010776","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11911065","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Fetal rat bone in organ culture: effect of bone growth and bone atrophy on the comparative losses of 45Ca and 3H-tetracycline. 器官培养胎鼠骨:骨生长和骨萎缩对45Ca和3h四环素相对损失的影响。
Calcified Tissue Research Pub Date : 1978-08-18 DOI: 10.1007/BF02010779
T L Chen, L Klein
{"title":"Fetal rat bone in organ culture: effect of bone growth and bone atrophy on the comparative losses of 45Ca and 3H-tetracycline.","authors":"T L Chen,&nbsp;L Klein","doi":"10.1007/BF02010779","DOIUrl":"https://doi.org/10.1007/BF02010779","url":null,"abstract":"<p><p>Fetal rat bones were cultured in either growth-inducing or resorption-inducing media to study mineral losses during bone growth and atrophy in vitro. Whole radii and ulnae from 19-day-old fetal rats, prelabeled with 45Ca and/or 3H-tetracycline, were cultured intact or cut, and then digested by collagenase to obtain the calcified portion of the bones. Three- to five-fold more 3H-tetracycline than 45Ca was lost from the calcified portion when the bones were cultured for 4 days in growth-inducing media. Similar small amounts of 45Ca were lost from live and killed bones, but more 3H-tetracycline was lost from live bones than from killed bones. More 3H-tetracycline was released into the growth medium with a low concentration of calcium (0.5 mM) than when the calcium concentration was high (1.0 mM); no significant difference was seen in the release of 45Ca into the medium at different calcium concentrations. Larger amounts of both isotopes were lost when the prelabeled bones were cultured in resorption-inducing media than in growth-inducing media. When parathyroid hormone stimulated bone resorption in a resorption-inducing medium, equal proportions of both isotopes and bone collagen were lost. Greater losses of 3H-tetracycline than of 45Ca suggest that 45Ca was conserved locally during the resorption that accompanies bone growth, but not during resorption that accompanies bone atrophy.</p>","PeriodicalId":9389,"journal":{"name":"Calcified Tissue Research","volume":"25 3","pages":"255-63"},"PeriodicalIF":0.0,"publicationDate":"1978-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/BF02010779","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11911068","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 6
Quantitative measurement of fractional bone volume using digital scanning videodensitometry. 用数字扫描视频密度法定量测量骨体积分数。
Calcified Tissue Research Pub Date : 1978-08-18 DOI: 10.1007/BF02010780
R A Robb, J Jowsey
{"title":"Quantitative measurement of fractional bone volume using digital scanning videodensitometry.","authors":"R A Robb,&nbsp;J Jowsey","doi":"10.1007/BF02010780","DOIUrl":"https://doi.org/10.1007/BF02010780","url":null,"abstract":"<p><p>A method is described for reproducible and rapid quantitative measurements of fractional bone volume in sections of a bone biopsy. The presence or absence of bone is determined at several thousand points over the entire surface area of each specimen by high-speed digitization and computer analysis of video scans of enlarged microradiographic images of bone sections. An operator interactive light-pen assembly permits selective delineation of desired areas of the video image to facilitate computation of regional bone mass within each specimen. Tests of the reproducibility of the method of performed and are described. The results obtained from application of the method to determine the amount of bone in various age groups and in two groups of patients before and after therapy are also presented. These data indicate the potential of this technique for high volume, high resolution measurements of the fractional bone volume in both investigative and clinical diagnostic studies of age dependent and disease dependent processes.</p>","PeriodicalId":9389,"journal":{"name":"Calcified Tissue Research","volume":"25 3","pages":"265-71"},"PeriodicalIF":0.0,"publicationDate":"1978-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/BF02010780","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11911069","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
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