Best practice & research. Clinical endocrinology & metabolism最新文献

Pregnancy with primary hyperparathyroidism.

Best practice & research. Clinical endocrinology & metabolism Pub Date : 2025-02-27 DOI: 10.1016/j.beem.2025.101983

Rimesh Pal, Soham Mukherjee, Trupti N Prasad, Sanjay Kumar Bhadada

引用次数: 0

Predominantly cystic craniopharyngiomas: Current management approaches, outcomes and limitations.

Best practice & research. Clinical endocrinology & metabolism Pub Date : 2025-02-05 DOI: 10.1016/j.beem.2025.101981

Francesco Calvanese, Gianpaolo Jannelli, Camille Sergeant, Romain Manet, Loic Feuvret, François Ducray, Gèrarld Raverot, Emmanuel Jouanneau

引用次数: 0

Congenital primary hyperparathyroidism.

Best practice & research. Clinical endocrinology & metabolism Pub Date : 2025-01-31 DOI: 10.1016/j.beem.2025.101982

Francesca Marini, Francesca Giusti, Maria Luisa Brandi

引用次数: 0

Changing trends in clinical presentation of primary hyperparathyroidism across countries over time.

Best practice & research. Clinical endocrinology & metabolism Pub Date : 2025-01-28 DOI: 10.1016/j.beem.2025.101980

Durairaj Arjunan, Salvatore Minisola, Sudhaker D Rao, Sanjay K Bhadada

{"title":"Changing trends in clinical presentation of primary hyperparathyroidism across countries over time.","authors":"Durairaj Arjunan, Salvatore Minisola, Sudhaker D Rao, Sanjay K Bhadada","doi":"10.1016/j.beem.2025.101980","DOIUrl":"https://doi.org/10.1016/j.beem.2025.101980","url":null,"abstract":"Primary hyperparathyroidism (PHPT), the third most common endocrine disorder, was so eloquently described first by Fuller Albright as a polymorphic condition in his classic paper and monograph as early as 1934. Over the decades, the clinical presentation of PHPT in developed countries has shifted significantly from a disease primarily affecting the bones and kidneys to an asymptomatic condition often discovered incidentally. In developing countries, the high prevalence of vitamin D deficiency is one of the main factors influencing the clinical presentation of PHPT. In Europe and North America, PHPT is predominantly asymptomatic. In South America, China, and Eastern parts of Europe, such as Turkey, Bulgaria, and Russia, there is an ongoing transition from symptomatic to asymptomatic cases. Asia shows variability: symptomatic cases dominate in the Indian subcontinent, Middle East, and Southeast Asia, while transitional patterns with predominant asymptomatic cases have now been reported in China, and Japan reports mostly asymptomatic cases. Factors influencing these changes include advancements in diagnostic technologies, detection of incidental parathyroid adenomas during thyroid ultrasonography, regional differences in vitamin D deficiency, dietary habits, and genetic polymorphisms in vitamin D and calcium-sensing receptors. A higher prevalence of nephrolithiasis in certain climates contributes to regional variations. This review examines the dynamic nature of PHPT's clinical presentation, shaped by geographic, genetic, and environmental influences. Also, this review highlights the importance of addressing global disparities in an attempt to optimize patient outcomes.","PeriodicalId":93894,"journal":{"name":"Best practice & research. Clinical endocrinology & metabolism","volume":" ","pages":"101980"},"PeriodicalIF":0.0,"publicationDate":"2025-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143371407","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association of primary hyperparathyroidism with pituitary adenoma and management issues.

