男性早发性腺功能减退的心脏代谢结果。

IF 6.1 1区医学 Q1 ENDOCRINOLOGY & METABOLISM

Best practice & research. Clinical endocrinology & metabolism Pub Date : 2025-07-01 DOI:10.1016/j.beem.2025.102004

Mariska Peck (Academic Foundation Programme Doctor) , Paul Connelly (Consultant in Endocrinology) , Angela K. Lucas-Herald (Senior Lecturer in Child Health, Honorary Consultant in Paediatric Endocrinology)

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引用次数: 0

摘要

睾酮是一种重要的血管激素，对脉管系统有多种作用。因此，早发性腺功能减退的男孩和男性可能会改变心血管功能，有可能导致成年后不良的心脏代谢结果。鉴于年轻人的心血管变化会影响未来的心血管健康，有必要更好地了解雄激素对46、XY性发育障碍和Klinefelter综合征等疾病患者血管系统的影响。这篇综述总结了关于性腺功能减退的已知知识和睾酮补充对成年性腺功能减退的影响，以及目前对早期性腺功能减退的理解。在这一领域仍然存在一些研究差距，需要进行国际合作研究，为受影响的后代解决这些问题。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Cardiometabolic outcomes of early onset hypogonadism in males

Testosterone is an important vascular hormone, with multiple effects reported on the vasculature. As such, boys and men with early onset hypogonadism may have altered cardiovascular function, with the potential to result in adverse cardiometabolic outcomes in adulthood. Given the fact that cardiovascular changes in the young can affect future cardiovascular health, there is a need to better understand the influence of androgens on the vasculature in those with conditions such as 46, XY Disorders of Sex Development and Klinefelter Syndrome. This review summarises what is known about hypogonadism and the effects of testosterone supplementation in adults with hypogonadism, as well as what is currently understood in those with early onset hypogonadism specifically. A number of research gaps persist in this area and there is a need for international collaborative studies to address these for future generations of affected individuals.

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来源期刊

Best practice & research. Clinical endocrinology & metabolism 医学-内分泌学与代谢

CiteScore

11.90

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： Best Practice & Research Clinical Endocrinology & Metabolism is a serial publication that integrates the latest original research findings into evidence-based review articles. These articles aim to address key clinical issues related to diagnosis, treatment, and patient management. Each issue adopts a problem-oriented approach, focusing on key questions and clearly outlining what is known while identifying areas for future research. Practical management strategies are described to facilitate application to individual patients. The series targets physicians in practice or training.