Best practice & research. Clinical endocrinology & metabolism Pub Date : 2025-01-28 DOI: 10.1016/j.beem.2025.101978

Liza Das, Pinaki Dutta

{"title":"Association of primary hyperparathyroidism with pituitary adenoma and management issues.","authors":"Liza Das, Pinaki Dutta","doi":"10.1016/j.beem.2025.101978","DOIUrl":"https://doi.org/10.1016/j.beem.2025.101978","url":null,"abstract":"The co-occurrence of primary hyperparathyroidism (PHPT) and pituitary adenomas (PAs) is often indicative of underlying genetic syndromes such as Multiple Endocrine Neoplasia type 1 (MEN1) and, less commonly, MEN4. Although both conditions can occur sporadically, their simultaneous presence warrants evaluation for genetic mutations, with MEN1 mutations being the most frequent cause. The management of concurrent PHPT and PAs, especially in MEN1 patients, presents unique challenges. Management complexities arise from the syndromic nature, involving both surgical and medical interventions tailored to each condition. PHPT often manifests earlier and more aggressively in MEN1, requiring surgical intervention. However, recurrence rates remain high due to multiglandular involvement. Pituitary adenomas in MEN1 are primarily prolactinomas, and treatment with dopamine agonists results in significant tumour control in most cases. Overall, PAs associated with MEN1 are generally responsive to medical therapy, but careful long-term monitoring is essential. The utility of genetic screening cannot be overstated, as it aids in early detection, risk stratification, and management of both the index case and affected family members by cascade screening. A multidisciplinary approach is crucial for optimizing outcomes, with ongoing surveillance to manage recurrence and associated complications. In summary, the co-occurrence of PHPT and PAs, particularly in the context of MEN1, necessitates an integrated management strategy. Genetic testing is key in confirming diagnosis and guiding treatment, while surgical and medical interventions should be tailored to the extent and nature of glandular involvement. Close monitoring for recurrence and proactive family screening are essential components of long-term care.","PeriodicalId":93894,"journal":{"name":"Best practice & research. Clinical endocrinology & metabolism","volume":" ","pages":"101978"},"PeriodicalIF":0.0,"publicationDate":"2025-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143367053","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Adolescent primary hyperparathyroidism. 青少年原发性甲状旁腺功能亢进。

Best practice & research. Clinical endocrinology & metabolism Pub Date : 2025-01-10 DOI: 10.1016/j.beem.2025.101975

Anima Sharma, Saba Samad Memon, Manjiri Karlekar, Tushar Bandgar

{"title":"Adolescent primary hyperparathyroidism.","authors":"Anima Sharma, Saba Samad Memon, Manjiri Karlekar, Tushar Bandgar","doi":"10.1016/j.beem.2025.101975","DOIUrl":"https://doi.org/10.1016/j.beem.2025.101975","url":null,"abstract":"Adolescent primary hyperparathyroidism (PHPT) is a rare endocrine disorder bearing distinctions from the adult form. This review examines its unique aspects, focusing on clinical presentation, genetic etiologies, genotype-phenotype correlations, and therapeutic management. Adolescent PHPT often has a genetic basis, whether familial, syndromic, or apparently sporadic, and identifying the underlying genetic cause is important for patient care. The clinical presentation is predominantly symptomatic worldwide. Unique manifestations in this age group include rickets, short stature, and slipped capital femoral epiphysis. Genotype-specific differences are evident in the adolescent PHPT characteristics. Diagnostic evaluation requires careful interpretation of biochemical and dual-energy X-ray absorptiometry findings using age and gender-specific reference ranges, with targeted screening for syndrome-associated neoplasms. Surgery remains the cornerstone of management. Current knowledge gaps in their management include treatment protocols for multiple endocrine neoplasia type 1-associated PHPT, the efficacy and safety of nonsurgical options, and long-term post-surgical outcomes.","PeriodicalId":93894,"journal":{"name":"Best practice & research. Clinical endocrinology & metabolism","volume":" ","pages":"101975"},"PeriodicalIF":0.0,"publicationDate":"2025-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143018079","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Localization in primary hyperparathyroidism. 原发性甲状旁腺功能亢进的定位。

Best practice & research. Clinical endocrinology & metabolism Pub Date : 2024-12-30 DOI: 10.1016/j.beem.2024.101967

Piyush Aggarwal, Vinisha Gunasekaran, Ashwani Sood, Bhagwant Rai Mittal

{"title":"Localization in primary hyperparathyroidism.","authors":"Piyush Aggarwal, Vinisha Gunasekaran, Ashwani Sood, Bhagwant Rai Mittal","doi":"10.1016/j.beem.2024.101967","DOIUrl":"https://doi.org/10.1016/j.beem.2024.101967","url":null,"abstract":"Primary hyperparathyroidism is the main cause of hypercalcemia, resulting predominantly from parathyroid adenomas followed by hyperplasia. Diagnosis relies on clinical and biochemical parameters. Accurate pre-operative localization is mandatory for better surgical outcome. Various non-invasive imaging modalities includes cervical ultrasound, radionuclide scintigraphy with 99mTc-Methoxyisobutyl isonitrile combined with SPECT/CT, 4DCT, MRI and 18F-Choline PET/CT. Functional imaging has shown higher accuracy in localization especially in ectopic parathyroid adenomas and persistent or recurrent hyperparathyroidism. Combined ultrasound and 99mTc-MIBI has shown high sensitivity and specificity than individual imaging modality. 18F-Choline PET/CT has better diagnostic performance in identifying parathyroid hyperplasia and multiple adenomas. In patients with equivocal findings and concurrent thyroid nodular diseases, 18F-Choline PET/MRI and 4DCT helps in better characterization of lesion. Intraoperative probe guided surgery facilitates targeted and minimally invasive surgery resulting in better surgical outcome. More specific radiopharmaceuticals for parathyroid imaging need to be developed to reduce false positive results.","PeriodicalId":93894,"journal":{"name":"Best practice & research. Clinical endocrinology & metabolism","volume":" ","pages":"101967"},"PeriodicalIF":0.0,"publicationDate":"2024-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142928740","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Parathyroid carcinoma: New insights. 甲状旁腺癌：新见解。

Best practice & research. Clinical endocrinology & metabolism Pub Date : 2024-12-27 DOI: 10.1016/j.beem.2024.101966

Abhishek Viswanath, Eftychia E Drakou, Fannie Lajeunesse-Trempe, Ashley B Grossman, Georgios K Dimitriadis

{"title":"Parathyroid carcinoma: New insights.","authors":"Abhishek Viswanath, Eftychia E Drakou, Fannie Lajeunesse-Trempe, Ashley B Grossman, Georgios K Dimitriadis","doi":"10.1016/j.beem.2024.101966","DOIUrl":"https://doi.org/10.1016/j.beem.2024.101966","url":null,"abstract":"Parathyroid carcinoma (PC) is a rare malignancy, comprising 1 % of all cases of primary hyperparathyroidism (PHPT). This narrative review explores recent advances in PC management, with a focus on molecular insights, diagnostic advancements, surgical innovations, and emerging targeted therapies. Manuscripts published between 2023 and 2024 were obtained from PubMed, EMBASE, and the Cochrane Central Register of Controlled Trials (CENTRAL). The review highlights advances in biochemical markers, such as circulating tumour cells (CTCs), and imaging modalities such as 18F-FDG PET/CT and 4D-CT, which are improving diagnostic accuracy. Surgical resection remains central to localised and metastatic disease management. For patients with widespread metastatic or unresectable disease, newer targeted approaches such as tyrosine kinase inhibitors (TKIs), temozolomide, and immune checkpoint inhibitors (ICIs) may offer clinical benefit to specific patient cohorts. This review identifies future research areas to improve outcomes and recommends that patients with advanced PC continue to be managed in centres of excellence.","PeriodicalId":93894,"journal":{"name":"Best practice & research. Clinical endocrinology & metabolism","volume":" ","pages":"101966"},"PeriodicalIF":0.0,"publicationDate":"2024-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142916546","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Autoimmune Addison's disease. 自身免疫性艾迪生病。

Best practice & research. Clinical endocrinology & metabolism Pub Date : 2020-01-01 DOI: 10.1056/nejm196312122692422

Serena Saverino, A. Falorni

引用次数: 10

Puberty. 青春期。

Best practice & research. Clinical endocrinology & metabolism Pub Date : 2019-02-15 DOI: 10.1002/9781119386230.ch5

M. Zacharin

引用次数: 0